KEGG   PATHWAY: pmib00260
Entry
pmib00260                   Pathway                                
Name
Glycine, serine and threonine metabolism - Proteus mirabilis BB2000
Description
Serine is derived from 3-phospho-D-glycerate, an intermediate of glycolysis [MD:M00020], and glycine is derived from serine. Threonine is an essential amino acid, which animals cannot synthesize. In bacteria and plants, threonine is derived from aspartate [MD:M00018].
Class
Metabolism; Amino acid metabolism
Pathway map
pmib00260  Glycine, serine and threonine metabolism
pmib00260

Module
pmib_M00018  Threonine biosynthesis, aspartate => homoserine => threonine [PATH:pmib00260]
pmib_M00020  Serine biosynthesis, glycerate-3P => serine [PATH:pmib00260]
pmib_M00555  Betaine biosynthesis, choline => betaine [PATH:pmib00260]
pmib_M00621  Glycine cleavage system [PATH:pmib00260]
Other DBs
GO: 0006544 0006563 0070178 0006566
Organism
Proteus mirabilis BB2000 [GN:pmib]
Gene
BB2000_2760  lysC; aspartate kinase III [KO:K00928] [EC:2.7.2.4]
BB2000_0165  thrA; bifunctional aspartokinase I/homoserine dehydrogenase I [KO:K12524] [EC:2.7.2.4 1.1.1.3]
BB2000_3242  metL; bifunctional aspartate kinase II/homoserine dehydrogenase II [KO:K12525] [EC:2.7.2.4 1.1.1.3]
BB2000_3150  asd; aspartate-semialdehyde dehydrogenase [KO:K00133] [EC:1.2.1.11]
BB2000_0166  thrB; homoserine kinase [KO:K00872] [EC:2.7.1.39]
BB2000_0167  thrC; threonine synthase [KO:K01733] [EC:4.2.3.1]
BB2000_1292  beta-eliminating lyase [KO:K01620] [EC:4.1.2.48]
BB2000_1983  glyA; serine hydroxymethyltransferase [KO:K00600] [EC:2.1.2.1]
BB2000_1132  2-hydroxyacid dehydrogenase [KO:K12972] [EC:1.1.1.79 1.1.1.81]
BB2000_2063  tkrA; 2-ketogluconate reductase (2-ketoaldonate reductase) [KO:K00090] [EC:1.1.1.79 1.1.1.81 1.1.1.215]
BB2000_0053  garK; glycerate kinase [KO:K00865] [EC:2.7.1.165]
BB2000_0659  gpmA; phosphoglyceromutase [KO:K01834] [EC:5.4.2.11]
BB2000_0161  gpmB; phosphoglycerate mutase [KO:K15634] [EC:5.4.2.11]
BB2000_2103  serA; D-3-phosphoglycerate dehydrogenase [KO:K00058] [EC:1.1.1.95 1.1.1.399]
BB2000_0783  serC; phosphoserine aminotransferase [KO:K00831] [EC:2.6.1.52]
BB2000_2573  serB; phosphoserine phosphatase [KO:K01079] [EC:3.1.3.3]
BB2000_1307  ydfG; NADP-dependent L-serine/L-allo-threonine dehydrogenase [KO:K16066] [EC:1.1.1.381 1.1.1.-]
BB2000_3187  kbl; 2-amino-3-ketobutyrate coenzyme A ligase [KO:K00639] [EC:2.3.1.29]
BB2000_3188  tdh; L-threonine 3-dehydrogenase [KO:K00060] [EC:1.1.1.103]
BB2000_2091  gcvP; glycine dehydrogenase [KO:K00281] [EC:1.4.4.2]
BB2000_2093  gcvT; glycine cleavage system aminomethyltransferase T [KO:K00605] [EC:2.1.2.10]
BB2000_2118  lpdA; dihydrolipoamide dehydrogenase [KO:K00382] [EC:1.8.1.4]
BB2000_2092  gcvH; glycine cleavage system protein H [KO:K02437]
BB2000_0542  pssA; phosphatidylserine synthase [KO:K00998] [EC:2.7.8.8]
BB2000_1489  betA; choline dehydrogenase [KO:K00108] [EC:1.1.99.1]
BB2000_1490  betB; betaine aldehyde dehydrogenase [KO:K00130] [EC:1.2.1.8]
BB2000_0386  pyridoxal-phosphate dependent enzyme [KO:K01697] [EC:4.2.1.22]
BB2000_0741  sdaB; L-serine dehydratase [KO:K01752] [EC:4.3.1.17]
BB2000_1697  sdaA; L-serine deaminase 1 (L-serine deaminase 1) [KO:K01752] [EC:4.3.1.17]
BB2000_3335  ilvA; threonine dehydratase [KO:K01754] [EC:4.3.1.19]
BB2000_0346  dsdA; D-serine dehydratase [KO:K01753] [EC:4.3.1.18]
BB2000_1881  alanine racemase [KO:K25317] [EC:5.1.1.10]
BB2000_1368  trpA; tryptophan synthase alpha chain [KO:K01695] [EC:4.2.1.20]
BB2000_1367  trpB; tryptophan synthase subunit beta [KO:K01696] [EC:4.2.1.20]
Compound
C00011  CO2
C00014  Ammonia
C00022  Pyruvate
C00037  Glycine
C00048  Glyoxylate
C00049  L-Aspartate
C00065  L-Serine
C00078  L-Tryptophan
C00097  L-Cysteine
C00101  Tetrahydrofolate
C00109  2-Oxobutanoate
C00114  Choline
C00143  5,10-Methylenetetrahydrofolate
C00168  Hydroxypyruvate
C00188  L-Threonine
C00197  3-Phospho-D-glycerate
C00213  Sarcosine
C00258  D-Glycerate
C00263  L-Homoserine
C00300  Creatine
C00430  5-Aminolevulinate
C00441  L-Aspartate 4-semialdehyde
C00546  Methylglyoxal
C00576  Betaine aldehyde
C00581  Guanidinoacetate
C00631  2-Phospho-D-glycerate
C00719  Betaine
C00740  D-Serine
C00986  1,3-Diaminopropane
C01005  O-Phospho-L-serine
C01026  N,N-Dimethylglycine
C01102  O-Phospho-L-homoserine
C01242  [Protein]-S8-aminomethyldihydrolipoyllysine
C01888  Aminoacetone
C02051  Lipoylprotein
C02291  L-Cystathionine
C02737  Phosphatidylserine
C02972  Dihydrolipoylprotein
C03082  4-Phospho-L-aspartate
C03194  (R)-1-Aminopropan-2-ol
C03232  3-Phosphonooxypyruvate
C03283  L-2,4-Diaminobutanoate
C03508  L-2-Amino-3-oxobutanoic acid
C05519  L-Allothreonine
C06231  Ectoine
C06442  N(gamma)-Acetyldiaminobutyrate
C16432  5-Hydroxyectoine
C19929  N(alpha)-Acetyl-L-2,4-diaminobutyrate
Reference
  Authors
Nishizuka Y, Seyama Y, Ikai A, Ishimura Y, Kawaguchi A (eds).
