KEGG   PATHWAY: rim02010
Entry
rim02010                    Pathway                                
Name
ABC transporters - Roseburia intestinalis M50/1
Description
The ATP-binding cassette (ABC) transporters form one of the largest known protein families, and are widespread in bacteria, archaea, and eukaryotes. They couple ATP hydrolysis to active transport of a wide variety of substrates such as ions, sugars, lipids, sterols, peptides, proteins, and drugs. The structure of a prokaryotic ABC transporter usually consists of three components; typically two integral membrane proteins each having six transmembrane segments, two peripheral proteins that bind and hydrolyze ATP, and a periplasmic (or lipoprotein) substrate-binding protein. Many of the genes for the three components form operons as in fact observed in many bacterial and archaeal genomes. On the other hand, in a typical eukaryotic ABC transporter, the membrane spanning protein and the ATP-binding protein are fused, forming a multi-domain protein with the membrane-spanning domain (MSD) and the nucleotide-binding domain (NBD).
Class
Environmental Information Processing; Membrane transport
Pathway map
rim02010  ABC transporters
rim02010

Other DBs
GO: 0043190 0043191 0043192
TC: 3.A.1
Organism
Roseburia intestinalis M50/1 [GN:rim]
Gene
ROI_15940  sulfate/thiosulfate-binding protein [KO:K23163]
ROI_15950  sulfate ABC transporter, permease protein CysT [KO:K02046]
ROI_15960  sulfate ABC transporter, permease protein CysW [KO:K02047]
ROI_15970  sulfate ABC transporter, ATP-binding protein [KO:K02045] [EC:7.3.2.3]
ROI_02570  molybdenum ABC transporter, periplasmic molybdate-binding protein [KO:K02020]
ROI_02580  molybdate ABC transporter, permease protein [KO:K02018]
ROI_02590  ABC-type sulfate/molybdate transport systems, ATPase component [KO:K02017] [EC:7.3.2.5]
ROI_06290  ABC-type Fe3+ transport system, periplasmic component [KO:K02012]
ROI_06310  ABC-type Fe3+ transport system, permease component [KO:K02011]
ROI_06300  ABC-type spermidine/putrescine transport systems, ATPase components [KO:K02010] [EC:7.2.2.7]
ROI_24980  Spermidine/putrescine-binding periplasmic protein [KO:K11069 K11070]
ROI_24970  ABC-type spermidine/putrescine transport system, permease component II [KO:K11070]
ROI_24960  ABC-type spermidine/putrescine transport system, permease component I [KO:K11071]
ROI_24950  spermidine/putrescine ABC transporter ATP-binding subunit [KO:K11072] [EC:7.6.2.11]
ROI_11300  carbohydrate ABC transporter ATP-binding protein, CUT1 family (TC 3.A.1.1.-) [KO:K10112] [EC:7.5.2.-]
ROI_37920  Maltose-binding periplasmic proteins/domains [KO:K15770]
ROI_17950  hypothetical protein [KO:K15770]
ROI_20720  carbohydrate ABC transporter substrate-binding protein, CUT1 family (TC 3.A.1.1.-) [KO:K15770]
ROI_37930  carbohydrate ABC transporter membrane protein 1, CUT1 family (TC 3.A.1.1.-) [KO:K15771]
ROI_37940  carbohydrate ABC transporter membrane protein 2, CUT1 family (TC 3.A.1.1.-) [KO:K15772]
ROI_03520  carbohydrate ABC transporter membrane protein 2, CUT1 family (TC 3.A.1.1.-) [KO:K15772]
ROI_36300  carbohydrate ABC transporter substrate-binding protein, CUT1 family (TC 3.A.1.1.-) [KO:K10117]
