KEGG   PATHWAY: pmac04150
Entry
pmac04150                   Pathway                                
Name
mTOR signaling pathway - Papilio machaon (common yellow swallowtail)
Description
The mammalian (mechanistic) target of rapamycin (mTOR) is a highly conserved serine/threonine protein kinase, which exists in two complexes termed mTOR complex 1 (mTORC1) and 2 (mTORC2). mTORC1 contains mTOR, Raptor, PRAS40, Deptor, mLST8, Tel2 and Tti1. mTORC1 is activated by the presence of growth factors, amino acids, energy status, stress and oxygen levels to regulate several biological processes, including lipid metabolism, autophagy, protein synthesis and ribosome biogenesis. On the other hand, mTORC2, which consists of mTOR, mSin1, Rictor, Protor, Deptor, mLST8, Tel2 and Tti1, responds to growth factors and controls cytoskeletal organization, metabolism and survival.
Class
Environmental Information Processing; Signal transduction
Pathway map
pmac04150  mTOR signaling pathway
pmac04150

Organism
Papilio machaon (common yellow swallowtail) [GN:pmac]
Gene
106719850  large neutral amino acids transporter small subunit 1 [KO:K13780]
106719892  Y+L amino acid transporter 2 isoform X1 [KO:K13780]
106719864  large neutral amino acids transporter small subunit 2 [KO:K13780]
106716120  uncharacterized protein LOC106716120 [KO:K06519]
106713170  sodium-coupled neutral amino acid transporter 9 homolog isoform X1 [KO:K14995]
106708426  V-type proton ATPase catalytic subunit A isoform X1 [KO:K02145] [EC:7.1.2.2]
106717345  V-type proton ATPase subunit B [KO:K02147]
106716870  V-type proton ATPase subunit C [KO:K02148]
106709980  V-type proton ATPase subunit D-like [KO:K02149]
106713945  V-type proton ATPase subunit D [KO:K02149]
106715344  V-type proton ATPase subunit E-like [KO:K02150]
106715352  V-type proton ATPase subunit E-like [KO:K02150]
106715392  V-type proton ATPase subunit E [KO:K02150]
106708192  V-type proton ATPase subunit G [KO:K02152]
106721015  V-type proton ATPase subunit H isoform X1 [KO:K02144]
106713881  uncharacterized protein LOC106713881 isoform X1 [KO:K20397]
106718179  ragulator complex protein LAMTOR2 homolog [KO:K20398]
106720992  ragulator complex protein LAMTOR3 homolog [KO:K04370]
106717940  ragulator complex protein LAMTOR4 homolog [KO:K20399]
106712797  ragulator complex protein LAMTOR5 homolog [KO:K16344]
106718313  folliculin [KO:K09594]
106715984  folliculin-interacting protein 1 [KO:K20401]
106712284  ras-related GTP-binding protein A [KO:K16185]
106708993  ras-related GTP-binding protein C [KO:K16186]
106710279  WD repeat-containing protein mio [KO:K20407]
106715845  nucleoporin seh1 [KO:K14299]
106710280  LOW QUALITY PROTEIN: WD repeat-containing protein 24-like [KO:K20408]
106713299  WD repeat-containing protein 59 [KO:K20409]
106712057  protein SEC13 homolog [KO:K14004]
106718524  DEP domain-containing protein 5 isoform X1 [KO:K20404]
106719307  nitrogen permease regulator 2-like protein [KO:K20405]
106715877  nitrogen permease regulator 2-like protein [KO:K20405]
106710899  nitrogen permease regulator 3-like protein [KO:K20406]
106711902  S-phase kinase-associated protein 2-like [KO:K03875]
106721370  regulatory-associated protein of mTOR [KO:K07204]
106721009  serine/threonine-protein kinase mTOR [KO:K07203] [EC:2.7.11.1]
106721012  target of rapamycin-like [KO:K07203] [EC:2.7.11.1]
106717836  target of rapamycin complex subunit lst8 [KO:K08266]
106712827  TELO2-interacting protein 1 homolog [KO:K20403]
106720297  restin homolog isoform X1 [KO:K10421]
106708947  phosphatidate phosphatase LPIN2 [KO:K15728] [EC:3.1.3.4]
106717803  LOW QUALITY PROTEIN: serine/threonine-protein kinase unc-51 [KO:K08269] [EC:2.7.11.1]
