KEGG   PATHWAY: mmer00983
Entry
mmer00983                   Pathway                                
Name
Drug metabolism - other enzymes - Mercenaria mercenaria (northern quahog)
Class
Metabolism; Xenobiotics biodegradation and metabolism
Pathway map
mmer00983  Drug metabolism - other enzymes
mmer00983

Organism
Mercenaria mercenaria (northern quahog) [GN:mmer]
Gene
123531366  hypoxanthine-guanine phosphoribosyltransferase-like [KO:K00760] [EC:2.4.2.8]
123528705  inosine-5'-monophosphate dehydrogenase 1a-like [KO:K00088] [EC:1.1.1.205]
123526466  GMP synthase [glutamine-hydrolyzing]-like [KO:K01951] [EC:6.3.5.2]
123524685  probable thiopurine S-methyltransferase isoform X2 [KO:K00569] [EC:2.1.1.67]
123524686  probable thiopurine S-methyltransferase [KO:K00569] [EC:2.1.1.67]
123525422  probable thiopurine S-methyltransferase [KO:K00569] [EC:2.1.1.67]
123544928  xanthine dehydrogenase/oxidase-like isoform X1 [KO:K00106] [EC:1.17.1.4 1.17.3.2]
123523256  xanthine dehydrogenase/oxidase-like [KO:K00106] [EC:1.17.1.4 1.17.3.2]
123523267  xanthine dehydrogenase/oxidase-like [KO:K00106] [EC:1.17.1.4 1.17.3.2]
123535767  uncharacterized protein LOC123535767 isoform X1 [KO:K00106] [EC:1.17.1.4 1.17.3.2]
123535779  uncharacterized protein LOC123535779 [KO:K00106] [EC:1.17.1.4 1.17.3.2]
123558173  xanthine dehydrogenase/oxidase-like [KO:K00106] [EC:1.17.1.4 1.17.3.2]
123536060  xanthine dehydrogenase-like [KO:K00106] [EC:1.17.1.4 1.17.3.2]
123536061  xanthine dehydrogenase-like [KO:K00106] [EC:1.17.1.4 1.17.3.2]
123561824  xanthine dehydrogenase/oxidase-like isoform X1 [KO:K00106] [EC:1.17.1.4 1.17.3.2]
128556121  xanthine dehydrogenase/oxidase-like isoform X1 [KO:K00106] [EC:1.17.1.4 1.17.3.2]
123524589  inosine triphosphate pyrophosphatase-like [KO:K01519] [EC:3.6.1.66]
123550608  uncharacterized protein LOC123550608 [KO:K03927] [EC:3.1.1.1 3.1.1.84 3.1.1.56]
123533402  beta-glucuronidase-like [KO:K01195] [EC:3.2.1.31]
123533553  beta-glucuronidase-like isoform X1 [KO:K01195] [EC:3.2.1.31]
123527276  cytidine deaminase-like [KO:K01489] [EC:3.5.4.5]
123527503  cytidine deaminase-like [KO:K01489] [EC:3.5.4.5]
123552360  thymidine phosphorylase-like isoform X1 [KO:K00758] [EC:2.4.2.4]
123524345  dihydropyrimidine dehydrogenase [NADP(+)]-like [KO:K00207] [EC:1.3.1.2]
123536740  dihydropyrimidinase-like isoform X3 [KO:K01464] [EC:3.5.2.2]
123533838  beta-ureidopropionase-like [KO:K01431] [EC:3.5.1.6]
123559640  uridine phosphorylase 2-like [KO:K00757] [EC:2.4.2.3]
123559781  uridine phosphorylase 1-like isoform X1 [KO:K00757] [EC:2.4.2.3]
123524958  uridine-cytidine kinase-like 1 isoform X1 [KO:K00876] [EC:2.7.1.48]
123549854  uridine-cytidine kinase 2-like [KO:K00876] [EC:2.7.1.48]
123526166  thymidine kinase 2, mitochondrial-like [KO:K00857] [EC:2.7.1.21]
123548985  thymidine kinase 2, mitochondrial-like [KO:K00857] [EC:2.7.1.21]
123527944  thymidine kinase 2, mitochondrial-like [KO:K00857] [EC:2.7.1.21]
123563017  thymidine kinase, cytosolic-like [KO:K00857] [EC:2.7.1.21]
