KEGG   PATHWAY: oke00983
Entry
oke00983                    Pathway                                
Name
Drug metabolism - other enzymes - Oncorhynchus keta (chum salmon)
Class
Metabolism; Xenobiotics biodegradation and metabolism
Pathway map
oke00983  Drug metabolism - other enzymes
oke00983

Organism
Oncorhynchus keta (chum salmon) [GN:oke]
Gene
118395721  hypoxanthine-guanine phosphoribosyltransferase-like isoform X1 [KO:K00760] [EC:2.4.2.8]
118363285  hprt1; hypoxanthine-guanine phosphoribosyltransferase [KO:K00760] [EC:2.4.2.8]
118376234  hypoxanthine-guanine phosphoribosyltransferase-like [KO:K00760] [EC:2.4.2.8]
118401174  inosine-5'-monophosphate dehydrogenase 1b isoform X1 [KO:K00088] [EC:1.1.1.205]
118361312  impdh2; inosine-5'-monophosphate dehydrogenase 2 isoform X1 [KO:K00088] [EC:1.1.1.205]
118396156  inosine-5'-monophosphate dehydrogenase 1b-like [KO:K00088] [EC:1.1.1.205]
118365999  inosine-5'-monophosphate dehydrogenase 1b isoform X1 [KO:K00088] [EC:1.1.1.205]
118377256  inosine-5'-monophosphate dehydrogenase 1b-like [KO:K00088] [EC:1.1.1.205]
127922041  inosine-5'-monophosphate dehydrogenase 1a-like [KO:K00088] [EC:1.1.1.205]
118359704  inosine-5'-monophosphate dehydrogenase 2-like isoform X1 [KO:K00088] [EC:1.1.1.205]
118374648  gmps; GMP synthase [glutamine-hydrolyzing] [KO:K01951] [EC:6.3.5.2]
118373398  GMP synthase [glutamine-hydrolyzing]-like isoform X1 [KO:K01951] [EC:6.3.5.2]
118398278  probable thiopurine S-methyltransferase isoform X1 [KO:K00569] [EC:2.1.1.67]
118380403  xdh; xanthine dehydrogenase/oxidase isoform X1 [KO:K00106] [EC:1.17.1.4 1.17.3.2]
118359072  itpa; inosine triphosphate pyrophosphatase [KO:K01519] [EC:3.6.1.66]
118395789  ces2b; neuroligin-1 [KO:K03927] [EC:3.1.1.1 3.1.1.84 3.1.1.56]
118371686  UDP-glucuronosyltransferase 2B13-like [KO:K00699] [EC:2.4.1.17]
118379237  ugt2a5; UDP glucuronosyltransferase 2 family, polypeptide A5 isoform X1 [KO:K00699] [EC:2.4.1.17]
127907337  UDP-glucuronosyltransferase 2A1-like [KO:K00699] [EC:2.4.1.17]
127907338  UDP-glucuronosyltransferase 2A1-like [KO:K00699] [EC:2.4.1.17]
127907429  UDP-glucuronosyltransferase 2A1-like [KO:K00699] [EC:2.4.1.17]
118368839  UDP-glucuronosyltransferase 2A1 isoform X1 [KO:K00699] [EC:2.4.1.17]
118385175  ugt5g2; UDP glucuronosyltransferase 5 family, polypeptide G2 [KO:K00699] [EC:2.4.1.17]
118393030  UDP-glucuronosyltransferase 2A2-like [KO:K00699] [EC:2.4.1.17]
118357834  UDP-glucuronosyltransferase 2B15-like [KO:K00699] [EC:2.4.1.17]
118371684  UDP-glucuronosyltransferase 2C1-like isoform X1 [KO:K00699] [EC:2.4.1.17]
118386012  UDP-glucuronosyltransferase-like [KO:K00699] [EC:2.4.1.17]
118394158  UDP-glucuronosyltransferase 2C1-like [KO:K00699] [EC:2.4.1.17]
127907242  UDP-glucuronosyltransferase 2A1-like [KO:K00699] [EC:2.4.1.17]
118393813  UDP-glucuronosyltransferase 2C1-like [KO:K00699] [EC:2.4.1.17]
118373834  UDP-glucuronosyltransferase 2A1-like [KO:K00699] [EC:2.4.1.17]
118380644  UDP-glucuronosyltransferase 1-6-like [KO:K00699] [EC:2.4.1.17]
118370601  UDP-glucuronosyltransferase-like isoform X1 [KO:K00699] [EC:2.4.1.17]
