KEGG   PATHWAY: msim00230
Entry
msim00230                   Pathway                                
Name
Purine metabolism - Mycobacterium simiae
Class
Metabolism; Nucleotide metabolism
Pathway map
msim00230  Purine metabolism
msim00230

Module
msim_M00005  PRPP biosynthesis, ribose 5P => PRPP [PATH:msim00230]
msim_M00048  De novo purine biosynthesis, PRPP + glutamine => IMP [PATH:msim00230]
msim_M00049  Adenine ribonucleotide biosynthesis, IMP => ADP,ATP [PATH:msim00230]
msim_M00050  Guanine ribonucleotide biosynthesis, IMP => GDP,GTP [PATH:msim00230]
msim_M00053  Deoxyribonucleotide biosynthesis, ADP/GDP/CDP/UDP => dATP/dGTP/dCTP/dUTP [PATH:msim00230]
Other DBs
GO: 0006163 0042278
Organism
Mycobacterium simiae [GN:msim]
Gene
MSIM_09910  pgmA; phosphoglucomutase, alpha-D-glucose phosphate-specific [KO:K01835] [EC:5.4.2.2]
MSIM_36670  prs; ribose-phosphate pyrophosphokinase [KO:K00948] [EC:2.7.6.1]
MSIM_30870  purF; amidophosphoribosyltransferase [KO:K00764] [EC:2.4.2.14]
MSIM_30400  purD; phosphoribosylamine--glycine ligase [KO:K01945] [EC:6.3.4.13]
MSIM_34790  purN; phosphoribosylglycinamide formyltransferase [KO:K11175] [EC:2.1.2.2]
MSIM_18800  purT; phosphoribosylglycinamide formyltransferase 2 [KO:K08289] [EC:6.3.1.21]
MSIM_30840  purL; phosphoribosylformylglycinamidine synthase subunit PurL [KO:K23269] [EC:6.3.5.3]
MSIM_30580  purS; phosphoribosylformylglycinamidine synthase subunit PurS [KO:K23264] [EC:6.3.5.3]
MSIM_30590  purQ; phosphoribosylformylglycinamidine synthase subunit PurQ [KO:K23265] [EC:6.3.5.3 3.5.1.2]
MSIM_30880  purM; phosphoribosylformylglycinamidine cyclo-ligase [KO:K01933] [EC:6.3.3.1]
MSIM_13540  purK; N5-carboxyaminoimidazole ribonucleotide synthase [KO:K01589] [EC:6.3.4.18]
MSIM_13530  purE; N5-carboxyaminoimidazole ribonucleotide mutase [KO:K01588] [EC:5.4.99.18]
MSIM_30480  purC; phosphoribosylaminoimidazole-succinocarboxamide synthase [KO:K01923] [EC:6.3.2.6]
MSIM_30450  purB; adenylosuccinate lyase [KO:K01756] [EC:4.3.2.2]
MSIM_34800  purH; bifunctional purine biosynthesis protein PurH [KO:K00602] [EC:2.1.2.3 3.5.4.10]
MSIM_03860  apt; adenine phosphoribosyltransferase [KO:K00759] [EC:2.4.2.7]
MSIM_13850  punA; purine nucleoside phosphorylase [KO:K03783] [EC:2.4.2.1]
MSIM_46360  laccase domain protein [KO:K05810] [EC:2.4.2.1 2.4.2.28 3.5.4.4]
MSIM_14490  nucleoside hydrolase [KO:K01239] [EC:3.2.2.1]
MSIM_28400  hpt; hypoxanthine-guanine phosphoribosyltransferase [KO:K00760] [EC:2.4.2.8]
MSIM_14620  guaB3; putative oxidoreductase [KO:K00088] [EC:1.1.1.205]
MSIM_14630  guaB; inosine-5'-monophosphate dehydrogenase [KO:K00088] [EC:1.1.1.205]
MSIM_41810  ndkA; nucleoside diphosphate kinase [KO:K00940] [EC:2.7.4.6]
MSIM_40050  rdgB; non-canonical purine NTP pyrophosphatase [KO:K01519] [EC:3.6.1.66]
MSIM_14540  guaA; GMP synthase [glutamine-hydrolyzing] [KO:K01951] [EC:6.3.5.2]
MSIM_51690  guaB1; putative oxidoreductase [KO:K26110] [EC:1.7.1.7]
