KEGG   PATHWAY: one00480
Entry
one00480                    Pathway                                
Name
Glutathione metabolism - Oncorhynchus nerka (sockeye salmon)
Class
Metabolism; Metabolism of other amino acids
Pathway map
one00480  Glutathione metabolism
one00480

Module
one_M00118  Glutathione biosynthesis, glutamate => glutathione [PATH:one00480]
Other DBs
GO: 0006749
Organism
Oncorhynchus nerka (sockeye salmon) [GN:one]
Gene
115143753  glutathione hydrolase 7-like isoform X1 [KO:K00681] [EC:2.3.2.2 3.4.19.13]
115145283  uncharacterized protein LOC115145283 [KO:K00681] [EC:2.3.2.2 3.4.19.13]
115101996  ggt7; glutathione hydrolase 7 [KO:K00681] [EC:2.3.2.2 3.4.19.13]
115111019  glutathione hydrolase 1 proenzyme-like [KO:K18592] [EC:2.3.2.2 3.4.19.13 3.4.19.14]
115111509  glutathione hydrolase 5 proenzyme-like [KO:K18592] [EC:2.3.2.2 3.4.19.13 3.4.19.14]
115105813  LOW QUALITY PROTEIN: glutathione hydrolase 5 proenzyme-like [KO:K18592] [EC:2.3.2.2 3.4.19.13 3.4.19.14]
115124623  glutathione hydrolase 5 proenzyme-like [KO:K18592] [EC:2.3.2.2 3.4.19.13 3.4.19.14]
115124631  glutathione hydrolase 1 proenzyme-like [KO:K18592] [EC:2.3.2.2 3.4.19.13 3.4.19.14]
115139947  glutathione hydrolase 1 proenzyme-like [KO:K18592] [EC:2.3.2.2 3.4.19.13 3.4.19.14]
115128635  gamma-glutamylcyclotransferase-like isoform X1 [KO:K00682] [EC:4.3.2.9]
115114447  gamma-glutamylcyclotransferase-like [KO:K00682] [EC:4.3.2.9]
115114455  gamma-glutamylcyclotransferase-like [KO:K00682] [EC:4.3.2.9]
115140908  gamma-glutamylcyclotransferase-like [KO:K00682] [EC:4.3.2.9]
115119134  glutathione-specific gamma-glutamylcyclotransferase 1-like [KO:K07232] [EC:4.3.2.7]
115138966  chac1; glutathione-specific gamma-glutamylcyclotransferase 1 [KO:K07232] [EC:4.3.2.7]
115146651  glutathione-specific gamma-glutamylcyclotransferase 1-like [KO:K07232] [EC:4.3.2.7]
115104492  oplah; 5-oxoprolinase [KO:K01469] [EC:3.5.2.9]
115113039  glutamate--cysteine ligase catalytic subunit-like isoform X1 [KO:K11204] [EC:6.3.2.2]
115144409  glutamate--cysteine ligase catalytic subunit-like isoform X1 [KO:K11204] [EC:6.3.2.2]
115145003  glutamate--cysteine ligase regulatory subunit-like [KO:K11205]
115108420  glutamate--cysteine ligase regulatory subunit-like isoform X1 [KO:K11205]
115132173  gss; glutathione synthetase [KO:K21456] [EC:6.3.2.3]
115111739  putative aminopeptidase W07G4.4 [KO:K01255] [EC:3.4.11.1]
115140205  putative aminopeptidase W07G4.4 [KO:K01255] [EC:3.4.11.1]
115134402  anpep; aminopeptidase N isoform X1 [KO:K11140] [EC:3.4.11.2]
115109399  aminopeptidase N-like [KO:K11140] [EC:3.4.11.2]
115134268  aminopeptidase N-like [KO:K11140] [EC:3.4.11.2]
115111476  glutathione S-transferase theta-1-like [KO:K00799] [EC:2.5.1.18]
115130679  microsomal glutathione S-transferase 2-like [KO:K00799] [EC:2.5.1.18]
115131372  glutathione S-transferase A-like [KO:K00799] [EC:2.5.1.18]
115113034  glutathione S-transferase 3-like [KO:K00799] [EC:2.5.1.18]
115113219  gsto1; glutathione S-transferase omega-1 [KO:K00799] [EC:2.5.1.18]
115144414  glutathione S-transferase 3-like [KO:K00799] [EC:2.5.1.18]
115113988  microsomal glutathione S-transferase 3-like [KO:K00799] [EC:2.5.1.18]
115146300  microsomal glutathione S-transferase 3-like [KO:K00799] [EC:2.5.1.18]
115126007  glutathione S-transferase Mu 3-like [KO:K00799] [EC:2.5.1.18]
