KEGG   PATHWAY: rcn00053
Entry
rcn00053                    Pathway                                
Name
Ascorbate and aldarate metabolism - Rosa chinensis (China rose)
Class
Metabolism; Carbohydrate metabolism
Pathway map
rcn00053  Ascorbate and aldarate metabolism
rcn00053

Module
rcn_M00114  Ascorbate biosynthesis, plants, fructose-6P => ascorbate [PATH:rcn00053]
Other DBs
GO: 0019852 0019577 0019572
Organism
Rosa chinensis (China rose) [GN:rcn]
Gene
112177071  UDP-glucose 6-dehydrogenase 4 [KO:K00012] [EC:1.1.1.22]
112168133  UDP-glucose 6-dehydrogenase 1 [KO:K00012] [EC:1.1.1.22]
112194110  UDP-glucose 6-dehydrogenase 1 [KO:K00012] [EC:1.1.1.22]
112197159  UDP-glucose 6-dehydrogenase 2 [KO:K00012] [EC:1.1.1.22]
112201718  UDP-glucose 6-dehydrogenase 1 [KO:K00012] [EC:1.1.1.22]
112172726  UDP-sugar pyrophosphorylase [KO:K12447] [EC:2.7.7.64]
112185592  glucuronokinase 1 [KO:K16190] [EC:2.7.1.43]
112180888  inositol oxygenase 2 [KO:K00469] [EC:1.13.99.1]
112179107  inositol oxygenase 1 [KO:K00469] [EC:1.13.99.1]
112188078  inositol oxygenase 1 [KO:K00469] [EC:1.13.99.1]
112195900  inositol oxygenase 1 [KO:K00469] [EC:1.13.99.1]
112188549  inositol oxygenase 4 [KO:K00469] [EC:1.13.99.1]
112192898  NADPH-dependent aldo-keto reductase, chloroplastic [KO:K00002] [EC:1.1.1.2]
112192899  NADPH-dependent aldo-keto reductase, chloroplastic [KO:K00002] [EC:1.1.1.2]
112192896  NADPH-dependent aldo-keto reductase, chloroplastic [KO:K00002] [EC:1.1.1.2]
112195899  aldo-keto reductase family 4 member C10 [KO:K00002] [EC:1.1.1.2]
112191370  LOW QUALITY PROTEIN: NADPH-dependent aldo-keto reductase, chloroplastic [KO:K00002] [EC:1.1.1.2]
112193826  NADPH-dependent aldo-keto reductase, chloroplastic [KO:K00002] [EC:1.1.1.2]
112193828  aldo-keto reductase family 4 member C10 [KO:K00002] [EC:1.1.1.2]
112193829  NADPH-dependent aldo-keto reductase, chloroplastic [KO:K00002] [EC:1.1.1.2]
112193830  NADPH-dependent aldo-keto reductase, chloroplastic [KO:K00002] [EC:1.1.1.2]
112193831  NADPH-dependent aldo-keto reductase, chloroplastic [KO:K00002] [EC:1.1.1.2]
112196598  probable L-gulonolactone oxidase 6 [KO:K00103] [EC:1.1.3.8]
112195429  probable L-gulonolactone oxidase 6 [KO:K00103] [EC:1.1.3.8]
112181889  probable L-gulonolactone oxidase 6 [KO:K00103] [EC:1.1.3.8]
112172675  L-gulonolactone oxidase 3 [KO:K00103] [EC:1.1.3.8]
112197732  GDP-mannose 3,5-epimerase 2 isoform X1 [KO:K10046] [EC:5.1.3.18 5.1.3.-]
112193348  GDP-mannose 3,5-epimerase 2 [KO:K10046] [EC:5.1.3.18 5.1.3.-]
112180559  GDP-L-galactose phosphorylase 2 [KO:K14190] [EC:2.7.7.69]
112167903  GDP-L-galactose phosphorylase 1 [KO:K14190] [EC:2.7.7.69]
112201755  GDP-L-galactose phosphorylase 2 [KO:K14190] [EC:2.7.7.69]
112172659  inositol monophosphatase 3 isoform X1 [KO:K10047] [EC:3.1.3.25 3.1.3.93]
112167446  inositol monophosphatase 3 [KO:K10047] [EC:3.1.3.25 3.1.3.93]
112173712  bifunctional phosphatase IMPL2, chloroplastic [KO:K18649] [EC:3.1.3.25 3.1.3.93 3.1.3.15]
112173603  L-galactose dehydrogenase [KO:K17744] [EC:1.1.1.316]
112187885  L-galactono-1,4-lactone dehydrogenase, mitochondrial [KO:K00225] [EC:1.3.2.3]
