KEGG   PATHWAY: morg00982
Entry
morg00982                   Pathway                                
Name
Drug metabolism - cytochrome P450 - Microtus oregoni (creeping vole)
Class
Metabolism; Xenobiotics biodegradation and metabolism
Pathway map
morg00982  Drug metabolism - cytochrome P450
morg00982

Organism
Microtus oregoni (creeping vole) [GN:morg]
Gene
121454978  flavin-containing monooxygenase 5-like [KO:K00485] [EC:1.14.13.8 1.8.1.-]
121454979  flavin-containing monooxygenase 5-like [KO:K00485] [EC:1.14.13.8 1.8.1.-]
121455151  Fmo1; dimethylaniline monooxygenase [N-oxide-forming] 1 [KO:K00485] [EC:1.14.13.8 1.8.1.-]
121455186  Fmo2; dimethylaniline monooxygenase [N-oxide-forming] 2 [KO:K00485] [EC:1.14.13.8 1.8.1.-]
121455244  dimethylaniline monooxygenase [N-oxide-forming] 4-like [KO:K00485] [EC:1.14.13.8 1.8.1.-]
121455257  putative dimethylaniline monooxygenase [N-oxide-forming] 6 [KO:K00485] [EC:1.14.13.8 1.8.1.-]
121455281  dimethylaniline monooxygenase [N-oxide-forming] 4-like [KO:K00485] [EC:1.14.13.8 1.8.1.-]
121455323  flavin-containing monooxygenase 5-like [KO:K00485] [EC:1.14.13.8 1.8.1.-]
121455451  dimethylaniline monooxygenase [N-oxide-forming] 3 [KO:K00485] [EC:1.14.13.8 1.8.1.-]
121437917  Fmo5; flavin-containing monooxygenase 5 isoform X1 [KO:K00485] [EC:1.14.13.8 1.8.1.-]
121454117  glutathione S-transferase Mu 1-like [KO:K00799] [EC:2.5.1.18]
121454276  Gsto1; glutathione S-transferase omega-1 [KO:K00799] [EC:2.5.1.18]
121454595  glutathione S-transferase omega-2 [KO:K00799] [EC:2.5.1.18]
121455456  Mgst3; microsomal glutathione S-transferase 3 [KO:K00799] [EC:2.5.1.18]
121452882  glutathione S-transferase Mu 1-like [KO:K00799] [EC:2.5.1.18]
121452929  Mgst2; microsomal glutathione S-transferase 2 [KO:K00799] [EC:2.5.1.18]
121466001  glutathione S-transferase A2-like [KO:K00799] [EC:2.5.1.18]
121466002  glutathione S-transferase A2-like [KO:K00799] [EC:2.5.1.18]
121466003  glutathione S-transferase A2-like [KO:K00799] [EC:2.5.1.18]
121466058  glutathione S-transferase A2-like [KO:K00799] [EC:2.5.1.18]
121466059  glutathione S-transferase A2-like isoform X1 [KO:K00799] [EC:2.5.1.18]
121466100  glutathione S-transferase A4 [KO:K00799] [EC:2.5.1.18]
121466106  glutathione S-transferase A2-like [KO:K00799] [EC:2.5.1.18]
121466110  glutathione S-transferase A2 isoform X1 [KO:K00799] [EC:2.5.1.18]
121466123  glutathione S-transferase A2-like [KO:K00799] [EC:2.5.1.18]
121466126  glutathione S-transferase A2-like [KO:K00799] [EC:2.5.1.18]
121450740  glutathione S-transferase alpha-3 [KO:K00799] [EC:2.5.1.18]
121450779  glutathione S-transferase alpha-3-like [KO:K00799] [EC:2.5.1.18]
121450871  glutathione S-transferase-like [KO:K00799] [EC:2.5.1.18]
121437837  glutathione S-transferase Mu 1-like [KO:K00799] [EC:2.5.1.18]
121437838  glutathione S-transferase Mu 1-like [KO:K00799] [EC:2.5.1.18]