ROI_36310  carbohydrate ABC transporter membrane protein 1, CUT1 family (TC 3.A.1.1.-) [KO:K10118]
ROI_36320  carbohydrate ABC transporter membrane protein 2, CUT1 family (TC 3.A.1.1.-) [KO:K10119]
ROI_24310  carbohydrate ABC transporter substrate-binding protein, CUT1 family (TC 3.A.1.1.-) [KO:K10188]
ROI_24300  carbohydrate ABC transporter membrane protein 1, CUT1 family (TC 3.A.1.1.-) [KO:K10189]
ROI_38310  carbohydrate ABC transporter membrane protein 2, CUT1 family (TC 3.A.1.1.-) [KO:K10190]
ROI_32890  hypothetical protein [KO:K17318]
ROI_24780  carbohydrate ABC transporter substrate-binding protein, CUT1 family (TC 3.A.1.1.-) [KO:K17318]
ROI_06470  ABC-type sugar transport system, periplasmic component [KO:K17318]
ROI_23970  ABC-type sugar transport system, periplasmic component [KO:K17318]
ROI_24720  ABC-type sugar transport system, periplasmic component [KO:K17318]
ROI_37820  carbohydrate ABC transporter substrate-binding protein, CUT1 family (TC 3.A.1.1.-) [KO:K17318]
ROI_10000  ABC-type sugar transport system, periplasmic component [KO:K17318]
ROI_32870  carbohydrate ABC transporter membrane protein 1, CUT1 family (TC 3.A.1.1.-) [KO:K17319]
ROI_24800  carbohydrate ABC transporter membrane protein 1, CUT1 family (TC 3.A.1.1.-) [KO:K17319]
ROI_06480  ABC-type polysaccharide transport system, permease component [KO:K17319]
ROI_23950  ABC-type polysaccharide transport system, permease component [KO:K17319]
ROI_37830  carbohydrate ABC transporter membrane protein 1, CUT1 family (TC 3.A.1.1.-) [KO:K17319]
ROI_32880  carbohydrate ABC transporter membrane protein 2, CUT1 family (TC 3.A.1.1.-) [KO:K17320]
ROI_24790  carbohydrate ABC transporter membrane protein 2, CUT1 family (TC 3.A.1.1.-) [KO:K17320]
ROI_37840  carbohydrate ABC transporter membrane protein 2, CUT1 family (TC 3.A.1.1.-) [KO:K17320]
ROI_06490  carbohydrate ABC transporter membrane protein 2, CUT1 family (TC 3.A.1.1.-) [KO:K17320]
ROI_23940  carbohydrate ABC transporter membrane protein 2, CUT1 family (TC 3.A.1.1.-) [KO:K17320]
ROI_29150  hypothetical protein [KO:K10240]
ROI_20430  hypothetical protein [KO:K10240]
ROI_29160  carbohydrate ABC transporter membrane protein 1, CUT1 family (TC 3.A.1.1.-) [KO:K10241]
ROI_20440  carbohydrate ABC transporter membrane protein 1, CUT1 family (TC 3.A.1.1.-) [KO:K10241]
ROI_29170  carbohydrate ABC transporter membrane protein 2, CUT1 family (TC 3.A.1.1.-) [KO:K10242]
ROI_20450  carbohydrate ABC transporter membrane protein 2, CUT1 family (TC 3.A.1.1.-) [KO:K10242]
ROI_16870  carbohydrate ABC transporter substrate-binding protein, CUT1 family (TC 3.A.1.1.-) [KO:K17234]
ROI_16880  carbohydrate ABC transporter membrane protein 1, CUT1 family (TC 3.A.1.1.-) [KO:K17235]
ROI_16890  carbohydrate ABC transporter membrane protein 2, CUT1 family (TC 3.A.1.1.-) [KO:K17236]
ROI_10980  nucleoside-binding protein [KO:K07335]
ROI_11000  nucleoside ABC transporter membrane protein [KO:K23535]
ROI_11010  nucleoside ABC transporter membrane protein [KO:K23536]
ROI_11790  monosaccharide ABC transporter substrate-binding protein, CUT2 family (TC 3.A.1.2.-) [KO:K23508]
ROI_11830  monosaccharide ABC transporter substrate-binding protein, CUT2 family (TC 3.A.1.2.-) [KO:K23508]
