KEGG   PATHWAY: ppa00230
Entry
ppa00230                    Pathway                                
Name
Purine metabolism - Komagataella phaffii
Class
Metabolism; Nucleotide metabolism
Pathway map
ppa00230  Purine metabolism
ppa00230

Module
ppa_M00005  PRPP biosynthesis, ribose 5P => PRPP [PATH:ppa00230]
ppa_M00048  De novo purine biosynthesis, PRPP + glutamine => IMP [PATH:ppa00230]
ppa_M00049  Adenine ribonucleotide biosynthesis, IMP => ADP,ATP [PATH:ppa00230]
ppa_M00053  Deoxyribonucleotide biosynthesis, ADP/GDP/CDP/UDP => dATP/dGTP/dCTP/dUTP [PATH:ppa00230]
ppa_M00958  Adenine ribonucleotide degradation, AMP => Urate [PATH:ppa00230]
ppa_M00959  Guanine ribonucleotide degradation, GMP => Urate [PATH:ppa00230]
Other DBs
GO: 0006163 0042278
Organism
Komagataella phaffii [GN:ppa]
Gene
PAS_chr2-1_0760  Spermidine synthase, involved in biosynthesis of spermidine and also in biosynthesis of pantothenic [KO:K01515] [EC:3.6.1.13 3.6.1.-]
PAS_chr1-4_0264  Phosphoglucomutase [KO:K01835] [EC:5.4.2.2]
PAS_chr2-1_0771  Phosphoglucomutase, catalyzes interconversion of glucose-1-phosphate and glucose-6-phospate [KO:K01835] [EC:5.4.2.2]
PAS_chr2-2_0174  5-phospho-ribosyl-1(alpha)-pyrophosphate synthetase, synthesizes PRPP [KO:K00948] [EC:2.7.6.1]
PAS_chr1-1_0006  Ribose-phosphate pyrophosphokinase [KO:K00948] [EC:2.7.6.1]
PAS_chr1-1_0436  5-phospho-ribosyl-1(alpha)-pyrophosphate synthetase, synthesizes PRPP [KO:K00948] [EC:2.7.6.1]
PAS_chr3_0062  5-phospho-ribosyl-1(alpha)-pyrophosphate synthetase, synthesizes PRPP, which is required for nucleot [KO:K00948] [EC:2.7.6.1]
PAS_chr1-1_0430  Phosphoribosylpyrophosphate amidotransferase [KO:K00764] [EC:2.4.2.14]
PAS_chr3_0770  Bifunctional enzyme of the 'de novo' purine nucleotide biosynthetic pathway [KO:K11788] [EC:6.3.4.13 6.3.3.1]
PAS_chr2-1_0121  Phosphoribosyl-glycinamide transformylase, catalyzes a step in the 'de novo' purine nucleotide biosy [KO:K00601] [EC:2.1.2.2]
PAS_chr1-4_0551  Formylglycinamidine-ribonucleotide (FGAM)-synthetase [KO:K01952] [EC:6.3.5.3]
PAS_chr3_0085  Phosphoribosylaminoimidazole carboxylase, catalyzes a step in the 'de novo' purine nucleotide biosyn [KO:K11808] [EC:4.1.1.21]
PAS_chr1-4_0450  N-succinyl-5-aminoimidazole-4-carboxamide ribotide (SAICAR) synthetase [KO:K01923] [EC:6.3.2.6]
PAS_chr2-2_0329  Adenylosuccinate lyase, catalyzes two steps in the 'de novo' purine nucleotide biosynthetic pathway [KO:K01756] [EC:4.3.2.2]
PAS_chr2-1_0660  Enzyme of 'de novo' purine biosynthesis [KO:K00602] [EC:2.1.2.3 3.5.4.10]
PAS_chr3_1138  Adenine phosphoribosyltransferase, catalyzes the formation of AMP [KO:K00759] [EC:2.4.2.7]
PAS_chr2-1_0685  hypothetical protein [KO:K03787] [EC:3.1.3.5 3.1.3.6]
PAS_chr1-1_0132  Purine nucleoside phosphorylase, specifically metabolizes inosine & guanosine nucleosides [KO:K03783] [EC:2.4.2.1]
PAS_chr3_0887  Dimeric hypoxanthine-guanine phosphoribosyltransferase [KO:K19836] [EC:2.4.2.8]
PAS_chr2-2_0059  Nucleoside diphosphate kinase [KO:K00940] [EC:2.7.4.6]
PAS_chr1-1_0063  Apyrase with wide substrate specificity [KO:K14642] [EC:3.6.1.5]
PAS_chr2-2_0017  Apyrase with wide substrate specificity [KO:K14642] [EC:3.6.1.5]
