KEGG   PATHWAY: mnz04146
Entry
mnz04146                    Pathway                                
Name
Peroxisome - Macrobrachium nipponense (oriental river prawn)
Description
Peroxisomes are essential organelles that play a key role in redox signalling and lipid homeostasis. They contribute to many crucial metabolic processes such as fatty acid oxidation, biosynthesis of ether lipids and free radical detoxification. The biogenesis of peroxisomes starts with the early peroxins PEX3, PEX16 and PEX19 and proceeds via several steps. The import of membrane proteins into peroxisomes needs PEX19 for recognition, targeting and insertion via docking at PEX3. Matrix proteins in the cytosol are recognized by peroxisomal targeting signals (PTS) and transported to the docking complex at the peroxisomal membrane. Peroxisomes' deficiencies lead to severe and often fatal inherited peroxisomal disorders (PD). PDs are usually classified in two groups. The first group is disorders of peroxisome biogenesis which include Zellweger syndrome, and the second group is single peroxisomal enzyme deficiencies.
Class
Cellular Processes; Transport and catabolism
Pathway map
mnz04146  Peroxisome
mnz04146

Other DBs
GO: 0005777
Organism
Macrobrachium nipponense (oriental river prawn) [GN:mnz]
Gene
135218259  LOW QUALITY PROTEIN: peroxisomal membrane protein PEX16-like [KO:K13335]
135222812  peroxisomal biogenesis factor 3-like [KO:K13336]
135227058  peroxisomal biogenesis factor 19-like [KO:K13337]
135217158  ATP-binding cassette sub-family D member 3-like [KO:K05677] [EC:7.6.2.4]
135217425  LOW QUALITY PROTEIN: ATP-binding cassette sub-family D member 3-like [KO:K05677] [EC:7.6.2.4]
135215965  peroxisomal ATPase PEX1-like [KO:K13338]
135223515  LOW QUALITY PROTEIN: peroxisomal ATPase PEX6-like [KO:K13339]
135213020  peroxisomal targeting signal 1 receptor-like [KO:K13342]
135200012  peroxisomal membrane protein PEX14-like isoform X1 [KO:K13343]
135214342  peroxisomal membrane protein PEX13-like isoform X1 [KO:K13344]
135202559  peroxisome assembly protein 12-like [KO:K13345]
135195379  LOW QUALITY PROTEIN: peroxisome biogenesis factor 10-like [KO:K13346]
135195478  LOW QUALITY PROTEIN: peroxisome assembly protein 10-B-like [KO:K13346]
135206625  peroxisome biogenesis factor 2-like [KO:K06664]
135218318  peroxisomal membrane protein 2-like [KO:K13347]
135214338  mpv17-like protein [KO:K13348]
135206197  protein Mpv17-like [KO:K13348]
135224669  mpv17-like protein 2 [KO:K13348]
135212457  PXMP2/4 family protein 4-like [KO:K13348]
135205109  mpv17-like protein [KO:K13349]
135220684  peroxisomal membrane protein 11B-like [KO:K13352]
135202964  peroxisomal membrane protein 11C-like isoform X1 [KO:K13353]
135209167  peroxisomal membrane protein PMP34-like [KO:K13354]
135207748  2-hydroxyacyl-CoA lyase 1-like [KO:K12261] [EC:4.1.2.63]
135206408  alpha-methylacyl-CoA racemase-like [KO:K01796] [EC:5.1.99.4]
135216391  phytanoyl-CoA dioxygenase, peroxisomal-like [KO:K00477] [EC:1.14.11.18]
135216808  LOW QUALITY PROTEIN: phytanoyl-CoA dioxygenase, peroxisomal-like [KO:K00477] [EC:1.14.11.18]
135209033  phytanoyl-CoA dioxygenase, peroxisomal-like isoform X1 [KO:K00477] [EC:1.14.11.18]
