KEGG   PATHWAY: ppp00053
Entry
ppp00053                    Pathway                                
Name
Ascorbate and aldarate metabolism - Physcomitrium patens (spreading earthmoss)
Class
Metabolism; Carbohydrate metabolism
Pathway map
ppp00053  Ascorbate and aldarate metabolism
ppp00053

Module
ppp_M00114  Ascorbate biosynthesis, plants, fructose-6P => ascorbate [PATH:ppp00053]
Other DBs
GO: 0019852 0019577 0019572
Organism
Physcomitrium patens (spreading earthmoss) [GN:ppp]
Gene
112273324  UDP-glucose 6-dehydrogenase 4-like [KO:K00012] [EC:1.1.1.22]
112275958  UDP-glucose 6-dehydrogenase 4 [KO:K00012] [EC:1.1.1.22]
112276866  UDP-glucose 6-dehydrogenase 3-like [KO:K00012] [EC:1.1.1.22]
112285842  UDP-glucose 6-dehydrogenase 4-like [KO:K00012] [EC:1.1.1.22]
112291294  UDP-sugar pyrophosphorylase-like [KO:K12447] [EC:2.7.7.64]
112284456  UDP-sugar pyrophosphorylase-like isoform X1 [KO:K12447] [EC:2.7.7.64]
112274695  glucuronokinase 1-like [KO:K16190] [EC:2.7.1.43]
112273496  inositol oxygenase 1-like [KO:K00469] [EC:1.13.99.1]
112282467  aldo-keto reductase family 4 member C10-like [KO:K00002] [EC:1.1.1.2]
112287463  NADPH-dependent aldo-keto reductase, chloroplastic-like [KO:K00002] [EC:1.1.1.2]
112290038  NADPH-dependent aldo-keto reductase, chloroplastic-like isoform X1 [KO:K00002] [EC:1.1.1.2]
112278083  uncharacterized protein LOC112278083 isoform X1 [KO:K01053] [EC:3.1.1.17]
112280515  uncharacterized protein LOC112280515 isoform X1 [KO:K01053] [EC:3.1.1.17]
112282284  uncharacterized protein LOC112282284 [KO:K01053] [EC:3.1.1.17]
112281902  uncharacterized protein LOC112281902 [KO:K01053] [EC:3.1.1.17]
112284276  regucalcin-like [KO:K01053] [EC:3.1.1.17]
112280369  L-gulonolactone oxidase 3-like [KO:K00103] [EC:1.1.3.8]
112283902  probable L-gulonolactone oxidase 4 [KO:K00103] [EC:1.1.3.8]
112284099  probable L-gulonolactone oxidase 4 [KO:K00103] [EC:1.1.3.8]
112285475  uncharacterized protein LOC112285475 [KO:K00103] [EC:1.1.3.8]
112274181  L-gulonolactone oxidase 5-like [KO:K00103] [EC:1.1.3.8]
112276157  GDP-mannose 3,5-epimerase 2 [KO:K10046] [EC:5.1.3.18 5.1.3.-]
112281831  GDP-mannose 3,5-epimerase 2-like [KO:K10046] [EC:5.1.3.18 5.1.3.-]
112294838  GDP-mannose 3,5-epimerase 2-like [KO:K10046] [EC:5.1.3.18 5.1.3.-]
112273041  GDP-L-galactose phosphorylase 2-like [KO:K14190] [EC:2.7.7.69]
112276770  GDP-L-galactose phosphorylase 2-like [KO:K14190] [EC:2.7.7.69]
112285991  GDP-L-galactose phosphorylase 2-like [KO:K14190] [EC:2.7.7.69]
112274227  inositol monophosphatase 2-like [KO:K10047] [EC:3.1.3.25 3.1.3.93]
112275224  inositol-phosphate phosphatase-like isoform X1 [KO:K10047] [EC:3.1.3.25 3.1.3.93]
112295845  inositol monophosphatase 3-like [KO:K10047] [EC:3.1.3.25 3.1.3.93]
112285229  bifunctional phosphatase IMPL2, chloroplastic-like [KO:K18649] [EC:3.1.3.25 3.1.3.93 3.1.3.15]
112291813  bifunctional phosphatase IMPL2, chloroplastic-like [KO:K18649] [EC:3.1.3.25 3.1.3.93 3.1.3.15]
112288452  bifunctional phosphatase IMPL2, chloroplastic-like isoform X1 [KO:K18649] [EC:3.1.3.25 3.1.3.93 3.1.3.15]
112284227  L-galactose dehydrogenase-like [KO:K17744] [EC:1.1.1.316]
112284471  L-galactose dehydrogenase-like isoform X1 [KO:K17744] [EC:1.1.1.316]
