KEGG   PATHWAY: paro00260
Entry
paro00260                   Pathway                                
Name
Glycine, serine and threonine metabolism - Paracoccus tegillarcae
Description
Serine is derived from 3-phospho-D-glycerate, an intermediate of glycolysis [MD:M00020], and glycine is derived from serine. Threonine is an essential amino acid, which animals cannot synthesize. In bacteria and plants, threonine is derived from aspartate [MD:M00018].
Class
Metabolism; Amino acid metabolism
Pathway map
paro00260  Glycine, serine and threonine metabolism
paro00260

Module
paro_M00020  Serine biosynthesis, glycerate-3P => serine [PATH:paro00260]
paro_M00033  Ectoine biosynthesis, aspartate => ectoine [PATH:paro00260]
paro_M00555  Betaine biosynthesis, choline => betaine [PATH:paro00260]
paro_M00621  Glycine cleavage system [PATH:paro00260]
paro_M00919  Ectoine degradation, ectoine => aspartate [PATH:paro00260]
Other DBs
GO: 0006544 0006563 0070178 0006566
Organism
Paracoccus tegillarcae [GN:paro]
Gene
CUV01_03835  aspartate kinase [KO:K00928] [EC:2.7.2.4]
CUV01_03430  aspartate kinase [KO:K00928] [EC:2.7.2.4]
CUV01_07280  aspartate-semialdehyde dehydrogenase [KO:K00133] [EC:1.2.1.11]
CUV01_06905  asd; aspartate-semialdehyde dehydrogenase [KO:K00133] [EC:1.2.1.11]
CUV01_01365  homoserine dehydrogenase [KO:K00003] [EC:1.1.1.3]
CUV01_03155  threonine synthase [KO:K01733] [EC:4.2.3.1]
CUV01_15105  low specificity L-threonine aldolase [KO:K01620] [EC:4.1.2.48]
CUV01_13230  glyA; serine hydroxymethyltransferase [KO:K00600] [EC:2.1.2.1]
CUV01_14820  glyA; serine hydroxymethyltransferase [KO:K00600] [EC:2.1.2.1]
CUV01_11715  serine--glyoxylate aminotransferase [KO:K00830] [EC:2.6.1.44 2.6.1.45 2.6.1.51]
CUV01_05195  aminotransferase [KO:K00830] [EC:2.6.1.44 2.6.1.45 2.6.1.51]
CUV01_14560  glyoxylate/hydroxypyruvate reductase A [KO:K12972] [EC:1.1.1.79 1.1.1.81]
CUV01_11410  hydroxypyruvate reductase [KO:K11529] [EC:2.7.1.165]
CUV01_08665  2,3-bisphosphoglycerate-independent phosphoglycerate mutase [KO:K15633] [EC:5.4.2.12]
CUV01_06980  phosphoglycerate dehydrogenase [KO:K00058] [EC:1.1.1.95 1.1.1.399]
CUV01_06985  phosphoserine transaminase [KO:K00831] [EC:2.6.1.52]
CUV01_06995  serB; phosphoserine phosphatase SerB [KO:K01079] [EC:3.1.3.3]
CUV01_15015  hemA; 5-aminolevulinate synthase [KO:K00643] [EC:2.3.1.37]
CUV01_07750  gcvP; glycine dehydrogenase (aminomethyl-transferring) [KO:K00281] [EC:1.4.4.2]
CUV01_07740  gcvT; glycine cleavage system protein T [KO:K00605] [EC:2.1.2.10]
CUV01_17790  lpdA; dihydrolipoyl dehydrogenase [KO:K00382] [EC:1.8.1.4]
CUV01_00570  lpdA; dihydrolipoyl dehydrogenase [KO:K00382] [EC:1.8.1.4]
CUV01_18525  lpdA; dihydrolipoyl dehydrogenase [KO:K00382] [EC:1.8.1.4]
CUV01_07745  gcvH; glycine cleavage system protein H [KO:K02437]
CUV01_13195  creatininase [KO:K08688] [EC:3.5.3.3]
CUV01_15695  betA; choline dehydrogenase [KO:K00108] [EC:1.1.99.1]
CUV01_15685  betaine-aldehyde dehydrogenase [KO:K00130] [EC:1.2.1.8]
CUV01_07780  sorbosone dehydrogenase [KO:K00130] [EC:1.2.1.8]