118365189  UDP-glucuronosyltransferase 2A2-like [KO:K00699] [EC:2.4.1.17]
118375418  UDP-glucuronosyltransferase 2C1-like [KO:K00699] [EC:2.4.1.17]
127932960  UDP-glucuronosyltransferase 2C1-like [KO:K00699] [EC:2.4.1.17]
118391267  UDP-glucuronosyltransferase-like isoform X1 [KO:K00699] [EC:2.4.1.17]
118359007  UDP-glucuronosyltransferase 2C1-like [KO:K00699] [EC:2.4.1.17]
118391909  UDP-glucuronosyltransferase 2A1-like [KO:K00699] [EC:2.4.1.17]
118359757  UDP-glucuronosyltransferase 2A1-like [KO:K00699] [EC:2.4.1.17]
118390632  beta-glucuronidase-like [KO:K01195] [EC:3.2.1.31]
118391001  beta-glucuronidase isoform X1 [KO:K01195] [EC:3.2.1.31]
118359988  cytidine deaminase-like [KO:K01489] [EC:3.5.4.5]
118360760  cytidine deaminase-like isoform X2 [KO:K01489] [EC:3.5.4.5]
118399915  cytidine deaminase-like [KO:K01489] [EC:3.5.4.5]
118392636  zgc:103586 [KO:K01489] [EC:3.5.4.5]
118372474  thymidine phosphorylase [KO:K00758] [EC:2.4.2.4]
118361160  dihydropyrimidine dehydrogenase [NADP(+)]-like isoform X1 [KO:K00207] [EC:1.3.1.2]
118402232  dpydb; dihydropyrimidine dehydrogenase [NADP(+)] [KO:K00207] [EC:1.3.1.2]
118374708  dihydropyrimidinase-like [KO:K01464] [EC:3.5.2.2]
118358211  upb1; beta-ureidopropionase [KO:K01431] [EC:3.5.1.6]
118385988  uridine phosphorylase 2-like isoform X1 [KO:K00757] [EC:2.4.2.3]
118373602  upp1; uridine phosphorylase 1 isoform X1 [KO:K00757] [EC:2.4.2.3]
118367124  uridine phosphorylase 2-like [KO:K00757] [EC:2.4.2.3]
118385531  uridine-cytidine kinase 1-like [KO:K00876] [EC:2.7.1.48]
118393540  uridine-cytidine kinase 2-A-like [KO:K00876] [EC:2.7.1.48]
118359588  uridine-cytidine kinase-like 1 [KO:K00876] [EC:2.7.1.48]
118387361  uck1; uridine-cytidine kinase 1 isoform X1 [KO:K00876] [EC:2.7.1.48]
118386937  uridine-cytidine kinase-like 1 isoform X1 [KO:K00876] [EC:2.7.1.48]
118358837  uridine-cytidine kinase 2-A isoform X1 [KO:K00876] [EC:2.7.1.48]
118401774  uck2b; uridine-cytidine kinase 2-B [KO:K00876] [EC:2.7.1.48]
118393758  thymidine kinase 2, mitochondrial-like isoform X1 [KO:K00857] [EC:2.7.1.21]
118377767  thymidine kinase, cytosolic [KO:K00857] [EC:2.7.1.21]
127931947  tk1; thymidine kinase, cytosolic [KO:K00857] [EC:2.7.1.21]
118358239  thymidine kinase 2, mitochondrial isoform X1 [KO:K00857] [EC:2.7.1.21]
118385966  umps; uridine 5'-monophosphate synthase [KO:K13421] [EC:2.4.2.10 4.1.1.23]
118367139  uridine 5'-monophosphate synthase-like [KO:K13421] [EC:2.4.2.10 4.1.1.23]
118402359  UMP-CMP kinase [KO:K13800] [EC:2.7.4.14]
118390178  ribonucleoside-diphosphate reductase large subunit-like [KO:K10807] [EC:1.17.4.1]
118391243  ribonucleoside-diphosphate reductase large subunit isoform X1 [KO:K10807] [EC:1.17.4.1]
118386682  ribonucleoside-diphosphate reductase subunit M2 [KO:K10808] [EC:1.17.4.1]
118397925  rrm2b; ribonucleoside-diphosphate reductase subunit M2 B [KO:K10808] [EC:1.17.4.1]
118398808  ribonucleoside-diphosphate reductase subunit M2 [KO:K10808] [EC:1.17.4.1]
118384114  nme3; nucleoside diphosphate kinase 3 isoform X1 [KO:K00940] [EC:2.7.4.6]