115126080  glutathione S-transferase A-like [KO:K00799] [EC:2.5.1.18]
115102909  microsomal glutathione S-transferase 3-like [KO:K00799] [EC:2.5.1.18]
115140540  glutathione S-transferase theta-1-like isoform X1 [KO:K00799] [EC:2.5.1.18]
115147113  glutathione S-transferase theta-3-like [KO:K00799] [EC:2.5.1.18]
115129573  glutathione S-transferase P-like [KO:K23790] [EC:2.5.1.18]
115129946  glutathione S-transferase P-like isoform X1 [KO:K23790] [EC:2.5.1.18]
115130839  glutathione S-transferase P-like [KO:K23790] [EC:2.5.1.18]
115101231  glutathione S-transferase kappa 1-like isoform X1 [KO:K13299] [EC:2.5.1.18]
115140807  glutathione S-transferase kappa 1-like [KO:K13299] [EC:2.5.1.18]
115111261  hpgds; hematopoietic prostaglandin D synthase isoform X1 [KO:K04097] [EC:5.3.99.2 2.5.1.18]
115144432  collagen alpha-1(II) chain-like [KO:K25210] [EC:2.5.1.18]
115120942  LOW QUALITY PROTEIN: probable N-acetyltransferase camello [KO:K20838] [EC:2.3.1.80 2.3.1.-]
115101688  N-acetyltransferase 8-like [KO:K20838] [EC:2.3.1.80 2.3.1.-]
115130891  gsr; glutathione reductase, mitochondrial [KO:K00383] [EC:1.8.1.7]
115110344  isocitrate dehydrogenase [NADP] cytoplasmic-like isoform X1 [KO:K00031] [EC:1.1.1.42]
115130242  isocitrate dehydrogenase [NADP] cytoplasmic-like isoform X1 [KO:K00031] [EC:1.1.1.42]
115109431  isocitrate dehydrogenase [NADP], mitochondrial-like [KO:K00031] [EC:1.1.1.42]
115134227  idh2; isocitrate dehydrogenase [NADP], mitochondrial [KO:K00031] [EC:1.1.1.42]
115132200  pgd; 6-phosphogluconate dehydrogenase, decarboxylating [KO:K00033] [EC:1.1.1.44 1.1.1.343]
115131922  glucose-6-phosphate 1-dehydrogenase isoform X1 [KO:K00036] [EC:1.1.1.49 1.1.1.363]
115132516  glucose-6-phosphate 1-dehydrogenase-like isoform X1 [KO:K00036] [EC:1.1.1.49 1.1.1.363]
115102144  glucose-6-phosphate 1-dehydrogenase-like isoform X1 [KO:K00036] [EC:1.1.1.49 1.1.1.363]
115103396  txndc12; thioredoxin domain-containing protein 12 [KO:K05360] [EC:1.8.4.2]
115114709  phospholipid hydroperoxide glutathione peroxidase-like isoform X1 [KO:K05361] [EC:1.11.1.12]
115123726  glutathione peroxidase 1-like [KO:K00432] [EC:1.11.1.9]
115108623  gpx7; glutathione peroxidase 7 [KO:K00432] [EC:1.11.1.9]
115115624  glutathione peroxidase 3-like [KO:K00432] [EC:1.11.1.9]
115146652  gpx2; glutathione peroxidase 2 [KO:K00432] [EC:1.11.1.9]
115140359  gpx8; probable glutathione peroxidase 8 isoform X1 [KO:K00432] [EC:1.11.1.9]
115145073  peroxiredoxin-6-like [KO:K11188] [EC:1.11.1.7 1.11.1.27 3.1.1.-]
115114610  peroxiredoxin-6-like [KO:K11188] [EC:1.11.1.7 1.11.1.27 3.1.1.-]
115138620  ornithine decarboxylase 1-like [KO:K01581] [EC:4.1.1.17]
115146108  odc1; ornithine decarboxylase [KO:K01581] [EC:4.1.1.17]
115132192  srm; spermidine synthase [KO:K00797] [EC:2.5.1.16]
115135569  spermine synthase-like [KO:K00802] [EC:2.5.1.22]
115101397  spermine synthase-like isoform X1 [KO:K00802] [EC:2.5.1.22]
115135824  ribonucleoside-diphosphate reductase large subunit-like [KO:K10807] [EC:1.17.4.1]
115105642  ribonucleoside-diphosphate reductase large subunit [KO:K10807] [EC:1.17.4.1]
115131254  ribonucleoside-diphosphate reductase subunit M2 B-like [KO:K10808] [EC:1.17.4.1]
115107615  ribonucleoside-diphosphate reductase subunit M2 [KO:K10808] [EC:1.17.4.1]
115139636  rrm2; ribonucleoside-diphosphate reductase subunit M2 [KO:K10808] [EC:1.17.4.1]
Compound
C00005  NADPH
C00006  NADP+