ROI_11820  monosaccharide ABC transporter membrane protein, CUT2 family (TC 3.A.1.2.-) [KO:K23509]
ROI_11810  monosaccharide ABC transporter membrane protein, CUT2 family (TC 3.A.1.2.-) [KO:K23509]
ROI_11800  monosaccharide ABC transporter ATP-binding protein, CUT2 family (TC 3.A.1.2.-) [KO:K10820] [EC:7.5.2.9]
ROI_36070  monosaccharide ABC transporter substrate-binding protein, CUT2 family (TC 3.A.1.2.-) [KO:K10540]
ROI_36000  monosaccharide ABC transporter substrate-binding protein, CUT2 family (TC 3.A.1.2.-) [KO:K10540]
ROI_36020  monosaccharide ABC transporter membrane protein, CUT2 family (TC 3.A.1.2.-) [KO:K10541]
ROI_36010  monosaccharide ABC transporter ATP-binding protein, CUT2 family (TC 3.A.1.2.-) [KO:K10542] [EC:7.5.2.11]
ROI_40350  phosphate ABC transporter substrate-binding protein, PhoT family (TC 3.A.1.7.1) [KO:K02040]
ROI_40360  phosphate ABC transporter membrane protein 1, PhoT family (TC 3.A.1.7.1) [KO:K02037]
ROI_40370  phosphate ABC transporter membrane protein 2, PhoT family (TC 3.A.1.7.1) [KO:K02038]
ROI_40380  phosphate ABC transporter ATP-binding protein, PhoT family (TC 3.A.1.7.1) [KO:K02036] [EC:7.3.2.1]
ROI_34420  phosphate/phosphite/phosphonate ABC transporters, periplasmic binding protein [KO:K02044]
ROI_34440  phosphonate ABC transporter, permease protein PhnE [KO:K02042]
ROI_34450  phosphonate ABC transporter, permease protein PhnE [KO:K02042]
ROI_34430  phosphonate ABC transporter, ATP-binding protein [KO:K02041] [EC:7.3.2.2]
ROI_01220  ABC-type amino acid transport/signal transduction systems, periplasmic component/domain [KO:K02424]
ROI_01210  amino acid ABC transporter membrane protein, PAAT family (TC 3.A.1.3.-) [KO:K10009]
ROI_01200  ABC-type polar amino acid transport system, ATPase component [KO:K10010] [EC:7.4.2.1]
ROI_10780  amine acid ABC transporter, permease protein, 3-TM region, His/Glu/Gln/Arg/opine family [KO:K17077 K23059]
ROI_10800  amino acid ABC transporter ATP-binding protein, PAAT family (TC 3.A.1.3.-) [KO:K23060] [EC:7.4.2.1]
ROI_07850  amino acid/amide ABC transporter substrate-binding protein, HAAT family (TC 3.A.1.4.-) [KO:K01999]
ROI_07860  amino acid/amide ABC transporter membrane protein 1, HAAT family (TC 3.A.1.4.-) [KO:K01997]
ROI_07870  amino acid/amide ABC transporter membrane protein 2, HAAT family (TC 3.A.1.4.-) [KO:K01998]
ROI_07880  amino acid/amide ABC transporter ATP-binding protein 1, HAAT family (TC 3.A.1.4.-) [KO:K01995]
ROI_07890  amino acid/amide ABC transporter ATP-binding protein 2, HAAT family (TC 3.A.1.4.-) [KO:K01996]
ROI_03930  ABC-type metal ion transport system, periplasmic component/surface antigen [KO:K02073]
ROI_03920  ABC-type metal ion transport system, permease component [KO:K02072]
ROI_03910  ABC-type metal ion transport system, ATPase component [KO:K02071]
ROI_06670  ABC-type oligopeptide transport system, periplasmic component [KO:K15580]
ROI_06690  ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [KO:K15582]
ROI_06700  oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain [KO:K15583]
ROI_06710  ATPase components of various ABC-type transport systems, contain duplicated ATPase [KO:K10823]
ROI_07710  ABC-type Co2+ transport system, permease component [KO:K02007]