135209035  probable alpha-ketoglutarate-dependent hypophosphite dioxygenase [KO:K00477] [EC:1.14.11.18]
135209180  peroxisomal acyl-coenzyme A oxidase 1-like [KO:K00232] [EC:1.3.3.6]
135209181  peroxisomal acyl-coenzyme A oxidase 1-like [KO:K00232] [EC:1.3.3.6]
135211991  probable peroxisomal acyl-coenzyme A oxidase 1 [KO:K00232] [EC:1.3.3.6]
135212067  uncharacterized protein LOC135212067 [KO:K00232] [EC:1.3.3.6]
135212213  LOW QUALITY PROTEIN: uncharacterized protein LOC135212213 [KO:K00232] [EC:1.3.3.6]
135206760  peroxisomal multifunctional enzyme type 2-like [KO:K12405] [EC:1.1.1.- 4.2.1.107 4.2.1.119]
135212140  sterol carrier protein 2-like [KO:K08764] [EC:2.3.1.176]
135216472  ATP-binding cassette sub-family D member 1-like [KO:K05676] [EC:7.6.2.4]
135216473  ATP-binding cassette sub-family D member 2-like [KO:K05676] [EC:7.6.2.4]
135220585  lysosomal cobalamin transporter ABCD4-like isoform X1 [KO:K05678] [EC:7.6.2.8]
135213525  long-chain-fatty-acid--CoA ligase 1-like isoform X1 [KO:K01897] [EC:6.2.1.3]
135202925  long-chain-fatty-acid--CoA ligase 4-like isoform X1 [KO:K01897] [EC:6.2.1.3]
135204825  long-chain-fatty-acid--CoA ligase 4-like [KO:K01897] [EC:6.2.1.3]
135224614  long-chain-fatty-acid--CoA ligase 4-like [KO:K01897] [EC:6.2.1.3]
135215424  peroxisomal trans-2-enoyl-CoA reductase-like isoform X1 [KO:K07753] [EC:1.3.1.38]
135222947  enoyl-CoA delta isomerase 2-like [KO:K13239] [EC:5.3.3.8]
135209139  enoyl-CoA delta isomerase 2-like [KO:K13239] [EC:5.3.3.8]
135209143  enoyl-CoA delta isomerase 2-like [KO:K13239] [EC:5.3.3.8]
135219093  NAD(P)H pyrophosphatase NUDT13, mitochondrial-like isoform X1 [KO:K03426] [EC:3.6.1.22]
135224572  acyl-coenzyme A diphosphatase NUDT19-like isoform X1 [KO:K13355] [EC:3.6.1.77]
135221714  carnitine O-acetyltransferase-like [KO:K00624] [EC:2.3.1.7]
135221719  carnitine O-acetyltransferase-like [KO:K00624] [EC:2.3.1.7]
135226492  peroxisomal carnitine O-octanoyltransferase-like [KO:K05940] [EC:2.3.1.137]
135206676  malonyl-CoA decarboxylase, mitochondrial-like isoform X1 [KO:K01578] [EC:4.1.1.9]
135215632  dihydroxyacetone phosphate acyltransferase-like [KO:K00649] [EC:2.3.1.42]
135215634  dihydroxyacetone phosphate acyltransferase-like isoform X1 [KO:K00649] [EC:2.3.1.42]
135212073  alkyldihydroxyacetonephosphate synthase, peroxisomal-like [KO:K00803] [EC:2.5.1.26]
135199434  putative fatty acyl-CoA reductase CG5065 isoform X1 [KO:K13356] [EC:1.2.1.84]
135199478  putative fatty acyl-CoA reductase CG5065 isoform X1 [KO:K13356] [EC:1.2.1.84]
135209171  mevalonate kinase-like [KO:K00869] [EC:2.7.1.36]
135209660  phosphomevalonate kinase-like isoform X1 [KO:K13273] [EC:2.7.4.2]
135200346  D-aspartate oxidase-like isoform X1 [KO:K00273] [EC:1.4.3.3]
135200801  D-aspartate oxidase-like isoform X1 [KO:K00272] [EC:1.4.3.1]
135200255  isocitrate dehydrogenase [NADP] cytoplasmic-like [KO:K00031] [EC:1.1.1.42]
135212086  isocitrate dehydrogenase [NADP], mitochondrial-like [KO:K00031] [EC:1.1.1.42]
135201654  peroxisomal N(1)-acetyl-spermine/spermidine oxidase-like [KO:K00308] [EC:1.5.3.13]
135226415  peroxisomal N(1)-acetyl-spermine/spermidine oxidase-like [KO:K00308] [EC:1.5.3.13]