106710936  eukaryotic translation initiation factor 4E-like [KO:K03259]
106710982  eukaryotic translation initiation factor 4E-like [KO:K03259]
106712939  eukaryotic translation initiation factor 4E type 2 [KO:K03259]
106710712  ribosomal protein S6 kinase beta-1 [KO:K04688] [EC:2.7.11.1]
106713141  eukaryotic translation initiation factor 4B [KO:K03258]
106716365  40S ribosomal protein S6 [KO:K02991]
106719439  STE20-related kinase adapter protein alpha isoform X1 [KO:K08271]
106716596  serine/threonine-protein kinase STK11 isoform X1 [KO:K07298] [EC:2.7.11.1]
106719875  protein Mo25 [KO:K08272]
106711118  5'-AMP-activated protein kinase catalytic subunit alpha-2 isoform X1 [KO:K07198] [EC:2.7.11.31]
106721369  LOW QUALITY PROTEIN: tuberin [KO:K07207]
106716224  TBC1 domain family member 7-like [KO:K20396]
106714900  GTP-binding protein Rheb homolog [KO:K07208]
106714251  protein Wnt-1 [KO:K03209]
106716318  protein Wnt-4-like [KO:K00408]
106721095  protein Wnt-5b-like [KO:K00444]
106714253  protein Wnt-6 [KO:K00445]
106713271  protein Wnt-7b-like [KO:K00572]
106714245  protein Wnt-10a [KO:K01357]
106712368  protein Wnt-11b-2-like [KO:K01384]
106710723  frizzled-7-B-like [KO:K02432]
106710253  frizzled-4 [KO:K02354]
106718897  frizzled-2-like [KO:K02375]
106713169  frizzled-10-like [KO:K02842]
106710551  low-density lipoprotein receptor-related protein 6-like [KO:K03068]
106720864  segment polarity protein dishevelled [KO:K02353]
106711245  glycogen synthase kinase-3 beta isoform X1 [KO:K03083] [EC:2.7.11.26]
106711966  inhibitor of nuclear factor kappa-B kinase subunit alpha [KO:K07209] [EC:2.7.11.10]
106715286  bombyxin A-6-like [KO:K04526]
106720292  bombyxin A-3-like [KO:K04526]
106709220  bombyxin A-1 homolog [KO:K04526]
106717572  insulin-like receptor [KO:K04527] [EC:2.7.10.1]
106718231  protein enhancer of sevenless 2B [KO:K04364]
106708263  protein son of sevenless-like [KO:K03099]
106714669  GTPase HRas [KO:K07827]
106708128  LOW QUALITY PROTEIN: raf homolog serine/threonine-protein kinase phl-like [KO:K04365] [EC:2.7.11.1]
106716354  dual specificity mitogen-activated protein kinase kinase dSOR1 [KO:K04368] [EC:2.7.12.2]
106720637  LOW QUALITY PROTEIN: mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
106719710  LOW QUALITY PROTEIN: ribosomal protein S6 kinase 2 beta-like [KO:K04373] [EC:2.7.11.1]
106718294  insulin receptor substrate 1 [KO:K16172]
106714800  phosphatidylinositol 3-kinase regulatory subunit gamma [KO:K02649]
106718395  phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform [KO:K00922] [EC:2.7.1.153]
106718558  phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN [KO:K01110] [EC:3.1.3.16 3.1.3.48 3.1.3.67]
106708826  3-phosphoinositide-dependent protein kinase 1 isoform X1 [KO:K06276] [EC:2.7.11.1]
106708391  RAC serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
106719663  stress-activated map kinase-interacting protein 1 [KO:K20410]
106714756  rapamycin-insensitive companion of mTOR [KO:K08267]
106716548  ras-like GTP-binding protein Rho1 isoform X1 [KO:K04513]
106709219  protein kinase C, brain isozyme [KO:K02677] [EC:2.7.11.13]
Compound
C00020  AMP
C00062  L-Arginine
C00123  L-Leucine
C05981  Phosphatidylinositol-3,4,5-trisphosphate
Reference
PMID:27304501
  Authors
Kennedy BK, Lamming DW
  Title
The Mechanistic Target of Rapamycin: The Grand ConducTOR of Metabolism and Aging.
  Journal
Cell Metab 23:990-1003 (2016)
DOI:10.1016/j.cmet.2016.05.009
Reference
PMID:24556838
  Authors
Shimobayashi M, Hall MN
  Title
Making new contacts: the mTOR network in metabolism and signalling crosstalk.