118374304  nucleoside diphosphate kinase A-like [KO:K00940] [EC:2.7.4.6]
118383330  nme6; LOW QUALITY PROTEIN: nucleoside diphosphate kinase 6 [KO:K00940] [EC:2.7.4.6]
118365219  nucleoside diphosphate kinase A-like [KO:K00940] [EC:2.7.4.6]
118389450  nucleoside diphosphate kinase-like isoform X1 [KO:K00940] [EC:2.7.4.6]
118357423  nme2a; NME/NM23 nucleoside diphosphate kinase 2a isoform X1 [KO:K00940] [EC:2.7.4.6]
118378298  nme7; LOW QUALITY PROTEIN: nucleoside diphosphate kinase 7 [KO:K00940] [EC:2.7.4.6]
118381765  nucleoside diphosphate kinase 6 [KO:K00940] [EC:2.7.4.6]
118384236  nme4; nucleoside diphosphate kinase, mitochondrial [KO:K00940] [EC:2.7.4.6]
118384464  nucleoside diphosphate kinase A-like [KO:K00940] [EC:2.7.4.6]
118375231  dut; deoxyuridine 5'-triphosphate nucleotidohydrolase, mitochondrial isoform X1 [KO:K01520] [EC:3.6.1.23]
127918383  deoxyuridine 5'-triphosphate nucleotidohydrolase-like [KO:K01520] [EC:3.6.1.23]
118382098  arylamine N-acetyltransferase, pineal gland isozyme NAT-10-like [KO:K00622] [EC:2.3.1.5]
118393065  gstt1a; glutathione S-transferase theta-1a [KO:K00799] [EC:2.5.1.18]
118385549  glutathione S-transferase theta-3-like [KO:K00799] [EC:2.5.1.18]
118401935  microsomal glutathione S-transferase 3-like [KO:K00799] [EC:2.5.1.18]
118402757  glutathione S-transferase 3-like [KO:K00799] [EC:2.5.1.18]
127928493  microsomal glutathione S-transferase 1-like [KO:K00799] [EC:2.5.1.18]
127928494  microsomal glutathione S-transferase 1-like [KO:K00799] [EC:2.5.1.18]
118362391  mgst3b; microsomal glutathione S-transferase 3b [KO:K00799] [EC:2.5.1.18]
118394856  microsomal glutathione S-transferase 3-like [KO:K00799] [EC:2.5.1.18]
118371953  glutathione S-transferase A-like [KO:K00799] [EC:2.5.1.18]
118375432  glutathione S-transferase Mu 3-like [KO:K00799] [EC:2.5.1.18]
118398311  glutathione S-transferase 3-like [KO:K00799] [EC:2.5.1.18]
118381378  gstr; glutathione S-transferase rho isoform X1 [KO:K00799] [EC:2.5.1.18]
118377821  mgst2; microsomal glutathione S-transferase 2 [KO:K00799] [EC:2.5.1.18]
118358051  gstt2; glutathione S-transferase theta-2 [KO:K00799] [EC:2.5.1.18]
118400180  glutathione S-transferase omega-1-like [KO:K00799] [EC:2.5.1.18]
118363614  glutathione S-transferase P-like [KO:K23790] [EC:2.5.1.18]
118363615  glutathione S-transferase P-like [KO:K23790] [EC:2.5.1.18]
118380048  glutathione S-transferase P-like [KO:K23790] [EC:2.5.1.18]
Compound
C00003  NAD+
C00006  NADP+
C02320  R-S-Glutathione
C02380  6-Mercaptopurine
C04242  5-Fluorodeoxyuridine monophosphate
C04646  6-Thioinosine-5'-monophosphate
C05361  Hydrazine
C06108  Fluoroacetate
C06837  Azathioprine
C07054  Isoniazid
C07446  Isonicotinic acid
C07447  Acetylhydrazine
C07585  N-Acetylisoniazid
C07648  Thioguanine
C07649  5-FU
C11173  SN-38
C11376  SN38 glucuronide
C11736  5-Fluorodeoxyuridine
C12650  Capecitabine
C12673  Tegafur
C12739  5'-Deoxy-5-fluorouridine
C13252  Carmofur
C16542  APC
C16543  NPC
C16613  6-Thiourate
C16614  6-Methylmercaptopurine
C16615  6-Methylthiopurine 5'-monophosphate ribonucleotide
C16616  6-Mercaptopurine ribonucleoside 5'-diphosphate
