KEGG   PATHWAY: rad00260
Entry
rad00260                    Pathway                                
Name
Glycine, serine and threonine metabolism - Rhizobium acidisoli
Description
Serine is derived from 3-phospho-D-glycerate, an intermediate of glycolysis [MD:M00020], and glycine is derived from serine. Threonine is an essential amino acid, which animals cannot synthesize. In bacteria and plants, threonine is derived from aspartate [MD:M00018].
Class
Metabolism; Amino acid metabolism
Pathway map
rad00260  Glycine, serine and threonine metabolism
rad00260

Module
rad_M00018  Threonine biosynthesis, aspartate => homoserine => threonine [PATH:rad00260]
rad_M00020  Serine biosynthesis, glycerate-3P => serine [PATH:rad00260]
rad_M00555  Betaine biosynthesis, choline => betaine [PATH:rad00260]
rad_M00621  Glycine cleavage system [PATH:rad00260]
rad_M00919  Ectoine degradation, ectoine => aspartate [PATH:rad00260]
rad_M00975  Betaine degradation, bacteria, betaine => pyruvate [PATH:rad00260]
Other DBs
GO: 0006544 0006563 0070178 0006566
Organism
Rhizobium acidisoli [GN:rad]
Gene
CO657_18125  aspartate kinase [KO:K00928] [EC:2.7.2.4]
CO657_24940  uridylate kinase [KO:K00928] [EC:2.7.2.4]
CO657_20085  aspartate-semialdehyde dehydrogenase [KO:K00133] [EC:1.2.1.11]
CO657_07850  homoserine dehydrogenase [KO:K00003] [EC:1.1.1.3]
CO657_28660  homoserine dehydrogenase [KO:K00003] [EC:1.1.1.3]
CO657_03225  homoserine kinase [KO:K02204] [EC:2.7.1.39]
CO657_28705  kinase [KO:K02204] [EC:2.7.1.39]
CO657_03345  threonine synthase [KO:K01733] [EC:4.2.3.1]
CO657_17070  low specificity L-threonine aldolase [KO:K01620] [EC:4.1.2.48]
CO657_05940  serine hydroxymethyltransferase [KO:K00600] [EC:2.1.2.1]
CO657_21325  glyoxylate/hydroxypyruvate reductase A [KO:K12972] [EC:1.1.1.79 1.1.1.81]
CO657_33805  glyoxylate/hydroxypyruvate reductase A [KO:K12972] [EC:1.1.1.79 1.1.1.81]
CO657_07430  glycerate kinase [KO:K11529] [EC:2.7.1.165]
CO657_09985  phosphoglycerate mutase family protein [KO:K01834] [EC:5.4.2.11]
CO657_21275  2,3-bisphosphoglycerate-dependent phosphoglycerate mutase [KO:K01834] [EC:5.4.2.11]
CO657_16420  phosphoglycerate dehydrogenase [KO:K00058] [EC:1.1.1.95 1.1.1.399]
CO657_23050  phosphoglycerate dehydrogenase [KO:K00058] [EC:1.1.1.95 1.1.1.399]
CO657_27335  phosphoglycerate dehydrogenase [KO:K00058] [EC:1.1.1.95 1.1.1.399]
CO657_16425  phosphoserine transaminase [KO:K00831] [EC:2.6.1.52]
CO657_12850  serB; phosphoserine phosphatase SerB [KO:K01079] [EC:3.1.3.3]
CO657_13810  glycine C-acetyltransferase [KO:K00639] [EC:2.3.1.29]
CO657_13800  L-threonine 3-dehydrogenase [KO:K00060] [EC:1.1.1.103]
CO657_18610  hemA; 5-aminolevulinate synthase [KO:K00643] [EC:2.3.1.37]
CO657_29015  FAD-dependent oxidoreductase [KO:K00274] [EC:1.4.3.4]
CO657_09500  gcvP; glycine dehydrogenase (aminomethyl-transferring) [KO:K00281] [EC:1.4.4.2]
CO657_09490  gcvT; glycine cleavage system aminomethyltransferase GcvT [KO:K00605] [EC:2.1.2.10]
CO657_28940  aminomethyl transferase family protein [KO:K00605] [EC:2.1.2.10]
CO657_29000  DUF1989 domain-containing protein [KO:K00605] [EC:2.1.2.10]
CO657_35185  lpdA; dihydrolipoyl dehydrogenase [KO:K00382] [EC:1.8.1.4]
CO657_08195  lpdA; dihydrolipoyl dehydrogenase [KO:K00382] [EC:1.8.1.4]
CO657_18805  dihydrolipoyl dehydrogenase [KO:K00382] [EC:1.8.1.4]
CO657_09495  gcvH; glycine cleavage system protein GcvH [KO:K02437]
CO657_05420  pssA; CDP-diacylglycerol--serine O-phosphatidyltransferase [KO:K17103] [EC:2.7.8.8]