121437849  glutathione S-transferase Mu 2-like isoform X1 [KO:K00799] [EC:2.5.1.18]
121437851  glutathione S-transferase Mu 4-like [KO:K00799] [EC:2.5.1.18]
121437862  glutathione S-transferase Mu 1 [KO:K00799] [EC:2.5.1.18]
121437864  glutathione S-transferase Mu 1-like [KO:K00799] [EC:2.5.1.18]
121437865  glutathione S-transferase Mu 2 [KO:K00799] [EC:2.5.1.18]
121437869  glutathione S-transferase Mu 5 [KO:K00799] [EC:2.5.1.18]
121437892  glutathione S-transferase Mu 6 [KO:K00799] [EC:2.5.1.18]
121445615  glutathione S-transferase theta-1 isoform X1 [KO:K00799] [EC:2.5.1.18]
121445621  glutathione S-transferase theta-4 [KO:K00799] [EC:2.5.1.18]
121445622  glutathione S-transferase theta-3 [KO:K00799] [EC:2.5.1.18]
121451054  glutathione S-transferase A6 isoform X1 [KO:K00799] [EC:2.5.1.18]
121437991  glutathione S-transferase Mu 7 [KO:K00799] [EC:2.5.1.18]
121437992  glutathione S-transferase Mu 4 [KO:K00799] [EC:2.5.1.18]
121438021  Mgst1; microsomal glutathione S-transferase 1 [KO:K00799] [EC:2.5.1.18]
121446269  glutathione S-transferase Mu 1-like [KO:K00799] [EC:2.5.1.18]
121446276  glutathione S-transferase Mu 1-like [KO:K00799] [EC:2.5.1.18]
121446284  glutathione S-transferase Mu 1-like [KO:K00799] [EC:2.5.1.18]
121446286  glutathione S-transferase Mu 1-like [KO:K00799] [EC:2.5.1.18]
121446771  glutathione S-transferase Mu 5 [KO:K00799] [EC:2.5.1.18]
121440061  glutathione S-transferase Mu 4-like [KO:K00799] [EC:2.5.1.18]
121448764  glutathione S-transferase Mu 2-like isoform X1 [KO:K00799] [EC:2.5.1.18]
121448897  glutathione S-transferase Mu 1-like [KO:K00799] [EC:2.5.1.18]
121449022  glutathione S-transferase Mu 7 [KO:K00799] [EC:2.5.1.18]
121449108  glutathione S-transferase Mu 6 [KO:K00799] [EC:2.5.1.18]
121449179  glutathione S-transferase Mu 2-like [KO:K00799] [EC:2.5.1.18]
121449253  glutathione S-transferase Mu 3 [KO:K00799] [EC:2.5.1.18]
121449564  glutathione S-transferase Mu 4 [KO:K00799] [EC:2.5.1.18]
121454159  glutathione S-transferase P isoform X1 [KO:K23790] [EC:2.5.1.18]
121454468  glutathione S-transferase P-like isoform X1 [KO:K23790] [EC:2.5.1.18]
121455227  glutathione S-transferase P-like [KO:K23790] [EC:2.5.1.18]
121463946  glutathione S-transferase P-like [KO:K23790] [EC:2.5.1.18]
121458543  glutathione S-transferase P-like [KO:K23790] [EC:2.5.1.18]
121464850  glutathione S-transferase P-like [KO:K23790] [EC:2.5.1.18]
121452712  glutathione S-transferase P-like [KO:K23790] [EC:2.5.1.18]
121459291  glutathione S-transferase P [KO:K23790] [EC:2.5.1.18]
121465360  glutathione S-transferase P-like [KO:K23790] [EC:2.5.1.18]
121465383  glutathione S-transferase P-like [KO:K23790] [EC:2.5.1.18]
121453635  glutathione S-transferase P-like [KO:K23790] [EC:2.5.1.18]
121436401  glutathione S-transferase P [KO:K23790] [EC:2.5.1.18]
121444537  glutathione S-transferase P-like [KO:K23790] [EC:2.5.1.18]
121450805  glutathione S-transferase P [KO:K23790] [EC:2.5.1.18]
