KEGG   PATHWAY: ptet00983
Entry
ptet00983                   Pathway                                
Name
Drug metabolism - other enzymes - Puntigrus tetrazona (Sumatra barb)
Class
Metabolism; Xenobiotics biodegradation and metabolism
Pathway map
ptet00983  Drug metabolism - other enzymes
ptet00983

Organism
Puntigrus tetrazona (Sumatra barb) [GN:ptet]
Gene
122331165  hprt1l; hypoxanthine phosphoribosyltransferase 1, like [KO:K00760] [EC:2.4.2.8]
122358129  hprt1; hypoxanthine-guanine phosphoribosyltransferase [KO:K00760] [EC:2.4.2.8]
122363098  impdh1a; inosine-5'-monophosphate dehydrogenase 1a isoform X1 [KO:K00088] [EC:1.1.1.205]
122342586  impdh1b; inosine-5'-monophosphate dehydrogenase 1b isoform X1 [KO:K00088] [EC:1.1.1.205]
122350388  impdh2; inosine-5'-monophosphate dehydrogenase 2 isoform X1 [KO:K00088] [EC:1.1.1.205]
122335086  GMP synthase [glutamine-hydrolyzing] [KO:K01951] [EC:6.3.5.2]
122323257  probable thiopurine S-methyltransferase [KO:K00569] [EC:2.1.1.67]
122362132  xdh; xanthine dehydrogenase/oxidase [KO:K00106] [EC:1.17.1.4 1.17.3.2]
122325280  itpa; inosine triphosphate pyrophosphatase [KO:K01519] [EC:3.6.1.66]
122330893  ces2b; uncharacterized protein ces2b [KO:K03927] [EC:3.1.1.1 3.1.1.84 3.1.1.56]
122329753  UDP-glucuronosyltransferase 2A1-like [KO:K00699] [EC:2.4.1.17]
122330725  UDP-glucuronosyltransferase 2A3-like [KO:K00699] [EC:2.4.1.17]
122330726  UDP-glucuronosyltransferase 2A2-like [KO:K00699] [EC:2.4.1.17]
122330727  ugt5a1; UDP glucuronosyltransferase 5 family, polypeptide A1 [KO:K00699] [EC:2.4.1.17]
122330729  UDP-glucuronosyltransferase 2A1-like [KO:K00699] [EC:2.4.1.17]
122330730  UDP-glucuronosyltransferase 2A1-like [KO:K00699] [EC:2.4.1.17]
122354577  UDP-glucuronosyltransferase 1-6-like isoform X1 [KO:K00699] [EC:2.4.1.17]
122362572  ugt5f1; LOW QUALITY PROTEIN: UDP glucuronosyltransferase 5 family, polypeptide F1 [KO:K00699] [EC:2.4.1.17]
122348506  ugt5g1; UDP glucuronosyltransferase 5 family, polypeptide G1 [KO:K00699] [EC:2.4.1.17]
122350443  ugt5e1; UDP glucuronosyltransferase 5 family, polypeptide E1 [KO:K00699] [EC:2.4.1.17]
122345389  UDP-glucuronosyltransferase 2C1-like isoform X1 [KO:K00699] [EC:2.4.1.17]
122345390  UDP-glucuronosyltransferase 2C1-like [KO:K00699] [EC:2.4.1.17]
122345391  UDP-glucuronosyltransferase 2C1-like [KO:K00699] [EC:2.4.1.17]
122345394  UDP-glucuronosyltransferase 2A1-like [KO:K00699] [EC:2.4.1.17]
122351877  UDP-glucuronosyltransferase-like isoform X1 [KO:K00699] [EC:2.4.1.17]
122351878  UDP-glucuronosyltransferase 1A1-like [KO:K00699] [EC:2.4.1.17]
122351879  UDP-glucuronosyltransferase 1A1-like [KO:K00699] [EC:2.4.1.17]
122351880  UDP-glucuronosyltransferase 1A5-like [KO:K00699] [EC:2.4.1.17]
122351881  UDP-glucuronosyltransferase 1A1-like [KO:K00699] [EC:2.4.1.17]
122352924  ugt5g2; UDP glucuronosyltransferase 5 family, polypeptide G2 [KO:K00699] [EC:2.4.1.17]
122346185  UDP-glucuronosyltransferase 2C1-like isoform X1 [KO:K00699] [EC:2.4.1.17]