112176040  UDP-glucuronate 4-epimerase 3 [KO:K08679] [EC:5.1.3.6]
112177173  LOW QUALITY PROTEIN: UDP-glucuronate 4-epimerase 3-like [KO:K08679] [EC:5.1.3.6]
112197227  UDP-glucuronate 4-epimerase 1 [KO:K08679] [EC:5.1.3.6]
112197056  UDP-glucuronate 4-epimerase 6 [KO:K08679] [EC:5.1.3.6]
112180478  D-galacturonate reductase [KO:K19642] [EC:1.1.1.365]
112179335  D-galacturonate reductase [KO:K19642] [EC:1.1.1.365]
112197683  D-galacturonate reductase [KO:K19642] [EC:1.1.1.365]
112166452  monodehydroascorbate reductase [KO:K08232] [EC:1.6.5.4]
112179200  monodehydroascorbate reductase, chloroplastic/mitochondrial isoform X1 [KO:K08232] [EC:1.6.5.4]
112193014  monodehydroascorbate reductase, seedling isozyme [KO:K08232] [EC:1.6.5.4]
112188943  monodehydroascorbate reductase 4, peroxisomal [KO:K08232] [EC:1.6.5.4]
112172888  probable L-ascorbate peroxidase 6, chloroplastic/mitochondrial isoform X1 [KO:K00434] [EC:1.11.1.11]
112173456  L-ascorbate peroxidase 3 [KO:K00434] [EC:1.11.1.11]
112167733  L-ascorbate peroxidase, cytosolic [KO:K00434] [EC:1.11.1.11]
112183427  L-ascorbate peroxidase 3 [KO:K00434] [EC:1.11.1.11]
112183428  L-ascorbate peroxidase 3 [KO:K00434] [EC:1.11.1.11]
112172770  putative L-ascorbate peroxidase 6 isoform X1 [KO:K00434] [EC:1.11.1.11]
112193157  L-ascorbate peroxidase 2, cytosolic isoform X1 [KO:K00434] [EC:1.11.1.11]
112184608  glutathione S-transferase DHAR2 [KO:K21888] [EC:1.8.5.1 2.5.1.18]
112195020  glutathione S-transferase DHAR3, chloroplastic [KO:K21888] [EC:1.8.5.1 2.5.1.18]
112168216  L-ascorbate oxidase homolog [KO:K00423] [EC:1.10.3.3]
112167001  L-ascorbate oxidase isoform X1 [KO:K00423] [EC:1.10.3.3]
112191581  L-ascorbate oxidase homolog [KO:K00423] [EC:1.10.3.3]
112194304  L-ascorbate oxidase homolog [KO:K00423] [EC:1.10.3.3]
112173279  aldehyde dehydrogenase family 3 member H1 [KO:K00128] [EC:1.2.1.3]
112178817  aldehyde dehydrogenase family 2 member B4, mitochondrial [KO:K00128] [EC:1.2.1.3]
112187009  aldehyde dehydrogenase family 3 member H1 isoform X1 [KO:K00128] [EC:1.2.1.3]
112168869  aldehyde dehydrogenase family 3 member H1 isoform X2 [KO:K00128] [EC:1.2.1.3]
112197938  aldehyde dehydrogenase family 2 member B7, mitochondrial [KO:K00128] [EC:1.2.1.3]
112199504  aldehyde dehydrogenase family 3 member H1 [KO:K00128] [EC:1.2.1.3]
112190240  aldehyde dehydrogenase family 3 member F1 [KO:K00128] [EC:1.2.1.3]
112187805  aldehyde dehydrogenase family 7 member A1 [KO:K14085] [EC:1.2.1.31 1.2.1.8 1.2.1.3]
Compound
C00022  Pyruvate
C00026  2-Oxoglutarate
C00029  UDP-glucose
C00072  Ascorbate
C00096  GDP-mannose
C00137  myo-Inositol
C00167  UDP-glucuronate
C00191  D-Glucuronate
C00216  D-Arabinose
C00231  D-Xylulose 5-phosphate
C00259  L-Arabinose
C00333  D-Galacturonate
C00433  2,5-Dioxopentanoate
C00545  L-Arabinonate
C00558  D-Tagaturonate
C00617  UDP-D-galacturonate
C00618  3-Dehydro-L-gulonate
C00652  D-Arabinono-1,4-lactone
C00679  5-Dehydro-4-deoxy-D-glucarate
C00684  2-Dehydro-3-deoxy-L-arabinonate
C00800  L-Gulonate
C00818  D-Glucarate
C00878  D-Arabinonate
C00879  D-Galactarate
C01040  L-Gulono-1,4-lactone