121441244  glutathione S-transferase P-like [KO:K23790] [EC:2.5.1.18]
121441256  glutathione S-transferase P-like [KO:K23790] [EC:2.5.1.18]
121441261  glutathione S-transferase P-like [KO:K23790] [EC:2.5.1.18]
121441267  glutathione S-transferase P-like [KO:K23790] [EC:2.5.1.18]
121441288  glutathione S-transferase P-like [KO:K23790] [EC:2.5.1.18]
121441302  glutathione S-transferase P-like [KO:K23790] [EC:2.5.1.18]
121441304  glutathione S-transferase P-like [KO:K23790] [EC:2.5.1.18]
121441538  glutathione S-transferase P-like [KO:K23790] [EC:2.5.1.18]
121441597  glutathione S-transferase P-like [KO:K23790] [EC:2.5.1.18]
121449222  glutathione S-transferase P [KO:K23790] [EC:2.5.1.18]
121449559  glutathione S-transferase P-like [KO:K23790] [EC:2.5.1.18]
121435493  glutathione S-transferase kappa 1-like [KO:K13299] [EC:2.5.1.18]
121435506  glutathione S-transferase kappa 1-like [KO:K13299] [EC:2.5.1.18]
121435511  glutathione S-transferase kappa 1-like [KO:K13299] [EC:2.5.1.18]
121443234  Hpgds; hematopoietic prostaglandin D synthase [KO:K04097] [EC:5.3.99.2 2.5.1.18]
121445963  alcohol dehydrogenase 1-like [KO:K13951] [EC:1.1.1.1]
121446657  alcohol dehydrogenase 1-like [KO:K13951] [EC:1.1.1.1]
121446978  alcohol dehydrogenase 1 [KO:K13951] [EC:1.1.1.1]
121446988  alcohol dehydrogenase 1-like [KO:K13951] [EC:1.1.1.1]
121450079  LOW QUALITY PROTEIN: all-trans-retinol dehydrogenase [NAD(+)] ADH7-like [KO:K13951] [EC:1.1.1.1]
121450014  all-trans-retinol dehydrogenase [NAD(+)] ADH4 [KO:K13980] [EC:1.1.1.1]
121446608  alcohol dehydrogenase class-3 [KO:K00121] [EC:1.1.1.284 1.1.1.1]
121450022  alcohol dehydrogenase 6 [KO:K13952] [EC:1.1.1.1]
121454242  Aldh3b1; aldehyde dehydrogenase family 3 member B1 isoform X1 [KO:K00129] [EC:1.2.1.5]
121454501  aldehyde dehydrogenase family 3 member B3 isoform X1 [KO:K00129] [EC:1.2.1.5]
121456346  Aldh3a1; aldehyde dehydrogenase, dimeric NADP-preferring [KO:K00129] [EC:1.2.1.5]
121453982  aldehyde dehydrogenase family 3 member B2 [KO:K00129] [EC:1.2.1.5]
121441029  amine oxidase [flavin-containing] B isoform X1 [KO:K00274] [EC:1.4.3.4]
121441037  amine oxidase [flavin-containing] A-like [KO:K00274] [EC:1.4.3.4]
121441131  amine oxidase [flavin-containing] B-like isoform X1 [KO:K00274] [EC:1.4.3.4]
121441151  amine oxidase [flavin-containing] A [KO:K00274] [EC:1.4.3.4]
121458912  aldehyde oxidase 4 [KO:K00157] [EC:1.2.3.1]
121458936  aldehyde oxidase 1 [KO:K00157] [EC:1.2.3.1]
121458975  aldehyde oxidase 2 [KO:K00157] [EC:1.2.3.1]
121444847  aldehyde oxidase 4-like [KO:K00157] [EC:1.2.3.1]
121444853  aldehyde oxidase 1 [KO:K00157] [EC:1.2.3.1]
121444857  aldehyde oxidase 2 [KO:K00157] [EC:1.2.3.1]
121460674  UDP-glucuronosyltransferase 2B31-like [KO:K00699] [EC:2.4.1.17]
121460703  UDP-glucuronosyltransferase 2B31-like [KO:K00699] [EC:2.4.1.17]
121460704  UDP-glucuronosyltransferase 2B31-like [KO:K00699] [EC:2.4.1.17]