123564764  thymidine kinase 2, mitochondrial-like [KO:K00857] [EC:2.7.1.21]
123536315  uridine 5'-monophosphate synthase-like isoform X1 [KO:K13421] [EC:2.4.2.10 4.1.1.23]
123525398  UMP-CMP kinase-like [KO:K13800] [EC:2.7.4.14]
123557554  ribonucleoside-diphosphate reductase large subunit-like [KO:K10807] [EC:1.17.4.1]
123525277  ribonucleoside-diphosphate reductase small chain [KO:K10808] [EC:1.17.4.1]
128553850  nucleoside diphosphate kinase 7-like [KO:K00940] [EC:2.7.4.6]
123555151  nucleoside diphosphate kinase 7-like [KO:K00940] [EC:2.7.4.6]
123557978  nucleoside diphosphate kinase B-like [KO:K00940] [EC:2.7.4.6]
123526245  nucleoside diphosphate kinase 6-like [KO:K00940] [EC:2.7.4.6]
123542210  deoxyuridine 5'-triphosphate nucleotidohydrolase-like [KO:K01520] [EC:3.6.1.23]
123546341  peroxidase-like [KO:K10789] [EC:1.11.2.2]
123537740  myeloperoxidase-like isoform X1 [KO:K10789] [EC:1.11.2.2]
123538598  peroxidase-like protein isoform X1 [KO:K10789] [EC:1.11.2.2]
123539213  peroxidase-like protein 3 [KO:K10789] [EC:1.11.2.2]
123541376  myeloperoxidase-like isoform X1 [KO:K10789] [EC:1.11.2.2]
123542169  steroid 17-alpha-hydroxylase/17,20 lyase-like isoform X1 [KO:K07415] [EC:1.14.14.-]
123533687  microsomal glutathione S-transferase 3-like isoform X1 [KO:K00799] [EC:2.5.1.18]
123533773  microsomal glutathione S-transferase 3-like [KO:K00799] [EC:2.5.1.18]
123534191  glutathione S-transferase theta-1-like [KO:K00799] [EC:2.5.1.18]
123534451  glutathione S-transferase theta-1-like [KO:K00799] [EC:2.5.1.18]
123534469  glutathione S-transferase theta-1-like isoform X1 [KO:K00799] [EC:2.5.1.18]
123534703  glutathione S-transferase theta-1-like [KO:K00799] [EC:2.5.1.18]
123556705  microsomal glutathione S-transferase 2-like [KO:K00799] [EC:2.5.1.18]
123534896  glutathione S-transferase theta-1-like [KO:K00799] [EC:2.5.1.18]
123535246  glutathione S-transferase theta-1-like [KO:K00799] [EC:2.5.1.18]
123535469  glutathione S-transferase theta-1-like [KO:K00799] [EC:2.5.1.18]
123548297  pyrimidodiazepine synthase-like [KO:K00799] [EC:2.5.1.18]
123548298  pyrimidodiazepine synthase-like [KO:K00799] [EC:2.5.1.18]
123558839  microsomal glutathione S-transferase 2-like [KO:K00799] [EC:2.5.1.18]
123537178  glutathione S-transferase class-mu 28 kDa isozyme-like [KO:K00799] [EC:2.5.1.18]
123548652  glutathione S-transferase theta-3-like [KO:K00799] [EC:2.5.1.18]
123559587  microsomal glutathione S-transferase 1-like [KO:K00799] [EC:2.5.1.18]
123549215  uncharacterized protein LOC123549215 [KO:K00799] [EC:2.5.1.18]
123527591  glutathione S-transferase 1-like [KO:K00799] [EC:2.5.1.18]
123549780  glutathione S-transferase omega-1-like isoform X1 [KO:K00799] [EC:2.5.1.18]
123549781  glutathione S-transferase omega-1-like [KO:K00799] [EC:2.5.1.18]
123550000  uncharacterized protein LOC123550000 [KO:K00799] [EC:2.5.1.18]
123528494  S-crystallin SL11-like [KO:K00799] [EC:2.5.1.18]
123528786  probable glutathione S-transferase 8 [KO:K00799] [EC:2.5.1.18]
123528787  glutathione S-transferase 1-like [KO:K00799] [EC:2.5.1.18]