CO657_04155  betA; choline dehydrogenase [KO:K00108] [EC:1.1.99.1]
CO657_04165  betaine-aldehyde dehydrogenase [KO:K00130] [EC:1.2.1.8]
CO657_27715  aldehyde dehydrogenase family protein [KO:K00130] [EC:1.2.1.8]
CO657_27195  aromatic ring-hydroxylating dioxygenase subunit alpha [KO:K00479] [EC:1.14.13.251]
CO657_02835  aromatic ring-hydroxylating dioxygenase subunit alpha [KO:K00479] [EC:1.14.13.251]
CO657_27200  hybrid-cluster NAD(P)-dependent oxidoreductase [KO:K21832] [EC:1.14.13.251]
CO657_17030  FAD-dependent oxidoreductase [KO:K00315] [EC:1.5.8.4]
CO657_17265  sarcosine oxidase subunit alpha [KO:K00302] [EC:1.5.3.24 1.5.3.1]
CO657_17275  sarcosine oxidase subunit beta family protein [KO:K00303] [EC:1.5.3.24 1.5.3.1]
CO657_17260  soxG; sarcosine oxidase subunit gamma family protein [KO:K00305] [EC:1.5.3.24 1.5.3.1]
CO657_17270  sarcosine oxidase subunit delta family protein [KO:K00304] [EC:1.5.3.24 1.5.3.1]
CO657_09350  L-serine ammonia-lyase [KO:K01752] [EC:4.3.1.17]
CO657_07215  ilvA; threonine ammonia-lyase [KO:K01754] [EC:4.3.1.19]
CO657_16885  threonine/serine dehydratase [KO:K01754] [EC:4.3.1.19]
CO657_26075  eutB; hydroxyectoine utilization dehydratase EutB [KO:K01754] [EC:4.3.1.19]
CO657_33775  threonine/serine dehydratase [KO:K01754] [EC:4.3.1.19]
CO657_20040  pyridoxal-phosphate dependent enzyme [KO:K17989] [EC:4.3.1.17 4.3.1.19]
CO657_34470  amino acid deaminase [KO:K01753] [EC:4.3.1.18]
CO657_20335  tryptophan synthase subunit alpha [KO:K01695] [EC:4.2.1.20]
CO657_20330  trpB; tryptophan synthase subunit beta [KO:K01696] [EC:4.2.1.20]
CO657_25170  ectB; diaminobutyrate--2-oxoglutarate transaminase [KO:K00836] [EC:2.6.1.76]
CO657_02970  ectoine synthase [KO:K06720] [EC:4.2.1.108]
CO657_24830  aminopeptidase P family protein [KO:K15783] [EC:3.5.4.44]
CO657_26065  doeA; ectoine hydrolase DoeA [KO:K15783] [EC:3.5.4.44]
CO657_26060  doeB; N-alpha-acetyl diaminobutyric acid deacetylase DoeB [KO:K15784] [EC:3.5.1.125]
CO657_24790  aspartate aminotransferase family protein [KO:K15785] [EC:2.6.1.76]
CO657_26120  aspartate aminotransferase family protein [KO:K15785] [EC:2.6.1.76]
CO657_26115  NAD-dependent succinate-semialdehyde dehydrogenase [KO:K15786] [EC:1.2.1.-]
Compound
C00011  CO2
C00014  Ammonia
C00022  Pyruvate
C00037  Glycine
C00048  Glyoxylate
C00049  L-Aspartate
C00065  L-Serine
C00078  L-Tryptophan
C00097  L-Cysteine
C00101  Tetrahydrofolate
C00109  2-Oxobutanoate
C00114  Choline
C00143  5,10-Methylenetetrahydrofolate
C00168  Hydroxypyruvate
C00188  L-Threonine
C00197  3-Phospho-D-glycerate
C00213  Sarcosine
C00258  D-Glycerate
C00263  L-Homoserine
C00300  Creatine
C00430  5-Aminolevulinate
C00441  L-Aspartate 4-semialdehyde
C00546  Methylglyoxal
C00576  Betaine aldehyde
C00581  Guanidinoacetate
C00631  2-Phospho-D-glycerate
C00719  Betaine
C00740  D-Serine
C00986  1,3-Diaminopropane
C01005  O-Phospho-L-serine
C01026  N,N-Dimethylglycine
C01102  O-Phospho-L-homoserine
C01242  [Protein]-S8-aminomethyldihydrolipoyllysine
C01888  Aminoacetone
C02051  Lipoylprotein
C02291  L-Cystathionine
C02737  Phosphatidylserine
C02972  Dihydrolipoylprotein
C03082  4-Phospho-L-aspartate
C03194  (R)-1-Aminopropan-2-ol
C03232  3-Phosphonooxypyruvate
C03283  L-2,4-Diaminobutanoate
C03508  L-2-Amino-3-oxobutanoic acid
C05519  L-Allothreonine
C06231  Ectoine
C06442  N(gamma)-Acetyldiaminobutyrate
C16432  5-Hydroxyectoine
C19929  N(alpha)-Acetyl-L-2,4-diaminobutyrate
Reference
  Authors
Nishizuka Y, Seyama Y, Ikai A, Ishimura Y, Kawaguchi A (eds).
