KEGG   PATHWAY: pgis00260
Entry
pgis00260                   Pathway                                
Name
Glycine, serine and threonine metabolism - Paraburkholderia ginsengisoli
Description
Serine is derived from 3-phospho-D-glycerate, an intermediate of glycolysis [MD:M00020], and glycine is derived from serine. Threonine is an essential amino acid, which animals cannot synthesize. In bacteria and plants, threonine is derived from aspartate [MD:M00018].
Class
Metabolism; Amino acid metabolism
Pathway map
pgis00260  Glycine, serine and threonine metabolism
pgis00260

Module
pgis_M00018  Threonine biosynthesis, aspartate => homoserine => threonine [PATH:pgis00260]
pgis_M00020  Serine biosynthesis, glycerate-3P => serine [PATH:pgis00260]
pgis_M00621  Glycine cleavage system [PATH:pgis00260]
pgis_M00975  Betaine degradation, bacteria, betaine => pyruvate [PATH:pgis00260]
Other DBs
GO: 0006544 0006563 0070178 0006566
Organism
Paraburkholderia ginsengisoli [GN:pgis]
Gene
I6I06_01995  aspartate kinase [KO:K00928] [EC:2.7.2.4]
I6I06_17270  asd; aspartate-semialdehyde dehydrogenase [KO:K00133] [EC:1.2.1.11]
I6I06_04885  homoserine dehydrogenase [KO:K00003] [EC:1.1.1.3]
I6I06_17515  homoserine kinase [KO:K02204] [EC:2.7.1.39]
I6I06_04880  threonine synthase [KO:K01733] [EC:4.2.3.1]
I6I06_19440  ltaE; low-specificity L-threonine aldolase [KO:K01620] [EC:4.1.2.48]
I6I06_00680  low specificity L-threonine aldolase [KO:K01620] [EC:4.1.2.48]
I6I06_08920  serine hydroxymethyltransferase [KO:K00600] [EC:2.1.2.1]
I6I06_22235  serine hydroxymethyltransferase [KO:K00600] [EC:2.1.2.1]
I6I06_08790  alanine--glyoxylate aminotransferase family protein [KO:K00830] [EC:2.6.1.44 2.6.1.45 2.6.1.51]
I6I06_28265  aminotransferase class V-fold PLP-dependent enzyme [KO:K00830] [EC:2.6.1.44 2.6.1.45 2.6.1.51]
I6I06_18730  D-2-hydroxyacid dehydrogenase [KO:K00018] [EC:1.1.1.29]
I6I06_10425  glyoxylate/hydroxypyruvate reductase A [KO:K12972] [EC:1.1.1.79 1.1.1.81]
I6I06_00125  D-glycerate dehydrogenase [KO:K00090] [EC:1.1.1.79 1.1.1.81 1.1.1.215]
I6I06_03330  D-glycerate dehydrogenase [KO:K00090] [EC:1.1.1.79 1.1.1.81 1.1.1.215]
I6I06_04490  glycerate kinase [KO:K00865] [EC:2.7.1.165]
I6I06_10045  gpmA; 2,3-diphosphoglycerate-dependent phosphoglycerate mutase [KO:K01834] [EC:5.4.2.11]
I6I06_14665  histidine phosphatase family protein [KO:K15634] [EC:5.4.2.11]
I6I06_11185  D-2-hydroxyacid dehydrogenase family protein [KO:K00058] [EC:1.1.1.95 1.1.1.399]
I6I06_16595  serC; 3-phosphoserine/phosphohydroxythreonine transaminase [KO:K00831] [EC:2.6.1.52]
I6I06_04645  serB; phosphoserine phosphatase SerB [KO:K01079] [EC:3.1.3.3]
I6I06_08925  ydfG; bifunctional NADP-dependent 3-hydroxy acid dehydrogenase/3-hydroxypropionate dehydrogenase YdfG [KO:K16066] [EC:1.1.1.381 1.1.1.-]
I6I06_28140  glycine C-acetyltransferase [KO:K00639] [EC:2.3.1.29]
I6I06_28145  tdh; L-threonine 3-dehydrogenase [KO:K00060] [EC:1.1.1.103]
I6I06_23540  NAD(P)/FAD-dependent oxidoreductase [KO:K00274] [EC:1.4.3.4]
I6I06_04060  primary-amine oxidase [KO:K00276] [EC:1.4.3.21]
I6I06_11835  gcvP; aminomethyl-transferring glycine dehydrogenase [KO:K00281] [EC:1.4.4.2]
