KEGG   PATHWAY: mtn00630
Entry
mtn00630                    Pathway                                
Name
Glyoxylate and dicarboxylate metabolism - Mycobacterium tuberculosis Erdman = ATCC 35801
Class
Metabolism; Carbohydrate metabolism
Pathway map
mtn00630  Glyoxylate and dicarboxylate metabolism
mtn00630

Module
mtn_M00012  Glyoxylate cycle [PATH:mtn00630]
mtn_M00621  Glycine cleavage system [PATH:mtn00630]
mtn_M00741  Propanoyl-CoA metabolism, propanoyl-CoA => succinyl-CoA [PATH:mtn00630]
Other DBs
GO: 0046487 0043648
Organism
Mycobacterium tuberculosis Erdman = ATCC 35801 [GN:mtn]
Gene
ERDMAN_0512  icl; isocitrate lyase [KO:K01637] [EC:4.1.3.1 4.1.3.30]
ERDMAN_2108  aceAb; isocitrate lyase [KO:K01637] [EC:4.1.3.1 4.1.3.30]
ERDMAN_4014  acs; acetyl-CoA synthetase [KO:K01895] [EC:6.2.1.1]
ERDMAN_2026  glcB; malate synthase G [KO:K01638] [EC:2.3.3.9]
ERDMAN_1386  mdh; malate dehydrogenase [KO:K00024] [EC:1.1.1.37]
ERDMAN_0984  citA; citrate synthase 2 [KO:K01647] [EC:2.3.3.1]
ERDMAN_0991  gltA; type II citrate synthase [KO:K01647] [EC:2.3.3.1]
ERDMAN_1267  gltA1; methylcitrate synthase [KO:K01659] [EC:2.3.3.5]
ERDMAN_1643  acn; aconitate hydratase [KO:K27802] [EC:4.2.1.3 4.2.1.99]
ERDMAN_2059  acetyl-CoA acetyltransferase [KO:K00626] [EC:2.3.1.9]
ERDMAN_0951  fadA; acetyl-CoA acetyltransferase [KO:K00626] [EC:2.3.1.9]
ERDMAN_1011  acetyl-CoA acetyltransferase [KO:K00626] [EC:2.3.1.9]
ERDMAN_0272  fadA2; acetyl-CoA acetyltransferase [KO:K00626] [EC:2.3.1.9]
ERDMAN_1483  fadA4; acetyl-CoA acetyltransferase [KO:K00626] [EC:2.3.1.9]
ERDMAN_3863  ltp3; acetyl-CoA acetyltransferase [KO:K00626] [EC:2.3.1.9]
ERDMAN_3891  fadA5; acetyl-CoA acetyltransferase [KO:K00626] [EC:2.3.1.9]
ERDMAN_3901  fadA6; acetyl-CoA acetyltransferase [KO:K00626] [EC:2.3.1.9]
ERDMAN_1199  fadA3; acetyl-CoA acetyltransferase [KO:K00626] [EC:2.3.1.9]
ERDMAN_1481  hypothetical protein [KO:K05606] [EC:5.1.99.1]
ERDMAN_3601  accA3; bifunctional acetyl-/propionyl-coenzyme Acarboxylase subunit alpha [KO:K11263] [EC:6.4.1.2 6.4.1.3 6.4.1.- 6.3.4.14]
ERDMAN_3596  accD5; propionyl-CoA carboxylase beta chain [KO:K27094] [EC:6.4.1.3 6.4.1.- 2.1.3.15]
ERDMAN_3597  hypothetical protein [KO:K27095]
ERDMAN_2472  accD6; acetyl/propionyl-CoA carboxylase beta subunit [KO:K18472] [EC:6.4.1.2 6.4.1.3 2.1.3.15]
ERDMAN_1662  mutA; methylmalonyl-CoA mutase small subunit [KO:K01847] [EC:5.4.99.2]
ERDMAN_1663  mutB; methylmalonyl-CoA mutase [KO:K01847] [EC:5.4.99.2]
ERDMAN_1404  oxidoreductase [KO:K00104] [EC:1.1.99.14]
ERDMAN_2495  dehydrogenase [KO:K00104] [EC:1.1.99.14]
ERDMAN_2456  hypothetical protein [KO:K01091] [EC:3.1.3.18]
