KEGG   PATHWAY: paem00260
Entry
paem00260                   Pathway                                
Name
Glycine, serine and threonine metabolism - Pseudomonas aeruginosa MTB-1
Description
Serine is derived from 3-phospho-D-glycerate, an intermediate of glycolysis [MD:M00020], and glycine is derived from serine. Threonine is an essential amino acid, which animals cannot synthesize. In bacteria and plants, threonine is derived from aspartate [MD:M00018].
Class
Metabolism; Amino acid metabolism
Pathway map
paem00260  Glycine, serine and threonine metabolism
paem00260

Module
paem_M00018  Threonine biosynthesis, aspartate => homoserine => threonine [PATH:paem00260]
paem_M00020  Serine biosynthesis, glycerate-3P => serine [PATH:paem00260]
paem_M00338  Cysteine biosynthesis, homocysteine + serine => cysteine [PATH:paem00260]
paem_M00555  Betaine biosynthesis, choline => betaine [PATH:paem00260]
paem_M00621  Glycine cleavage system [PATH:paem00260]
paem_M00975  Betaine degradation, bacteria, betaine => pyruvate [PATH:paem00260]
Other DBs
GO: 0006544 0006563 0070178 0006566
Organism
Pseudomonas aeruginosa MTB-1 [GN:paem]
Gene
U769_21290  aspartokinase [KO:K00928] [EC:2.7.2.4]
U769_09315  aspartate-semialdehyde dehydrogenase [KO:K00133] [EC:1.2.1.11]
U769_06195  homoserine dehydrogenase [KO:K00003] [EC:1.1.1.3]
U769_30170  homoserine kinase [KO:K02204] [EC:2.7.1.39]
U769_16930  thrH; phosphoserine phosphatase [KO:K02203] [EC:3.1.3.3 2.7.1.39]
U769_06200  threonine synthase [KO:K01733] [EC:4.2.3.1]
U769_29750  threonine aldolase [KO:K01620] [EC:4.1.2.48]
U769_21300  threonine aldolase [KO:K01620] [EC:4.1.2.48]
U769_25205  glyA; serine hydroxymethyltransferase [KO:K00600] [EC:2.1.2.1]
U769_29760  glyA; serine hydroxymethyltransferase [KO:K00600] [EC:2.1.2.1]
U769_13005  glyA; serine hydroxymethyltransferase [KO:K00600] [EC:2.1.2.1]
U769_25330  glycerate dehydrogenase [KO:K00018] [EC:1.1.1.29]
U769_05375  2-ketogluconate reductase [KO:K00090] [EC:1.1.1.79 1.1.1.81 1.1.1.215]
U769_20535  glycerate kinase [KO:K00865] [EC:2.7.1.165]
U769_18265  TtuD3 hydroxypyruvate reductase [KO:K11529] [EC:2.7.1.165]
U769_28015  phosphoglyceromutase [KO:K15633] [EC:5.4.2.12]
U769_01625  3-phosphoglycerate dehydrogenase [KO:K00058] [EC:1.1.1.95 1.1.1.399]
U769_09080  MFS transporter [KO:K00831] [EC:2.6.1.52]
U769_27175  phosphoserine phosphatase [KO:K01079] [EC:3.1.3.3]
U769_02170  amine oxidase [KO:K00274] [EC:1.4.3.4]
U769_28710  glycine dehydrogenase [KO:K00281] [EC:1.4.4.2]
U769_13000  glycine dehydrogenase [KO:K00281] [EC:1.4.4.2]
U769_28720  gcvT; glycine cleavage system aminomethyltransferase T [KO:K00605] [EC:2.1.2.10]
U769_13015  gcvT; glycine cleavage system protein T [KO:K00605] [EC:2.1.2.10]
U769_26505  dihydrolipoamide dehydrogenase [KO:K00382] [EC:1.8.1.4]
U769_17805  dihydrolipoamide dehydrogenase [KO:K00382] [EC:1.8.1.4]
U769_13955  dihydrolipoamide dehydrogenase [KO:K00382] [EC:1.8.1.4]
U769_08775  glycine cleavage system protein H [KO:K02437]
U769_28715  glycine cleavage system protein H [KO:K02437]
U769_12995  glycine cleavage system protein H [KO:K02437]