122353230  ugt5d1; UDP glucuronosyltransferase 5 family, polypeptide D1 isoform X1 [KO:K00699] [EC:2.4.1.17]
122353598  UDP-glucuronosyltransferase 1-6-like [KO:K00699] [EC:2.4.1.17]
122353606  UDP-glucuronosyltransferase 1A4-like [KO:K00699] [EC:2.4.1.17]
122346971  UDP-glucuronosyltransferase 2C1-like [KO:K00699] [EC:2.4.1.17]
122346986  UDP-glucuronosyltransferase 2A1-like [KO:K00699] [EC:2.4.1.17]
122344902  gusb; beta-glucuronidase isoform X1 [KO:K01195] [EC:3.2.1.31]
122328417  cytidine deaminase-like [KO:K01489] [EC:3.5.4.5]
122328575  cytidine deaminase-like [KO:K01489] [EC:3.5.4.5]
122332911  cytidine deaminase-like [KO:K01489] [EC:3.5.4.5]
122332912  cytidine deaminase-like [KO:K01489] [EC:3.5.4.5]
122354035  cdab; cytidine deaminase b [KO:K01489] [EC:3.5.4.5]
122343333  thymidine phosphorylase [KO:K00758] [EC:2.4.2.4]
122330059  dpyda.1; dihydropyrimidine dehydrogenase a, tandem duplicate 1 isoform X1 [KO:K00207] [EC:1.3.1.2]
122360317  dpydb; dihydropyrimidine dehydrogenase [NADP(+)] [KO:K00207] [EC:1.3.1.2]
122360532  dpys; dihydropyrimidinase isoform X1 [KO:K01464] [EC:3.5.2.2]
122350313  upb1; beta-ureidopropionase [KO:K01431] [EC:3.5.1.6]
122352036  upp2; uridine phosphorylase 2 [KO:K00757] [EC:2.4.2.3]
122360685  upp1; uridine phosphorylase 1 [KO:K00757] [EC:2.4.2.3]
122324978  si:ch211-243j20.2; uridine-cytidine kinase-like 1 isoform X1 [KO:K00876] [EC:2.7.1.48]
122328587  uckl1b; uridine-cytidine kinase-like 1 isoform X1 [KO:K00876] [EC:2.7.1.48]
122329289  uridine-cytidine kinase-like 1 isoform X1 [KO:K00876] [EC:2.7.1.48]
122332575  uck1; uridine-cytidine kinase 1 [KO:K00876] [EC:2.7.1.48]
122350182  uckl1a; uridine-cytidine kinase-like 1a isoform X1 [KO:K00876] [EC:2.7.1.48]
122350463  uck2a; uridine-cytidine kinase 2-A [KO:K00876] [EC:2.7.1.48]
122360229  uck2b; uridine-cytidine kinase 2-B [KO:K00876] [EC:2.7.1.48]
122354634  tk1; thymidine kinase, cytosolic [KO:K00857] [EC:2.7.1.21]
122348918  tk2; thymidine kinase 2, mitochondrial [KO:K00857] [EC:2.7.1.21]
122351169  umps; uridine 5'-monophosphate synthase [KO:K13421] [EC:2.4.2.10 4.1.1.23]
122358704  LOW QUALITY PROTEIN: UMP-CMP kinase-like [KO:K13800] [EC:2.7.4.14]
122326769  rrm1; ribonucleoside-diphosphate reductase large subunit [KO:K10807] [EC:1.17.4.1]
122324271  ribonucleoside-diphosphate reductase subunit M2 [KO:K10808] [EC:1.17.4.1]
122323495  rrm2b; ribonucleoside-diphosphate reductase subunit M2 B [KO:K10808] [EC:1.17.4.1]
122324400  nucleoside diphosphate kinase 6 [KO:K00940] [EC:2.7.4.6]
122324412  LOW QUALITY PROTEIN: nucleoside diphosphate kinase 6-like [KO:K00940] [EC:2.7.4.6]
122331520  nme3; nucleoside diphosphate kinase 3 isoform X1 [KO:K00940] [EC:2.7.4.6]
122340561  nucleoside diphosphate kinase B [KO:K00940] [EC:2.7.4.6]
122355281  nme2a; NME/NM23 nucleoside diphosphate kinase 2a isoform X1 [KO:K00940] [EC:2.7.4.6]
122341771  nme4; nucleoside diphosphate kinase, mitochondrial [KO:K00940] [EC:2.7.4.6]