ERDMAN_2070  glnA3; glutamine synthetase [KO:K01915] [EC:6.3.1.2]
ERDMAN_3137  glnA4; glutamine synthetase [KO:K01915] [EC:6.3.1.2]
ERDMAN_2439  glnA1; glutamine synthetase [KO:K01915] [EC:6.3.1.2]
ERDMAN_2441  glnA2; glutamine synthetase [KO:K01915] [EC:6.3.1.2]
ERDMAN_0083  glyA2; serine hydroxymethyltransferase [KO:K00600] [EC:2.1.2.1]
ERDMAN_1225  glyA; serine hydroxymethyltransferase [KO:K00600] [EC:2.1.2.1]
ERDMAN_2021  gcvB; glycine dehydrogenase [KO:K00281] [EC:1.4.4.2]
ERDMAN_2429  gcvT; glycine cleavage system aminomethyltransferase [KO:K00605] [EC:2.1.2.10]
ERDMAN_0507  lpd; dihydrolipoamide dehydrogenase [KO:K00382] [EC:1.8.1.4]
ERDMAN_2016  gcvH; glycine cleavage system protein H [KO:K02437]
ERDMAN_2423  hypothetical protein [KO:K00865] [EC:2.7.1.165]
ERDMAN_1394  kgd; alpha-ketoglutarate decarboxylase [KO:K01616] [EC:2.2.1.5 4.1.1.71 1.2.4.2 2.3.1.61]
ERDMAN_3247  purU; formyltetrahydrofolate deformylase [KO:K01433] [EC:3.5.1.10]
ERDMAN_0137  oxcA; putative oxalyl-CoA decarboxylase [KO:K01577] [EC:4.1.1.8]
Compound
C00007  Oxygen
C00011  CO2
C00014  Ammonia
C00022  Pyruvate
C00024  Acetyl-CoA
C00025  L-Glutamate
C00026  2-Oxoglutarate
C00027  Hydrogen peroxide
C00033  Acetate
C00036  Oxaloacetate
C00037  Glycine
C00042  Succinate
C00048  Glyoxylate
C00058  Formate
C00064  L-Glutamine
C00065  L-Serine
C00091  Succinyl-CoA
C00100  Propanoyl-CoA
C00111  Glycerone phosphate
C00136  Butanoyl-CoA
C00149  (S)-Malate
C00158  Citrate
C00160  Glycolate
C00168  Hydroxypyruvate
C00197  3-Phospho-D-glycerate
C00209  Oxalate
C00258  D-Glycerate
C00266  Glycolaldehyde
C00311  Isocitrate
C00313  Oxalyl-CoA
C00332  Acetoacetyl-CoA
C00417  cis-Aconitate
C00552  meso-Tartaric acid
C00631  2-Phospho-D-glycerate
C00683  (S)-Methylmalonyl-CoA
C00798  Formyl-CoA
C00877  Crotonoyl-CoA
C00888  Pentanoyl-CoA
C00898  (R,R)-Tartaric acid
C00975  Dihydroxyfumarate
C00988  2-Phosphoglycolate
C01127  4-Hydroxy-2-oxoglutarate
C01146  2-Hydroxy-3-oxopropanoate
C01182  D-Ribulose 1,5-bisphosphate
C01213  (R)-Methylmalonyl-CoA
C01380  Ethylene glycol
C01732  Mesaconate
C01989  3-Ethylmalate
C01990  3-Oxalomalate
C02123  3-Propylmalate
C02405  Formyl phosphate
C03217  2-Hydroxy-3-oxoadipate
C03459  2-Hydroxy-3-oxosuccinate
C03548  trans-2,3-Epoxysuccinate
C03561  (R)-3-Hydroxybutanoyl-CoA
C03618  L-threo-3-Methylaspartate
C04348  L-Malyl-CoA
C06027  L-erythro-3-Methylmalyl-CoA
C06028  2-Methylfumaryl-CoA
C06049  N-Formylderivatives
C18026  (2S)-Ethylmalonyl-CoA
C18324  (2S)-Methylsuccinyl-CoA
C20238  (2R)-Ethylmalonyl-CoA
C22337  D-Ribulose 1-phosphate
Reference
PMID:10978349
  Authors
Njau RK, Herndon CA, Hawes JW.