  Title
[Cellular Functions and Metabolic Maps] (In Japanese)
  Journal
Tokyo Kagaku Dojin (1997)
Reference
PMID:11823218
  Authors
Kuhlmann AU, Bremer E.
  Title
Osmotically regulated synthesis of the compatible solute ectoine in Bacillus pasteurii and related Bacillus spp.
  Journal
Appl Environ Microbiol 68:772-83 (2002)
DOI:10.1128/AEM.68.2.772-783.2002
Reference
PMID:10473374
  Authors
Canovas D, Borges N, Vargas C, Ventosa A, Nieto JJ, Santos H.
  Title
Role of Ngamma-acetyldiaminobutyrate as an enzyme stabilizer and an intermediate in the biosynthesis of hydroxyectoine.
  Journal
Appl Environ Microbiol 65:3774-9 (1999)
DOI:10.1128/AEM.65.9.3774-3779.1999
Reference
PMID:17636255
  Authors
Bursy J, Pierik AJ, Pica N, Bremer E.
  Title
Osmotically induced synthesis of the compatible solute hydroxyectoine is mediated by an evolutionarily conserved ectoine hydroxylase.
  Journal
J Biol Chem 282:31147-55 (2007)
DOI:10.1074/jbc.M704023200
Reference
PMID:16707670
  Authors
Garcia-Estepa R, Argandona M, Reina-Bueno M, Capote N, Iglesias-Guerra F, Nieto JJ, Vargas C.
  Title
The ectD gene, which is involved in the synthesis of the compatible solute hydroxyectoine, is essential for thermoprotection of the halophilic bacterium Chromohalobacter salexigens.
  Journal
J Bacteriol 188:3774-84 (2006)
DOI:10.1128/JB.00136-06
Reference
PMID:15470257
  Authors
Arevalo-Rodriguez M, Pan X, Boeke JD, Heitman J
  Title
FKBP12 controls aspartate pathway flux in Saccharomyces cerevisiae to prevent toxic intermediate accumulation.
  Journal
Eukaryot Cell 3:1287-96 (2004)
DOI:10.1128/EC.3.5.1287-1296.2004
Reference
PMID:7639721
  Authors
Rees WD, Hay SM
  Title
The biosynthesis of threonine by mammalian cells: expression of a complete bacterial biosynthetic pathway in an animal cell.
  Journal
Biochem J 309 ( Pt 3):999-1007 (1995)
DOI:10.1042/bj3090999
Reference
PMID:11341914
  Authors
Jacques SL, Nieman C, Bareich D, Broadhead G, Kinach R, Honek JF, Wright GD
  Title
Characterization of yeast homoserine dehydrogenase, an antifungal target: the invariant histidine 309 is important for enzyme integrity.
  Journal
Biochim Biophys Acta 1544:28-41 (2001)
DOI:10.1016/S0167-4838(00)00203-X
Reference
PMID:15520012
  Authors
Chen X, Jhee KH, Kruger WD
  Title
Production of the neuromodulator H2S by cystathionine beta-synthase via the condensation of cysteine and homocysteine.
  Journal
J Biol Chem 279:52082-6 (2004)
DOI:10.1074/jbc.C400481200
Related
pathway
rad00010  Glycolysis / Gluconeogenesis
rad00020  Citrate cycle (TCA cycle)
rad00230  Purine metabolism
rad00250  Alanine, aspartate and glutamate metabolism
rad00270  Cysteine and methionine metabolism
rad00290  Valine, leucine and isoleucine biosynthesis
rad00300  Lysine biosynthesis
rad00330  Arginine and proline metabolism
rad00460  Cyanoamino acid metabolism
rad00470  D-Amino acid metabolism
rad00564  Glycerophospholipid metabolism
rad00600  Sphingolipid metabolism
rad00620  Pyruvate metabolism
rad00630  Glyoxylate and dicarboxylate metabolism
rad00640  Propanoate metabolism
rad00680  Methane metabolism
rad00860  Porphyrin metabolism
rad00920  Sulfur metabolism
KO pathway
ko00260   
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