KEGG   PATHWAY: myi00260
Entry
myi00260                    Pathway                                
Name
Glycine, serine and threonine metabolism - Mizuhopecten yessoensis (Yesso scallop)
Description
Serine is derived from 3-phospho-D-glycerate, an intermediate of glycolysis [MD:M00020], and glycine is derived from serine. Threonine is an essential amino acid, which animals cannot synthesize. In bacteria and plants, threonine is derived from aspartate [MD:M00018].
Class
Metabolism; Amino acid metabolism
Pathway map
myi00260  Glycine, serine and threonine metabolism
myi00260

Module
myi_M00020  Serine biosynthesis, glycerate-3P => serine [PATH:myi00260]
myi_M00338  Cysteine biosynthesis, homocysteine + serine => cysteine [PATH:myi00260]
myi_M00555  Betaine biosynthesis, choline => betaine [PATH:myi00260]
myi_M00621  Glycine cleavage system [PATH:myi00260]
Other DBs
GO: 0006544 0006563 0070178 0006566
Organism
Mizuhopecten yessoensis (Yesso scallop) [GN:myi]
Gene
110463860  probable low-specificity L-threonine aldolase 2 isoform X1 [KO:K01620] [EC:4.1.2.48]
110447502  serine hydroxymethyltransferase, cytosolic-like [KO:K00600] [EC:2.1.2.1]
110452752  serine hydroxymethyltransferase, mitochondrial-like [KO:K00600] [EC:2.1.2.1]
110455287  serine--pyruvate aminotransferase-like [KO:K00830] [EC:2.6.1.44 2.6.1.45 2.6.1.51]
110441392  glyoxylate reductase/hydroxypyruvate reductase-like [KO:K00049] [EC:1.1.1.79 1.1.1.81]
110458929  glyoxylate reductase/hydroxypyruvate reductase-like [KO:K00049] [EC:1.1.1.79 1.1.1.81]
110452426  glyoxylate reductase/hydroxypyruvate reductase-like [KO:K00049] [EC:1.1.1.79 1.1.1.81]
110452427  glyoxylate reductase/hydroxypyruvate reductase-like isoform X1 [KO:K00049] [EC:1.1.1.79 1.1.1.81]
110452452  glyoxylate reductase/hydroxypyruvate reductase-like [KO:K00049] [EC:1.1.1.79 1.1.1.81]
110461594  glyoxylate reductase/hydroxypyruvate reductase-like isoform X1 [KO:K00049] [EC:1.1.1.79 1.1.1.81]
110458822  glyoxylate reductase/hydroxypyruvate reductase-like [KO:K00049] [EC:1.1.1.79 1.1.1.81]
110462256  glycerate kinase-like isoform X1 [KO:K11529] [EC:2.7.1.165]
110464962  probable phosphoglycerate mutase [KO:K01834] [EC:5.4.2.11]
110465020  D-3-phosphoglycerate dehydrogenase-like [KO:K00058] [EC:1.1.1.95 1.1.1.399]
110451458  phosphoserine aminotransferase-like [KO:K00831] [EC:2.6.1.52]
110443108  phosphoserine phosphatase-like [KO:K01079] [EC:3.1.3.3]
110442908  2-amino-3-ketobutyrate coenzyme A ligase, mitochondrial-like [KO:K00639] [EC:2.3.1.29]
110442179  L-threonine 3-dehydrogenase, mitochondrial-like [KO:K15789] [EC:1.1.1.103]
110452629  5-aminolevulinate synthase, erythroid-specific, mitochondrial-like isoform X1 [KO:K00643] [EC:2.3.1.37]
110441471  probable flavin-containing monoamine oxidase A [KO:K00274] [EC:1.4.3.4]
110440594  amine oxidase [flavin-containing]-like isoform X1 [KO:K00274] [EC:1.4.3.4]
110440759  amine oxidase [flavin-containing]-like [KO:K00274] [EC:1.4.3.4]
110452665  probable flavin-containing monoamine oxidase A [KO:K00274] [EC:1.4.3.4]
110454725  amine oxidase [flavin-containing] A-like [KO:K00274] [EC:1.4.3.4]
110464211  probable flavin-containing monoamine oxidase A [KO:K00274] [EC:1.4.3.4]
110464212  probable flavin-containing monoamine oxidase A isoform X1 [KO:K00274] [EC:1.4.3.4]
110453888  probable flavin-containing monoamine oxidase A [KO:K00274] [EC:1.4.3.4]
110467306  amiloride-sensitive amine oxidase [copper-containing]-like [KO:K00276] [EC:1.4.3.21]
110454425  glycine dehydrogenase (decarboxylating), mitochondrial-like [KO:K00281] [EC:1.4.4.2]