  Title
Novel beta-hydroxyacid dehydrogenases in Escherichia coli and Haemophilus influenzae.
  Journal
J Biol Chem 275:38780-6 (2000)
DOI:10.1074/jbc.M007432200
Reference
PMID:18065535
  Authors
Zarzycki J, Schlichting A, Strychalsky N, Muller M, Alber BE, Fuchs G
  Title
Mesaconyl-coenzyme A hydratase, a new enzyme of two central carbon metabolic pathways in bacteria.
  Journal
J Bacteriol 190:1366-74 (2008)
DOI:10.1128/JB.01621-07
Reference
PMID:18819910
  Authors
Erb TJ, Retey J, Fuchs G, Alber BE
  Title
Ethylmalonyl-CoA mutase from Rhodobacter sphaeroides defines a new subclade of coenzyme B12-dependent acyl-CoA mutases.
  Journal
J Biol Chem 283:32283-93 (2008)
DOI:10.1074/jbc.M805527200
Reference
PMID:9596633
  Authors
Coschigano KT, Melo-Oliveira R, Lim J, Coruzzi GM
  Title
Arabidopsis gls mutants and distinct Fd-GOGAT genes. Implications for photorespiration and primary nitrogen assimilation.
  Journal
Plant Cell 10:741-52 (1998)
DOI:10.1105/tpc.10.5.741
Reference
PMID:16407450
  Authors
Masclaux-Daubresse C, Reisdorf-Cren M, Pageau K, Lelandais M, Grandjean O, Kronenberger J, Valadier MH, Feraud M, Jouglet T, Suzuki A
  Title
Glutamine synthetase-glutamate synthase pathway and glutamate dehydrogenase play distinct roles in the sink-source nitrogen cycle in tobacco.
  Journal
Plant Physiol 140:444-56 (2006)
DOI:10.1104/pp.105.071910
Reference
PMID:21252347
  Authors
Khomyakova M, Bukmez O, Thomas LK, Erb TJ, Berg IA
  Title
A methylaspartate cycle in haloarchaea.
  Journal
Science 331:334-7 (2011)
DOI:10.1126/science.1196544
Reference
PMID:11513957
  Authors
Serrano JA, Bonete MJ
  Title
Sequencing, phylogenetic and transcriptional analysis of the glyoxylate bypass operon (ace) in the halophilic archaeon Haloferax volcanii.
  Journal
Biochim Biophys Acta 1520:154-62 (2001)
DOI:10.1016/S0167-4781(01)00263-9
Related
pathway
mtn00010  Glycolysis / Gluconeogenesis
mtn00020  Citrate cycle (TCA cycle)
mtn00030  Pentose phosphate pathway
mtn00053  Ascorbate and aldarate metabolism
mtn00071  Fatty acid degradation
mtn00230  Purine metabolism
mtn00250  Alanine, aspartate and glutamate metabolism
mtn00260  Glycine, serine and threonine metabolism
mtn00620  Pyruvate metabolism
mtn00710  Carbon fixation by Calvin cycle
mtn00750  Vitamin B6 metabolism
mtn00910  Nitrogen metabolism
KO pathway
ko00630   
LinkDB

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