KEGG   PATHWAY: psoa00260
Entry
psoa00260                   Pathway                                
Name
Glycine, serine and threonine metabolism - Pseudomonas solani
Description
Serine is derived from 3-phospho-D-glycerate, an intermediate of glycolysis [MD:M00020], and glycine is derived from serine. Threonine is an essential amino acid, which animals cannot synthesize. In bacteria and plants, threonine is derived from aspartate [MD:M00018].
Class
Metabolism; Amino acid metabolism
Pathway map
psoa00260  Glycine, serine and threonine metabolism
psoa00260

Module
psoa_M00018  Threonine biosynthesis, aspartate => homoserine => threonine [PATH:psoa00260]
psoa_M00020  Serine biosynthesis, glycerate-3P => serine [PATH:psoa00260]
psoa_M00555  Betaine biosynthesis, choline => betaine [PATH:psoa00260]
psoa_M00621  Glycine cleavage system [PATH:psoa00260]
psoa_M00975  Betaine degradation, bacteria, betaine => pyruvate [PATH:psoa00260]
Other DBs
GO: 0006544 0006563 0070178 0006566
Organism
Pseudomonas solani [GN:psoa]
Gene
PSm6_03550  aspartokinase [KO:K00928] [EC:2.7.2.4]
PSm6_37790  asd; aspartate-semialdehyde dehydrogenase [KO:K00133] [EC:1.2.1.11]
PSm6_08700  hom; homoserine dehydrogenase [KO:K00003] [EC:1.1.1.3]
PSm6_21050  thrB; homoserine kinase [KO:K02204] [EC:2.7.1.39]
PSm6_40290  thrH; phosphoserine phosphatase ThrH [KO:K02203] [EC:3.1.3.3 2.7.1.39]
PSm6_08690  thrC; threonine synthase [KO:K01733] [EC:4.2.3.1]
PSm6_03570  hypothetical protein [KO:K01620] [EC:4.1.2.48]
PSm6_25340  ltaE; low specificity L-threonine aldolase [KO:K01620] [EC:4.1.2.48]
PSm6_25370  glyA1_1; serine hydroxymethyltransferase 1 [KO:K00600] [EC:2.1.2.1]
PSm6_30690  glyA2; serine hydroxymethyltransferase 3 [KO:K00600] [EC:2.1.2.1]
PSm6_34860  glyA1_2; serine hydroxymethyltransferase 1 [KO:K00600] [EC:2.1.2.1]
PSm6_10980  hprA; glycerate dehydrogenase [KO:K00018] [EC:1.1.1.29]
PSm6_35530  hypothetical protein [KO:K00865] [EC:2.7.1.165]
PSm6_42810  glycerate kinase [KO:K11529] [EC:2.7.1.165]
PSm6_16570  gpmI; 2,3-bisphosphoglycerate-independent phosphoglycerate mutase [KO:K15633] [EC:5.4.2.12]
PSm6_23510  serA; D-3-phosphoglycerate dehydrogenase [KO:K00058] [EC:1.1.1.95 1.1.1.399]
PSm6_37330  serC; phosphoserine aminotransferase [KO:K00831] [EC:2.6.1.52]
PSm6_14770  phosphoserine phosphatase SerB [KO:K01079] [EC:3.1.3.3]
PSm6_11790  aofH; putative flavin-containing monoamine oxidase AofH [KO:K00274] [EC:1.4.3.4]
PSm6_20380  monoamine oxidase [KO:K00274] [EC:1.4.3.4]
PSm6_24540  hypothetical protein [KO:K00274] [EC:1.4.3.4]
PSm6_51700  monoamine oxidase [KO:K00274] [EC:1.4.3.4]
PSm6_22930  gcvP2; glycine dehydrogenase (decarboxylating) 2 [KO:K00281] [EC:1.4.4.2]
PSm6_50440  gcvP; glycine dehydrogenase (decarboxylating) [KO:K00281] [EC:1.4.4.2]
PSm6_22910  gcvT; aminomethyltransferase [KO:K00605] [EC:2.1.2.10]
PSm6_50420  aminomethyltransferase [KO:K00605] [EC:2.1.2.10]
PSm6_60460  lpdG; dihydrolipoyl dehydrogenase [KO:K00382] [EC:1.8.1.4]
PSm6_49880  lpd3; dihydrolipoyl dehydrogenase 3 [KO:K00382] [EC:1.8.1.4]
PSm6_22920  gcvH2; glycine cleavage system H protein 2 [KO:K02437]
