KEGG   PATHWAY: onl00983
Entry
onl00983                    Pathway                                
Name
Drug metabolism - other enzymes - Oreochromis niloticus (Nile tilapia)
Class
Metabolism; Xenobiotics biodegradation and metabolism
Pathway map
onl00983  Drug metabolism - other enzymes
onl00983

Organism
Oreochromis niloticus (Nile tilapia) [GN:onl]
Gene
100698553  hypoxanthine-guanine phosphoribosyltransferase isoform X1 [KO:K00760] [EC:2.4.2.8]
100703204  hprt1; hypoxanthine-guanine phosphoribosyltransferase [KO:K00760] [EC:2.4.2.8]
100693341  inosine-5'-monophosphate dehydrogenase 1b isoform X1 [KO:K00088] [EC:1.1.1.205]
100701529  inosine-5'-monophosphate dehydrogenase 1a isoform X1 [KO:K00088] [EC:1.1.1.205]
100690015  impdh2; inosine-5'-monophosphate dehydrogenase 2 isoform X1 [KO:K00088] [EC:1.1.1.205]
100691980  gmps; GMP synthase [glutamine-hydrolyzing] isoform X1 [KO:K01951] [EC:6.3.5.2]
100707454  probable thiopurine S-methyltransferase isoform X1 [KO:K00569] [EC:2.1.1.67]
100707189  probable thiopurine S-methyltransferase [KO:K00569] [EC:2.1.1.67]
100706331  xdh; xanthine dehydrogenase/oxidase [KO:K00106] [EC:1.17.1.4 1.17.3.2]
100705475  itpa; inosine triphosphate pyrophosphatase [KO:K01519] [EC:3.6.1.66]
106096794  UDP-glucuronosyltransferase isoform X1 [KO:K00699] [EC:2.4.1.17]
112841656  UDP-glucuronosyltransferase 2C1-like isoform X1 [KO:K00699] [EC:2.4.1.17]
109204525  UDP-glucuronosyltransferase 2A2 [KO:K00699] [EC:2.4.1.17]
100701704  UDP-glucuronosyltransferase 2A2 [KO:K00699] [EC:2.4.1.17]
109204526  UDP-glucuronosyltransferase 2A2-like [KO:K00699] [EC:2.4.1.17]
109204527  UDP-glucuronosyltransferase 2A2 [KO:K00699] [EC:2.4.1.17]
109201007  LOW QUALITY PROTEIN: uncharacterized protein LOC109201007 [KO:K00699] [EC:2.4.1.17]
102077353  UDP-glucuronosyltransferase 2C1 [KO:K00699] [EC:2.4.1.17]
112841630  UDP-glucuronosyltransferase 2C1-like isoform X2 [KO:K00699] [EC:2.4.1.17]
109196189  UDP-glucuronosyltransferase 2A2 isoform X2 [KO:K00699] [EC:2.4.1.17]
100692828  UDP-glucuronosyltransferase 2A2 isoform X3 [KO:K00699] [EC:2.4.1.17]
100694776  UDP-glucuronosyltransferase 2C1 isoform X1 [KO:K00699] [EC:2.4.1.17]
100695035  UDP-glucuronosyltransferase 2C1 isoform X1 [KO:K00699] [EC:2.4.1.17]
100694509  LOW QUALITY PROTEIN: UDP-glucuronosyltransferase 2C1 [KO:K00699] [EC:2.4.1.17]
100706335  UDP-glucuronosyltransferase 2C1 [KO:K00699] [EC:2.4.1.17]
109203870  UDP-glucuronosyltransferase 2C1 [KO:K00699] [EC:2.4.1.17]
109194418  UDP-glucuronosyltransferase 2C1 [KO:K00699] [EC:2.4.1.17]
109204569  UDP-glucuronosyltransferase 2B31-like isoform X1 [KO:K00699] [EC:2.4.1.17]
100708034  UDP-glucuronosyltransferase 2C1 isoform X1 [KO:K00699] [EC:2.4.1.17]
100708305  UDP-glucuronosyltransferase 2C1 [KO:K00699] [EC:2.4.1.17]
106098479  UDP-glucuronosyltransferase 2B31 [KO:K00699] [EC:2.4.1.17]
100707235  UDP-glucuronosyltransferase 2C1 isoform X2 [KO:K00699] [EC:2.4.1.17]
102077549  UDP-glucuronosyltransferase 2B17 [KO:K00699] [EC:2.4.1.17]