110461700  aminomethyltransferase, mitochondrial-like isoform X1 [KO:K00605] [EC:2.1.2.10]
110461708  dihydrolipoyl dehydrogenase, mitochondrial-like isoform X1 [KO:K00382] [EC:1.8.1.4]
110467498  uncharacterized protein LOC110467498 [KO:K02437]
110445951  D-amino-acid oxidase-like isoform X1 [KO:K00273] [EC:1.4.3.3]
110456851  D-amino-acid oxidase-like isoform X1 [KO:K00273] [EC:1.4.3.3]
110453623  alanine--glyoxylate aminotransferase 2, mitochondrial-like [KO:K00827] [EC:2.6.1.44 2.6.1.40]
110458447  uncharacterized protein LOC110458447 isoform X1 [KO:K00108] [EC:1.1.99.1]
110455019  alpha-aminoadipic semialdehyde dehydrogenase-like [KO:K14085] [EC:1.2.1.31 1.2.1.8 1.2.1.3]
110456469  betaine--homocysteine S-methyltransferase 1-like [KO:K00544] [EC:2.1.1.5]
110455538  betaine--homocysteine S-methyltransferase 1-like [KO:K00544] [EC:2.1.1.5]
110464929  betaine--homocysteine S-methyltransferase 1-like [KO:K00544] [EC:2.1.1.5]
110464943  betaine--homocysteine S-methyltransferase 1-like isoform X1 [KO:K00544] [EC:2.1.1.5]
110467328  betaine--homocysteine S-methyltransferase 1-like [KO:K00544] [EC:2.1.1.5]
110458153  betaine--homocysteine S-methyltransferase 1-like isoform X1 [KO:K00544] [EC:2.1.1.5]
110456381  betaine--homocysteine S-methyltransferase 1-like [KO:K00544] [EC:2.1.1.5]
110456382  betaine--homocysteine S-methyltransferase 1-like [KO:K00544] [EC:2.1.1.5]
110456384  betaine--homocysteine S-methyltransferase 1-like [KO:K00544] [EC:2.1.1.5]
110460728  peroxisomal sarcosine oxidase-like isoform X1 [KO:K00306] [EC:1.5.3.1 1.5.3.7]
110457682  peroxisomal sarcosine oxidase-like isoform X1 [KO:K00306] [EC:1.5.3.1 1.5.3.7]
110457683  peroxisomal sarcosine oxidase-like [KO:K00306] [EC:1.5.3.1 1.5.3.7]
110457684  peroxisomal sarcosine oxidase-like [KO:K00306] [EC:1.5.3.1 1.5.3.7]
110457846  cystathionine beta-synthase-like isoform X1 [KO:K01697] [EC:4.2.1.22]
110442827  cystathionine gamma-lyase-like [KO:K01758] [EC:4.4.1.1]
110443690  uncharacterized protein LOC110443690 isoform X1 [KO:K01754] [EC:4.3.1.19]
110452881  L-serine dehydratase/L-threonine deaminase-like [KO:K17989] [EC:4.3.1.17 4.3.1.19]
110441658  uncharacterized protein LOC110441658 [KO:K20498] [EC:4.3.1.18]
110450642  probable serine racemase isoform X1 [KO:K12235] [EC:5.1.1.18]
Compound
C00011  CO2
C00014  Ammonia
C00022  Pyruvate
C00037  Glycine
C00048  Glyoxylate
C00049  L-Aspartate
C00065  L-Serine
C00078  L-Tryptophan
C00097  L-Cysteine
C00101  Tetrahydrofolate
C00109  2-Oxobutanoate
C00114  Choline
C00143  5,10-Methylenetetrahydrofolate
C00168  Hydroxypyruvate
C00188  L-Threonine
C00197  3-Phospho-D-glycerate
C00213  Sarcosine
C00258  D-Glycerate
C00263  L-Homoserine
C00300  Creatine
C00430  5-Aminolevulinate
C00441  L-Aspartate 4-semialdehyde
C00546  Methylglyoxal
C00576  Betaine aldehyde
C00581  Guanidinoacetate
C00631  2-Phospho-D-glycerate
C00719  Betaine
C00740  D-Serine
C00986  1,3-Diaminopropane
C01005  O-Phospho-L-serine
C01026  N,N-Dimethylglycine
C01102  O-Phospho-L-homoserine
C01242  [Protein]-S8-aminomethyldihydrolipoyllysine
C01888  Aminoacetone
C02051  Lipoylprotein
C02291  L-Cystathionine
C02737  Phosphatidylserine
C02972  Dihydrolipoylprotein
C03082  4-Phospho-L-aspartate
C03194  (R)-1-Aminopropan-2-ol
C03232  3-Phosphonooxypyruvate
C03283  L-2,4-Diaminobutanoate
C03508  L-2-Amino-3-oxobutanoic acid
C05519  L-Allothreonine
C06231  Ectoine
C06442  N(gamma)-Acetyldiaminobutyrate
C16432  5-Hydroxyectoine
C19929  N(alpha)-Acetyl-L-2,4-diaminobutyrate
Reference
  Authors
Nishizuka Y, Seyama Y, Ikai A, Ishimura Y, Kawaguchi A (eds).
