KEGG   PATHWAY: nle04814
Entry
nle04814                    Pathway                                
Name
Motor proteins - Nomascus leucogenys (northern white-cheeked gibbon)
Class
Cellular Processes; Cell motility
Pathway map
nle04814  Motor proteins
nle04814

Organism
Nomascus leucogenys (northern white-cheeked gibbon) [GN:nle]
Gene
100601904  DYNC1H1; cytoplasmic dynein 1 heavy chain 1 [KO:K10413]
100585639  DYNC2H1; cytoplasmic dynein 2 heavy chain 1 isoform X1 [KO:K10414]
100597127  DYNC1I2; cytoplasmic dynein 1 intermediate chain 2 isoform X6 [KO:K10415]
100605578  DYNC1I1; cytoplasmic dynein 1 intermediate chain 1 isoform X1 [KO:K10415]
100599226  DYNC1LI2; cytoplasmic dynein 1 light intermediate chain 2 isoform X1 [KO:K10416]
100582206  DYNC1LI1; cytoplasmic dynein 1 light intermediate chain 1 [KO:K10416]
100600928  DYNC2LI1; cytoplasmic dynein 2 light intermediate chain 1 isoform X2 [KO:K10417]
100584241  DYNLL1; dynein light chain 1, cytoplasmic [KO:K10418]
100592344  dynein light chain 1, cytoplasmic-like [KO:K10418]
100604359  DYNLL2; dynein light chain 2, cytoplasmic [KO:K10418]
100582636  DYNLRB2; dynein light chain roadblock-type 2 [KO:K10419]
100601652  DYNLRB1; dynein light chain roadblock-type 1 isoform X4 [KO:K10419]
100598597  DYNLT1; dynein light chain Tctex-type 1 isoform X1 [KO:K10420]
100605681  DYNLT3; dynein light chain Tctex-type 3 [KO:K10420]
100605536  TCTE3; tctex1 domain-containing protein 3 [KO:K25419]
100603394  TCTEX1D4; tctex1 domain-containing protein 4 [KO:K25420]
100606316  TCTEX1D1; tctex1 domain-containing protein 1 [KO:K25421]
100580425  DNAH7; dynein heavy chain 7, axonemal [KO:K10408]
100580821  DNAH5; dynein heavy chain 5, axonemal [KO:K10408]
100600498  DNAH6; dynein heavy chain 6, axonemal [KO:K10408]
100584743  DNAH11; dynein heavy chain 11, axonemal [KO:K10408]
100600100  DNAH12; dynein heavy chain 12, axonemal isoform X1 [KO:K10408]
100581769  DNAH8; dynein heavy chain 8, axonemal [KO:K10408]
100599306  DNAH10; dynein heavy chain 10, axonemal isoform X2 [KO:K10408]
100594647  DNAH14; dynein heavy chain 14, axonemal isoform X1 [KO:K10408]
100580229  DNAH17; dynein heavy chain 17, axonemal [KO:K10408]
100587033  DNAH9; dynein heavy chain 9, axonemal [KO:K10408]
100581416  dynein heavy chain 2, axonemal [KO:K10408]
100595944  dynein heavy chain 3, axonemal [KO:K10408]
100599644  DNAH1; dynein heavy chain 1, axonemal [KO:K10408]
100583045  DNAI1; dynein intermediate chain 1, axonemal [KO:K10409]
100597971  DNAI2; dynein intermediate chain 2, axonemal [KO:K11143]
100591497  WDR63; WD repeat-containing protein 63 isoform X1 [KO:K24722]
100607133  WDR78; LOW QUALITY PROTEIN: WD repeat-containing protein 78 [KO:K24723]
100595541  DNALI1; axonemal dynein light intermediate polypeptide 1 [KO:K10410]
100602373  DNAL1; dynein light chain 1, axonemal isoform X1 [KO:K10411]
100583936  DNAL4; dynein light chain 4, axonemal [KO:K10412]