C01041  Monodehydroascorbate
C01101  L-Ribulose 5-phosphate
C01114  L-Arabinono-1,4-lactone
C01115  L-Galactono-1,4-lactone
C01146  2-Hydroxy-3-oxopropanoate
C01620  Threonate
C01825  L-Galactose
C02280  GDP-L-galactose
C02670  D-Glucuronolactone
C03033  beta-D-Glucuronoside
C03064  3-Dehydro-L-threonate
C03289  L-xylo-Hexulonolactone
C03291  L-Xylulose 5-phosphate
C03826  2-Dehydro-3-deoxy-D-xylonate
C03921  2-Dehydro-3-deoxy-D-glucarate
C04037  1-Phospho-alpha-D-galacturonate
C04575  (4R,5S)-4,5,6-Trihydroxy-2,3-dioxohexanoate
C05385  D-Glucuronate 1-phosphate
C05411  L-Xylonate
C05412  L-Lyxonate
C05422  Dehydroascorbate
C06316  Dehydro-D-arabinono-1,4-lactone
C14899  3-Dehydro-L-gulonate 6-phosphate
C15923  L-Gulose
C15924  L-Gulose 1-phosphate
C15925  GDP-L-gulose
C15926  beta-L-Galactose 1-phosphate
C15930  L-Galactonate
C16186  L-Ascorbate 6-phosphate
C20889  D-Galactaro-1,5-lactone
C20896  D-Galactaro-1,4-lactone
C21955  L-Galactono-1,5-lactone
Reference
PMID:17222174
  Authors
Linster CL, Van Schaftingen E
  Title
Vitamin C. Biosynthesis, recycling and degradation in mammals.
  Journal
FEBS J 274:1-22 (2007)
DOI:10.1111/j.1742-4658.2006.05607.x
Reference
PMID:15564123
  Authors
Valpuesta V, Botella MA.
  Title
Biosynthesis of L-ascorbic acid in plants: new pathways for an old antioxidant.
  Journal
Trends Plant Sci 9:573-7 (2004)
DOI:10.1016/j.tplants.2004.10.002
Reference
PMID:10517845
  Authors
Davey MW, Gilot C, Persiau G, Ostergaard J, Han Y, Bauw GC, Van Montagu MC.
  Title
Ascorbate biosynthesis in Arabidopsis cell suspension culture.
  Journal
Plant Physiol 121:535-43 (1999)
DOI:10.1104/pp.121.2.535
Reference
PMID:16595667
  Authors
Conklin PL, Gatzek S, Wheeler GL, Dowdle J, Raymond MJ, Rolinski S, Isupov M, Littlechild JA, Smirnoff N.
  Title
Arabidopsis thaliana VTC4 encodes L-galactose-1-P phosphatase, a plant ascorbic acid biosynthetic enzyme.
  Journal
J Biol Chem 281:15662-70 (2006)
DOI:10.1074/jbc.M601409200
Reference
PMID:17462988
  Authors
Linster CL, Gomez TA, Christensen KC, Adler LN, Young BD, Brenner C, Clarke SG.
  Title
Arabidopsis VTC2 Encodes a GDP-L-Galactose Phosphorylase, the Last Unknown Enzyme in the Smirnoff-Wheeler Pathway to Ascorbic Acid in Plants.
  Journal
J Biol Chem 282:18879-85 (2007)
DOI:10.1074/jbc.M702094200
Reference
PMID:14996803
  Authors
Campos E, Baldoma L, Aguilar J, Badia J.
  Title
Regulation of expression of the divergent ulaG and ulaABCDEF operons involved in LaAscorbate dissimilation in Escherichia coli.
  Journal
J Bacteriol 186:1720-8 (2004)
DOI:10.1128/JB.186.6.1720-1728.2004
Reference
PMID:12644495
  Authors
Zhang Z, Aboulwafa M, Smith MH, Saier MH Jr.
  Title
The ascorbate transporter of Escherichia coli.
  Journal
J Bacteriol 185:2243-50 (2003)
DOI:10.1128/JB.185.7.2243-2250.2003
Related
pathway
rcn00020  Citrate cycle (TCA cycle)
rcn00040  Pentose and glucuronate interconversions
rcn00051  Fructose and mannose metabolism
rcn00520  Amino sugar and nucleotide sugar metabolism
rcn00630  Glyoxylate and dicarboxylate metabolism
KO pathway
ko00053   
LinkDB

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