  Journal
Nat Rev Mol Cell Biol 15:155-62 (2014)
DOI:10.1038/nrm3757
Reference
PMID:25242279
  Authors
Huang K, Fingar DC
  Title
Growing knowledge of the mTOR signaling network.
  Journal
Semin Cell Dev Biol 36:79-90 (2014)
DOI:10.1016/j.semcdb.2014.09.011
Reference
PMID:26269525
  Authors
Bockaert J, Marin P
  Title
mTOR in Brain Physiology and Pathologies.
  Journal
Physiol Rev 95:1157-87 (2015)
DOI:10.1152/physrev.00038.2014
Reference
PMID:26185979
  Authors
Caron A, Richard D, Laplante M
  Title
The Roles of mTOR Complexes in Lipid Metabolism.
  Journal
Annu Rev Nutr 35:321-48 (2015)
DOI:10.1146/annurev-nutr-071714-034355
Reference
PMID:26658722
  Authors
Shimobayashi M, Hall MN
  Title
Multiple amino acid sensing inputs to mTORC1.
  Journal
Cell Res 26:7-20 (2016)
DOI:10.1038/cr.2015.146
Reference
PMID:24698685
  Authors
Bar-Peled L, Sabatini DM
  Title
Regulation of mTORC1 by amino acids.
  Journal
Trends Cell Biol 24:400-6 (2014)
DOI:10.1016/j.tcb.2014.03.003
Reference
PMID:26046644
  Authors
Fingar DC
  Title
Rag Ubiquitination Recruits a GATOR1: Attenuation of Amino Acid-Induced mTORC1 Signaling.
  Journal
Mol Cell 58:713-5 (2015)
DOI:10.1016/j.molcel.2015.05.029
Reference
PMID:26700098
  Authors
Cai H, Dong LQ, Liu F
  Title
Recent Advances in Adipose mTOR Signaling and Function: Therapeutic Prospects.
  Journal
Trends Pharmacol Sci 37:303-17 (2016)
DOI:10.1016/j.tips.2015.11.011
Reference
PMID:24842496
  Authors
Eyre TA, Collins GP, Goldstone AH, Cwynarski K
  Title
Time now to TORC the TORC? New developments in mTOR pathway inhibition in lymphoid malignancies.
  Journal
Br J Haematol 166:336-51 (2014)
DOI:10.1111/bjh.12945
Reference
PMID:23465396
  Authors
Jewell JL, Guan KL
  Title
Nutrient signaling to mTOR and cell growth.
  Journal
Trends Biochem Sci 38:233-42 (2013)
DOI:10.1016/j.tibs.2013.01.004
Reference
PMID:23421405
  Authors
Wood TL, Bercury KK, Cifelli SE, Mursch LE, Min J, Dai J, Macklin WB
  Title
mTOR: a link from the extracellular milieu to transcriptional regulation of oligodendrocyte development.
  Journal
ASN Neuro 5:e00108 (2013)
DOI:10.1042/AN20120092
Reference
PMID:23694989
  Authors
Kim SG, Buel GR, Blenis J
  Title
Nutrient regulation of the mTOR complex 1 signaling pathway.
  Journal
Mol Cells 35:463-73 (2013)
DOI:10.1007/s10059-013-0138-2
Reference
PMID:19812304
  Authors
Laplante M, Sabatini DM
  Title
mTOR signaling at a glance.
  Journal
J Cell Sci 122:3589-94 (2009)
DOI:10.1242/jcs.051011
Reference
PMID:16756488
  Authors
Alessi DR, Sakamoto K, Bayascas JR
  Title
LKB1-dependent signaling pathways.
  Journal
Annu Rev Biochem 75:137-63 (2006)
DOI:10.1146/annurev.biochem.75.103004.142702
Reference
PMID:27027448
  Authors
Dan HC, Antonia RJ, Baldwin AS
  Title
PI3K/Akt promotes feedforward mTORC2 activation through IKKalpha.
  Journal
Oncotarget 7:21064-75 (2016)
DOI:10.18632/oncotarget.8383
Reference
PMID:28283069
  Authors
Saxton RA, Sabatini DM
  Title
mTOR Signaling in Growth, Metabolism, and Disease.
  Journal
Cell 168:960-976 (2017)
DOI:10.1016/j.cell.2017.02.004
Related
pathway
pmac00561  Glycerolipid metabolism
pmac04140  Autophagy - animal
KO pathway
ko04150   
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