100705564  UDP-glucuronosyltransferase 2A1 [KO:K00699] [EC:2.4.1.17]
102076912  UDP-glucuronosyltransferase 2C1 [KO:K00699] [EC:2.4.1.17]
100534482  UDP-glucuronosyltransferase [KO:K00699] [EC:2.4.1.17]
100699240  beta-glucuronidase [KO:K01195] [EC:3.2.1.31]
100708292  beta-glucuronidase [KO:K01195] [EC:3.2.1.31]
100693418  cytidine deaminase [KO:K01489] [EC:3.5.4.5]
100699134  cytidine deaminase [KO:K01489] [EC:3.5.4.5]
100699577  tymp; thymidine phosphorylase isoform X1 [KO:K00758] [EC:2.4.2.4]
100689784  dpyd; dihydropyrimidine dehydrogenase [NADP(+)] isoform X1 [KO:K00207] [EC:1.3.1.2]
100702568  dpys; dihydropyrimidinase [KO:K01464] [EC:3.5.2.2]
100711121  upb1; beta-ureidopropionase [KO:K01431] [EC:3.5.1.6]
100708084  upp2; uridine phosphorylase 2 [KO:K00757] [EC:2.4.2.3]
100690403  uridine phosphorylase 1 [KO:K00757] [EC:2.4.2.3]
100696242  uckl1; uridine-cytidine kinase-like 1 isoform X4 [KO:K00876] [EC:2.7.1.48]
100703739  uridine-cytidine kinase 2-B [KO:K00876] [EC:2.7.1.48]
100698935  uridine-cytidine kinase 2-A isoform X1 [KO:K00876] [EC:2.7.1.48]
100701937  uck1; uridine-cytidine kinase 1 [KO:K00876] [EC:2.7.1.48]
100697655  uridine-cytidine kinase-like 1 isoform X1 [KO:K00876] [EC:2.7.1.48]
100703583  uridine-cytidine kinase-like 1 isoform X1 [KO:K00876] [EC:2.7.1.48]
100712150  tk2; thymidine kinase 2, mitochondrial isoform X1 [KO:K00857] [EC:2.7.1.21]
100700310  tk1; thymidine kinase, cytosolic [KO:K00857] [EC:2.7.1.21]
102076953  LOW QUALITY PROTEIN: uridine 5'-monophosphate synthase [KO:K13421] [EC:2.4.2.10 4.1.1.23]
100691324  LOW QUALITY PROTEIN: uridine 5'-monophosphate synthase-like [KO:K13421] [EC:2.4.2.10 4.1.1.23]
100695554  uridine 5'-monophosphate synthase [KO:K13421] [EC:2.4.2.10 4.1.1.23]
100703671  cmpk1; UMP-CMP kinase [KO:K13800] [EC:2.7.4.14]
100694900  ribonucleoside-diphosphate reductase large subunit [KO:K10807] [EC:1.17.4.1]
100696561  ribonucleoside-diphosphate reductase large subunit [KO:K10807] [EC:1.17.4.1]
100710041  ribonucleoside-diphosphate reductase subunit M2 B [KO:K10808] [EC:1.17.4.1]
100698853  ribonucleoside-diphosphate reductase subunit M2 isoform X1 [KO:K10808] [EC:1.17.4.1]
100699570  ribonucleoside-diphosphate reductase subunit M2 isoform X1 [KO:K10808] [EC:1.17.4.1]
100703020  nucleoside diphosphate kinase, mitochondrial [KO:K00940] [EC:2.7.4.6]
100710533  nme6; nucleoside diphosphate kinase 6 isoform X1 [KO:K00940] [EC:2.7.4.6]
100699112  nme7; nucleoside diphosphate kinase 7 [KO:K00940] [EC:2.7.4.6]
100696772  nucleoside diphosphate kinase A2 [KO:K00940] [EC:2.7.4.6]
100696922  nme3; nucleoside diphosphate kinase 3 isoform X1 [KO:K00940] [EC:2.7.4.6]
100697135  nucleoside diphosphate kinase B [KO:K00940] [EC:2.7.4.6]
100694899  dut; deoxyuridine 5'-triphosphate nucleotidohydrolase, mitochondrial isoform X2 [KO:K01520] [EC:3.6.1.23]
100704032  arylamine N-acetyltransferase, pineal gland isozyme NAT-10 [KO:K00622] [EC:2.3.1.5]
100704303  nat1; arylamine N-acetyltransferase 1 isoform X1 [KO:K00622] [EC:2.3.1.5]