112290963  L-galactono-1,4-lactone dehydrogenase, mitochondrial-like [KO:K00225] [EC:1.3.2.3]
112278819  UDP-glucuronate 4-epimerase 1-like [KO:K08679] [EC:5.1.3.6]
112281899  UDP-glucuronate 4-epimerase 1-like isoform X1 [KO:K08679] [EC:5.1.3.6]
112284961  UDP-glucuronate 4-epimerase 1-like isoform X1 [KO:K08679] [EC:5.1.3.6]
112285775  UDP-glucuronate 4-epimerase 1-like [KO:K08679] [EC:5.1.3.6]
112288709  UDP-glucuronate 4-epimerase 1-like isoform X1 [KO:K08679] [EC:5.1.3.6]
112289559  UDP-glucuronate 4-epimerase 1-like isoform X1 [KO:K08679] [EC:5.1.3.6]
112289571  UDP-glucuronate 4-epimerase 1-like isoform X1 [KO:K08679] [EC:5.1.3.6]
112290445  UDP-glucuronate 4-epimerase 1-like [KO:K08679] [EC:5.1.3.6]
112278733  monodehydroascorbate reductase, seedling isozyme-like [KO:K08232] [EC:1.6.5.4]
112287000  monodehydroascorbate reductase, seedling isozyme-like [KO:K08232] [EC:1.6.5.4]
112291911  monodehydroascorbate reductase 4, peroxisomal-like [KO:K08232] [EC:1.6.5.4]
112292445  monodehydroascorbate reductase, seedling isozyme-like [KO:K08232] [EC:1.6.5.4]
112273052  probable L-ascorbate peroxidase 4, peroxisomal [KO:K00434] [EC:1.11.1.11]
112273380  L-ascorbate peroxidase 1, cytosolic-like [KO:K00434] [EC:1.11.1.11]
112273527  L-ascorbate peroxidase 1, cytosolic-like isoform X1 [KO:K00434] [EC:1.11.1.11]
112285230  probable L-ascorbate peroxidase 6, chloroplastic/mitochondrial [KO:K00434] [EC:1.11.1.11]
112294750  putative L-ascorbate peroxidase 6 isoform X1 [KO:K00434] [EC:1.11.1.11]
112273233  glutathione S-transferase DHAR1, mitochondrial-like [KO:K21888] [EC:1.8.5.1 2.5.1.18]
112275199  probable glutathione S-transferase DHAR1, cytosolic [KO:K21888] [EC:1.8.5.1 2.5.1.18]
112292200  probable glutathione S-transferase DHAR1, cytosolic [KO:K21888] [EC:1.8.5.1 2.5.1.18]
112280552  L-ascorbate oxidase-like [KO:K00423] [EC:1.10.3.3]
112279727  L-ascorbate oxidase-like [KO:K00423] [EC:1.10.3.3]
112281351  L-ascorbate oxidase-like [KO:K00423] [EC:1.10.3.3]
112293195  L-ascorbate oxidase-like [KO:K00423] [EC:1.10.3.3]
112293700  L-ascorbate oxidase-like [KO:K00423] [EC:1.10.3.3]
112274791  aldehyde dehydrogenase family 3 member H1-like [KO:K00128] [EC:1.2.1.3]
112282926  aldehyde dehydrogenase family 2 member B7, mitochondrial-like isoform X1 [KO:K00128] [EC:1.2.1.3]
112281305  aldehyde dehydrogenase family 2 member B7, mitochondrial-like [KO:K00128] [EC:1.2.1.3]
112286636  aldehyde dehydrogenase family 3 member H1-like isoform X1 [KO:K00128] [EC:1.2.1.3]
112294761  aldehyde dehydrogenase-like [KO:K00128] [EC:1.2.1.3]
112295892  aldehyde dehydrogenase family 3 member H1-like isoform X1 [KO:K00128] [EC:1.2.1.3]
112278756  aldehyde dehydrogenase family 7 member B4-like [KO:K14085] [EC:1.2.1.31 1.2.1.8 1.2.1.3]
Compound
C00022  Pyruvate
C00026  2-Oxoglutarate
C00029  UDP-glucose
C00072  Ascorbate
C00096  GDP-mannose
C00137  myo-Inositol
C00167  UDP-glucuronate
C00191  D-Glucuronate
C00216  D-Arabinose
C00231  D-Xylulose 5-phosphate
C00259  L-Arabinose
C00333  D-Galacturonate
C00433  2,5-Dioxopentanoate
C00545  L-Arabinonate
C00558  D-Tagaturonate
C00617  UDP-D-galacturonate
C00618  3-Dehydro-L-gulonate
C00652  D-Arabinono-1,4-lactone
C00679  5-Dehydro-4-deoxy-D-glucarate
C00684  2-Dehydro-3-deoxy-L-arabinonate