122346711  nme7; nucleoside diphosphate kinase 7 isoform X1 [KO:K00940] [EC:2.7.4.6]
122363156  dut; deoxyuridine 5'-triphosphate nucleotidohydrolase, mitochondrial isoform X1 [KO:K01520] [EC:3.6.1.23]
122363038  zgc:101040 [KO:K00622] [EC:2.3.1.5]
122363039  arylamine N-acetyltransferase, pineal gland isozyme NAT-10-like [KO:K00622] [EC:2.3.1.5]
122349706  arylamine N-acetyltransferase, pineal gland isozyme NAT-10-like [KO:K00622] [EC:2.3.1.5]
122324707  mgst3a; microsomal glutathione S-transferase 3a [KO:K00799] [EC:2.5.1.18]
122326154  gstt1b; glutathione S-transferase theta-1b [KO:K00799] [EC:2.5.1.18]
122335234  glutathione S-transferase A-like [KO:K00799] [EC:2.5.1.18]
122335235  glutathione S-transferase A-like [KO:K00799] [EC:2.5.1.18]
122356356  glutathione S-transferase omega-1-like [KO:K00799] [EC:2.5.1.18]
122356357  glutathione S-transferase omega-1-like isoform X1 [KO:K00799] [EC:2.5.1.18]
122356374  mgst3b; microsomal glutathione S-transferase 3b [KO:K00799] [EC:2.5.1.18]
122357101  gsta.1; glutathione S-transferase, alpha tandem duplicate 1 [KO:K00799] [EC:2.5.1.18]
122342529  mgst1.1; microsomal glutathione S-transferase 1.1 isoform X1 [KO:K00799] [EC:2.5.1.18]
122342530  mgst1.2; microsomal glutathione S-transferase 1.2 [KO:K00799] [EC:2.5.1.18]
122350230  glutathione S-transferase Mu 4-like [KO:K00799] [EC:2.5.1.18]
122350246  gstm.1; glutathione S-transferase mu, tandem duplicate 1 [KO:K00799] [EC:2.5.1.18]
122357504  mgst2; microsomal glutathione S-transferase 2 [KO:K00799] [EC:2.5.1.18]
122351097  gstt1a; glutathione S-transferase theta-1a [KO:K00799] [EC:2.5.1.18]
122344762  glutathione S-transferase theta-1-like [KO:K00799] [EC:2.5.1.18]
122344993  glutathione S-transferase theta-1-like [KO:K00799] [EC:2.5.1.18]
122358282  gstp1; glutathione S-transferase P [KO:K23790] [EC:2.5.1.18]
Compound
C00003  NAD+
C00006  NADP+
C02320  R-S-Glutathione
C02380  6-Mercaptopurine
C04242  5-Fluorodeoxyuridine monophosphate
C04646  6-Thioinosine-5'-monophosphate
C05361  Hydrazine
C06108  Fluoroacetate
C06837  Azathioprine
C07054  Isoniazid
C07446  Isonicotinic acid
C07447  Acetylhydrazine
C07585  N-Acetylisoniazid
C07648  Thioguanine
C07649  5-FU
C11173  SN-38
C11376  SN38 glucuronide
C11736  5-Fluorodeoxyuridine
C12650  Capecitabine
C12673  Tegafur
C12739  5'-Deoxy-5-fluorouridine
C13252  Carmofur
C16542  APC
C16543  NPC
C16613  6-Thiourate
C16614  6-Methylmercaptopurine
C16615  6-Methylthiopurine 5'-monophosphate ribonucleotide
C16616  6-Mercaptopurine ribonucleoside 5'-diphosphate
C16617  6-Mercaptopurine ribonucleoside triphosphate
C16618  6-Thioxanthine 5'-monophosphate
C16619  6-Thioguanosine monophosphate
C16620  6-Methylthioguanosine monophosphate
C16621  1-Methyl-4-nitroimidazole
C16622  N,N'-Diacetylhydrazine
C16623  Isonicotinylglycine
C16624  Isoniazid pyruvate
C16625  Isoniazid alpha-ketoglutaric acid
C16630  5,6-Dihydro-5-fluorouracil