MSIM_19550  putative amidohydrolase [KO:K01487] [EC:3.5.4.3]
MSIM_02890  gmk; guanylate kinase [KO:K00942] [EC:2.7.4.8]
MSIM_09280  nrdE; ribonucleoside-diphosphate reductase subunit alpha [KO:K00525] [EC:1.17.4.1]
MSIM_08910  nrdF; ribonucleoside-diphosphate reductase subunit beta [KO:K00526] [EC:1.17.4.1]
MSIM_20410  nrdB; R2-like ligand binding oxidase [KO:K00526] [EC:1.17.4.1]
MSIM_42940  dgt; deoxyguanosinetriphosphate triphosphohydrolase-like protein [KO:K01129] [EC:3.1.5.1]
MSIM_03850  relA; putative GTP pyrophosphokinase [KO:K01139] [EC:2.7.6.5 3.1.7.2]
MSIM_17570  hypothetical protein [KO:K01524] [EC:3.6.1.11 3.6.1.40]
MSIM_36790  hypothetical protein [KO:K01524] [EC:3.6.1.11 3.6.1.40]
MSIM_00730  cya; adenylate cyclase [KO:K01768] [EC:4.6.1.1]
MSIM_14810  hypothetical protein [KO:K01768] [EC:4.6.1.1]
MSIM_16720  cyaO; guanylate cyclase [KO:K01768] [EC:4.6.1.1]
MSIM_19630  cyclase [KO:K01768] [EC:4.6.1.1]
MSIM_28270  adenylate/guanylate cyclase domain-containing protein [KO:K01768] [EC:4.6.1.1]
MSIM_37320  adenylate/guanylate cyclase domain-containing protein [KO:K01768] [EC:4.6.1.1]
MSIM_39100  pH-sensitive adenylate cyclase [KO:K01768] [EC:4.6.1.1]
MSIM_50980  hypothetical protein [KO:K01768] [EC:4.6.1.1]
MSIM_18820  purA; adenylosuccinate synthetase [KO:K01939] [EC:6.3.4.4]
MSIM_45820  adoK; adenosine kinase [KO:K00856] [EC:2.7.1.20]
MSIM_13970  add; adenosine deaminase [KO:K01488] [EC:3.5.4.4]
MSIM_10270  ymdB; hypothetical protein [KO:K09769] [EC:3.1.4.16]
MSIM_15540  adk; adenylate kinase [KO:K00939] [EC:2.7.4.3]
MSIM_36730  nucleoside triphosphate pyrophosphohydrolase [KO:K04765] [EC:3.6.1.9]
MSIM_04180  AP-4-A phosphorylase [KO:K19710] [EC:2.7.7.53]
MSIM_38360  adenylyl-sulfate kinase [KO:K00955] [EC:2.7.7.4 2.7.1.25]
MSIM_39440  cysNC; bifunctional enzyme CysN/CysC [KO:K00955] [EC:2.7.7.4 2.7.1.25]
MSIM_38370  sulfate adenylyltransferase [KO:K00957] [EC:2.7.7.4]
MSIM_39430  cysD; sulfate adenylyltransferase subunit 2 [KO:K00957] [EC:2.7.7.4]
MSIM_51620  ureC; urease subunit alpha [KO:K01428] [EC:3.5.1.5]
MSIM_51630  ureB; urease subunit beta [KO:K01429] [EC:3.5.1.5]
MSIM_51640  ureA; urease subunit gamma [KO:K01430] [EC:3.5.1.5]
Compound
C00002  ATP
C00008  ADP
C00011  CO2
C00014  Ammonia
C00020  AMP
C00035  GDP
C00037  Glycine
C00039  DNA
C00044  GTP
C00046  RNA
C00048  Glyoxylate
C00053  3'-Phosphoadenylyl sulfate
C00054  Adenosine 3',5'-bisphosphate
C00059  Sulfate
C00064  L-Glutamine
C00081  ITP
C00086  Urea
C00104  IDP
C00117  D-Ribose 5-phosphate
C00119  5-Phospho-alpha-D-ribose 1-diphosphate
C00130  IMP
C00131  dATP
C00144  GMP
C00147  Adenine
C00169  Carbamoyl phosphate
C00206  dADP
C00209  Oxalate
C00212  Adenosine
C00224  Adenylyl sulfate
C00242  Guanine
C00262  Hypoxanthine
C00286  dGTP
C00288  HCO3-
C00294  Inosine
C00301  ADP-ribose
C00330  Deoxyguanosine
C00360  dAMP
C00361  dGDP
C00362  dGMP
C00366  Urate
C00385  Xanthine
C00387  Guanosine
C00499  Allantoate
C00559  Deoxyadenosine