123528901  glutathione S-transferase A-like [KO:K00799] [EC:2.5.1.18]
123529003  S-crystallin SL11-like isoform X1 [KO:K00799] [EC:2.5.1.18]
123529042  glutathione S-transferase Mu 3-like [KO:K00799] [EC:2.5.1.18]
123529089  glutathione S-transferase 1-like [KO:K00799] [EC:2.5.1.18]
123529302  glutathione S-transferase A-like [KO:K00799] [EC:2.5.1.18]
123551380  microsomal glutathione S-transferase 3-like isoform X1 [KO:K00799] [EC:2.5.1.18]
123529399  glutathione S-transferase-like [KO:K00799] [EC:2.5.1.18]
123529566  glutathione S-transferase A-like [KO:K00799] [EC:2.5.1.18]
123529904  glutathione S-transferase Mu 1-like [KO:K00799] [EC:2.5.1.18]
123530109  probable glutathione S-transferase 7 [KO:K00799] [EC:2.5.1.18]
123542572  microsomal glutathione S-transferase 1-like [KO:K00799] [EC:2.5.1.18]
123564812  glutathione S-transferase 1-like isoform X1 [KO:K00799] [EC:2.5.1.18]
123543394  microsomal glutathione S-transferase 1-like [KO:K00799] [EC:2.5.1.18]
123532605  glutathione S-transferase-like [KO:K00799] [EC:2.5.1.18]
123556194  glutathione S-transferase P 1 [KO:K23790] [EC:2.5.1.18]
Compound
C00003  NAD+
C00006  NADP+
C02320  R-S-Glutathione
C02380  6-Mercaptopurine
C04242  5-Fluorodeoxyuridine monophosphate
C04646  6-Thioinosine-5'-monophosphate
C05361  Hydrazine
C06108  Fluoroacetate
C06837  Azathioprine
C07054  Isoniazid
C07446  Isonicotinic acid
C07447  Acetylhydrazine
C07585  N-Acetylisoniazid
C07648  Thioguanine
C07649  5-FU
C11173  SN-38
C11376  SN38 glucuronide
C11736  5-Fluorodeoxyuridine
C12650  Capecitabine
C12673  Tegafur
C12739  5'-Deoxy-5-fluorouridine
C13252  Carmofur
C16542  APC
C16543  NPC
C16613  6-Thiourate
C16614  6-Methylmercaptopurine
C16615  6-Methylthiopurine 5'-monophosphate ribonucleotide
C16616  6-Mercaptopurine ribonucleoside 5'-diphosphate
C16617  6-Mercaptopurine ribonucleoside triphosphate
C16618  6-Thioxanthine 5'-monophosphate
C16619  6-Thioguanosine monophosphate
C16620  6-Methylthioguanosine monophosphate
C16621  1-Methyl-4-nitroimidazole
C16622  N,N'-Diacetylhydrazine
C16623  Isonicotinylglycine
C16624  Isoniazid pyruvate
C16625  Isoniazid alpha-ketoglutaric acid
C16630  5,6-Dihydro-5-fluorouracil
C16631  alpha-Fluoro-beta-ureidopropionic acid
C16632  alpha-Fluoro-beta-alanine
C16633  5-Fluorouridine
C16634  5-Fluorouridine monophosphate
C16635  5'-Deoxy-5-fluorocytidine
C16641  Irinotecan
C21748  5-Fluorouridine diphosphate
C21749  5-Fluorouridine triphosphate
C21750  5-Fluorodeoxyuridine diphosphate
C21751  5-Fluorodeoxyuridine triphosphate
C21754  Isonicotinoyl radical
C21758  Hepatotoxins
C21759  Isonicotinoyl-NAD adduct
C21760  Isonicotinoyl-NADP adduct
D00238  Azathioprine (JP18/USP/INN)
D00346  Isoniazid (JP18/USP/INN)
D00584  Fluorouracil (JP18/USP/INN)
D01223  Capecitabine (JAN/USP/INN)
D01244  Tegafur (JP18/USAN/INN)
D01309  Doxifluridine (JP18/INN)
D01784  Carmofur (JP18/INN)
D04197  Floxuridine (USP/INN)
D04931  Mercaptopurine (INN)
D08086  Irinotecan (INN)
D08603  Tioguanine (INN)
Reference
  Authors
Kato R, Kamatari T (eds).
