KEGG   PATHWAY: rtg00260
Entry
rtg00260                    Pathway                                
Name
Glycine, serine and threonine metabolism - Raoultella terrigena
Description
Serine is derived from 3-phospho-D-glycerate, an intermediate of glycolysis [MD:M00020], and glycine is derived from serine. Threonine is an essential amino acid, which animals cannot synthesize. In bacteria and plants, threonine is derived from aspartate [MD:M00018].
Class
Metabolism; Amino acid metabolism
Pathway map
rtg00260  Glycine, serine and threonine metabolism
rtg00260

Module
rtg_M00020  Serine biosynthesis, glycerate-3P => serine [PATH:rtg00260]
rtg_M00621  Glycine cleavage system [PATH:rtg00260]
Other DBs
GO: 0006544 0006563 0070178 0006566
Organism
Raoultella terrigena [GN:rtg]
Gene
NCTC13098_06882  lysC_2; Lysine-sensitive aspartokinase 3 [KO:K00928] [EC:2.7.2.4]
NCTC13098_06326  thrA; Aspartokinase I/homoserine dehydrogenase I [KO:K12524] [EC:2.7.2.4 1.1.1.3]
NCTC13098_07097  metL; Aspartokinase II/homoserine dehydrogenase II [KO:K12525] [EC:2.7.2.4 1.1.1.3]
NCTC13098_00400  asd; Aspartate-semialdehyde dehydrogenase [KO:K00133] [EC:1.2.1.11]
NCTC13098_06325  thrB; Homoserine kinase [KO:K00872] [EC:2.7.1.39]
NCTC13098_05090  ltaE; Low specificity L-threonine aldolase [KO:K01620] [EC:4.1.2.48]
NCTC13098_01729  glyA; Pyridoxal-phosphate-dependent serine hydroxymethyltransferase [KO:K00600] [EC:2.1.2.1]
NCTC13098_01617  ghrA_1; Glyoxylate/hydroxypyruvate reductase A [KO:K12972] [EC:1.1.1.79 1.1.1.81]
NCTC13098_04495  ghrA_2; Glyoxylate/hydroxypyruvate reductase A [KO:K12972] [EC:1.1.1.79 1.1.1.81]
NCTC13098_00226  ghrB_1; Glyoxylate/hydroxypyruvate reductase B [KO:K00090] [EC:1.1.1.79 1.1.1.81 1.1.1.215]
NCTC13098_00763  glxK_1; Glycerate kinase [KO:K00865] [EC:2.7.1.165]
NCTC13098_04561  MOFRL family [KO:K11529] [EC:2.7.1.165]
NCTC13098_05260  gpmA; 2,3-bisphosphoglycerate-dependent phosphoglycerate mutase [KO:K01834] [EC:5.4.2.11]
NCTC13098_06336  cobC_3; Alpha-ribazole phosphatase [KO:K15634] [EC:5.4.2.11]
NCTC13098_00154  gpmI; 2,3-bisphosphoglycerate-independent phosphoglycerate mutase [KO:K15633] [EC:5.4.2.12]
NCTC13098_05402  Putative 2-hydroxyacid dehydrogenase HI_1556 [KO:K00058] [EC:1.1.1.95 1.1.1.399]
NCTC13098_01047  serA; D-3-phosphoglycerate dehydrogenase [KO:K00058] [EC:1.1.1.95 1.1.1.399]
NCTC13098_05041  serC_1; Phosphoserine aminotransferase [KO:K00831] [EC:2.6.1.52]
NCTC13098_06349  serB; Phosphoserine phosphatase [KO:K01079] [EC:3.1.3.3]
NCTC13098_03464  ydfG_2; NADP-dependent 3-hydroxy acid dehydrogenase YdfG [KO:K16066] [EC:1.1.1.381 1.1.1.-]
NCTC13098_00149  kbl; 2-amino-3-ketobutyrate coenzyme A ligase [KO:K00639] [EC:2.3.1.29]
NCTC13098_00150  tdh_1; L-threonine 3-dehydrogenase [KO:K00060] [EC:1.1.1.103]
NCTC13098_04029  maoA; Primary amine oxidase precursor [KO:K00276] [EC:1.4.3.21]
NCTC13098_01062  gcvP_2; Glycine dehydrogenase [decarboxylating] [KO:K00281] [EC:1.4.4.2]
NCTC13098_01059  gcvT; Aminomethyltransferase [KO:K00605] [EC:2.1.2.10]
NCTC13098_06164  lpdA; Dihydrolipoyl dehydrogenase [KO:K00382] [EC:1.8.1.4]
NCTC13098_01060  gcvH; Glycine cleavage system H protein [KO:K02437]
NCTC13098_04904  Creatinase [KO:K08688] [EC:3.5.3.3]
NCTC13098_01685  pssA; CDP-diacylglycerol--serine O-phosphatidyltransferase [KO:K00998] [EC:2.7.8.8]
NCTC13098_00955  metC_3; Cystathionine beta-lyase [KO:K01758] [EC:4.4.1.1]
NCTC13098_03206  metC_4; Cystathionine beta-lyase [KO:K01758] [EC:4.4.1.1]
NCTC13098_02785  sdaA_1; L-serine dehydratase 1 [KO:K01752] [EC:4.3.1.17]
NCTC13098_07057  ilvA; L-threonine dehydratase biosynthetic IlvA [KO:K01754] [EC:4.3.1.19]
NCTC13098_06398  D-threonine aldolase [KO:K01753] [EC:4.3.1.18]
NCTC13098_00025  dsdA; D-serine dehydratase [KO:K01753] [EC:4.3.1.18]
NCTC13098_01264  ygeA; putative racemase [KO:K25316] [EC:5.1.1.10]