100696000  glutathione S-transferase theta-1 [KO:K00799] [EC:2.5.1.18]
100690646  microsomal glutathione S-transferase 3 [KO:K00799] [EC:2.5.1.18]
100534425  glutathione S-transferase [KO:K00799] [EC:2.5.1.18]
100534426  gsta; glutathione S-transferase [KO:K00799] [EC:2.5.1.18]
100690298  glutathione S-transferase A-like isoform X1 [KO:K00799] [EC:2.5.1.18]
100700381  glutathione S-transferase A [KO:K00799] [EC:2.5.1.18]
102075633  glutathione S-transferase A [KO:K00799] [EC:2.5.1.18]
100690031  glutathione S-transferase A [KO:K00799] [EC:2.5.1.18]
100697013  mgst2; microsomal glutathione S-transferase 2 [KO:K00799] [EC:2.5.1.18]
100702716  glutathione S-transferase Mu 3 isoform X1 [KO:K00799] [EC:2.5.1.18]
100702985  glutathione S-transferase Mu 3 [KO:K00799] [EC:2.5.1.18]
100705617  mgst3; microsomal glutathione S-transferase 3 [KO:K00799] [EC:2.5.1.18]
100700109  glutathione S-transferase A isoform X1 [KO:K00799] [EC:2.5.1.18]
109194248  glutathione S-transferase A [KO:K00799] [EC:2.5.1.18]
100689761  glutathione S-transferase A isoform X2 [KO:K00799] [EC:2.5.1.18]
100699992  glutathione S-transferase omega-1 [KO:K00799] [EC:2.5.1.18]
100692070  glutathione S-transferase theta-1 [KO:K00799] [EC:2.5.1.18]
100694673  microsomal glutathione S-transferase 1 [KO:K00799] [EC:2.5.1.18]
100534455  glutathione S-transferase theta-3 isoform X2 [KO:K00799] [EC:2.5.1.18]
100699397  glutathione S-transferase A [KO:K00799] [EC:2.5.1.18]
100707162  glutathione S-transferase A2 [KO:K00799] [EC:2.5.1.18]
109194535  microsomal glutathione S-transferase 1-like [KO:K00799] [EC:2.5.1.18]
100696412  glutathione S-transferase omega-1 [KO:K00799] [EC:2.5.1.18]
100699693  glutathione S-transferase theta-1 [KO:K00799] [EC:2.5.1.18]
100696147  glutathione S-transferase omega-1 [KO:K00799] [EC:2.5.1.18]
106098252  glutathione S-transferase omega-1 [KO:K00799] [EC:2.5.1.18]
100695721  glutathione S-transferase A [KO:K00799] [EC:2.5.1.18]
Compound
C00003  NAD+
C00006  NADP+
C02320  R-S-Glutathione
C02380  6-Mercaptopurine
C04242  5-Fluorodeoxyuridine monophosphate
C04646  6-Thioinosine-5'-monophosphate
C05361  Hydrazine
C06108  Fluoroacetate
C06837  Azathioprine
C07054  Isoniazid
C07446  Isonicotinic acid
C07447  Acetylhydrazine
C07585  N-Acetylisoniazid
C07648  Thioguanine
C07649  5-FU
C11173  SN-38
C11376  SN38 glucuronide
C11736  5-Fluorodeoxyuridine
C12650  Capecitabine
C12673  Tegafur
C12739  5'-Deoxy-5-fluorouridine
C13252  Carmofur
C16542  APC
C16543  NPC
C16613  6-Thiourate
C16614  6-Methylmercaptopurine
C16615  6-Methylthiopurine 5'-monophosphate ribonucleotide
C16616  6-Mercaptopurine ribonucleoside 5'-diphosphate
C16617  6-Mercaptopurine ribonucleoside triphosphate
C16618  6-Thioxanthine 5'-monophosphate
C16619  6-Thioguanosine monophosphate
C16620  6-Methylthioguanosine monophosphate
C16621  1-Methyl-4-nitroimidazole
C16622  N,N'-Diacetylhydrazine
C16623  Isonicotinylglycine
C16624  Isoniazid pyruvate
C16625  Isoniazid alpha-ketoglutaric acid