PSm6_50450  gcvH; glycine cleavage system H protein [KO:K02437]
PSm6_11990  pssA; phosphatidylserine synthase [KO:K17103] [EC:2.7.8.8]
PSm6_25000  betA; oxygen-dependent choline dehydrogenase [KO:K00108] [EC:1.1.99.1]
PSm6_25010  betB; NAD/NADP-dependent betaine aldehyde dehydrogenase [KO:K00130] [EC:1.2.1.8]
PSm6_29910  betaine-aldehyde dehydrogenase [KO:K00130] [EC:1.2.1.8]
PSm6_25320  gbcA; protein GbcA [KO:K00479] [EC:1.14.13.251]
PSm6_25330  gbcB; hybrid-cluster NAD(P)-dependent oxidoreductase [KO:K21832] [EC:1.14.13.251]
PSm6_25150  dgcA; dimethylglycine catabolism protein DgcA [KO:K21833] [EC:1.5.7.3]
PSm6_25140  dgcB; dimethylglycine catabolism protein DgcB [KO:K21834]
PSm6_25130  electron transfer flavoprotein subunit alpha [KO:K25960]
PSm6_25120  hypothetical protein [KO:K25961]
PSm6_25410  sarcosine oxidase subunit alpha [KO:K00302] [EC:1.5.3.24 1.5.3.1]
PSm6_25380  soxB_1; sarcosine oxidase subunit beta [KO:K00303] [EC:1.5.3.24 1.5.3.1]
PSm6_25420  soxG-1; sarcosine oxidase subunit gamma [KO:K00305] [EC:1.5.3.24 1.5.3.1]
PSm6_25390  soxD; sarcosine oxidase subunit delta [KO:K00304] [EC:1.5.3.24 1.5.3.1]
PSm6_25090  sdaB; L-serine dehydratase [KO:K01752] [EC:4.3.1.17]
PSm6_50430  sdaA; L-serine dehydratase [KO:K01752] [EC:4.3.1.17]
PSm6_23680  ilvA1; L-threonine dehydratase [KO:K01754] [EC:4.3.1.19]
PSm6_30280  ilvA2; L-threonine dehydratase [KO:K01754] [EC:4.3.1.19]
PSm6_53640  hypothetical protein [KO:K17989] [EC:4.3.1.17 4.3.1.19]
PSm6_43790  hypothetical protein [KO:K01753] [EC:4.3.1.18]
PSm6_15350  aspartate/glutamate racemase [KO:K25316] [EC:5.1.1.10]
PSm6_20410  trpA; tryptophan synthase alpha chain [KO:K01695] [EC:4.2.1.20]
PSm6_20420  trpB; tryptophan synthase beta chain [KO:K01696] [EC:4.2.1.20]
PSm6_48870  pvdH; diaminobutyrate--2-oxoglutarate aminotransferase [KO:K00836] [EC:2.6.1.76]
Compound
C00011  CO2
C00014  Ammonia
C00022  Pyruvate
C00037  Glycine
C00048  Glyoxylate
C00049  L-Aspartate
C00065  L-Serine
C00078  L-Tryptophan
C00097  L-Cysteine
C00101  Tetrahydrofolate
C00109  2-Oxobutanoate
C00114  Choline
C00143  5,10-Methylenetetrahydrofolate
C00168  Hydroxypyruvate
C00188  L-Threonine
C00197  3-Phospho-D-glycerate
C00213  Sarcosine
C00258  D-Glycerate
C00263  L-Homoserine
C00300  Creatine
C00430  5-Aminolevulinate
C00441  L-Aspartate 4-semialdehyde
C00546  Methylglyoxal
C00576  Betaine aldehyde
C00581  Guanidinoacetate
C00631  2-Phospho-D-glycerate
C00719  Betaine
C00740  D-Serine
C00986  1,3-Diaminopropane
C01005  O-Phospho-L-serine
C01026  N,N-Dimethylglycine
C01102  O-Phospho-L-homoserine
C01242  [Protein]-S8-aminomethyldihydrolipoyllysine
C01888  Aminoacetone
C02051  Lipoylprotein
C02291  L-Cystathionine
C02737  Phosphatidylserine
C02972  Dihydrolipoylprotein
C03082  4-Phospho-L-aspartate
C03194  (R)-1-Aminopropan-2-ol
C03232  3-Phosphonooxypyruvate
C03283  L-2,4-Diaminobutanoate
C03508  L-2-Amino-3-oxobutanoic acid
C05519  L-Allothreonine
C06231  Ectoine
C06442  N(gamma)-Acetyldiaminobutyrate
C16432  5-Hydroxyectoine
C19929  N(alpha)-Acetyl-L-2,4-diaminobutyrate
Reference
  Authors
Nishizuka Y, Seyama Y, Ikai A, Ishimura Y, Kawaguchi A (eds).
