KEGG   PATHWAY: panr00260
Entry
panr00260                   Pathway                                
Name
Glycine, serine and threonine metabolism - Pseudomonas antarctica
Description
Serine is derived from 3-phospho-D-glycerate, an intermediate of glycolysis [MD:M00020], and glycine is derived from serine. Threonine is an essential amino acid, which animals cannot synthesize. In bacteria and plants, threonine is derived from aspartate [MD:M00018].
Class
Metabolism; Amino acid metabolism
Pathway map
panr00260  Glycine, serine and threonine metabolism
panr00260

Module
panr_M00018  Threonine biosynthesis, aspartate => homoserine => threonine [PATH:panr00260]
panr_M00020  Serine biosynthesis, glycerate-3P => serine [PATH:panr00260]
panr_M00338  Cysteine biosynthesis, homocysteine + serine => cysteine [PATH:panr00260]
panr_M00555  Betaine biosynthesis, choline => betaine [PATH:panr00260]
panr_M00621  Glycine cleavage system [PATH:panr00260]
panr_M00975  Betaine degradation, bacteria, betaine => pyruvate [PATH:panr00260]
Other DBs
GO: 0006544 0006563 0070178 0006566
Organism
Pseudomonas antarctica [GN:panr]
Gene
A7J50_4510  Aspartokinase [KO:K00928] [EC:2.7.2.4]
A7J50_3873  aspartate-semialdehyde dehydrogenase [KO:K00133] [EC:1.2.1.11]
A7J50_4774  Homoserine dehydrogenase [KO:K00003] [EC:1.1.1.3]
A7J50_0080  homoserine kinase [KO:K02204] [EC:2.7.1.39]
A7J50_4773  threonine synthase [KO:K01733] [EC:4.2.3.1]
A7J50_4512  L-allo-threonine aldolase [KO:K01620] [EC:4.1.2.48]
A7J50_5382  threonine aldolase [KO:K01620] [EC:4.1.2.48]
A7J50_5380  Serine hydroxymethyltransferase [KO:K00600] [EC:2.1.2.1]
A7J50_5054  serine hydroxymethyltransferase [KO:K00600] [EC:2.1.2.1]
A7J50_0921  Glycerate dehydrogenase [KO:K00018] [EC:1.1.1.29]
A7J50_0967  2-ketogluconate reductase [KO:K00090] [EC:1.1.1.79 1.1.1.81 1.1.1.215]
A7J50_3000  glycerate kinase [KO:K00865] [EC:2.7.1.165]
A7J50_1929  hydroxypyruvate reductase [KO:K11529] [EC:2.7.1.165]
A7J50_0324  phosphoglyceromutase [KO:K15633] [EC:5.4.2.12]
A7J50_5557  3-phosphoglycerate dehydrogenase [KO:K00058] [EC:1.1.1.95 1.1.1.399]
A7J50_1801  MFS transporter [KO:K00831] [EC:2.6.1.52]
A7J50_0492  phosphoserine phosphatase [KO:K01079] [EC:3.1.3.3]
A7J50_3729  monoamine oxidase [KO:K00274] [EC:1.4.3.4]
A7J50_4659  Glycine dehydrogenase [KO:K00281] [EC:1.4.4.2]
A7J50_4661  Aminomethyltransferase [KO:K00605] [EC:2.1.2.10]
A7J50_5605  glycine cleavage system protein T [KO:K00605] [EC:2.1.2.10]
A7J50_3622  dihydrolipoamide dehydrogenase [KO:K00382] [EC:1.8.1.4]
A7J50_1956  Dihydrolipoyl dehydrogenase [KO:K00382] [EC:1.8.1.4]
A7J50_4658  Glycine cleavage system H protein [KO:K02437]
A7J50_5604  glycine cleavage system protein H [KO:K02437]
A7J50_2183  Inosamine-phosphate amidinotransferase 1 [KO:K00613] [EC:2.1.4.1]
A7J50_2747  CDP-diacylglycerol-serine O-phosphatidyltransferase [KO:K00998] [EC:2.7.8.8]
A7J50_4965  putative phosphatidyltransferase [KO:K17103] [EC:2.7.8.8]