C16617  6-Mercaptopurine ribonucleoside triphosphate
C16618  6-Thioxanthine 5'-monophosphate
C16619  6-Thioguanosine monophosphate
C16620  6-Methylthioguanosine monophosphate
C16621  1-Methyl-4-nitroimidazole
C16622  N,N'-Diacetylhydrazine
C16623  Isonicotinylglycine
C16624  Isoniazid pyruvate
C16625  Isoniazid alpha-ketoglutaric acid
C16630  5,6-Dihydro-5-fluorouracil
C16631  alpha-Fluoro-beta-ureidopropionic acid
C16632  alpha-Fluoro-beta-alanine
C16633  5-Fluorouridine
C16634  5-Fluorouridine monophosphate
C16635  5'-Deoxy-5-fluorocytidine
C16641  Irinotecan
C21748  5-Fluorouridine diphosphate
C21749  5-Fluorouridine triphosphate
C21750  5-Fluorodeoxyuridine diphosphate
C21751  5-Fluorodeoxyuridine triphosphate
C21754  Isonicotinoyl radical
C21758  Hepatotoxins
C21759  Isonicotinoyl-NAD adduct
C21760  Isonicotinoyl-NADP adduct
D00238  Azathioprine (JP18/USP/INN)
D00346  Isoniazid (JP18/USP/INN)
D00584  Fluorouracil (JP18/USP/INN)
D01223  Capecitabine (JAN/USP/INN)
D01244  Tegafur (JP18/USAN/INN)
D01309  Doxifluridine (JP18/INN)
D01784  Carmofur (JP18/INN)
D04197  Floxuridine (USP/INN)
D04931  Mercaptopurine (INN)
D08086  Irinotecan (INN)
D08603  Tioguanine (INN)
Reference
  Authors
Kato R, Kamatari T (eds).
  Title
[Drug Metabolism] (In Japanese)
  Journal
Tokyo Kagaku Dojin (2000)
Reference
  Authors
Al Hadithy AF, de Boer NK, Derijks LJ, Escher JC, Mulder CJ, Brouwers JR.
  Title
Thiopurines in inflammatory bowel disease: pharmacogenetics, therapeutic drug monitoring and clinical recommendations.
  Journal
Dig Liver Dis 37:282-97 (2005)
DOI:10.1016/j.dld.2004.09.029
Reference
  Authors
Gearry RB, Barclay ML.
  Title
Azathioprine and 6-mercaptopurine pharmacogenetics and metabolite monitoring in inflammatory bowel disease.
  Journal
J Gastroenterol Hepatol 20:1149-57 (2005)
DOI:10.1111/j.1440-1746.2005.03832.x
Reference
  Authors
Gilissen LP, Derijks LJ, Verhoeven HM, Bierau J, Hooymans PM, Hommes DW, Engels LG.
  Title
Pancytopenia due to high 6-methylmercaptopurine levels in a 6-mercaptopurine treated patient with Crohn's disease.
  Journal
Dig Liver Dis 39:182-6 (2007)
DOI:10.1016/j.dld.2006.05.026
Reference
  Authors
Fischel JL, Formento P, Ciccolini J, Etienne-Grimaldi MC, Milano G.
  Title
Lack of contribution of dihydrofluorouracil and alpha-fluoro-beta-alanine to the cytotoxicity of 5'-deoxy-5-fluorouridine on human keratinocytes.
  Journal
Anticancer Drugs 15:969-74 (2004)
DOI:10.1097/00001813-200411000-00006
Reference
  Authors
Shimma N, Umeda I, Arasaki M, Murasaki C, Masubuchi K, Kohchi Y, Miwa M, Ura M, Sawada N, Tahara H, Kuruma I, Horii I, Ishitsuka H.
  Title
The design and synthesis of a new tumor-selective fluoropyrimidine carbamate, capecitabine.
  Journal
Bioorg Med Chem 8:1697-706 (2000)
DOI:10.1016/S0968-0896(00)00087-0
Reference
  Authors
Chung YL, Troy H, Judson IR, Leek R, Leach MO, Stubbs M, Harris AL, Griffiths JR
  Title
Noninvasive measurements of capecitabine metabolism in bladder tumors overexpressing thymidine phosphorylase by fluorine-19 magnetic resonance spectroscopy.