ROI_07730  ABC-type cobalt transport system, ATPase component [KO:K02006]
ROI_40190  Uncharacterized conserved protein [KO:K03523]
ROI_26800  Uncharacterized conserved protein [KO:K03523]
ROI_16330  ABC-type cobalt transport system, permease component CbiQ and related transporters [KO:K16785]
ROI_16300  ABC-type cobalt transport system, ATPase component [KO:K16786] [EC:7.-.-.-]
ROI_16320  ABC-type cobalt transport system, ATPase component [KO:K16787] [EC:7.-.-.-]
ROI_04770  ABC-type polysaccharide/polyol phosphate export systems, permease component [KO:K09690]
ROI_04980  ABC-type polysaccharide/polyol phosphate export systems, permease component [KO:K09690]
ROI_04990  ABC-type polysaccharide/polyol phosphate transport system, ATPase component [KO:K09691] [EC:7.5.2.14]
ROI_04780  ABC-type polysaccharide/polyol phosphate transport system, ATPase component [KO:K09691] [EC:7.5.2.14]
ROI_04460  ABC-type polysaccharide/polyol phosphate export systems, permease component [KO:K09692]
ROI_04470  ABC-type polysaccharide/polyol phosphate transport system, ATPase component [KO:K09693] [EC:7.5.2.4]
ROI_08700  ABC-2 type transporter. [KO:K09696]
ROI_08690  ABC-type multidrug transport system, ATPase component [KO:K09697] [EC:7.2.2.4]
ROI_39480  Uncharacterized protein conserved in bacteria [KO:K20460]
ROI_39490  Uncharacterized protein conserved in bacteria [KO:K20461]
ROI_39470  ABC-type multidrug transport system, ATPase component [KO:K20459]
ROI_06040  hypothetical protein [KO:K20491]
ROI_06050  hypothetical protein [KO:K20492]
ROI_06030  ABC-type multidrug transport system, ATPase component [KO:K20490]
ROI_34950  Predicted permease. [KO:K19084]
ROI_34940  ABC-type antimicrobial peptide transport system, ATPase component [KO:K19083]
ROI_30450  cell division protein FtsX [KO:K09811]
ROI_30440  cell division ATP-binding protein FtsE [KO:K09812]
ROI_11210  hypothetical protein [KO:K16919]
ROI_11200  ABC-type multidrug transport system, ATPase component [KO:K16921]
ROI_28980  ABC-type multidrug transport system, ATPase and permease components [KO:K18889]
ROI_19620  ABC-type multidrug transport system, ATPase and permease components [KO:K18889]
ROI_27300  ABC-type multidrug transport system, ATPase and permease components [KO:K18889]
ROI_19640  ABC-type multidrug transport system, ATPase and permease components [KO:K18890]
ROI_28990  ABC-type multidrug transport system, ATPase and permease components [KO:K18890]
ROI_27290  ABC-type multidrug transport system, ATPase and permease components [KO:K18890]
ROI_25240  ABC-type multidrug transport system, ATPase and permease components [KO:K18887]
ROI_28480  ABC-type multidrug transport system, ATPase and permease components [KO:K18887]
ROI_06420  ABC-type multidrug transport system, ATPase and permease components [KO:K18887]
ROI_38450  ABC-type multidrug transport system, ATPase and permease components [KO:K18887]
ROI_38460  ABC-type multidrug transport system, ATPase and permease components [KO:K18888]
ROI_28490  ABC-type multidrug transport system, ATPase and permease components [KO:K18888]
ROI_06430  ABC-type multidrug transport system, ATPase and permease components [KO:K18888]