  Title
[Drug Metabolism] (In Japanese)
  Journal
Tokyo Kagaku Dojin (2000)
Reference
  Authors
Al Hadithy AF, de Boer NK, Derijks LJ, Escher JC, Mulder CJ, Brouwers JR.
  Title
Thiopurines in inflammatory bowel disease: pharmacogenetics, therapeutic drug monitoring and clinical recommendations.
  Journal
Dig Liver Dis 37:282-97 (2005)
DOI:10.1016/j.dld.2004.09.029
Reference
  Authors
Gearry RB, Barclay ML.
  Title
Azathioprine and 6-mercaptopurine pharmacogenetics and metabolite monitoring in inflammatory bowel disease.
  Journal
J Gastroenterol Hepatol 20:1149-57 (2005)
DOI:10.1111/j.1440-1746.2005.03832.x
Reference
  Authors
Gilissen LP, Derijks LJ, Verhoeven HM, Bierau J, Hooymans PM, Hommes DW, Engels LG.
  Title
Pancytopenia due to high 6-methylmercaptopurine levels in a 6-mercaptopurine treated patient with Crohn's disease.
  Journal
Dig Liver Dis 39:182-6 (2007)
DOI:10.1016/j.dld.2006.05.026
Reference
  Authors
Fischel JL, Formento P, Ciccolini J, Etienne-Grimaldi MC, Milano G.
  Title
Lack of contribution of dihydrofluorouracil and alpha-fluoro-beta-alanine to the cytotoxicity of 5'-deoxy-5-fluorouridine on human keratinocytes.
  Journal
Anticancer Drugs 15:969-74 (2004)
DOI:10.1097/00001813-200411000-00006
Reference
  Authors
Shimma N, Umeda I, Arasaki M, Murasaki C, Masubuchi K, Kohchi Y, Miwa M, Ura M, Sawada N, Tahara H, Kuruma I, Horii I, Ishitsuka H.
  Title
The design and synthesis of a new tumor-selective fluoropyrimidine carbamate, capecitabine.
  Journal
Bioorg Med Chem 8:1697-706 (2000)
DOI:10.1016/S0968-0896(00)00087-0
Reference
  Authors
Chung YL, Troy H, Judson IR, Leek R, Leach MO, Stubbs M, Harris AL, Griffiths JR
  Title
Noninvasive measurements of capecitabine metabolism in bladder tumors overexpressing thymidine phosphorylase by fluorine-19 magnetic resonance spectroscopy.
  Journal
Clin Cancer Res 10:3863-70 (2004)
DOI:10.1158/1078-0432.CCR-03-0237
Reference
  Authors
Mathijssen RH, van Alphen RJ, Verweij J, Loos WJ, Nooter K, Stoter G, Sparreboom A
  Title
Clinical pharmacokinetics and metabolism of irinotecan (CPT-11).
  Journal
Clin Cancer Res 7:2182-94 (2001)
Reference
  Authors
Kita T, Tanigawara Y, Chikazawa S, Hatanaka H, Sakaeda T, Komada F, Iwakawa S, Okumura K.