C00800  L-Gulonate
C00818  D-Glucarate
C00878  D-Arabinonate
C00879  D-Galactarate
C01040  L-Gulono-1,4-lactone
C01041  Monodehydroascorbate
C01101  L-Ribulose 5-phosphate
C01114  L-Arabinono-1,4-lactone
C01115  L-Galactono-1,4-lactone
C01146  2-Hydroxy-3-oxopropanoate
C01620  Threonate
C01825  L-Galactose
C02280  GDP-L-galactose
C02670  D-Glucuronolactone
C03033  beta-D-Glucuronoside
C03064  3-Dehydro-L-threonate
C03289  L-xylo-Hexulonolactone
C03291  L-Xylulose 5-phosphate
C03826  2-Dehydro-3-deoxy-D-xylonate
C03921  2-Dehydro-3-deoxy-D-glucarate
C04037  1-Phospho-alpha-D-galacturonate
C04575  (4R,5S)-4,5,6-Trihydroxy-2,3-dioxohexanoate
C05385  D-Glucuronate 1-phosphate
C05411  L-Xylonate
C05412  L-Lyxonate
C05422  Dehydroascorbate
C06316  Dehydro-D-arabinono-1,4-lactone
C14899  3-Dehydro-L-gulonate 6-phosphate
C15923  L-Gulose
C15924  L-Gulose 1-phosphate
C15925  GDP-L-gulose
C15926  beta-L-Galactose 1-phosphate
C15930  L-Galactonate
C16186  L-Ascorbate 6-phosphate
C20889  D-Galactaro-1,5-lactone
C20896  D-Galactaro-1,4-lactone
C21955  L-Galactono-1,5-lactone
Reference
PMID:17222174
  Authors
Linster CL, Van Schaftingen E
  Title
Vitamin C. Biosynthesis, recycling and degradation in mammals.
  Journal
FEBS J 274:1-22 (2007)
DOI:10.1111/j.1742-4658.2006.05607.x
Reference
PMID:15564123
  Authors
Valpuesta V, Botella MA.
  Title
Biosynthesis of L-ascorbic acid in plants: new pathways for an old antioxidant.
  Journal
Trends Plant Sci 9:573-7 (2004)
DOI:10.1016/j.tplants.2004.10.002
Reference
PMID:10517845
  Authors
Davey MW, Gilot C, Persiau G, Ostergaard J, Han Y, Bauw GC, Van Montagu MC.
  Title
Ascorbate biosynthesis in Arabidopsis cell suspension culture.
  Journal
Plant Physiol 121:535-43 (1999)
DOI:10.1104/pp.121.2.535
Reference
PMID:16595667
  Authors
Conklin PL, Gatzek S, Wheeler GL, Dowdle J, Raymond MJ, Rolinski S, Isupov M, Littlechild JA, Smirnoff N.
  Title
Arabidopsis thaliana VTC4 encodes L-galactose-1-P phosphatase, a plant ascorbic acid biosynthetic enzyme.
  Journal
J Biol Chem 281:15662-70 (2006)
DOI:10.1074/jbc.M601409200
Reference
PMID:17462988
  Authors
Linster CL, Gomez TA, Christensen KC, Adler LN, Young BD, Brenner C, Clarke SG.
  Title
Arabidopsis VTC2 Encodes a GDP-L-Galactose Phosphorylase, the Last Unknown Enzyme in the Smirnoff-Wheeler Pathway to Ascorbic Acid in Plants.
  Journal
J Biol Chem 282:18879-85 (2007)
DOI:10.1074/jbc.M702094200
Reference
PMID:14996803
  Authors
Campos E, Baldoma L, Aguilar J, Badia J.
  Title
Regulation of expression of the divergent ulaG and ulaABCDEF operons involved in LaAscorbate dissimilation in Escherichia coli.
  Journal
J Bacteriol 186:1720-8 (2004)
DOI:10.1128/JB.186.6.1720-1728.2004
Reference
PMID:12644495
  Authors
Zhang Z, Aboulwafa M, Smith MH, Saier MH Jr.
  Title
The ascorbate transporter of Escherichia coli.
  Journal
J Bacteriol 185:2243-50 (2003)
DOI:10.1128/JB.185.7.2243-2250.2003
Related
pathway
ppp00020  Citrate cycle (TCA cycle)
ppp00040  Pentose and glucuronate interconversions
ppp00051  Fructose and mannose metabolism
ppp00520  Amino sugar and nucleotide sugar metabolism
ppp00630  Glyoxylate and dicarboxylate metabolism
KO pathway
ko00053   
LinkDB

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