ROI_25230  ABC-type multidrug transport system, ATPase and permease components [KO:K18888]
Compound
C00009  Orthophosphate
C00025  L-Glutamate
C00031  D-Glucose
C00032  Heme
C00034  Manganese
C00037  Glycine
C00038  Zinc cation
C00041  L-Alanine
C00047  L-Lysine
C00049  L-Aspartate
C00051  Glutathione
C00059  Sulfate
C00062  L-Arginine
C00064  L-Glutamine
C00065  L-Serine
C00070  Copper
C00077  L-Ornithine
C00079  L-Phenylalanine
C00086  Urea
C00088  Nitrite
C00089  Sucrose
C00093  sn-Glycerol 3-phosphate
C00095  D-Fructose
C00098  Oligopeptide
C00107  Dipeptide
C00114  Choline
C00116  Glycerol
C00120  Biotin
C00121  D-Ribose
C00123  L-Leucine
C00134  Putrescine
C00135  L-Histidine
C00137  myo-Inositol
C00140  N-Acetyl-D-glucosamine
C00148  L-Proline
C00151  L-Amino acid
C00159  D-Mannose
C00175  Cobalt ion
C00181  D-Xylose
C00183  L-Valine
C00185  Cellobiose
C00188  L-Threonine
C00208  Maltose
C00212  Adenosine
C00243  Lactose
C00244  Nitrate
C00245  Taurine
C00255  Riboflavin
C00259  L-Arabinose
C00288  HCO3-
C00291  Nickel
C00294  Inosine
C00299  Uridine
C00315  Spermidine
C00320  Thiosulfate
C00330  Deoxyguanosine
C00333  D-Galacturonate
C00338  Lipopolysaccharide
C00378  Thiamine
C00379  Xylitol
C00387  Guanosine
C00392  Mannitol
C00407  L-Isoleucine
C00430  5-Aminolevulinate
C00470  Pectate
C00475  Cytidine
C00487  Carnitine
C00491  L-Cystine
C00492  Raffinose
C00503  Erythritol
C00526  Deoxyuridine
C00559  Deoxyadenosine
C00719  Betaine
C00794  D-Sorbitol
C00855  D-Methionine
C00865  Phospholipid
C00881  Deoxycytidine
C00919  Choline sulfate
C00973  Cyclomaltodextrin
C01083  alpha,alpha-Trehalose
C01153  Orthophosphoric monoester
C01157  Hydroxyproline
C01177  Inositol 1-phosphate
C01181  4-Trimethylammoniobutanoate
C01279  4-Amino-5-hydroxymethyl-2-methylpyrimidine
C01330  Sodium cation
C01417  Cyanate
C01487  D-Allose
C01606  Phthalate
C01630  Xylobiose
C01667  Bacitracin
C01674  Chitobiose
C01682  Nopaline
C01684  D-Rhamnose
C01762  Xanthosine
C01834  Lipoprotein
C01835  Maltotriose
C01935  Maltodextrin
C01946  Oleandomycin
C02160  Isomaltotriose
C02273  Digalacturonate
C03557  2-Aminoethylphosphonate
C03611  Galactose oligosaccharide
C03619  Methyl beta-D-galactoside
C04114  (E)-4-(Trimethylammonio)but-2-enoate
C04137  Octopine
C05349  Ciprofloxacin
C05402  Melibiose
C05512  Deoxyinosine
C05776  Vitamin B12
C06227  Fe(III)hydroxamate
C06229  Fe(III)dicitrate
C06230  Fe-enterobactin
C06232  Molybdate
C06687  Norfloxacin
C06705  Capsular polysaccharide
C06706  Lipo-oligosaccharide
C06707  Teichoic acid
C06767  Hemine
C07662  Sparfloxacin
C07663  Moxifloxacin
C11612  Polymyxin B
C13768  Colistin sulfate
C14818  Fe2+
C14819  Fe3+
C15521  Alkanesulfonate
C15719  Coelichelin
C16421  AI-2
C16692  Mannopine
C19609  Nickel(2+)
C19872  N-Formyl-4-amino-5-aminomethyl-2-methylpyrimidine
C20570  alpha-1,5-L-Arabinobiose
C20571  alpha-1,5-L-Arabinotriose
C20572  alpha-1,5-L-Arabinotetraose
C20573  Aldotetraouronic acid
C20679  Tungstate
C21066  D-Galactofuranose
C22040  S-Methyl-L-cysteine
G00457  Maltotetraose
Reference
PMID:9799792
  Authors
Tomii K, Kanehisa M.
  Title
A comparative analysis of ABC transporters in complete microbial genomes.