  Title
[Cellular Functions and Metabolic Maps] (In Japanese)
  Journal
Tokyo Kagaku Dojin (1997)
Reference
PMID:11823218
  Authors
Kuhlmann AU, Bremer E.
  Title
Osmotically regulated synthesis of the compatible solute ectoine in Bacillus pasteurii and related Bacillus spp.
  Journal
Appl Environ Microbiol 68:772-83 (2002)
DOI:10.1128/AEM.68.2.772-783.2002
Reference
PMID:10473374
  Authors
Canovas D, Borges N, Vargas C, Ventosa A, Nieto JJ, Santos H.
  Title
Role of Ngamma-acetyldiaminobutyrate as an enzyme stabilizer and an intermediate in the biosynthesis of hydroxyectoine.
  Journal
Appl Environ Microbiol 65:3774-9 (1999)
DOI:10.1128/AEM.65.9.3774-3779.1999
Reference
PMID:17636255
  Authors
Bursy J, Pierik AJ, Pica N, Bremer E.
  Title
Osmotically induced synthesis of the compatible solute hydroxyectoine is mediated by an evolutionarily conserved ectoine hydroxylase.
  Journal
J Biol Chem 282:31147-55 (2007)
DOI:10.1074/jbc.M704023200
Reference
PMID:16707670
  Authors
Garcia-Estepa R, Argandona M, Reina-Bueno M, Capote N, Iglesias-Guerra F, Nieto JJ, Vargas C.
  Title
The ectD gene, which is involved in the synthesis of the compatible solute hydroxyectoine, is essential for thermoprotection of the halophilic bacterium Chromohalobacter salexigens.
  Journal
J Bacteriol 188:3774-84 (2006)
DOI:10.1128/JB.00136-06
Reference
PMID:15470257
  Authors
Arevalo-Rodriguez M, Pan X, Boeke JD, Heitman J
  Title
FKBP12 controls aspartate pathway flux in Saccharomyces cerevisiae to prevent toxic intermediate accumulation.
  Journal
Eukaryot Cell 3:1287-96 (2004)
DOI:10.1128/EC.3.5.1287-1296.2004
Reference
PMID:7639721
  Authors
Rees WD, Hay SM
  Title
The biosynthesis of threonine by mammalian cells: expression of a complete bacterial biosynthetic pathway in an animal cell.
  Journal
Biochem J 309 ( Pt 3):999-1007 (1995)
DOI:10.1042/bj3090999
Reference
PMID:11341914
  Authors
Jacques SL, Nieman C, Bareich D, Broadhead G, Kinach R, Honek JF, Wright GD
  Title
Characterization of yeast homoserine dehydrogenase, an antifungal target: the invariant histidine 309 is important for enzyme integrity.
  Journal
Biochim Biophys Acta 1544:28-41 (2001)
DOI:10.1016/S0167-4838(00)00203-X
Reference
PMID:15520012
  Authors
Chen X, Jhee KH, Kruger WD
  Title
Production of the neuromodulator H2S by cystathionine beta-synthase via the condensation of cysteine and homocysteine.
  Journal
J Biol Chem 279:52082-6 (2004)
DOI:10.1074/jbc.C400481200
Related
pathway
psoa00010  Glycolysis / Gluconeogenesis
psoa00020  Citrate cycle (TCA cycle)
psoa00230  Purine metabolism
psoa00250  Alanine, aspartate and glutamate metabolism
psoa00270  Cysteine and methionine metabolism
psoa00290  Valine, leucine and isoleucine biosynthesis
psoa00300  Lysine biosynthesis
psoa00330  Arginine and proline metabolism
psoa00460  Cyanoamino acid metabolism
psoa00470  D-Amino acid metabolism
psoa00564  Glycerophospholipid metabolism
psoa00620  Pyruvate metabolism
psoa00630  Glyoxylate and dicarboxylate metabolism
psoa00640  Propanoate metabolism
psoa00680  Methane metabolism
psoa00860  Porphyrin metabolism
psoa00920  Sulfur metabolism
KO pathway
ko00260   
LinkDB

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