CUV01_18175  diguanylate cyclase [KO:K00315] [EC:1.5.8.4]
CUV01_13220  sarcosine oxidase subunit alpha [KO:K00302] [EC:1.5.3.24 1.5.3.1]
CUV01_10260  sarcosine oxidase subunit alpha family protein [KO:K00302] [EC:1.5.3.24 1.5.3.1]
CUV01_13210  sarcosine oxidase subunit beta [KO:K00303] [EC:1.5.3.24 1.5.3.1]
CUV01_10240  sarcosine oxidase subunit beta [KO:K00303] [EC:1.5.3.24 1.5.3.1]
CUV01_13225  sarcosine oxidase subunit gamma [KO:K00305] [EC:1.5.3.24 1.5.3.1]
CUV01_10265  sarcosine oxidase subunit gamma [KO:K00305] [EC:1.5.3.24 1.5.3.1]
CUV01_13215  sarcosine oxidase subunit delta [KO:K00304] [EC:1.5.3.24 1.5.3.1]
CUV01_10255  sarcosine oxidase subunit delta [KO:K00304] [EC:1.5.3.24 1.5.3.1]
CUV01_13235  L-serine ammonia-lyase [KO:K01752] [EC:4.3.1.17]
CUV01_11100  L-serine ammonia-lyase [KO:K01752] [EC:4.3.1.17]
CUV01_03770  threonine dehydratase [KO:K01754] [EC:4.3.1.19]
CUV01_02770  hypothetical protein [KO:K01754] [EC:4.3.1.19]
CUV01_11720  serine dehydratase [KO:K01754] [EC:4.3.1.19]
CUV01_01775  hydroxyectoine utilization dehydratase EutB [KO:K01754] [EC:4.3.1.19]
CUV01_15375  tryptophan synthase subunit alpha [KO:K01695] [EC:4.2.1.20]
CUV01_15545  trpB; tryptophan synthase subunit beta [KO:K01696] [EC:4.2.1.20]
CUV01_03845  ectB; diaminobutyrate--2-oxoglutarate transaminase [KO:K00836] [EC:2.6.1.76]
CUV01_03850  ectA; diaminobutyrate acetyltransferase [KO:K06718] [EC:2.3.1.178]
CUV01_03840  L-ectoine synthase [KO:K06720] [EC:4.2.1.108]
CUV01_01765  doeA; ectoine hydrolase DoeA [KO:K15783] [EC:3.5.4.44]
CUV01_01760  doeB; N-alpha-acetyl diaminobutyric acid deacetylase DoeB [KO:K15784] [EC:3.5.1.125]
CUV01_01830  hypothetical protein [KO:K15785] [EC:2.6.1.76]
CUV01_01825  NAD-dependent succinate-semialdehyde dehydrogenase [KO:K15786] [EC:1.2.1.-]
Compound
C00011  CO2
C00014  Ammonia
C00022  Pyruvate
C00037  Glycine
C00048  Glyoxylate
C00049  L-Aspartate
C00065  L-Serine
C00078  L-Tryptophan
C00097  L-Cysteine
C00101  Tetrahydrofolate
C00109  2-Oxobutanoate
C00114  Choline
C00143  5,10-Methylenetetrahydrofolate
C00168  Hydroxypyruvate
C00188  L-Threonine
C00197  3-Phospho-D-glycerate
C00213  Sarcosine
C00258  D-Glycerate
C00263  L-Homoserine
C00300  Creatine
C00430  5-Aminolevulinate
C00441  L-Aspartate 4-semialdehyde
C00546  Methylglyoxal
C00576  Betaine aldehyde
C00581  Guanidinoacetate
C00631  2-Phospho-D-glycerate
C00719  Betaine
C00740  D-Serine
C00986  1,3-Diaminopropane
C01005  O-Phospho-L-serine
C01026  N,N-Dimethylglycine
C01102  O-Phospho-L-homoserine
C01242  [Protein]-S8-aminomethyldihydrolipoyllysine
C01888  Aminoacetone
C02051  Lipoylprotein
C02291  L-Cystathionine
C02737  Phosphatidylserine
C02972  Dihydrolipoylprotein
C03082  4-Phospho-L-aspartate
C03194  (R)-1-Aminopropan-2-ol
C03232  3-Phosphonooxypyruvate
C03283  L-2,4-Diaminobutanoate
C03508  L-2-Amino-3-oxobutanoic acid
C05519  L-Allothreonine
C06231  Ectoine
C06442  N(gamma)-Acetyldiaminobutyrate
C16432  5-Hydroxyectoine
C19929  N(alpha)-Acetyl-L-2,4-diaminobutyrate
Reference
  Authors
Nishizuka Y, Seyama Y, Ikai A, Ishimura Y, Kawaguchi A (eds).