C00024  Acetyl-CoA
C00025  L-Glutamate
C00037  Glycine
C00051  Glutathione
C00072  Ascorbate
C00077  L-Ornithine
C00097  L-Cysteine
C00127  Glutathione disulfide
C00134  Putrescine
C00151  L-Amino acid
C00315  Spermidine
C00669  gamma-L-Glutamyl-L-cysteine
C00750  Spermine
C01322  RX
C01419  Cys-Gly
C01672  Cadaverine
C01879  5-Oxoproline
C02090  Trypanothione
C02320  R-S-Glutathione
C03170  Trypanothione disulfide
C03646  Bis-gamma-glutamylcystine
C03740  (5-L-Glutamyl)-L-amino acid
C05422  Dehydroascorbate
C05726  S-Substituted L-cysteine
C05727  S-Substituted N-acetyl-L-cysteine
C05729  R-S-Cysteinylglycine
C05730  Glutathionylspermidine
C16562  Glutathionylspermine
C16563  Bis(glutathionyl)spermine
C16564  Bis(glutathionyl)spermine disulfide
C16565  Aminopropylcadaverine
C16566  Glutathionylaminopropylcadaverine
C16567  Homotrypanothione
C16568  Homotrypanothione disulfide
C16663  Tryparedoxin
C16664  Tryparedoxin disulfide
Reference
  Authors
Josch C, Klotz LO, Sies H.
  Title
Identification of cytosolic leucyl aminopeptidase (EC 3.4.11.1) as the major cysteinylglycine-hydrolysing activity in rat liver.
  Journal
Biol Chem 384:213-8 (2003)
DOI:10.1515/BC.2003.023
Reference
  Authors
Chu L, Lai Y, Xu X, Eddy S, Yang S, Song L, Kolodrubetz D.
  Title
A 52-kDa leucyl aminopeptidase from treponema denticola is a cysteinylglycinase that mediates the second step of glutathione metabolism.
  Journal
J Biol Chem 283:19351-8 (2008)
DOI:10.1074/jbc.M801034200
Reference
  Authors
Cappiello M, Lazzarotti A, Buono F, Scaloni A, D'Ambrosio C, Amodeo P, Mendez BL, Pelosi P, Del Corso A, Mura U.
  Title
New role for leucyl aminopeptidase in glutathione turnover.
  Journal
Biochem J 378:35-44 (2004)
DOI:10.1042/BJ20031336
Reference
  Authors
Suzuki H, Kamatani S, Kim ES, Kumagai H.
  Title
Aminopeptidases A, B, and N and dipeptidase D are the four cysteinylglycinases of Escherichia coli K-12.
  Journal
J Bacteriol 183:1489-90 (2001)
DOI:10.1128/JB.183.4.1489-1490.2001
Reference
  Authors
Oza SL, Shaw MP, Wyllie S, Fairlamb AH.
  Title
Trypanothione biosynthesis in Leishmania major.
  Journal
Mol Biochem Parasitol 139:107-16 (2005)
DOI:10.1016/j.molbiopara.2004.10.004
Reference
  Authors
Oza SL, Ariyanayagam MR, Fairlamb AH.
  Title
Characterization of recombinant glutathionylspermidine synthetase/amidase from Crithidia fasciculata.
  Journal
Biochem J 364:679-86 (2002)
DOI:10.1042/BJ20011370
Reference
PMID:9677355
  Authors
Tetaud E, Manai F, Barrett MP, Nadeau K, Walsh CT, Fairlamb AH.
  Title
Cloning and characterization of the two enzymes responsible for trypanothione biosynthesis in Crithidia fasciculata.
  Journal
J Biol Chem 273:19383-90 (1998)
DOI:10.1074/jbc.273.31.19383
Reference
  Authors
Ariyanayagam MR, Oza SL, Mehlert A, Fairlamb AH.
  Title
Bis(glutathionyl)spermine and other novel trypanothione analogues in Trypanosoma cruzi.
  Journal
J Biol Chem 278:27612-9 (2003)
DOI:10.1074/jbc.M302750200
Reference
  Authors
Oza SL, Ariyanayagam MR, Aitcheson N, Fairlamb AH.
  Title
Properties of trypanothione synthetase from Trypanosoma brucei.
  Journal
Mol Biochem Parasitol 131:25-33 (2003)
DOI:10.1016/S0166-6851(03)00176-2
Reference
  Authors
Oza SL, Tetaud E, Ariyanayagam MR, Warnon SS, Fairlamb AH.
  Title
A single enzyme catalyses formation of Trypanothione from glutathione and spermidine in Trypanosoma cruzi.