PAS_chr3_1255  hypothetical protein [KO:K01519] [EC:3.6.1.66]
PAS_chr2-2_0112  hypothetical protein [KO:K00106] [EC:1.17.1.4 1.17.3.2]
PAS_chr1-3_0191  GMP synthase, an enzyme that catalyzes the second step in the biosynthesis of GMP from IMP [KO:K01951] [EC:6.3.5.2]
PAS_chr1-4_0524  Guanine deaminase, a catabolic enzyme of the guanine salvage pathway [KO:K01487] [EC:3.5.4.3]
PAS_chr2-2_0219  Guanylate kinase, converts GMP to GDP [KO:K00942] [EC:2.7.4.8]
PAS_chr1-1_0282  One of two large regulatory subunits of ribonucleotide-diphosphate reductase [KO:K10807] [EC:1.17.4.1]
PAS_chr2-1_0209  One of two large regulatory subunits of ribonucleotide-diphosphate reductase [KO:K10807] [EC:1.17.4.1]
PAS_chr4_0197  Small subunit of the ribonucleotide-diphosphate reductase (RNR) complex [KO:K10808] [EC:1.17.4.1]
PAS_chr2-1_0101  Exopolyphosphatase, hydrolyzes inorganic polyphosphate (poly P) into Pi residues [KO:K01514] [EC:3.6.1.11]
PAS_chr4_0356  Adenylate cyclase, required for cAMP production and cAMP-dependent protein kinase signaling [KO:K01768] [EC:4.6.1.1]
PAS_FragB_0008  cyclic AMP phosphodiesterase [KO:K01120] [EC:3.1.4.17]
PAS_chr1-4_0566  Low-affinity cyclic AMP phosphodiesterase [KO:K01120] [EC:3.1.4.17]
PAS_chr4_0613  Adenylosuccinate synthase [KO:K01939] [EC:6.3.4.4]
PAS_c121_0009  hypothetical protein [KO:K01490] [EC:3.5.4.6]
PAS_chr2-2_0162  Adenosine kinase, required for the utilization of S-adenosylmethionine (AdoMet) [KO:K00856] [EC:2.7.1.20]
PAS_chr3_0257  Adenylate kinase [KO:K00939] [EC:2.7.4.3]
PAS_chr2-1_0493  Essential NTPase required for small ribosome subunit synthesis [KO:K18532] [EC:2.7.4.3]
PAS_chr2-1_0111  Mitochondrial adenylate kinase, catalyzes the reversible synthesis of GTP and AMP from GDP and ADP [KO:K00944] [EC:2.7.4.10]
PAS_chr2-1_0146  Dinucleoside triphosphate hydrolase [KO:K01522] [EC:3.6.1.29]
PAS_chr1-1_0323  Diadenosine 5',5''-P1,P4-tetraphosphate phosphorylase II (AP4A phosphorylase) [KO:K00988] [EC:2.7.7.5 2.7.7.53]
PAS_chr3_0667  Adenylylsulfate kinase, required for sulfate assimilation and involved in methionine metabolism [KO:K00860] [EC:2.7.1.25]
PAS_chr1-4_0253  ATP sulfurylase, catalyzes the primary step of intracellular sulfate activation [KO:K00958] [EC:2.7.7.4]
PAS_chr2-2_0279  hypothetical protein [KO:K00365] [EC:1.7.3.3]
PAS_chr1-4_0329  hypothetical protein [KO:K07127] [EC:3.5.2.17]
PAS_chr1-3_0023  allantoinase [KO:K01466] [EC:3.5.2.5]
PAS_chr2-1_0749  Allantoicase, converts allantoate to urea and ureidoglycolate [KO:K01477] [EC:3.5.3.4]
PAS_chr2-1_0292  Ureidoglycolate hydrolase [KO:K01483] [EC:4.3.2.3]
Compound
C00002  ATP
C00008  ADP
C00011  CO2
C00014  Ammonia
C00020  AMP
C00035  GDP
C00037  Glycine
C00039  DNA
C00044  GTP
C00046  RNA
C00048  Glyoxylate
C00053  3'-Phosphoadenylyl sulfate
C00054  Adenosine 3',5'-bisphosphate
C00059  Sulfate
C00064  L-Glutamine
C00081  ITP
C00086  Urea
C00104  IDP
C00117  D-Ribose 5-phosphate
C00119  5-Phospho-alpha-D-ribose 1-diphosphate
C00130  IMP
C00131  dATP
C00144  GMP
C00147  Adenine
C00169  Carbamoyl phosphate
C00206  dADP
C00209  Oxalate
C00212  Adenosine
C00224  Adenylyl sulfate
C00242  Guanine