  Journal
Clin Cancer Res 10:3863-70 (2004)
DOI:10.1158/1078-0432.CCR-03-0237
Reference
  Authors
Mathijssen RH, van Alphen RJ, Verweij J, Loos WJ, Nooter K, Stoter G, Sparreboom A
  Title
Clinical pharmacokinetics and metabolism of irinotecan (CPT-11).
  Journal
Clin Cancer Res 7:2182-94 (2001)
Reference
  Authors
Kita T, Tanigawara Y, Chikazawa S, Hatanaka H, Sakaeda T, Komada F, Iwakawa S, Okumura K.
  Title
N-Acetyltransferase2 genotype correlated with isoniazid acetylation in Japanese tuberculous patients.
  Journal
Biol Pharm Bull 24:544-9 (2001)
DOI:10.1248/bpb.24.544
Reference
  Authors
Miura K, Kinouchi M, Ishida K, Fujibuchi W, Naitoh T, Ogawa H, Ando T, Yazaki N, Watanabe K, Haneda S, Shibata C, Sasaki I
  Title
5-fu metabolism in cancer and orally-administrable 5-fu drugs.
  Journal
Cancers (Basel) 2:1717-30 (2010)
DOI:10.3390/cancers2031717
Reference
  Authors
Wang P, Pradhan K, Zhong XB, Ma X
  Title
Isoniazid metabolism and hepatotoxicity.
  Journal
Acta Pharm Sin B 6:384-392 (2016)
DOI:10.1016/j.apsb.2016.07.014
Reference
  Authors
Klein DJ, Boukouvala S, McDonagh EM, Shuldiner SR, Laurieri N, Thorn CF, Altman RB, Klein TE
  Title
PharmGKB summary: isoniazid pathway, pharmacokinetics.
  Journal
Pharmacogenet Genomics 26:436-44 (2016)
DOI:10.1097/FPC.0000000000000232
Reference
  Authors
Yamada S, Richardson K, Tang M, Halaschek-Wiener J, Cook VJ, Fitzgerald JM, Elwood K, Marra F, Brooks-Wilson A
  Title
Genetic variation in carboxylesterase genes and susceptibility to isoniazid-induced hepatotoxicity.
  Journal
Pharmacogenomics J 10:524-36 (2010)
DOI:10.1038/tpj.2010.5
Reference
  Authors
Vlasits J, Jakopitsch C, Bernroitner M, Zamocky M, Furtmuller PG, Obinger C
  Title
Mechanisms of catalase activity of heme peroxidases.
  Journal
Arch Biochem Biophys 500:74-81 (2010)
DOI:10.1016/j.abb.2010.04.018
Reference
  Authors
Khan SR, Morgan AG, Michail K, Srivastava N, Whittal RM, Aljuhani N, Siraki AG
  Title
Metabolism of isoniazid by neutrophil myeloperoxidase leads to isoniazid-NAD(+) adduct formation: A comparison of the reactivity of isoniazid with its known human metabolites.
  Journal
Biochem Pharmacol 106:46-55 (2016)
DOI:10.1016/j.bcp.2016.02.003
Reference
  Authors
Forbes LV, Furtmuller PG, Khalilova I, Turner R, Obinger C, Kettle AJ
  Title
Isoniazid as a substrate and inhibitor of myeloperoxidase: identification of amine adducts and the influence of superoxide dismutase on their formation.
  Journal
Biochem Pharmacol 84:949-60 (2012)
DOI:10.1016/j.bcp.2012.07.020
Reference
  Authors
Nguyen M, Quemard A, Broussy S, Bernadou J, Meunier B
  Title
Mn(III) pyrophosphate as an efficient tool for studying the mode of action of isoniazid on the InhA protein of Mycobacterium tuberculosis.
  Journal
Antimicrob Agents Chemother 46:2137-44 (2002)
DOI:10.1128/AAC.46.7.2137-2144.2002
Reference
PMID:9417034
  Authors
Rozwarski DA, Grant GA, Barton DH, Jacobs WR Jr, Sacchettini JC
  Title
Modification of the NADH of the isoniazid target (InhA) from Mycobacterium tuberculosis.
  Journal
Science 279:98-102 (1998)
DOI:10.1126/science.279.5347.98
Reference
  Authors
Argyrou A, Vetting MW, Blanchard JS
  Title
New insight into the mechanism of action of and resistance to isoniazid: interaction of Mycobacterium tuberculosis enoyl-ACP reductase with INH-NADP.
  Journal
J Am Chem Soc 129:9582-3 (2007)
DOI:10.1021/ja073160k
KO pathway
ko00983   
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