U769_26325  glycine cleavage system protein H [KO:K02437]
U769_25785  CDP-diacylglycerol--serine O-phosphatidyltransferase [KO:K17103] [EC:2.7.8.8]
U769_29540  choline dehydrogenase [KO:K00108] [EC:1.1.99.1]
U769_29545  betaine-aldehyde dehydrogenase [KO:K00130] [EC:1.2.1.8]
U769_29735  Rieske (2Fe-2S) protein [KO:K00479] [EC:1.14.13.251]
U769_29740  ferredoxin [KO:K21832] [EC:1.14.13.251]
U769_29670  N-methylproline demethylase [KO:K21833] [EC:1.5.7.3]
U769_29675  (Fe-S)-binding protein [KO:K21834]
U769_29680  electron transfer flavoprotein subunit alpha [KO:K25960]
U769_29685  electron transfer flavoprotein subunit beta [KO:K25961]
U769_29775  sarcosine oxidase subunit alpha [KO:K00302] [EC:1.5.3.24 1.5.3.1]
U769_29765  sarcosine oxidase subunit beta [KO:K00303] [EC:1.5.3.24 1.5.3.1]
U769_29780  sarcosine oxidase subunit gamma [KO:K00305] [EC:1.5.3.24 1.5.3.1]
U769_29770  sarcosine oxidase subunit delta [KO:K00304] [EC:1.5.3.24 1.5.3.1]
U769_02060  cystathionine beta-synthase [KO:K01697] [EC:4.2.1.22]
U769_02065  cystathionine beta-lyase [KO:K01758] [EC:4.4.1.1]
U769_29575  serine dehydratase [KO:K01752] [EC:4.3.1.17]
U769_13010  serine dehydratase [KO:K01752] [EC:4.3.1.17]
U769_01700  L-threonine dehydratase biosynthetic IlvA [KO:K01754] [EC:4.3.1.19]
U769_19120  L-threonine dehydratase biosynthetic IlvA [KO:K01754] [EC:4.3.1.19]
U769_21560  hypothetical protein [KO:K01754] [EC:4.3.1.19]
U769_08060  D-serine dehydratase [KO:K01753] [EC:4.3.1.18]
U769_00180  trpA; tryptophan synthase subunit alpha [KO:K01695] [EC:4.2.1.20]
U769_00185  tryptophan synthase subunit beta [KO:K01696] [EC:4.2.1.20]
U769_13170  diadenosine tetraphosphatase [KO:K00836] [EC:2.6.1.76]
U769_14175  diadenosine tetraphosphatase [KO:K00836] [EC:2.6.1.76]
Compound
C00011  CO2
C00014  Ammonia
C00022  Pyruvate
C00037  Glycine
C00048  Glyoxylate
C00049  L-Aspartate
C00065  L-Serine
C00078  L-Tryptophan
C00097  L-Cysteine
C00101  Tetrahydrofolate
C00109  2-Oxobutanoate
C00114  Choline
C00143  5,10-Methylenetetrahydrofolate
C00168  Hydroxypyruvate
C00188  L-Threonine
C00197  3-Phospho-D-glycerate
C00213  Sarcosine
C00258  D-Glycerate
C00263  L-Homoserine
C00300  Creatine
C00430  5-Aminolevulinate
C00441  L-Aspartate 4-semialdehyde
C00546  Methylglyoxal
C00576  Betaine aldehyde
C00581  Guanidinoacetate
C00631  2-Phospho-D-glycerate
C00719  Betaine
C00740  D-Serine
C00986  1,3-Diaminopropane
C01005  O-Phospho-L-serine
C01026  N,N-Dimethylglycine
C01102  O-Phospho-L-homoserine
C01242  [Protein]-S8-aminomethyldihydrolipoyllysine
C01888  Aminoacetone
C02051  Lipoylprotein
C02291  L-Cystathionine
C02737  Phosphatidylserine
C02972  Dihydrolipoylprotein
C03082  4-Phospho-L-aspartate
C03194  (R)-1-Aminopropan-2-ol
C03232  3-Phosphonooxypyruvate
C03283  L-2,4-Diaminobutanoate
C03508  L-2-Amino-3-oxobutanoic acid
C05519  L-Allothreonine
C06231  Ectoine
C06442  N(gamma)-Acetyldiaminobutyrate
C16432  5-Hydroxyectoine
C19929  N(alpha)-Acetyl-L-2,4-diaminobutyrate
Reference
  Authors
Nishizuka Y, Seyama Y, Ikai A, Ishimura Y, Kawaguchi A (eds).