100585622  DCTN1; dynactin subunit 1 isoform X6 [KO:K04648]
100580182  DCTN2; dynactin subunit 2 isoform X1 [KO:K10424]
100579587  DCTN3; dynactin subunit 3 [KO:K10425]
100605555  DCTN4; dynactin subunit 4 isoform X1 [KO:K10426]
100594791  DCTN5; dynactin subunit 5 isoform X1 [KO:K10427]
100595304  DCTN6; dynactin subunit 6 [KO:K10428]
100593710  ACTR1A; alpha-centractin isoform X1 [KO:K16575]
100594459  ACTR1B; beta-centractin isoform X1 [KO:K16575]
100601754  ACTR10; actin-related protein 10 isoform X1 [KO:K16576]
100580515  CAPZA1; F-actin-capping protein subunit alpha-1 [KO:K10364]
100581050  CAPZA3; F-actin-capping protein subunit alpha-3 [KO:K10364]
100607107  CAPZA2; F-actin-capping protein subunit alpha-2 [KO:K10364]
100599958  CAPZB; F-actin-capping protein subunit beta isoform X1 [KO:K10365]
100588180  BICDL2; BICD family-like cargo adapter 2 [KO:K16756]
100601025  BICDL1; BICD family-like cargo adapter 1 [KO:K16756]
100593349  HOOK3; protein Hook homolog 3 isoform X2 [KO:K16536]
100602904  TUBAL3; tubulin alpha chain-like 3 isoform X1 [KO:K07374]
100582452  TUBA8; tubulin alpha-8 chain [KO:K07374]
100585215  tubulin alpha-3 chain [KO:K07374]
100587604  tubulin alpha-3 chain [KO:K07374]
100599731  TUBA4B; putative tubulin-like protein alpha-4B [KO:K07374]
100602647  tubulin alpha-1C chain isoform X1 [KO:K07374]
100583522  TUBA4A; tubulin alpha-4A chain isoform X1 [KO:K07374]
100592992  TUBA3E; tubulin alpha-3E chain [KO:K07374]
100585634  tubulin alpha-1A chain [KO:K07374]
100604350  tubulin alpha-1B chain [KO:K07374]
100598146  TUBB; tubulin beta chain [KO:K07375]
100581245  LOW QUALITY PROTEIN: tubulin beta-3 chain [KO:K07375]
100601335  TUBB6; tubulin beta-6 chain isoform X1 [KO:K07375]
100600563  tubulin beta-8 chain isoform X10 [KO:K07375]
100595142  TUBB4A; tubulin beta-4A chain [KO:K07375]
100606187  TUBB1; tubulin beta-1 chain [KO:K07375]
100596954  TUBB4B; tubulin beta-4B chain [KO:K07375]
100600510  tubulin beta-2B chain [KO:K07375]
100599614  TUBB2A; tubulin beta-2A chain [KO:K07375]
100594805  tubulin beta-8 chain-like isoform X1 [KO:K07375]
100580376  tubulin beta-8 chain-like isoform X1 [KO:K07375]
100595133  TUBB8; tubulin beta-8 chain [KO:K07375]
115830336  tubulin beta-8 chain-like [KO:K07375]
100586264  tubulin beta-8 chain-like [KO:K07375]
115833773  tubulin beta-8 chain-like [KO:K07375]
100582845  tubulin beta chain-like isoform X1 [KO:K07375]
100603507  TUBG2; tubulin gamma-2 chain isoform X4 [KO:K10389]
100602375  tubulin gamma-1 chain [KO:K10389]
100595015  TUBD1; tubulin delta chain isoform X1 [KO:K10390]
100586868  TUBE1; tubulin epsilon chain isoform X1 [KO:K10391]
100589788  KIF5B; kinesin-1 heavy chain [KO:K10396]
100579859  KIF5A; kinesin heavy chain isoform X1 [KO:K10396]
100591941  KIF5C; kinesin heavy chain [KO:K10396]
100596908  KLC2; kinesin light chain 2 [KO:K10407]
100595792  KLC3; kinesin light chain 3 [KO:K10407]