121460705  UDP-glucuronosyltransferase 2B31-like [KO:K00699] [EC:2.4.1.17]
121460706  UDP-glucuronosyltransferase 2B31-like isoform X1 [KO:K00699] [EC:2.4.1.17]
121460707  UDP-glucuronosyltransferase 2B31-like [KO:K00699] [EC:2.4.1.17]
121460722  UDP-glucuronosyltransferase 2B17-like [KO:K00699] [EC:2.4.1.17]
121460723  UDP-glucuronosyltransferase 2B17-like [KO:K00699] [EC:2.4.1.17]
121460730  UDP-glucuronosyltransferase 2A3-like [KO:K00699] [EC:2.4.1.17]
121460734  UDP-glucuronosyltransferase 2B17-like isoform X1 [KO:K00699] [EC:2.4.1.17]
121460735  UDP-glucuronosyltransferase 2B17-like [KO:K00699] [EC:2.4.1.17]
121460758  UDP-glucuronosyltransferase 2B1 [KO:K00699] [EC:2.4.1.17]
121460764  UDP-glucuronosyltransferase 2B7-like [KO:K00699] [EC:2.4.1.17]
121460803  UDP-glucuronosyltransferase 2A2 isoform X1 [KO:K00699] [EC:2.4.1.17]
121460818  UDP-glucuronosyltransferase 2B7-like [KO:K00699] [EC:2.4.1.17]
121460879  UDP-glucuronosyltransferase 2B17-like [KO:K00699] [EC:2.4.1.17]
121460913  UDP-glucuronosyltransferase 2B17-like isoform X1 [KO:K00699] [EC:2.4.1.17]
121446879  UDP-glucuronosyltransferase 1-2-like [KO:K00699] [EC:2.4.1.17]
121446881  UDP-glucuronosyltransferase 1A7-like [KO:K00699] [EC:2.4.1.17]
121447020  UDP-glucuronosyltransferase 1A7-like [KO:K00699] [EC:2.4.1.17]
121447314  UDP-glucuronosyltransferase 1A8-like [KO:K00699] [EC:2.4.1.17]
121447552  UDP-glucuronosyltransferase 1A1 isoform X1 [KO:K00699] [EC:2.4.1.17]
121447554  UDP-glucuronosyltransferase 1A8-like [KO:K00699] [EC:2.4.1.17]
121447555  UDP-glucuronosyltransferase 1A8-like [KO:K00699] [EC:2.4.1.17]
121445350  cytochrome P450 1A2 [KO:K07409] [EC:1.14.14.1]
121445351  cytochrome P450 1A2-like [KO:K07409] [EC:1.14.14.1]
121445352  cytochrome P450 1A2-like [KO:K07409] [EC:1.14.14.1]
121457665  cytochrome P450 2E1 [KO:K07415] [EC:1.14.14.-]
Compound
C01471  Acrolein
C01516  Morphine
C05011  Hydroxytamoxifen
C06174  Codeine
C06754  Chloroacetaldehyde
C06868  Carbamazepine
C07047  Ifosfamide
C07073  Lidocaine
C07108  Tamoxifen
C07163  Methadone
C07185  Valproic acid
C07492  Oxcarbazepine
C07493  10-Hydroxycarbazepine
C07495  Dihydroxycarbazepine
C07496  Carbamazepine-10,11-epoxide
C07501  Felbamate
C07572  Citalopram
C07643  4-Hydroxycyclophosphamide
C07644  4-Ketocyclophosphamide
C07645  Aldophosphamide
C07646  Carboxyphosphamide
C07647  Phosphoramide mustard
C07888  Cyclophosphamide
C08012  Levomethadyl acetate
C11004  2,6-Dimethylaniline
C11583  4-Glutathionyl cyclophosphamide
C11785  Normorphine
C16544  alpha-Hydroxytamoxifen
C16545  Tamoxifen N-oxide
C16546  N-Desmethyltamoxifen
C16547  Endoxifen
C16548  N,N-Didesmethyltamoxifen
C16549  alpha-Hydroxy-N-desmethyltamoxifen
C16550  Dechloroethylcyclophosphamide
C16551  Alcophosphamide
C16552  Nornitrogen mustard
C16553  4-Hydroxyifosfamide
C16554  4-Ketoifosfamide
C16555  2-Dechloroethylifosfamide