  Journal
J Biol Chem 277:35853-61 (2002)
DOI:10.1074/jbc.M204403200
Reference
  Authors
Comini M, Menge U, Wissing J, Flohe L.
  Title
Trypanothione synthesis in crithidia revisited.
  Journal
J Biol Chem 280:6850-60 (2005)
DOI:10.1074/jbc.M404486200
Reference
PMID:7813456
  Authors
Hunter KJ, Le Quesne SA, Fairlamb AH.
  Title
Identification and biosynthesis of N1,N9-bis(glutathionyl)aminopropylcadaverine (homotrypanothione) in Trypanosoma cruzi.
  Journal
Eur J Biochem 226:1019-27 (1994)
DOI:10.1111/j.1432-1033.1994.t01-1-01019.x
Reference
  Authors
Krauth-Siegel RL, Meiering SK, Schmidt H.
  Title
The parasite-specific trypanothione metabolism of trypanosoma and leishmania.
  Journal
Biol Chem 384:539-49 (2003)
DOI:10.1515/BC.2003.062
Reference
  Authors
Krauth-Siegel RL, Comini MA.
  Title
Redox control in trypanosomatids, parasitic protozoa with trypanothione-based thiol metabolism.
  Journal
Biochim Biophys Acta 1780:1236-48 (2008)
DOI:10.1016/j.bbagen.2008.03.006
Reference
PMID:8892297
  Authors
Krauth-Siegel RL, Ludemann H.
  Title
Reduction of dehydroascorbate by trypanothione.
  Journal
Mol Biochem Parasitol 80:203-8 (1996)
DOI:10.1016/0166-6851(96)02689-8
Reference
  Authors
Dormeyer M, Reckenfelderbaumer N, Ludemann H, Krauth-Siegel RL.
  Title
Trypanothione-dependent synthesis of deoxyribonucleotides by Trypanosoma brucei ribonucleotide reductase.
  Journal
J Biol Chem 276:10602-6 (2001)
DOI:10.1074/jbc.M010352200
Reference
  Authors
Schmidt H, Krauth-Siegel RL.
  Title
Functional and physicochemical characterization of the thioredoxin system in Trypanosoma brucei.
  Journal
J Biol Chem 278:46329-36 (2003)
DOI:10.1074/jbc.M305338200
Reference
PMID:9851611
  Authors
Tetaud E, Fairlamb AH.
  Title
Cloning, expression and reconstitution of the trypanothione-dependent peroxidase system of Crithidia fasciculata.
  Journal
Mol Biochem Parasitol 96:111-23 (1998)
DOI:10.1016/S0166-6851(98)00120-0
Reference
  Authors
Castro H, Sousa C, Santos M, Cordeiro-da-Silva A, Flohe L, Tomas AM.
  Title
Complementary antioxidant defense by cytoplasmic and mitochondrial peroxiredoxins in Leishmania infantum.
  Journal
Free Radic Biol Med 33:1552-62 (2002)
DOI:10.1016/S0891-5849(02)01089-4
Reference
  Authors
Wilkinson SR, Temperton NJ, Mondragon A, Kelly JM.
  Title
Distinct mitochondrial and cytosolic enzymes mediate trypanothione-dependent peroxide metabolism in Trypanosoma cruzi.
  Journal
J Biol Chem 275:8220-5 (2000)
DOI:10.1074/jbc.275.11.8220
Reference
  Authors
Konig J, Fairlamb AH.
  Title
A comparative study of type I and type II tryparedoxin peroxidases in Leishmania major.
  Journal
FEBS J 274:5643-58 (2007)
DOI:10.1111/j.1742-4658.2007.06087.x
Reference
  Authors
Hillebrand H, Schmidt A, Krauth-Siegel RL.
  Title
A second class of peroxidases linked to the trypanothione metabolism.
  Journal
J Biol Chem 278:6809-15 (2003)
DOI:10.1074/jbc.M210392200
Reference
  Authors
Soksawatmaekhin W, Kuraishi A, Sakata K, Kashiwagi K, Igarashi K.
  Title
Excretion and uptake of cadaverine by CadB and its physiological functions in Escherichia coli.
  Journal
Mol Microbiol 51:1401-12 (2004)
DOI:10.1046/j.1365-2958.2003.03913.x
Reference
PMID:6798961
  Authors
Pegg AE, Shuttleworth K, Hibasami H.
  Title
Specificity of mammalian spermidine synthase and spermine synthase.
  Journal
Biochem J 197:315-20 (1981)
DOI:10.1042/bj1970315
Related
pathway
one00220  Arginine biosynthesis
one00250  Alanine, aspartate and glutamate metabolism
one00270  Cysteine and methionine metabolism
one00430  Taurine and hypotaurine metabolism
KO pathway
ko00480   
LinkDB

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