C16630  5,6-Dihydro-5-fluorouracil
C16631  alpha-Fluoro-beta-ureidopropionic acid
C16632  alpha-Fluoro-beta-alanine
C16633  5-Fluorouridine
C16634  5-Fluorouridine monophosphate
C16635  5'-Deoxy-5-fluorocytidine
C16641  Irinotecan
C21748  5-Fluorouridine diphosphate
C21749  5-Fluorouridine triphosphate
C21750  5-Fluorodeoxyuridine diphosphate
C21751  5-Fluorodeoxyuridine triphosphate
C21754  Isonicotinoyl radical
C21758  Hepatotoxins
C21759  Isonicotinoyl-NAD adduct
C21760  Isonicotinoyl-NADP adduct
D00238  Azathioprine (JP18/USP/INN)
D00346  Isoniazid (JP18/USP/INN)
D00584  Fluorouracil (JP18/USP/INN)
D01223  Capecitabine (JAN/USP/INN)
D01244  Tegafur (JP18/USAN/INN)
D01309  Doxifluridine (JP18/INN)
D01784  Carmofur (JP18/INN)
D04197  Floxuridine (USP/INN)
D04931  Mercaptopurine (INN)
D08086  Irinotecan (INN)
D08603  Tioguanine (INN)
Reference
  Authors
Kato R, Kamatari T (eds).
  Title
[Drug Metabolism] (In Japanese)
  Journal
Tokyo Kagaku Dojin (2000)
Reference
  Authors
Al Hadithy AF, de Boer NK, Derijks LJ, Escher JC, Mulder CJ, Brouwers JR.
  Title
Thiopurines in inflammatory bowel disease: pharmacogenetics, therapeutic drug monitoring and clinical recommendations.
  Journal
Dig Liver Dis 37:282-97 (2005)
DOI:10.1016/j.dld.2004.09.029
Reference
  Authors
Gearry RB, Barclay ML.
  Title
Azathioprine and 6-mercaptopurine pharmacogenetics and metabolite monitoring in inflammatory bowel disease.
  Journal
J Gastroenterol Hepatol 20:1149-57 (2005)
DOI:10.1111/j.1440-1746.2005.03832.x
Reference
  Authors
Gilissen LP, Derijks LJ, Verhoeven HM, Bierau J, Hooymans PM, Hommes DW, Engels LG.
  Title
Pancytopenia due to high 6-methylmercaptopurine levels in a 6-mercaptopurine treated patient with Crohn's disease.
  Journal
Dig Liver Dis 39:182-6 (2007)
DOI:10.1016/j.dld.2006.05.026
Reference
  Authors
Fischel JL, Formento P, Ciccolini J, Etienne-Grimaldi MC, Milano G.
  Title
Lack of contribution of dihydrofluorouracil and alpha-fluoro-beta-alanine to the cytotoxicity of 5'-deoxy-5-fluorouridine on human keratinocytes.
  Journal
Anticancer Drugs 15:969-74 (2004)
DOI:10.1097/00001813-200411000-00006
Reference
  Authors
Shimma N, Umeda I, Arasaki M, Murasaki C, Masubuchi K, Kohchi Y, Miwa M, Ura M, Sawada N, Tahara H, Kuruma I, Horii I, Ishitsuka H.
  Title
The design and synthesis of a new tumor-selective fluoropyrimidine carbamate, capecitabine.
  Journal
Bioorg Med Chem 8:1697-706 (2000)
DOI:10.1016/S0968-0896(00)00087-0
Reference
  Authors
Chung YL, Troy H, Judson IR, Leek R, Leach MO, Stubbs M, Harris AL, Griffiths JR
  Title
Noninvasive measurements of capecitabine metabolism in bladder tumors overexpressing thymidine phosphorylase by fluorine-19 magnetic resonance spectroscopy.
  Journal
Clin Cancer Res 10:3863-70 (2004)
DOI:10.1158/1078-0432.CCR-03-0237
Reference
  Authors
Mathijssen RH, van Alphen RJ, Verweij J, Loos WJ, Nooter K, Stoter G, Sparreboom A
  Title
Clinical pharmacokinetics and metabolism of irinotecan (CPT-11).