  Journal
Genome Res 8:1048-59 (1998)
DOI:10.1101/gr.8.10.1048
Reference
PMID:18424520
  Authors
Sperandeo P, Lau FK, Carpentieri A, De Castro C, Molinaro A, Deho G, Silhavy TJ, Polissi A
  Title
Functional analysis of the protein machinery required for transport of lipopolysaccharide to the outer membrane of Escherichia coli.
  Journal
J Bacteriol 190:4460-9 (2008)
DOI:10.1128/JB.00270-08
Reference
PMID:18375759
  Authors
Ruiz N, Gronenberg LS, Kahne D, Silhavy TJ
  Title
Identification of two inner-membrane proteins required for the transport of lipopolysaccharide to the outer membrane of Escherichia coli.
  Journal
Proc Natl Acad Sci U S A 105:5537-42 (2008)
DOI:10.1073/pnas.0801196105
Reference
PMID:10557362
  Authors
Omata T, Price GD, Badger MR, Okamura M, Gohta S, Ogawa T
  Title
Identification of an ATP-binding cassette transporter involved in bicarbonate uptake in the cyanobacterium Synechococcus sp. strain PCC 7942.
  Journal
Proc Natl Acad Sci U S A 96:13571-6 (1999)
DOI:10.1073/pnas.96.23.13571
Reference
PMID:11731493
  Authors
Quintero MJ, Montesinos ML, Herrero A, Flores E
  Title
Identification of genes encoding amino acid permeases by inactivation of selected ORFs from the Synechocystis genomic sequence.
  Journal
Genome Res 11:2034-40 (2001)
DOI:10.1101/gr.196301
Reference
PMID:16135226
  Authors
Picossi S, Montesinos ML, Pernil R, Lichtle C, Herrero A, Flores E
  Title
ABC-type neutral amino acid permease N-I is required for optimal diazotrophic growth and is repressed in the heterocysts of Anabaena sp. strain PCC 7120.
  Journal
Mol Microbiol 57:1582-92 (2005)
DOI:10.1111/j.1365-2958.2005.04791.x
Reference
PMID:11929526
  Authors
Valladares A, Montesinos ML, Herrero A, Flores E.
  Title
An ABC-type, high-affinity urea permease identified in cyanobacteria.
  Journal
Mol Microbiol 43:703-15 (2002)
DOI:10.1046/j.1365-2958.2002.02778.x
Reference
PMID:18326572
  Authors
Richard-Fogal CL, Frawley ER, Kranz RG
  Title
Topology and function of CcmD in cytochrome c maturation.
  Journal
J Bacteriol 190:3489-93 (2008)
DOI:10.1128/JB.00146-08
Reference
PMID:16109926
  Authors
Suzuki H, Koyanagi T, Izuka S, Onishi A, Kumagai H
  Title
The yliA, -B, -C, and -D genes of Escherichia coli K-12 encode a novel glutathione importer with an ATP-binding cassette.
  Journal
J Bacteriol 187:5861-7 (2005)
DOI:10.1128/JB.187.17.5861-5867.2005
Reference
PMID:17873039
  Authors
Novikova M, Metlitskaya A, Datsenko K, Kazakov T, Kazakov A, Wanner B, Severinov K
  Title
The Escherichia coli Yej transporter is required for the uptake of translation inhibitor microcin C.
  Journal
J Bacteriol 189:8361-5 (2007)
DOI:10.1128/JB.01028-07
Reference
PMID:17214741
  Authors
Tikhonova EB, Devroy VK, Lau SY, Zgurskaya HI
  Title
Reconstitution of the Escherichia coli macrolide transporter: the periplasmic membrane fusion protein MacA stimulates the ATPase activity of MacB.
  Journal
Mol Microbiol 63:895-910 (2007)
DOI:10.1111/j.1365-2958.2006.05549.x
Reference
PMID:18805970
  Authors
Yamanaka H, Kobayashi H, Takahashi E, Okamoto K
  Title
MacAB is involved in the secretion of Escherichia coli heat-stable enterotoxin II.
  Journal
J Bacteriol 190:7693-8 (2008)
DOI:10.1128/JB.00853-08
KO pathway
ko02010   
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