100604453  KLC4; kinesin light chain 4 isoform X1 [KO:K10407]
100582106  KLC1; kinesin light chain 1 isoform X1 [KO:K10407]
100597509  KIF3A; kinesin-like protein KIF3A isoform X1 [KO:K10394]
100589875  KIF3B; kinesin-like protein KIF3B [KO:K20196]
100585459  KIFAP3; kinesin-associated protein 3 isoform X1 [KO:K25388]
100591779  KIF3C; kinesin-like protein KIF3C [KO:K20197]
100600293  KIF17; kinesin-like protein KIF17 [KO:K20198]
100582798  KIF1A; kinesin-like protein KIF1A isoform X1 [KO:K10392]
105738625  kinesin-like protein KIF1C [KO:K10392]
100583208  KIF1B; kinesin-like protein KIF1B isoform X1 [KO:K10392]
100590824  KIF1C; kinesin-like protein KIF1C [KO:K10392]
115831451  LOW QUALITY PROTEIN: kinesin-like protein KIF1C [KO:K10392]
100603229  KIF13B; kinesin-like protein KIF13B isoform X1 [KO:K17914]
100605094  KIF13A; kinesin-like protein KIF13A isoform X1 [KO:K17914]
100579832  KIF14; kinesin-like protein KIF14 isoform X1 [KO:K17915]
100585746  KIF16B; kinesin-like protein KIF16B isoform X2 [KO:K17916]
100600167  STARD9; stAR-related lipid transfer protein 9 isoform X4 [KO:K16491]
100600625  KIF4A; chromosome-associated kinesin KIF4A isoform X1 [KO:K10395]
100584663  KIF4B; chromosome-associated kinesin KIF4B [KO:K10395]
100587965  KIF7; kinesin-like protein KIF7 isoform X1 [KO:K18806]
115836683  KIF21B; kinesin-like protein KIF21B isoform X1 [KO:K24185]
100584291  KIF21A; kinesin-like protein KIF21A isoform X9 [KO:K24185]
100600385  KIF27; kinesin-like protein KIF27 [KO:K24186]
100593604  KIF11; kinesin-like protein KIF11 [KO:K10398]
100587329  KIF20B; kinesin-like protein KIF20B isoform X2 [KO:K10402]
100586722  KIF20A; kinesin-like protein KIF20A isoform X1 [KO:K10402]
100593002  KIF23; kinesin-like protein KIF23 isoform X2 [KO:K17387]
100606050  CENPE; centromere-associated protein E [KO:K11498]
100597580  KIF18A; kinesin-like protein KIF18A [KO:K10401]
100605451  KIF18B; kinesin-like protein KIF18B isoform X1 [KO:K26156]
115838252  KIF19; LOW QUALITY PROTEIN: kinesin-like protein KIF19 [KO:K26157]
100603756  LOW QUALITY PROTEIN: kinesin-like protein KIF19 [KO:K26157]
115838285  LOW QUALITY PROTEIN: kinesin-like protein KIF19 [KO:K26157]
100584776  KIF9; kinesin-like protein KIF9 isoform X7 [KO:K10397]
100599461  KIF22; kinesin-like protein KIF22 isoform X2 [KO:K10403]
100598346  KIF26B; kinesin-like protein KIF26B [KO:K10404]
100592163  KIF26A; kinesin-like protein KIF26A isoform X1 [KO:K10404]
100586931  KIF12; kinesin-like protein KIF12 [KO:K10399]
100607195  KIF15; kinesin-like protein KIF15 isoform X1 [KO:K10400]
100587830  KIF24; kinesin-like protein KIF24 [KO:K10393]
100590717  KIF2C; kinesin-like protein KIF2C isoform X1 [KO:K10393]
100594029  KIF2A; kinesin-like protein KIF2A isoform X1 [KO:K10393]
100594853  KIF2B; LOW QUALITY PROTEIN: kinesin-like protein KIF2B [KO:K10393]
100582476  KIFC1; kinesin-like protein KIFC1 isoform X1 [KO:K10405]