C16556  Aldoifosfamide
C16557  Carboxyifosfamide
C16558  Alcoifosfamide
C16559  Isophosphoramide mustard
C16560  3-Hydroxylidocaine
C16561  Monoethylglycinexylidide
C16569  Glycinexylidide
C16570  4-Hydroxy-2,6-dimethylaniline
C16571  2-Amino-3-methylbenzoate
C16572  3-Hydroxymonoethylglycinexylidide
C16576  Norcodeine
C16577  Codeine-6-glucuronide
C16578  Morphine-6-glucuronide
C16582  2-Hydroxyfelbamate
C16584  p-Hydroxyfelbamate
C16586  2-Phenyl-1,3-propanediol monocarbamate
C16587  3-Carbamoyl-2-phenylpropionaldehyde
C16591  3-Carbamoyl-2-phenylpropionic acid
C16592  Atropaldehyde
C16595  4-Hydroxy-5-phenyltetrahydro-1,3-oxazin-2-one
C16596  5-Phenyl-1,3-oxazinane-2,4-dione
C16601  2-Hydroxycarbamazepine
C16602  3-Hydroxycarbamazepine
C16603  2,3-Dihydroxycarbamazepine
C16604  2-Hydroxyiminostilbene
C16605  2H-Dibenz[b,f]azepin-2-one
C16606  Carbamazepine-o-quinone
C16607  Citalopram N-oxide
C16608  Demethylcitalopram
C16609  Didemethylcitalopram
C16610  Citalopram propionic acid
C16612  Citalopram aldehyde
C16643  Morphine-3-glucuronide
C16648  2-n-Propyl-4-pentenoic acid
C16649  4-Hydroxyvalproic acid
C16650  5-Hydroxyvalproic acid
C16651  3-Hydroxyvalproic acid
C16652  3-Oxovalproic acid
C16653  2-n-Propyl-2-pentenoic acid
C16654  2-n-Propyl-3-pentenoic acid
C16655  2-n-Propyl-4-oxopentanoic acid
C16656  2-Propyl-2,4-pentadienoic acid
C16657  2-Propylsuccinic acid
C16658  2-Propylglutaric acid
C16659  2-Ethylidene-1,5-dimethyl-3,3-diphenylpyrrolidine
C16660  2-Ethyl-5-methyl-3,3-diphenyl-1-pyrroline
C16661  L-alpha-Acetyl-N-normethadol
C16662  L-alpha-Acetyl-N,N-dinormethadol
D00195  Codeine (USP)
D00252  Carbamazepine (JP18/USP/INN)
D00343  Ifosfamide (JAN/USP/INN)
D00358  Lidocaine (JP18/USP/INN)
D00399  Valproic acid (USP)
D00533  Oxcarbazepine (JAN/USP/INN)
D00536  Felbamate (USPINN)
D04716  Levomethadyl acetate (USAN)
D07704  Citalopram (USP/INN)
D07760  Cyclophosphamide (INN)
D08195  Methadone (BAN)
D08233  Morphine (BAN)
D08559  Tamoxifen (INN)
Reference
  Authors
Kato R, Kamatari T (eds).
  Title
[Drug Metabolism] (In Japanese)
  Journal
Tokyo Kagaku Dojin (2000)
Reference
PMID:16038189
  Authors
Gjerde J, Kisanga ER, Hauglid M, Holm PI, Mellgren G, Lien EA.
  Title
Identification and quantification of tamoxifen and four metabolites in serum by liquid chromatography-tandem mass spectrometry.
  Journal
J Chromatogr A 1082:6-14 (2005)
DOI:10.1016/j.chroma.2005.01.004
Reference
PMID:18043895
  Authors
Buck MB, Coller JK, Murdter TE, Eichelbaum M, Knabbe C.
  Title
TGFbeta2 and TbetaRII are valid molecular biomarkers for the antiproliferative effects of tamoxifen and tamoxifen metabolites in breast cancer cells.
  Journal
Breast Cancer Res Treat 107:15-24 (2008)
DOI:10.1007/s10549-007-9526-7
Reference
PMID:16550168
  Authors
Rodriguez-Antona C, Ingelman-Sundberg M.
  Title
Cytochrome P450 pharmacogenetics and cancer.