C16631  alpha-Fluoro-beta-ureidopropionic acid
C16632  alpha-Fluoro-beta-alanine
C16633  5-Fluorouridine
C16634  5-Fluorouridine monophosphate
C16635  5'-Deoxy-5-fluorocytidine
C16641  Irinotecan
C21748  5-Fluorouridine diphosphate
C21749  5-Fluorouridine triphosphate
C21750  5-Fluorodeoxyuridine diphosphate
C21751  5-Fluorodeoxyuridine triphosphate
C21754  Isonicotinoyl radical
C21758  Hepatotoxins
C21759  Isonicotinoyl-NAD adduct
C21760  Isonicotinoyl-NADP adduct
D00238  Azathioprine (JP18/USP/INN)
D00346  Isoniazid (JP18/USP/INN)
D00584  Fluorouracil (JP18/USP/INN)
D01223  Capecitabine (JAN/USP/INN)
D01244  Tegafur (JP18/USAN/INN)
D01309  Doxifluridine (JP18/INN)
D01784  Carmofur (JP18/INN)
D04197  Floxuridine (USP/INN)
D04931  Mercaptopurine (INN)
D08086  Irinotecan (INN)
D08603  Tioguanine (INN)
Reference
  Authors
Kato R, Kamatari T (eds).
  Title
[Drug Metabolism] (In Japanese)
  Journal
Tokyo Kagaku Dojin (2000)
Reference
  Authors
Al Hadithy AF, de Boer NK, Derijks LJ, Escher JC, Mulder CJ, Brouwers JR.
  Title
Thiopurines in inflammatory bowel disease: pharmacogenetics, therapeutic drug monitoring and clinical recommendations.
  Journal
Dig Liver Dis 37:282-97 (2005)
DOI:10.1016/j.dld.2004.09.029
Reference
  Authors
Gearry RB, Barclay ML.
  Title
Azathioprine and 6-mercaptopurine pharmacogenetics and metabolite monitoring in inflammatory bowel disease.
  Journal
J Gastroenterol Hepatol 20:1149-57 (2005)
DOI:10.1111/j.1440-1746.2005.03832.x
Reference
  Authors
Gilissen LP, Derijks LJ, Verhoeven HM, Bierau J, Hooymans PM, Hommes DW, Engels LG.
  Title
Pancytopenia due to high 6-methylmercaptopurine levels in a 6-mercaptopurine treated patient with Crohn's disease.
  Journal
Dig Liver Dis 39:182-6 (2007)
DOI:10.1016/j.dld.2006.05.026
Reference
  Authors
Fischel JL, Formento P, Ciccolini J, Etienne-Grimaldi MC, Milano G.
  Title
Lack of contribution of dihydrofluorouracil and alpha-fluoro-beta-alanine to the cytotoxicity of 5'-deoxy-5-fluorouridine on human keratinocytes.
  Journal
Anticancer Drugs 15:969-74 (2004)
DOI:10.1097/00001813-200411000-00006
Reference
  Authors
Shimma N, Umeda I, Arasaki M, Murasaki C, Masubuchi K, Kohchi Y, Miwa M, Ura M, Sawada N, Tahara H, Kuruma I, Horii I, Ishitsuka H.
  Title
The design and synthesis of a new tumor-selective fluoropyrimidine carbamate, capecitabine.
  Journal
Bioorg Med Chem 8:1697-706 (2000)
DOI:10.1016/S0968-0896(00)00087-0
Reference
  Authors
Chung YL, Troy H, Judson IR, Leek R, Leach MO, Stubbs M, Harris AL, Griffiths JR
  Title
Noninvasive measurements of capecitabine metabolism in bladder tumors overexpressing thymidine phosphorylase by fluorine-19 magnetic resonance spectroscopy.
  Journal
Clin Cancer Res 10:3863-70 (2004)
DOI:10.1158/1078-0432.CCR-03-0237
Reference
  Authors
Mathijssen RH, van Alphen RJ, Verweij J, Loos WJ, Nooter K, Stoter G, Sparreboom A
  Title
Clinical pharmacokinetics and metabolism of irinotecan (CPT-11).