135220836  peroxisomal sarcosine oxidase-like [KO:K00306] [EC:1.5.3.1 1.5.3.7]
135207574  LOW QUALITY PROTEIN: peroxisomal sarcosine oxidase-like [KO:K00306] [EC:1.5.3.1 1.5.3.7]
135204829  hydroxymethylglutaryl-CoA lyase, mitochondrial-like isoform X1 [KO:K01640] [EC:4.1.3.4]
135206734  2-Hydroxyacid oxidase 1-like isoform X1 [KO:K11517] [EC:1.1.3.15]
135205829  catalase-like [KO:K03781] [EC:1.11.1.6]
135206750  LOW QUALITY PROTEIN: peroxiredoxin-5, mitochondrial-like [KO:K11187] [EC:1.11.1.24]
135206816  LOW QUALITY PROTEIN: peroxiredoxin-5, mitochondrial-like [KO:K11187] [EC:1.11.1.24]
135203610  LOW QUALITY PROTEIN: superoxide dismutase [Cu-Zn]-like [KO:K04565] [EC:1.15.1.1]
135220001  superoxide dismutase [Cu-Zn]-like [KO:K04565] [EC:1.15.1.1]
135220002  superoxide dismutase [Cu-Zn]-like [KO:K04565] [EC:1.15.1.1]
135206067  superoxide dismutase [Cu-Zn]-like [KO:K04565] [EC:1.15.1.1]
135224390  superoxide dismutase [Mn], mitochondrial-like [KO:K04564] [EC:1.15.1.1]
135201606  peroxiredoxin 2-like [KO:K13279] [EC:1.11.1.24]
135208052  glutathione S-transferase kappa 1-like isoform X1 [KO:K13299] [EC:2.5.1.18]
135216146  uncharacterized protein LOC135216146 [KO:K00106] [EC:1.17.1.4 1.17.3.2]
135216406  uncharacterized protein LOC135216406 [KO:K00106] [EC:1.17.1.4 1.17.3.2]
135216806  xanthine dehydrogenase-like [KO:K00106] [EC:1.17.1.4 1.17.3.2]
135222924  xanthine dehydrogenase/oxidase-like [KO:K00106] [EC:1.17.1.4 1.17.3.2]
135209209  uncharacterized protein LOC135209209 [KO:K00106] [EC:1.17.1.4 1.17.3.2]
135197714  xanthine dehydrogenase/oxidase-like [KO:K00106] [EC:1.17.1.4 1.17.3.2]
135198079  xanthine dehydrogenase/oxidase-like [KO:K00106] [EC:1.17.1.4 1.17.3.2]
135215329  dehydrogenase/reductase SDR family member 4-like [KO:K11147] [EC:1.1.-.-]
135215657  dehydrogenase/reductase SDR family member 4-like isoform X1 [KO:K11147] [EC:1.1.-.-]
Reference
PMID:17055078
  Authors
Wanders RJ, Waterham HR
  Title
Peroxisomal disorders: the single peroxisomal enzyme deficiencies.
  Journal
Biochim Biophys Acta 1763:1707-20 (2006)
DOI:10.1016/j.bbamcr.2006.08.010
Reference
PMID:17055079
  Authors
Steinberg SJ, Dodt G, Raymond GV, Braverman NE, Moser AB, Moser HW
  Title
Peroxisome biogenesis disorders.
  Journal
Biochim Biophys Acta 1763:1733-48 (2006)
DOI:10.1016/j.bbamcr.2006.09.010
Reference
PMID:17010456
  Authors
Rottensteiner H, Theodoulou FL
  Title
The ins and outs of peroxisomes: co-ordination of membrane transport and peroxisomal metabolism.
  Journal
Biochim Biophys Acta 1763:1527-40 (2006)
DOI:10.1016/j.bbamcr.2006.08.012
Reference
PMID:16631601
  Authors
Iida R, Yasuda T, Tsubota E, Takatsuka H, Matsuki T, Kishi K
  Title
Human Mpv17-like protein is localized in peroxisomes and regulates expression of antioxidant enzymes.
  Journal
Biochem Biophys Res Commun 344:948-54 (2006)
DOI:10.1016/j.bbrc.2006.04.008
Related
pathway
mnz00071  Fatty acid degradation
mnz00230  Purine metabolism
mnz00564  Glycerophospholipid metabolism
mnz00565  Ether lipid metabolism
mnz00830  Retinol metabolism
mnz00900  Terpenoid backbone biosynthesis
KO pathway
ko04146   
LinkDB

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