100585355  KIFC3; kinesin-like protein KIFC3 isoform X1 [KO:K10406]
100598780  KIFC2; kinesin-like protein KIFC2 isoform X1 [KO:K10406]
100592539  KIF25; kinesin-like protein KIF25 [KO:K18627]
100597468  MYO1B; unconventional myosin-Ib isoform X5 [KO:K10356]
100581268  MYO1E; unconventional myosin-Ie [KO:K10356]
100596491  MYO1D; unconventional myosin-Id [KO:K10356]
100606538  MYO1C; unconventional myosin-Ic isoform X1 [KO:K10356]
100607102  MYO1H; unconventional myosin-Ih [KO:K10356]
100582509  MYO1A; unconventional myosin-Ia isoform X1 [KO:K10356]
100591187  MYO1F; unconventional myosin-If isoform X1 [KO:K10356]
100593688  MYO1G; unconventional myosin-Ig [KO:K10356]
100585760  MYO3B; myosin-IIIb isoform X1 [KO:K08834] [EC:2.7.11.1]
100597781  MYO3A; myosin-IIIa [KO:K08834] [EC:2.7.11.1]
100580623  MYO5B; unconventional myosin-Vb [KO:K10357]
100595056  MYO5A; unconventional myosin-Va isoform X1 [KO:K10357]
100594716  MYO5C; unconventional myosin-Vc isoform X1 [KO:K10357]
100588526  MYO6; unconventional myosin-VI [KO:K10358]
100587439  MYO7A; unconventional myosin-VIIa [KO:K10359]
100600532  MYO7B; unconventional myosin-VIIb [KO:K21868]
100598624  MYO9B; unconventional myosin-IXb isoform X1 [KO:K10360]
100599247  MYO9A; unconventional myosin-IXa isoform X2 [KO:K10360]
100586924  MYO10; unconventional myosin-X [KO:K12559]
100600019  MYO15A; unconventional myosin-XV isoform X1 [KO:K10361]
100606285  MYO15B; myosin XVB [KO:K10361]
100603101  MYO16; unconventional myosin-XVI [KO:K17481]
100594317  MYO18A; unconventional myosin-XVIIIa isoform X1 [KO:K10362]
100583016  MYO18B; unconventional myosin-XVIIIb [KO:K10362]
100606404  MYO19; LOW QUALITY PROTEIN: unconventional myosin-XIX [KO:K25838]
100599749  MYH1; myosin-1 [KO:K24220]
100600090  myosin-4 isoform X2 [KO:K24220]
100600636  MYH8; myosin-8 isoform X3 [KO:K24220]
100599179  myosin-2 isoform X1 [KO:K24220]
100600987  MYH3; myosin-3 [KO:K24220]
100604824  MYH7B; myosin-7B isoform X1 [KO:K24220]
100601931  MYH15; myosin-15 isoform X1 [KO:K24220]
100598847  MYH13; myosin-13 [KO:K24220]
100599213  myosin-6 [KO:K17751]
100601359  myosin-7 [KO:K17751]
100585776  MYH10; myosin-10 isoform X1 [KO:K10352]
100589070  myosin-14 isoform X1 [KO:K10352]
100591092  MYH9; myosin-9 isoform X1 [KO:K10352]
100601489  MYH11; myosin-11 isoform X1 [KO:K10352]
100595875  MYL1; myosin light chain 1/3, skeletal muscle isoform isoform X1 [KO:K05738]
100583112  MYL3; myosin light chain 3 [KO:K12749]
100594384  MYL4; myosin light chain 4 [KO:K12750]
100597763  MYL6B; myosin light chain 6B isoform X1 [KO:K12751]
100598109  MYL6; myosin light polypeptide 6 isoform X1 [KO:K12751]
100590389  MYL2; myosin regulatory light chain 2, ventricular/cardiac muscle isoform [KO:K10351]
100594437  MYL5; myosin light chain 5 isoform X1 [KO:K12753]
100589180  MYL7; myosin regulatory light chain 2, atrial isoform isoform X2 [KO:K12754]