A7J50_5412  choline dehydrogenase [KO:K00108] [EC:1.1.99.1]
A7J50_5411  betaine-aldehyde dehydrogenase [KO:K00130] [EC:1.2.1.8]
A7J50_1625  aldehyde dehydrogenase [KO:K00130] [EC:1.2.1.8]
A7J50_5386  Putative iron/sulfur-binding protein [KO:K00479] [EC:1.14.13.251]
A7J50_5385  ferredoxin [KO:K21832] [EC:1.14.13.251]
A7J50_5390  N-methylproline demethylase [KO:K21833] [EC:1.5.7.3]
A7J50_5389  (Fe-S)-binding protein [KO:K21834]
A7J50_5388  Electron transfer flavoprotein subunit alpha [KO:K25960]
A7J50_5387  electron transfer flavoprotein subunit beta [KO:K25961]
A7J50_3914  Methyltryptophan oxidase [KO:K00301] [EC:1.5.3.1]
A7J50_5377  Sarcosine oxidase, alpha subunit [KO:K00302] [EC:1.5.3.24 1.5.3.1]
A7J50_5379  Sarcosine oxidase subunit beta [KO:K00303] [EC:1.5.3.24 1.5.3.1]
A7J50_5376  Sarcosine oxidase subunit gamma [KO:K00305] [EC:1.5.3.24 1.5.3.1]
A7J50_5378  Sarcosine oxidase, delta subunit [KO:K00304] [EC:1.5.3.24 1.5.3.1]
A7J50_3129  cystathionine beta-synthase [KO:K01697] [EC:4.2.1.22]
A7J50_3130  cystathionine beta-lyase [KO:K01758] [EC:4.4.1.1]
A7J50_5405  serine dehydratase [KO:K01752] [EC:4.3.1.17]
A7J50_4660  Serine dehydratase [KO:K01752] [EC:4.3.1.17]
A7J50_1041  serine dehydratase [KO:K01752] [EC:4.3.1.17]
A7J50_5551  L-threonine dehydratase biosynthetic IlvA [KO:K01754] [EC:4.3.1.19]
A7J50_2994  aspartate racemase [KO:K25316] [EC:5.1.1.10]
A7J50_0036  tryptophan synthase subunit alpha [KO:K01695] [EC:4.2.1.20]
A7J50_0037  tryptophan synthase subunit beta [KO:K01696] [EC:4.2.1.20]
A7J50_4056  Diadenosine tetraphosphatase [KO:K00836] [EC:2.6.1.76]
Compound
C00011  CO2
C00014  Ammonia
C00022  Pyruvate
C00037  Glycine
C00048  Glyoxylate
C00049  L-Aspartate
C00065  L-Serine
C00078  L-Tryptophan
C00097  L-Cysteine
C00101  Tetrahydrofolate
C00109  2-Oxobutanoate
C00114  Choline
C00143  5,10-Methylenetetrahydrofolate
C00168  Hydroxypyruvate
C00188  L-Threonine
C00197  3-Phospho-D-glycerate
C00213  Sarcosine
C00258  D-Glycerate
C00263  L-Homoserine
C00300  Creatine
C00430  5-Aminolevulinate
C00441  L-Aspartate 4-semialdehyde
C00546  Methylglyoxal
C00576  Betaine aldehyde
C00581  Guanidinoacetate
C00631  2-Phospho-D-glycerate
C00719  Betaine
C00740  D-Serine
C00986  1,3-Diaminopropane
C01005  O-Phospho-L-serine
C01026  N,N-Dimethylglycine
C01102  O-Phospho-L-homoserine
C01242  [Protein]-S8-aminomethyldihydrolipoyllysine
C01888  Aminoacetone
C02051  Lipoylprotein
C02291  L-Cystathionine
C02737  Phosphatidylserine
C02972  Dihydrolipoylprotein
C03082  4-Phospho-L-aspartate
C03194  (R)-1-Aminopropan-2-ol
C03232  3-Phosphonooxypyruvate
C03283  L-2,4-Diaminobutanoate
C03508  L-2-Amino-3-oxobutanoic acid
C05519  L-Allothreonine
C06231  Ectoine
C06442  N(gamma)-Acetyldiaminobutyrate
C16432  5-Hydroxyectoine
C19929  N(alpha)-Acetyl-L-2,4-diaminobutyrate
Reference
  Authors
Nishizuka Y, Seyama Y, Ikai A, Ishimura Y, Kawaguchi A (eds).