I6I06_11845  gcvT; glycine cleavage system aminomethyltransferase GcvT [KO:K00605] [EC:2.1.2.10]
I6I06_01575  lpdA; dihydrolipoyl dehydrogenase [KO:K00382] [EC:1.8.1.4]
I6I06_05605  lpdA; dihydrolipoyl dehydrogenase [KO:K00382] [EC:1.8.1.4]
I6I06_11840  gcvH; glycine cleavage system protein GcvH [KO:K02437]
I6I06_06835  pssA; CDP-diacylglycerol--serine O-phosphatidyltransferase [KO:K17103] [EC:2.7.8.8]
I6I06_22270  aromatic ring-hydroxylating dioxygenase subunit alpha [KO:K00479] [EC:1.14.13.251]
I6I06_22275  hybrid-cluster NAD(P)-dependent oxidoreductase [KO:K21832] [EC:1.14.13.251]
I6I06_22250  NADH:flavin oxidoreductase [KO:K21833] [EC:1.5.7.3]
I6I06_22255  (Fe-S)-binding protein [KO:K21834]
I6I06_22260  electron transfer flavoprotein subunit alpha/FixB family protein [KO:K25960]
I6I06_22265  electron transfer flavoprotein subunit beta/FixA family protein [KO:K25961]
I6I06_22175  sarcosine oxidase subunit alpha family protein [KO:K00302] [EC:1.5.3.24 1.5.3.1]
I6I06_22165  sarcosine oxidase subunit beta family protein [KO:K00303] [EC:1.5.3.24 1.5.3.1]
I6I06_22180  sarcosine oxidase subunit gamma [KO:K00305] [EC:1.5.3.24 1.5.3.1]
I6I06_22170  sarcosine oxidase subunit delta [KO:K00304] [EC:1.5.3.24 1.5.3.1]
I6I06_11825  L-serine ammonia-lyase [KO:K01752] [EC:4.3.1.17]
I6I06_22160  L-serine ammonia-lyase [KO:K01752] [EC:4.3.1.17]
I6I06_09530  ilvA; threonine ammonia-lyase, biosynthetic [KO:K01754] [EC:4.3.1.19]
I6I06_03590  ilvA; threonine ammonia-lyase, biosynthetic [KO:K01754] [EC:4.3.1.19]
I6I06_04565  threonine/serine dehydratase [KO:K01754] [EC:4.3.1.19]
I6I06_09560  amino acid deaminase [KO:K01753] [EC:4.3.1.18]
I6I06_01520  aspartate/glutamate racemase family protein [KO:K25316] [EC:5.1.1.10]
I6I06_17300  tryptophan synthase subunit alpha [KO:K01695] [EC:4.2.1.20]
I6I06_17290  trpB; tryptophan synthase subunit beta [KO:K01696] [EC:4.2.1.20]
Compound
C00011  CO2
C00014  Ammonia
C00022  Pyruvate
C00037  Glycine
C00048  Glyoxylate
C00049  L-Aspartate
C00065  L-Serine
C00078  L-Tryptophan
C00097  L-Cysteine
C00101  Tetrahydrofolate
C00109  2-Oxobutanoate
C00114  Choline
C00143  5,10-Methylenetetrahydrofolate
C00168  Hydroxypyruvate
C00188  L-Threonine
C00197  3-Phospho-D-glycerate
C00213  Sarcosine
C00258  D-Glycerate
C00263  L-Homoserine
C00300  Creatine
C00430  5-Aminolevulinate
C00441  L-Aspartate 4-semialdehyde
C00546  Methylglyoxal
C00576  Betaine aldehyde
C00581  Guanidinoacetate
C00631  2-Phospho-D-glycerate
C00719  Betaine
C00740  D-Serine
C00986  1,3-Diaminopropane
C01005  O-Phospho-L-serine
C01026  N,N-Dimethylglycine
C01102  O-Phospho-L-homoserine
C01242  [Protein]-S8-aminomethyldihydrolipoyllysine
C01888  Aminoacetone
C02051  Lipoylprotein
C02291  L-Cystathionine
C02737  Phosphatidylserine
C02972  Dihydrolipoylprotein
C03082  4-Phospho-L-aspartate
C03194  (R)-1-Aminopropan-2-ol
C03232  3-Phosphonooxypyruvate
C03283  L-2,4-Diaminobutanoate
C03508  L-2-Amino-3-oxobutanoic acid
C05519  L-Allothreonine
C06231  Ectoine
C06442  N(gamma)-Acetyldiaminobutyrate
C16432  5-Hydroxyectoine
C19929  N(alpha)-Acetyl-L-2,4-diaminobutyrate
Reference
  Authors
Nishizuka Y, Seyama Y, Ikai A, Ishimura Y, Kawaguchi A (eds).