  Title
[Cellular Functions and Metabolic Maps] (In Japanese)
  Journal
Tokyo Kagaku Dojin (1997)
Reference
PMID:11823218
  Authors
Kuhlmann AU, Bremer E.
  Title
Osmotically regulated synthesis of the compatible solute ectoine in Bacillus pasteurii and related Bacillus spp.
  Journal
Appl Environ Microbiol 68:772-83 (2002)
DOI:10.1128/AEM.68.2.772-783.2002
Reference
PMID:10473374
  Authors
Canovas D, Borges N, Vargas C, Ventosa A, Nieto JJ, Santos H.
  Title
Role of Ngamma-acetyldiaminobutyrate as an enzyme stabilizer and an intermediate in the biosynthesis of hydroxyectoine.
  Journal
Appl Environ Microbiol 65:3774-9 (1999)
DOI:10.1128/AEM.65.9.3774-3779.1999
Reference
PMID:17636255
  Authors
Bursy J, Pierik AJ, Pica N, Bremer E.
  Title
Osmotically induced synthesis of the compatible solute hydroxyectoine is mediated by an evolutionarily conserved ectoine hydroxylase.
  Journal
J Biol Chem 282:31147-55 (2007)
DOI:10.1074/jbc.M704023200
Reference
PMID:16707670
  Authors
Garcia-Estepa R, Argandona M, Reina-Bueno M, Capote N, Iglesias-Guerra F, Nieto JJ, Vargas C.
  Title
The ectD gene, which is involved in the synthesis of the compatible solute hydroxyectoine, is essential for thermoprotection of the halophilic bacterium Chromohalobacter salexigens.
  Journal
J Bacteriol 188:3774-84 (2006)
DOI:10.1128/JB.00136-06
Reference
PMID:15470257
  Authors
Arevalo-Rodriguez M, Pan X, Boeke JD, Heitman J
  Title
FKBP12 controls aspartate pathway flux in Saccharomyces cerevisiae to prevent toxic intermediate accumulation.
  Journal
Eukaryot Cell 3:1287-96 (2004)
DOI:10.1128/EC.3.5.1287-1296.2004
Reference
PMID:7639721
  Authors
Rees WD, Hay SM
  Title
The biosynthesis of threonine by mammalian cells: expression of a complete bacterial biosynthetic pathway in an animal cell.
  Journal
Biochem J 309 ( Pt 3):999-1007 (1995)
DOI:10.1042/bj3090999
Reference
PMID:11341914
  Authors
Jacques SL, Nieman C, Bareich D, Broadhead G, Kinach R, Honek JF, Wright GD
  Title
Characterization of yeast homoserine dehydrogenase, an antifungal target: the invariant histidine 309 is important for enzyme integrity.
  Journal
Biochim Biophys Acta 1544:28-41 (2001)
DOI:10.1016/S0167-4838(00)00203-X
Reference
PMID:15520012
  Authors
Chen X, Jhee KH, Kruger WD
  Title
Production of the neuromodulator H2S by cystathionine beta-synthase via the condensation of cysteine and homocysteine.
  Journal
J Biol Chem 279:52082-6 (2004)
DOI:10.1074/jbc.C400481200
Related
pathway
pmib00010  Glycolysis / Gluconeogenesis
pmib00020  Citrate cycle (TCA cycle)
pmib00230  Purine metabolism
pmib00250  Alanine, aspartate and glutamate metabolism
pmib00270  Cysteine and methionine metabolism
pmib00290  Valine, leucine and isoleucine biosynthesis
pmib00300  Lysine biosynthesis
pmib00330  Arginine and proline metabolism
pmib00460  Cyanoamino acid metabolism
pmib00470  D-Amino acid metabolism
pmib00564  Glycerophospholipid metabolism
pmib00620  Pyruvate metabolism
pmib00630  Glyoxylate and dicarboxylate metabolism
pmib00640  Propanoate metabolism
pmib00680  Methane metabolism
pmib00860  Porphyrin metabolism
pmib00920  Sulfur metabolism
KO pathway
ko00260   
LinkDB

DBGET integrated database retrieval system