  Title
[Cellular Functions and Metabolic Maps] (In Japanese)
  Journal
Tokyo Kagaku Dojin (1997)
Reference
PMID:11823218
  Authors
Kuhlmann AU, Bremer E.
  Title
Osmotically regulated synthesis of the compatible solute ectoine in Bacillus pasteurii and related Bacillus spp.
  Journal
Appl Environ Microbiol 68:772-83 (2002)
DOI:10.1128/AEM.68.2.772-783.2002
Reference
PMID:10473374
  Authors
Canovas D, Borges N, Vargas C, Ventosa A, Nieto JJ, Santos H.
  Title
Role of Ngamma-acetyldiaminobutyrate as an enzyme stabilizer and an intermediate in the biosynthesis of hydroxyectoine.
  Journal
Appl Environ Microbiol 65:3774-9 (1999)
DOI:10.1128/AEM.65.9.3774-3779.1999
Reference
PMID:17636255
  Authors
Bursy J, Pierik AJ, Pica N, Bremer E.
  Title
Osmotically induced synthesis of the compatible solute hydroxyectoine is mediated by an evolutionarily conserved ectoine hydroxylase.
  Journal
J Biol Chem 282:31147-55 (2007)
DOI:10.1074/jbc.M704023200
Reference
PMID:16707670
  Authors
Garcia-Estepa R, Argandona M, Reina-Bueno M, Capote N, Iglesias-Guerra F, Nieto JJ, Vargas C.
  Title
The ectD gene, which is involved in the synthesis of the compatible solute hydroxyectoine, is essential for thermoprotection of the halophilic bacterium Chromohalobacter salexigens.
  Journal
J Bacteriol 188:3774-84 (2006)
DOI:10.1128/JB.00136-06
Reference
PMID:15470257
  Authors
Arevalo-Rodriguez M, Pan X, Boeke JD, Heitman J
  Title
FKBP12 controls aspartate pathway flux in Saccharomyces cerevisiae to prevent toxic intermediate accumulation.
  Journal
Eukaryot Cell 3:1287-96 (2004)
DOI:10.1128/EC.3.5.1287-1296.2004
Reference
PMID:7639721
  Authors
Rees WD, Hay SM
  Title
The biosynthesis of threonine by mammalian cells: expression of a complete bacterial biosynthetic pathway in an animal cell.
  Journal
Biochem J 309 ( Pt 3):999-1007 (1995)
DOI:10.1042/bj3090999
Reference
PMID:11341914
  Authors
Jacques SL, Nieman C, Bareich D, Broadhead G, Kinach R, Honek JF, Wright GD
  Title
Characterization of yeast homoserine dehydrogenase, an antifungal target: the invariant histidine 309 is important for enzyme integrity.
  Journal
Biochim Biophys Acta 1544:28-41 (2001)
DOI:10.1016/S0167-4838(00)00203-X
Reference
PMID:15520012
  Authors
Chen X, Jhee KH, Kruger WD
  Title
Production of the neuromodulator H2S by cystathionine beta-synthase via the condensation of cysteine and homocysteine.
  Journal
J Biol Chem 279:52082-6 (2004)
DOI:10.1074/jbc.C400481200
Related
pathway
paem00010  Glycolysis / Gluconeogenesis
paem00020  Citrate cycle (TCA cycle)
paem00230  Purine metabolism
paem00250  Alanine, aspartate and glutamate metabolism
paem00270  Cysteine and methionine metabolism
paem00290  Valine, leucine and isoleucine biosynthesis
paem00300  Lysine biosynthesis
paem00330  Arginine and proline metabolism
paem00460  Cyanoamino acid metabolism
paem00470  D-Amino acid metabolism
paem00564  Glycerophospholipid metabolism
paem00600  Sphingolipid metabolism
paem00620  Pyruvate metabolism
paem00630  Glyoxylate and dicarboxylate metabolism
paem00640  Propanoate metabolism
paem00680  Methane metabolism
paem00860  Porphyrin metabolism
paem00920  Sulfur metabolism
KO pathway
ko00260   
LinkDB

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