  Title
[Cellular Functions and Metabolic Maps] (In Japanese)
  Journal
Tokyo Kagaku Dojin (1997)
Reference
PMID:11823218
  Authors
Kuhlmann AU, Bremer E.
  Title
Osmotically regulated synthesis of the compatible solute ectoine in Bacillus pasteurii and related Bacillus spp.
  Journal
Appl Environ Microbiol 68:772-83 (2002)
DOI:10.1128/AEM.68.2.772-783.2002
Reference
PMID:10473374
  Authors
Canovas D, Borges N, Vargas C, Ventosa A, Nieto JJ, Santos H.
  Title
Role of Ngamma-acetyldiaminobutyrate as an enzyme stabilizer and an intermediate in the biosynthesis of hydroxyectoine.
  Journal
Appl Environ Microbiol 65:3774-9 (1999)
DOI:10.1128/AEM.65.9.3774-3779.1999
Reference
PMID:17636255
  Authors
Bursy J, Pierik AJ, Pica N, Bremer E.
  Title
Osmotically induced synthesis of the compatible solute hydroxyectoine is mediated by an evolutionarily conserved ectoine hydroxylase.
  Journal
J Biol Chem 282:31147-55 (2007)
DOI:10.1074/jbc.M704023200
Reference
PMID:16707670
  Authors
Garcia-Estepa R, Argandona M, Reina-Bueno M, Capote N, Iglesias-Guerra F, Nieto JJ, Vargas C.
  Title
The ectD gene, which is involved in the synthesis of the compatible solute hydroxyectoine, is essential for thermoprotection of the halophilic bacterium Chromohalobacter salexigens.
  Journal
J Bacteriol 188:3774-84 (2006)
DOI:10.1128/JB.00136-06
Reference
PMID:15470257
  Authors
Arevalo-Rodriguez M, Pan X, Boeke JD, Heitman J
  Title
FKBP12 controls aspartate pathway flux in Saccharomyces cerevisiae to prevent toxic intermediate accumulation.
  Journal
Eukaryot Cell 3:1287-96 (2004)
DOI:10.1128/EC.3.5.1287-1296.2004
Reference
PMID:7639721
  Authors
Rees WD, Hay SM
  Title
The biosynthesis of threonine by mammalian cells: expression of a complete bacterial biosynthetic pathway in an animal cell.
  Journal
Biochem J 309 ( Pt 3):999-1007 (1995)
DOI:10.1042/bj3090999
Reference
PMID:11341914
  Authors
Jacques SL, Nieman C, Bareich D, Broadhead G, Kinach R, Honek JF, Wright GD
  Title
Characterization of yeast homoserine dehydrogenase, an antifungal target: the invariant histidine 309 is important for enzyme integrity.
  Journal
Biochim Biophys Acta 1544:28-41 (2001)
DOI:10.1016/S0167-4838(00)00203-X
Reference
PMID:15520012
  Authors
Chen X, Jhee KH, Kruger WD
  Title
Production of the neuromodulator H2S by cystathionine beta-synthase via the condensation of cysteine and homocysteine.
  Journal
J Biol Chem 279:52082-6 (2004)
DOI:10.1074/jbc.C400481200
Related
pathway
pgis00010  Glycolysis / Gluconeogenesis
pgis00020  Citrate cycle (TCA cycle)
pgis00230  Purine metabolism
pgis00250  Alanine, aspartate and glutamate metabolism
pgis00270  Cysteine and methionine metabolism
pgis00290  Valine, leucine and isoleucine biosynthesis
pgis00300  Lysine biosynthesis
pgis00330  Arginine and proline metabolism
pgis00460  Cyanoamino acid metabolism
pgis00470  D-Amino acid metabolism
pgis00564  Glycerophospholipid metabolism
pgis00620  Pyruvate metabolism
pgis00630  Glyoxylate and dicarboxylate metabolism
pgis00640  Propanoate metabolism
pgis00680  Methane metabolism
pgis00860  Porphyrin metabolism
pgis00920  Sulfur metabolism
KO pathway
ko00260   
LinkDB

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