C00575  3',5'-Cyclic AMP
C00603  (S)-Ureidoglycolate
C00620  alpha-D-Ribose 1-phosphate
C00655  Xanthosine 5'-phosphate
C00700  XTP
C00802  Oxalureate
C00942  3',5'-Cyclic GMP
C01228  Guanosine 3',5'-bis(diphosphate)
C01260  P1,P4-Bis(5'-adenosyl)tetraphosphate
C01261  P1,P4-Bis(5'-guanosyl) tetraphosphate
C01344  dIDP
C01345  dITP
C01367  3'-AMP
C01444  Oxamate
C01762  Xanthosine
C02091  (S)-Ureidoglycine
C02348  (R)(-)-Allantoin
C02350  (S)-Allantoin
C02353  2',3'-Cyclic AMP
C02718  N-Formiminoglycine
C03090  5-Phosphoribosylamine
C03373  Aminoimidazole ribotide
C03483  Adenosine tetraphosphate
C03614  Inosine 5'-tetraphosphate
C03794  N6-(1,2-Dicarboxyethyl)-AMP
C03838  5'-Phosphoribosylglycinamide
C04051  5-Amino-4-imidazolecarboxyamide
C04376  5'-Phosphoribosyl-N-formylglycinamide
C04392  P1,P4-Bis(5'-xanthosyl) tetraphosphate
C04494  Guanosine 3'-diphosphate 5'-triphosphate
C04640  2-(Formamido)-N1-(5'-phosphoribosyl)acetamidine
C04677  1-(5'-Phosphoribosyl)-5-amino-4-imidazolecarboxamide
C04734  1-(5'-Phosphoribosyl)-5-formamido-4-imidazolecarboxamide
C04751  1-(5-Phospho-D-ribosyl)-5-amino-4-imidazolecarboxylate
C04823  1-(5'-Phosphoribosyl)-5-amino-4-(N-succinocarboxamide)-imidazole
C05239  5-Aminoimidazole
C05512  Deoxyinosine
C05513  Urate-3-ribonucleoside
C05515  5-Ureido-4-imidazole carboxylate
C05516  5-Amino-4-imidazole carboxylate
C05993  Acetyl adenylate
C06193  Guanosine 3'-phosphate
C06194  2',3'-Cyclic GMP
C06195  Imidazolone
C06196  2'-Deoxyinosine 5'-phosphate
C06197  P1,P3-Bis(5'-adenosyl) triphosphate
C06433  5'-Benzoylphosphoadenosine
C06435  5'-Butyrylphosphoinosine
C11821  5-Hydroxyisourate
C12248  5-Hydroxy-2-oxo-4-ureido-2,5-dihydro-1H-imidazole-5-carboxylate
C15667  5-Carboxyamino-1-(5-phospho-D-ribosyl)imidazole
C22395  N6-Succino-2-amino-2'-deoxyadenylate
C22441  dZMP
C22442  dZDP
C22443  dZTP
C22499  8-Hydroxyadenine
C22500  2,8-Dihydroxyadenine
Reference
PMID:10601204
  Authors
Cusa E, Obradors N, Baldoma L, Badia J, Aguilar J.
  Title
Genetic analysis of a chromosomal region containing genes required for assimilation of allantoin nitrogen and linked glyoxylate metabolism in Escherichia coli.
  Journal
J Bacteriol 181:7479-84 (1999)
DOI:10.1128/JB.181.24.7479-7484.1999
Reference
PMID:10986234
  Authors
Xi H, Schneider BL, Reitzer L.
  Title
Purine catabolism in Escherichia coli and function of xanthine dehydrogenase in purine salvage.
  Journal
J Bacteriol 182:5332-41 (2000)
DOI:10.1128/JB.182.19.5332-5341.2000
Related
pathway
msim00030  Pentose phosphate pathway
msim00220  Arginine biosynthesis
msim00250  Alanine, aspartate and glutamate metabolism
msim00260  Glycine, serine and threonine metabolism
msim00340  Histidine metabolism
msim00630  Glyoxylate and dicarboxylate metabolism
msim00730  Thiamine metabolism
msim00740  Riboflavin metabolism
msim00790  Folate biosynthesis
KO pathway
ko00230   
LinkDB

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