  Title
[Cellular Functions and Metabolic Maps] (In Japanese)
  Journal
Tokyo Kagaku Dojin (1997)
Reference
  Authors
Kuhlmann AU, Bremer E.
  Title
Osmotically regulated synthesis of the compatible solute ectoine in Bacillus pasteurii and related Bacillus spp.
  Journal
Appl Environ Microbiol 68:772-83 (2002)
DOI:10.1128/AEM.68.2.772-783.2002
Reference
  Authors
Canovas D, Borges N, Vargas C, Ventosa A, Nieto JJ, Santos H.
  Title
Role of Ngamma-acetyldiaminobutyrate as an enzyme stabilizer and an intermediate in the biosynthesis of hydroxyectoine.
  Journal
Appl Environ Microbiol 65:3774-9 (1999)
DOI:10.1128/AEM.65.9.3774-3779.1999
Reference
  Authors
Bursy J, Pierik AJ, Pica N, Bremer E.
  Title
Osmotically induced synthesis of the compatible solute hydroxyectoine is mediated by an evolutionarily conserved ectoine hydroxylase.
  Journal
J Biol Chem 282:31147-55 (2007)
DOI:10.1074/jbc.M704023200
Reference
  Authors
Garcia-Estepa R, Argandona M, Reina-Bueno M, Capote N, Iglesias-Guerra F, Nieto JJ, Vargas C.
  Title
The ectD gene, which is involved in the synthesis of the compatible solute hydroxyectoine, is essential for thermoprotection of the halophilic bacterium Chromohalobacter salexigens.
  Journal
J Bacteriol 188:3774-84 (2006)
DOI:10.1128/JB.00136-06
Reference
  Authors
Arevalo-Rodriguez M, Pan X, Boeke JD, Heitman J
  Title
FKBP12 controls aspartate pathway flux in Saccharomyces cerevisiae to prevent toxic intermediate accumulation.
  Journal
Eukaryot Cell 3:1287-96 (2004)
DOI:10.1128/EC.3.5.1287-1296.2004
Reference
PMID:7639721
  Authors
Rees WD, Hay SM
  Title
The biosynthesis of threonine by mammalian cells: expression of a complete bacterial biosynthetic pathway in an animal cell.
  Journal
Biochem J 309 ( Pt 3):999-1007 (1995)
DOI:10.1042/bj3090999
Reference
  Authors
Jacques SL, Nieman C, Bareich D, Broadhead G, Kinach R, Honek JF, Wright GD
  Title
Characterization of yeast homoserine dehydrogenase, an antifungal target: the invariant histidine 309 is important for enzyme integrity.
  Journal
Biochim Biophys Acta 1544:28-41 (2001)
DOI:10.1016/S0167-4838(00)00203-X
Reference
  Authors
Chen X, Jhee KH, Kruger WD
  Title
Production of the neuromodulator H2S by cystathionine beta-synthase via the condensation of cysteine and homocysteine.
  Journal
J Biol Chem 279:52082-6 (2004)
DOI:10.1074/jbc.C400481200
Related
pathway
myi00010  Glycolysis / Gluconeogenesis
myi00020  Citrate cycle (TCA cycle)
myi00230  Purine metabolism
myi00250  Alanine, aspartate and glutamate metabolism
myi00270  Cysteine and methionine metabolism
myi00290  Valine, leucine and isoleucine biosynthesis
myi00300  Lysine biosynthesis
myi00330  Arginine and proline metabolism
myi00470  D-Amino acid metabolism
myi00564  Glycerophospholipid metabolism
myi00600  Sphingolipid metabolism
myi00620  Pyruvate metabolism
myi00630  Glyoxylate and dicarboxylate metabolism
myi00640  Propanoate metabolism
myi00860  Porphyrin metabolism
myi00920  Sulfur metabolism
KO pathway
ko00260   
LinkDB

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