  Journal
Clin Cancer Res 7:2182-94 (2001)
Reference
  Authors
Kita T, Tanigawara Y, Chikazawa S, Hatanaka H, Sakaeda T, Komada F, Iwakawa S, Okumura K.
  Title
N-Acetyltransferase2 genotype correlated with isoniazid acetylation in Japanese tuberculous patients.
  Journal
Biol Pharm Bull 24:544-9 (2001)
DOI:10.1248/bpb.24.544
Reference
  Authors
Miura K, Kinouchi M, Ishida K, Fujibuchi W, Naitoh T, Ogawa H, Ando T, Yazaki N, Watanabe K, Haneda S, Shibata C, Sasaki I
  Title
5-fu metabolism in cancer and orally-administrable 5-fu drugs.
  Journal
Cancers (Basel) 2:1717-30 (2010)
DOI:10.3390/cancers2031717
Reference
  Authors
Wang P, Pradhan K, Zhong XB, Ma X
  Title
Isoniazid metabolism and hepatotoxicity.
  Journal
Acta Pharm Sin B 6:384-392 (2016)
DOI:10.1016/j.apsb.2016.07.014
Reference
  Authors
Klein DJ, Boukouvala S, McDonagh EM, Shuldiner SR, Laurieri N, Thorn CF, Altman RB, Klein TE
  Title
PharmGKB summary: isoniazid pathway, pharmacokinetics.
  Journal
Pharmacogenet Genomics 26:436-44 (2016)
DOI:10.1097/FPC.0000000000000232
Reference
  Authors
Yamada S, Richardson K, Tang M, Halaschek-Wiener J, Cook VJ, Fitzgerald JM, Elwood K, Marra F, Brooks-Wilson A
  Title
Genetic variation in carboxylesterase genes and susceptibility to isoniazid-induced hepatotoxicity.
  Journal
Pharmacogenomics J 10:524-36 (2010)
DOI:10.1038/tpj.2010.5
Reference
  Authors
Vlasits J, Jakopitsch C, Bernroitner M, Zamocky M, Furtmuller PG, Obinger C
  Title
Mechanisms of catalase activity of heme peroxidases.
  Journal
Arch Biochem Biophys 500:74-81 (2010)
DOI:10.1016/j.abb.2010.04.018
Reference
  Authors
Khan SR, Morgan AG, Michail K, Srivastava N, Whittal RM, Aljuhani N, Siraki AG
  Title
Metabolism of isoniazid by neutrophil myeloperoxidase leads to isoniazid-NAD(+) adduct formation: A comparison of the reactivity of isoniazid with its known human metabolites.
  Journal
Biochem Pharmacol 106:46-55 (2016)
DOI:10.1016/j.bcp.2016.02.003
Reference
  Authors
Forbes LV, Furtmuller PG, Khalilova I, Turner R, Obinger C, Kettle AJ
  Title
Isoniazid as a substrate and inhibitor of myeloperoxidase: identification of amine adducts and the influence of superoxide dismutase on their formation.
  Journal
Biochem Pharmacol 84:949-60 (2012)
DOI:10.1016/j.bcp.2012.07.020
Reference
  Authors
Nguyen M, Quemard A, Broussy S, Bernadou J, Meunier B
  Title
Mn(III) pyrophosphate as an efficient tool for studying the mode of action of isoniazid on the InhA protein of Mycobacterium tuberculosis.
  Journal
Antimicrob Agents Chemother 46:2137-44 (2002)
DOI:10.1128/AAC.46.7.2137-2144.2002
Reference
PMID:9417034
  Authors
Rozwarski DA, Grant GA, Barton DH, Jacobs WR Jr, Sacchettini JC
  Title
Modification of the NADH of the isoniazid target (InhA) from Mycobacterium tuberculosis.
  Journal
Science 279:98-102 (1998)
DOI:10.1126/science.279.5347.98
Reference
  Authors
Argyrou A, Vetting MW, Blanchard JS
  Title
New insight into the mechanism of action of and resistance to isoniazid: interaction of Mycobacterium tuberculosis enoyl-ACP reductase with INH-NADP.
  Journal
J Am Chem Soc 129:9582-3 (2007)
DOI:10.1021/ja073160k
KO pathway
ko00983   
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