  Title
N-Acetyltransferase2 genotype correlated with isoniazid acetylation in Japanese tuberculous patients.
  Journal
Biol Pharm Bull 24:544-9 (2001)
DOI:10.1248/bpb.24.544
Reference
  Authors
Miura K, Kinouchi M, Ishida K, Fujibuchi W, Naitoh T, Ogawa H, Ando T, Yazaki N, Watanabe K, Haneda S, Shibata C, Sasaki I
  Title
5-fu metabolism in cancer and orally-administrable 5-fu drugs.
  Journal
Cancers (Basel) 2:1717-30 (2010)
DOI:10.3390/cancers2031717
Reference
  Authors
Wang P, Pradhan K, Zhong XB, Ma X
  Title
Isoniazid metabolism and hepatotoxicity.
  Journal
Acta Pharm Sin B 6:384-392 (2016)
DOI:10.1016/j.apsb.2016.07.014
Reference
  Authors
Klein DJ, Boukouvala S, McDonagh EM, Shuldiner SR, Laurieri N, Thorn CF, Altman RB, Klein TE
  Title
PharmGKB summary: isoniazid pathway, pharmacokinetics.
  Journal
Pharmacogenet Genomics 26:436-44 (2016)
DOI:10.1097/FPC.0000000000000232
Reference
  Authors
Yamada S, Richardson K, Tang M, Halaschek-Wiener J, Cook VJ, Fitzgerald JM, Elwood K, Marra F, Brooks-Wilson A
  Title
Genetic variation in carboxylesterase genes and susceptibility to isoniazid-induced hepatotoxicity.
  Journal
Pharmacogenomics J 10:524-36 (2010)
DOI:10.1038/tpj.2010.5
Reference
  Authors
Vlasits J, Jakopitsch C, Bernroitner M, Zamocky M, Furtmuller PG, Obinger C
  Title
Mechanisms of catalase activity of heme peroxidases.
  Journal
Arch Biochem Biophys 500:74-81 (2010)
DOI:10.1016/j.abb.2010.04.018
Reference
  Authors
Khan SR, Morgan AG, Michail K, Srivastava N, Whittal RM, Aljuhani N, Siraki AG
  Title
Metabolism of isoniazid by neutrophil myeloperoxidase leads to isoniazid-NAD(+) adduct formation: A comparison of the reactivity of isoniazid with its known human metabolites.
  Journal
Biochem Pharmacol 106:46-55 (2016)
DOI:10.1016/j.bcp.2016.02.003
Reference
  Authors
Forbes LV, Furtmuller PG, Khalilova I, Turner R, Obinger C, Kettle AJ
  Title
Isoniazid as a substrate and inhibitor of myeloperoxidase: identification of amine adducts and the influence of superoxide dismutase on their formation.
  Journal
Biochem Pharmacol 84:949-60 (2012)
DOI:10.1016/j.bcp.2012.07.020
Reference
  Authors
Nguyen M, Quemard A, Broussy S, Bernadou J, Meunier B
  Title
Mn(III) pyrophosphate as an efficient tool for studying the mode of action of isoniazid on the InhA protein of Mycobacterium tuberculosis.
  Journal
Antimicrob Agents Chemother 46:2137-44 (2002)
DOI:10.1128/AAC.46.7.2137-2144.2002
Reference
PMID:9417034
  Authors
Rozwarski DA, Grant GA, Barton DH, Jacobs WR Jr, Sacchettini JC
  Title
Modification of the NADH of the isoniazid target (InhA) from Mycobacterium tuberculosis.
  Journal
Science 279:98-102 (1998)
DOI:10.1126/science.279.5347.98
Reference
  Authors
Argyrou A, Vetting MW, Blanchard JS
  Title
New insight into the mechanism of action of and resistance to isoniazid: interaction of Mycobacterium tuberculosis enoyl-ACP reductase with INH-NADP.
  Journal
J Am Chem Soc 129:9582-3 (2007)
DOI:10.1021/ja073160k
KO pathway
ko00983   
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