  Title
[Cellular Functions and Metabolic Maps] (In Japanese)
  Journal
Tokyo Kagaku Dojin (1997)
Reference
PMID:11823218
  Authors
Kuhlmann AU, Bremer E.
  Title
Osmotically regulated synthesis of the compatible solute ectoine in Bacillus pasteurii and related Bacillus spp.
  Journal
Appl Environ Microbiol 68:772-83 (2002)
DOI:10.1128/AEM.68.2.772-783.2002
Reference
PMID:10473374
  Authors
Canovas D, Borges N, Vargas C, Ventosa A, Nieto JJ, Santos H.
  Title
Role of Ngamma-acetyldiaminobutyrate as an enzyme stabilizer and an intermediate in the biosynthesis of hydroxyectoine.
  Journal
Appl Environ Microbiol 65:3774-9 (1999)
DOI:10.1128/AEM.65.9.3774-3779.1999
Reference
PMID:17636255
  Authors
Bursy J, Pierik AJ, Pica N, Bremer E.
  Title
Osmotically induced synthesis of the compatible solute hydroxyectoine is mediated by an evolutionarily conserved ectoine hydroxylase.
  Journal
J Biol Chem 282:31147-55 (2007)
DOI:10.1074/jbc.M704023200
Reference
PMID:16707670
  Authors
Garcia-Estepa R, Argandona M, Reina-Bueno M, Capote N, Iglesias-Guerra F, Nieto JJ, Vargas C.
  Title
The ectD gene, which is involved in the synthesis of the compatible solute hydroxyectoine, is essential for thermoprotection of the halophilic bacterium Chromohalobacter salexigens.
  Journal
J Bacteriol 188:3774-84 (2006)
DOI:10.1128/JB.00136-06
Reference
PMID:15470257
  Authors
Arevalo-Rodriguez M, Pan X, Boeke JD, Heitman J
  Title
FKBP12 controls aspartate pathway flux in Saccharomyces cerevisiae to prevent toxic intermediate accumulation.
  Journal
Eukaryot Cell 3:1287-96 (2004)
DOI:10.1128/EC.3.5.1287-1296.2004
Reference
PMID:7639721
  Authors
Rees WD, Hay SM
  Title
The biosynthesis of threonine by mammalian cells: expression of a complete bacterial biosynthetic pathway in an animal cell.
  Journal
Biochem J 309 ( Pt 3):999-1007 (1995)
DOI:10.1042/bj3090999
Reference
PMID:11341914
  Authors
Jacques SL, Nieman C, Bareich D, Broadhead G, Kinach R, Honek JF, Wright GD
  Title
Characterization of yeast homoserine dehydrogenase, an antifungal target: the invariant histidine 309 is important for enzyme integrity.
  Journal
Biochim Biophys Acta 1544:28-41 (2001)
DOI:10.1016/S0167-4838(00)00203-X
Reference
PMID:15520012
  Authors
Chen X, Jhee KH, Kruger WD
  Title
Production of the neuromodulator H2S by cystathionine beta-synthase via the condensation of cysteine and homocysteine.
  Journal
J Biol Chem 279:52082-6 (2004)
DOI:10.1074/jbc.C400481200
Related
pathway
panr00010  Glycolysis / Gluconeogenesis
panr00020  Citrate cycle (TCA cycle)
panr00230  Purine metabolism
panr00250  Alanine, aspartate and glutamate metabolism
panr00270  Cysteine and methionine metabolism
panr00290  Valine, leucine and isoleucine biosynthesis
panr00300  Lysine biosynthesis
panr00330  Arginine and proline metabolism
panr00460  Cyanoamino acid metabolism
panr00470  D-Amino acid metabolism
panr00564  Glycerophospholipid metabolism
panr00620  Pyruvate metabolism
panr00630  Glyoxylate and dicarboxylate metabolism
panr00640  Propanoate metabolism
panr00680  Methane metabolism
panr00860  Porphyrin metabolism
panr00920  Sulfur metabolism
KO pathway
ko00260   
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