100593242  MYL9; myosin regulatory light polypeptide 9 [KO:K12755]
100606269  MYL10; myosin regulatory light chain 10 [KO:K12756]
100586474  MYL12A; myosin regulatory light chain 12A isoform X1 [KO:K12757]
100585479  MYL12B; myosin regulatory light chain 12B [KO:K12757]
100583586  MYLPF; myosin regulatory light chain 2, skeletal muscle isoform [KO:K12758]
100589549  ACTA1; actin, alpha skeletal muscle [KO:K10354]
100579983  ACTA2; actin, aortic smooth muscle [KO:K12313]
100603570  ACTC1; actin, alpha cardiac muscle 1 [KO:K12314]
100581173  ACTG2; actin, gamma-enteric smooth muscle isoform X1 [KO:K12315]
100598167  ACTG1; actin, cytoplasmic 2 [KO:K05692]
100598411  ACTB; actin, cytoplasmic 1 [KO:K05692]
100581871  TNNC1; troponin C, slow skeletal and cardiac muscles [KO:K05865]
100585606  TNNI1; troponin I, slow skeletal muscle isoform X1 [KO:K10371]
100582187  TNNC2; troponin C, skeletal muscle isoform X1 [KO:K12042]
100583922  TNNI2; troponin I, fast skeletal muscle [KO:K12043]
100591624  TNNT3; troponin T, fast skeletal muscle isoform X1 [KO:K12046]
100590739  TNNI3; troponin I, cardiac muscle [KO:K12044]
100583829  TNNT2; troponin T, cardiac muscle isoform X1 [KO:K12045]
100591881  TPM1; tropomyosin alpha-1 chain isoform X18 [KO:K10373]
100597087  TPM2; tropomyosin beta chain isoform X3 [KO:K10374]
100600342  TPM3; tropomyosin alpha-3 chain isoform X8 [KO:K09290]
100598772  tropomyosin alpha-3 chain-like isoform X1 [KO:K09290]
100595904  TPM4; tropomyosin alpha-4 chain isoform X1 [KO:K10375]
Reference
PMID:21092854
  Authors
Hirokawa N, Niwa S, Tanaka Y
  Title
Molecular motors in neurons: transport mechanisms and roles in brain function, development, and disease.
  Journal
Neuron 68:610-38 (2010)
DOI:10.1016/j.neuron.2010.09.039
Reference
PMID:25470043 (PDB:4RH7)
  Authors
Schmidt H, Zalyte R, Urnavicius L, Carter AP
  Title
Structure of human cytoplasmic dynein-2 primed for its power stroke.
  Journal
Nature 518:435-438 (2015)
DOI:10.1038/nature14023
Reference
PMID:22398446 (PDB:3VKG 3VKH)
  Authors
Kon T, Oyama T, Shimo-Kon R, Imamula K, Shima T, Sutoh K, Kurisu G
  Title
The 2.8 A crystal structure of the dynein motor domain.
  Journal
Nature 484:345-50 (2012)
DOI:10.1038/nature10955
Reference
PMID:22997337 (PDB:3J1T 3J1U)
  Authors
Redwine WB, Hernandez-Lopez R, Zou S, Huang J, Reck-Peterson SL, Leschziner AE
  Title
Structural basis for microtubule binding and release by dynein.
  Journal
Science 337:1532-1536 (2012)
DOI:10.1126/science.1224151
Reference
PMID:26410600
  Authors
Gibbs KL, Greensmith L, Schiavo G
  Title
Regulation of Axonal Transport by Protein Kinases.
  Journal
Trends Biochem Sci 40:597-610 (2015)
DOI:10.1016/j.tibs.2015.08.003
Reference
PMID:28602352 (PDB:5NUG 5NVS 5NVU 5NW4)
  Authors
Zhang K, Foster HE, Rondelet A, Lacey SE, Bahi-Buisson N, Bird AW, Carter AP
  Title
Cryo-EM Reveals How Human Cytoplasmic Dynein Is Auto-inhibited and Activated.