C00262  Hypoxanthine
C00286  dGTP
C00288  HCO3-
C00294  Inosine
C00301  ADP-ribose
C00330  Deoxyguanosine
C00360  dAMP
C00361  dGDP
C00362  dGMP
C00366  Urate
C00385  Xanthine
C00387  Guanosine
C00499  Allantoate
C00559  Deoxyadenosine
C00575  3',5'-Cyclic AMP
C00603  (S)-Ureidoglycolate
C00620  alpha-D-Ribose 1-phosphate
C00655  Xanthosine 5'-phosphate
C00700  XTP
C00802  Oxalureate
C00942  3',5'-Cyclic GMP
C01228  Guanosine 3',5'-bis(diphosphate)
C01260  P1,P4-Bis(5'-adenosyl)tetraphosphate
C01261  P1,P4-Bis(5'-guanosyl) tetraphosphate
C01344  dIDP
C01345  dITP
C01367  3'-AMP
C01444  Oxamate
C01762  Xanthosine
C02091  (S)-Ureidoglycine
C02348  (R)(-)-Allantoin
C02350  (S)-Allantoin
C02353  2',3'-Cyclic AMP
C02718  N-Formiminoglycine
C03090  5-Phosphoribosylamine
C03373  Aminoimidazole ribotide
C03483  Adenosine tetraphosphate
C03614  Inosine 5'-tetraphosphate
C03794  N6-(1,2-Dicarboxyethyl)-AMP
C03838  5'-Phosphoribosylglycinamide
C04051  5-Amino-4-imidazolecarboxyamide
C04376  5'-Phosphoribosyl-N-formylglycinamide
C04392  P1,P4-Bis(5'-xanthosyl) tetraphosphate
C04494  Guanosine 3'-diphosphate 5'-triphosphate
C04640  2-(Formamido)-N1-(5'-phosphoribosyl)acetamidine
C04677  1-(5'-Phosphoribosyl)-5-amino-4-imidazolecarboxamide
C04734  1-(5'-Phosphoribosyl)-5-formamido-4-imidazolecarboxamide
C04751  1-(5-Phospho-D-ribosyl)-5-amino-4-imidazolecarboxylate
C04823  1-(5'-Phosphoribosyl)-5-amino-4-(N-succinocarboxamide)-imidazole
C05239  5-Aminoimidazole
C05512  Deoxyinosine
C05513  Urate-3-ribonucleoside
C05515  5-Ureido-4-imidazole carboxylate
C05516  5-Amino-4-imidazole carboxylate
C05993  Acetyl adenylate
C06193  Guanosine 3'-phosphate
C06194  2',3'-Cyclic GMP
C06195  Imidazolone
C06196  2'-Deoxyinosine 5'-phosphate
C06197  P1,P3-Bis(5'-adenosyl) triphosphate
C06433  5'-Benzoylphosphoadenosine
C06435  5'-Butyrylphosphoinosine
C11821  5-Hydroxyisourate
C12248  5-Hydroxy-2-oxo-4-ureido-2,5-dihydro-1H-imidazole-5-carboxylate
C15667  5-Carboxyamino-1-(5-phospho-D-ribosyl)imidazole
C22395  N6-Succino-2-amino-2'-deoxyadenylate
C22441  dZMP
C22442  dZDP
C22443  dZTP
C22499  8-Hydroxyadenine
C22500  2,8-Dihydroxyadenine
Reference
PMID:10601204
  Authors
Cusa E, Obradors N, Baldoma L, Badia J, Aguilar J.
  Title
Genetic analysis of a chromosomal region containing genes required for assimilation of allantoin nitrogen and linked glyoxylate metabolism in Escherichia coli.
  Journal
J Bacteriol 181:7479-84 (1999)
DOI:10.1128/JB.181.24.7479-7484.1999
Reference
PMID:10986234
  Authors
Xi H, Schneider BL, Reitzer L.
  Title
Purine catabolism in Escherichia coli and function of xanthine dehydrogenase in purine salvage.
  Journal
J Bacteriol 182:5332-41 (2000)
DOI:10.1128/JB.182.19.5332-5341.2000
Related
pathway
ppa00030  Pentose phosphate pathway
ppa00220  Arginine biosynthesis
ppa00250  Alanine, aspartate and glutamate metabolism
ppa00260  Glycine, serine and threonine metabolism
ppa00340  Histidine metabolism
ppa00630  Glyoxylate and dicarboxylate metabolism
ppa00730  Thiamine metabolism
ppa00740  Riboflavin metabolism
ppa00790  Folate biosynthesis
KO pathway
ko00230   
LinkDB

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