  Journal
Clin Cancer Res 7:2182-94 (2001)
Reference
  Authors
Kita T, Tanigawara Y, Chikazawa S, Hatanaka H, Sakaeda T, Komada F, Iwakawa S, Okumura K.
  Title
N-Acetyltransferase2 genotype correlated with isoniazid acetylation in Japanese tuberculous patients.
  Journal
Biol Pharm Bull 24:544-9 (2001)
DOI:10.1248/bpb.24.544
Reference
  Authors
Miura K, Kinouchi M, Ishida K, Fujibuchi W, Naitoh T, Ogawa H, Ando T, Yazaki N, Watanabe K, Haneda S, Shibata C, Sasaki I
  Title
5-fu metabolism in cancer and orally-administrable 5-fu drugs.
  Journal
Cancers (Basel) 2:1717-30 (2010)
DOI:10.3390/cancers2031717
Reference
  Authors
Wang P, Pradhan K, Zhong XB, Ma X
  Title
Isoniazid metabolism and hepatotoxicity.
  Journal
Acta Pharm Sin B 6:384-392 (2016)
DOI:10.1016/j.apsb.2016.07.014
Reference
  Authors
Klein DJ, Boukouvala S, McDonagh EM, Shuldiner SR, Laurieri N, Thorn CF, Altman RB, Klein TE
  Title
PharmGKB summary: isoniazid pathway, pharmacokinetics.
  Journal
Pharmacogenet Genomics 26:436-44 (2016)
DOI:10.1097/FPC.0000000000000232
Reference
  Authors
Yamada S, Richardson K, Tang M, Halaschek-Wiener J, Cook VJ, Fitzgerald JM, Elwood K, Marra F, Brooks-Wilson A
  Title
Genetic variation in carboxylesterase genes and susceptibility to isoniazid-induced hepatotoxicity.
  Journal
Pharmacogenomics J 10:524-36 (2010)
DOI:10.1038/tpj.2010.5
Reference
  Authors
Vlasits J, Jakopitsch C, Bernroitner M, Zamocky M, Furtmuller PG, Obinger C
  Title
Mechanisms of catalase activity of heme peroxidases.
  Journal
Arch Biochem Biophys 500:74-81 (2010)
DOI:10.1016/j.abb.2010.04.018
Reference
  Authors
Khan SR, Morgan AG, Michail K, Srivastava N, Whittal RM, Aljuhani N, Siraki AG
  Title
Metabolism of isoniazid by neutrophil myeloperoxidase leads to isoniazid-NAD(+) adduct formation: A comparison of the reactivity of isoniazid with its known human metabolites.
  Journal
Biochem Pharmacol 106:46-55 (2016)
DOI:10.1016/j.bcp.2016.02.003
Reference
  Authors
Forbes LV, Furtmuller PG, Khalilova I, Turner R, Obinger C, Kettle AJ
  Title
Isoniazid as a substrate and inhibitor of myeloperoxidase: identification of amine adducts and the influence of superoxide dismutase on their formation.
  Journal
Biochem Pharmacol 84:949-60 (2012)
DOI:10.1016/j.bcp.2012.07.020
Reference
  Authors
Nguyen M, Quemard A, Broussy S, Bernadou J, Meunier B
  Title
Mn(III) pyrophosphate as an efficient tool for studying the mode of action of isoniazid on the InhA protein of Mycobacterium tuberculosis.
  Journal
Antimicrob Agents Chemother 46:2137-44 (2002)
DOI:10.1128/AAC.46.7.2137-2144.2002
Reference
PMID:9417034
  Authors
Rozwarski DA, Grant GA, Barton DH, Jacobs WR Jr, Sacchettini JC
  Title
Modification of the NADH of the isoniazid target (InhA) from Mycobacterium tuberculosis.
  Journal
Science 279:98-102 (1998)
DOI:10.1126/science.279.5347.98
Reference
  Authors
Argyrou A, Vetting MW, Blanchard JS
  Title
New insight into the mechanism of action of and resistance to isoniazid: interaction of Mycobacterium tuberculosis enoyl-ACP reductase with INH-NADP.
  Journal
J Am Chem Soc 129:9582-3 (2007)
DOI:10.1021/ja073160k
KO pathway
ko00983   
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