  Title
[Cellular Functions and Metabolic Maps] (In Japanese)
  Journal
Tokyo Kagaku Dojin (1997)
Reference
PMID:11823218
  Authors
Kuhlmann AU, Bremer E.
  Title
Osmotically regulated synthesis of the compatible solute ectoine in Bacillus pasteurii and related Bacillus spp.
  Journal
Appl Environ Microbiol 68:772-83 (2002)
DOI:10.1128/AEM.68.2.772-783.2002
Reference
PMID:10473374
  Authors
Canovas D, Borges N, Vargas C, Ventosa A, Nieto JJ, Santos H.
  Title
Role of Ngamma-acetyldiaminobutyrate as an enzyme stabilizer and an intermediate in the biosynthesis of hydroxyectoine.
  Journal
Appl Environ Microbiol 65:3774-9 (1999)
DOI:10.1128/AEM.65.9.3774-3779.1999
Reference
PMID:17636255
  Authors
Bursy J, Pierik AJ, Pica N, Bremer E.
  Title
Osmotically induced synthesis of the compatible solute hydroxyectoine is mediated by an evolutionarily conserved ectoine hydroxylase.
  Journal
J Biol Chem 282:31147-55 (2007)
DOI:10.1074/jbc.M704023200
Reference
PMID:16707670
  Authors
Garcia-Estepa R, Argandona M, Reina-Bueno M, Capote N, Iglesias-Guerra F, Nieto JJ, Vargas C.
  Title
The ectD gene, which is involved in the synthesis of the compatible solute hydroxyectoine, is essential for thermoprotection of the halophilic bacterium Chromohalobacter salexigens.
  Journal
J Bacteriol 188:3774-84 (2006)
DOI:10.1128/JB.00136-06
Reference
PMID:15470257
  Authors
Arevalo-Rodriguez M, Pan X, Boeke JD, Heitman J
  Title
FKBP12 controls aspartate pathway flux in Saccharomyces cerevisiae to prevent toxic intermediate accumulation.
  Journal
Eukaryot Cell 3:1287-96 (2004)
DOI:10.1128/EC.3.5.1287-1296.2004
Reference
PMID:7639721
  Authors
Rees WD, Hay SM
  Title
The biosynthesis of threonine by mammalian cells: expression of a complete bacterial biosynthetic pathway in an animal cell.
  Journal
Biochem J 309 ( Pt 3):999-1007 (1995)
DOI:10.1042/bj3090999
Reference
PMID:11341914
  Authors
Jacques SL, Nieman C, Bareich D, Broadhead G, Kinach R, Honek JF, Wright GD
  Title
Characterization of yeast homoserine dehydrogenase, an antifungal target: the invariant histidine 309 is important for enzyme integrity.
  Journal
Biochim Biophys Acta 1544:28-41 (2001)
DOI:10.1016/S0167-4838(00)00203-X
Reference
PMID:15520012
  Authors
Chen X, Jhee KH, Kruger WD
  Title
Production of the neuromodulator H2S by cystathionine beta-synthase via the condensation of cysteine and homocysteine.
  Journal
J Biol Chem 279:52082-6 (2004)
DOI:10.1074/jbc.C400481200
Related
pathway
paro00010  Glycolysis / Gluconeogenesis
paro00020  Citrate cycle (TCA cycle)
paro00230  Purine metabolism
paro00250  Alanine, aspartate and glutamate metabolism
paro00270  Cysteine and methionine metabolism
paro00290  Valine, leucine and isoleucine biosynthesis
paro00300  Lysine biosynthesis
paro00330  Arginine and proline metabolism
paro00460  Cyanoamino acid metabolism
paro00470  D-Amino acid metabolism
paro00564  Glycerophospholipid metabolism
paro00620  Pyruvate metabolism
paro00630  Glyoxylate and dicarboxylate metabolism
paro00640  Propanoate metabolism
paro00680  Methane metabolism
paro00860  Porphyrin metabolism
paro00920  Sulfur metabolism
KO pathway
ko00260   
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