  Journal
Cell 169:1303-1314.e18 (2017)
DOI:10.1016/j.cell.2017.05.025
Reference
PMID:25814576 (PDB:5ADX 5AFR 5AFU)
  Authors
Urnavicius L, Zhang K, Diamant AG, Motz C, Schlager MA, Yu M, Patel NA, Robinson CV, Carter AP
  Title
The structure of the dynactin complex and its interaction with dynein.
  Journal
Science 347:1441-1446 (2015)
DOI:10.1126/science.aaa4080
Reference
PMID:29420470 (PDB:5OWO 6F1T 6F1U 6F1V 6F1Y 6F1Z 6F38 6F3A)
  Authors
Urnavicius L, Lau CK, Elshenawy MM, Morales-Rios E, Motz C, Yildiz A, Carter AP
  Title
Cryo-EM shows how dynactin recruits two dyneins for faster movement.
  Journal
Nature 554:202-206 (2018)
DOI:10.1038/nature25462
Reference
PMID:29662141
  Authors
Reck-Peterson SL, Redwine WB, Vale RD, Carter AP
  Title
The cytoplasmic dynein transport machinery and its many cargoes.
  Journal
Nat Rev Mol Cell Biol 19:382-398 (2018)
DOI:10.1038/s41580-018-0004-3
Reference
PMID:23434508 (PDB:3J2U)
  Authors
Asenjo AB, Chatterjee C, Tan D, DePaoli V, Rice WJ, Diaz-Avalos R, Silvestry M, Sosa H
  Title
Structural model for tubulin recognition and deformation by kinesin-13 microtubule depolymerases.
  Journal
Cell Rep 3:759-68 (2013)
DOI:10.1016/j.celrep.2013.01.030
Reference
PMID:10338210 (PDB:1B7T)
  Authors
Houdusse A, Kalabokis VN, Himmel D, Szent-Gyorgyi AG, Cohen C
  Title
Atomic structure of scallop myosin subfragment S1 complexed with MgADP: a novel conformation of the myosin head.
  Journal
Cell 97:459-70 (1999)
DOI:10.1016/s0092-8674(00)80756-4
Reference
PMID:9428521 (PDB:3KIN)
  Authors
Kozielski F, Sack S, Marx A, Thormahlen M, Schonbrunn E, Biou V, Thompson A, Mandelkow EM, Mandelkow E
  Title
The crystal structure of dimeric kinesin and implications for microtubule-dependent motility.
  Journal
Cell 91:985-94 (1997)
DOI:10.1016/s0092-8674(00)80489-4
Reference
PMID:8316857 (PDB:2MYS)
  Authors
Rayment I, Rypniewski WR, Schmidt-Base K, Smith R, Tomchick DR, Benning MM, Winkelmann DA, Wesenberg G, Holden HM
  Title
Three-dimensional structure of myosin subfragment-1: a molecular motor.
  Journal
Science 261:50-8 (1993)
DOI:10.1126/science.8316857
Reference
PMID:20428469
  Authors
Parker D, Bryant Z, Delp SL
  Title
Coarse-Grained Structural Modeling of Molecular Motors Using Multibody Dynamics.
  Journal
Cell Mol Bioeng 2:366-374 (2009)
DOI:10.1007/s12195-009-0084-4
Reference
PMID:21314430
  Authors
Dominguez R, Holmes KC
  Title
Actin structure and function.
  Journal
Annu Rev Biophys 40:169-86 (2011)
DOI:10.1146/annurev-biophys-042910-155359
Reference
PMID:31919429 (PDB:6KN7 6KN8)
  Authors
Yamada Y, Namba K, Fujii T
  Title
Cardiac muscle thin filament structures reveal calcium regulatory mechanism.
  Journal
Nat Commun 11:153 (2020)
DOI:10.1038/s41467-019-14008-1
Reference
PMID:33912943
  Authors
Kruppa AJ, Buss F
  Title
Motor proteins at the mitochondria-cytoskeleton interface.
  Journal
J Cell Sci 134:239092 (2021)
DOI:10.1242/jcs.226084
KO pathway
ko04814   
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