  Journal
Oncogene 25:1679-91 (2006)
DOI:10.1038/sj.onc.1209377
Reference
PMID:16393888
  Authors
Zhang J, Tian Q, Yung Chan S, Chuen Li S, Zhou S, Duan W, Zhu YZ.
  Title
Metabolism and transport of oxazaphosphorines and the clinical implications.
  Journal
Drug Metab Rev 37:611-703 (2005)
DOI:10.1080/03602530500364023
Reference
PMID:11226815
  Authors
Kosel M, Amey M, Aubert AC, Baumann P.
  Title
In vitro metabolism of citalopram by monoamine oxidase B in human blood.
  Journal
Eur Neuropsychopharmacol 11:75-8 (2001)
DOI:10.1016/S0924-977X(00)00128-0
Reference
PMID:10575324
  Authors
Olesen OV, Linnet K.
  Title
Studies on the stereoselective metabolism of citalopram by human liver microsomes and cDNA-expressed cytochrome P450 enzymes.
  Journal
Pharmacology 59:298-309 (1999)
DOI:10.1159/000028333
Reference
PMID:9698084
  Authors
Rochat B, Kosel M, Boss G, Testa B, Gillet M, Baumann P.
  Title
Stereoselective biotransformation of the selective serotonin reuptake inhibitor citalopram and its demethylated metabolites by monoamine oxidases in human liver.
  Journal
Biochem Pharmacol 56:15-23 (1998)
DOI:10.1016/S0006-2952(98)00008-2
Reference
  Authors
David AW, Thomas LL, William OF.
  Title
Foye's Principles of Medicinal Chemistry (5th ed)
  Journal
Lippincott Williams & Wilkins (2002)
Reference
PMID:11504799
  Authors
Oda Y, Kharasch ED.
  Title
Metabolism of methadone and levo-alpha-acetylmethadol (LAAM) by human intestinal cytochrome P450 3A4 (CYP3A4): potential contribution of intestinal metabolism to presystemic clearance and bioactivation.
  Journal
J Pharmacol Exp Ther 298:1021-32 (2001)
Reference
PMID:10901707
  Authors
Wang JS, Backman JT, Taavitsainen P, Neuvonen PJ, Kivisto KT.
  Title
Involvement of CYP1A2 and CYP3A4 in lidocaine N-deethylation and 3-hydroxylation in humans.
  Journal
Drug Metab Dispos 28:959-65 (2000)
Reference
PMID:12399158
  Authors
Dieckhaus CM, Thompson CD, Roller SG, Macdonald TL.
  Title
Mechanisms of idiosyncratic drug reactions: the case of felbamate.
  Journal
Chem Biol Interact 142:99-117 (2002)
DOI:10.1016/S0009-2797(02)00057-1
Reference
PMID:18463198
  Authors
Pearce RE, Lu W, Wang Y, Uetrecht JP, Correia MA, Leeder JS
  Title
Pathways of carbamazepine bioactivation in vitro. III. The role of human cytochrome P450 enzymes in the formation of 2,3-dihydroxycarbamazepine.
  Journal
Drug Metab Dispos 36:1637-49 (2008)
DOI:10.1124/dmd.107.019562
Reference
PMID:12386121
  Authors
Pearce RE, Vakkalagadda GR, Leeder JS.
  Title
Pathways of carbamazepine bioactivation in vitro I. Characterization of human cytochromes P450 responsible for the formation of 2- and 3-hydroxylated metabolites.
  Journal
Drug Metab Dispos 30:1170-9 (2002)
DOI:10.1124/dmd.30.11.1170
Reference
PMID:10859160
  Authors
Kumar S, Wong H, Yeung SA, Riggs KW, Abbott FS, Rurak DW.
  Title
Disposition of valproic acid in maternal, fetal, and newborn sheep. II: metabolism and renal elimination.
  Journal
Drug Metab Dispos 28:857-64 (2000)
Reference
  Authors
Bernad T, Joachim M.
  Title
Hydrolysis in Drug and Prodrug Metabolism: Chemistry, Biochemistry, and Enzymology
  Journal
Wiley-VCH (2003)
KO pathway
ko00982   
LinkDB

DBGET integrated database retrieval system