NCTC13098_04169  trpA; Tryptophan synthase alpha chain [KO:K01695] [EC:4.2.1.20]
NCTC13098_04168  trpB; Tryptophan synthase beta chain [KO:K01696] [EC:4.2.1.20]
NCTC13098_03726  dat; Diaminobutyrate--2-oxoglutarate aminotransferase [KO:K00836] [EC:2.6.1.76]
NCTC13098_03727  ddc; L-2,4-diaminobutyrate decarboxylase [KO:K13745] [EC:4.1.1.86]
Compound
C00011  CO2
C00014  Ammonia
C00022  Pyruvate
C00037  Glycine
C00048  Glyoxylate
C00049  L-Aspartate
C00065  L-Serine
C00078  L-Tryptophan
C00097  L-Cysteine
C00101  Tetrahydrofolate
C00109  2-Oxobutanoate
C00114  Choline
C00143  5,10-Methylenetetrahydrofolate
C00168  Hydroxypyruvate
C00188  L-Threonine
C00197  3-Phospho-D-glycerate
C00213  Sarcosine
C00258  D-Glycerate
C00263  L-Homoserine
C00300  Creatine
C00430  5-Aminolevulinate
C00441  L-Aspartate 4-semialdehyde
C00546  Methylglyoxal
C00576  Betaine aldehyde
C00581  Guanidinoacetate
C00631  2-Phospho-D-glycerate
C00719  Betaine
C00740  D-Serine
C00986  1,3-Diaminopropane
C01005  O-Phospho-L-serine
C01026  N,N-Dimethylglycine
C01102  O-Phospho-L-homoserine
C01242  [Protein]-S8-aminomethyldihydrolipoyllysine
C01888  Aminoacetone
C02051  Lipoylprotein
C02291  L-Cystathionine
C02737  Phosphatidylserine
C02972  Dihydrolipoylprotein
C03082  4-Phospho-L-aspartate
C03194  (R)-1-Aminopropan-2-ol
C03232  3-Phosphonooxypyruvate
C03283  L-2,4-Diaminobutanoate
C03508  L-2-Amino-3-oxobutanoic acid
C05519  L-Allothreonine
C06231  Ectoine
C06442  N(gamma)-Acetyldiaminobutyrate
C16432  5-Hydroxyectoine
C19929  N(alpha)-Acetyl-L-2,4-diaminobutyrate
Reference
  Authors
Nishizuka Y, Seyama Y, Ikai A, Ishimura Y, Kawaguchi A (eds).
  Title
[Cellular Functions and Metabolic Maps] (In Japanese)
  Journal
Tokyo Kagaku Dojin (1997)
Reference
PMID:11823218
  Authors
Kuhlmann AU, Bremer E.
  Title
Osmotically regulated synthesis of the compatible solute ectoine in Bacillus pasteurii and related Bacillus spp.
  Journal
Appl Environ Microbiol 68:772-83 (2002)
DOI:10.1128/AEM.68.2.772-783.2002
Reference
PMID:10473374
  Authors
Canovas D, Borges N, Vargas C, Ventosa A, Nieto JJ, Santos H.
  Title
Role of Ngamma-acetyldiaminobutyrate as an enzyme stabilizer and an intermediate in the biosynthesis of hydroxyectoine.
  Journal
Appl Environ Microbiol 65:3774-9 (1999)
DOI:10.1128/AEM.65.9.3774-3779.1999
Reference
PMID:17636255
  Authors
Bursy J, Pierik AJ, Pica N, Bremer E.
  Title
Osmotically induced synthesis of the compatible solute hydroxyectoine is mediated by an evolutionarily conserved ectoine hydroxylase.
  Journal
J Biol Chem 282:31147-55 (2007)
DOI:10.1074/jbc.M704023200
Reference
PMID:16707670
  Authors
Garcia-Estepa R, Argandona M, Reina-Bueno M, Capote N, Iglesias-Guerra F, Nieto JJ, Vargas C.
  Title
The ectD gene, which is involved in the synthesis of the compatible solute hydroxyectoine, is essential for thermoprotection of the halophilic bacterium Chromohalobacter salexigens.
  Journal
J Bacteriol 188:3774-84 (2006)
DOI:10.1128/JB.00136-06
Reference
PMID:15470257
  Authors
Arevalo-Rodriguez M, Pan X, Boeke JD, Heitman J
  Title
FKBP12 controls aspartate pathway flux in Saccharomyces cerevisiae to prevent toxic intermediate accumulation.
  Journal
Eukaryot Cell 3:1287-96 (2004)
DOI:10.1128/EC.3.5.1287-1296.2004
Reference
PMID:7639721
  Authors
Rees WD, Hay SM
  Title
The biosynthesis of threonine by mammalian cells: expression of a complete bacterial biosynthetic pathway in an animal cell.
  Journal
Biochem J 309 ( Pt 3):999-1007 (1995)
DOI:10.1042/bj3090999
Reference
PMID:11341914
  Authors
Jacques SL, Nieman C, Bareich D, Broadhead G, Kinach R, Honek JF, Wright GD
  Title
Characterization of yeast homoserine dehydrogenase, an antifungal target: the invariant histidine 309 is important for enzyme integrity.
  Journal
Biochim Biophys Acta 1544:28-41 (2001)
DOI:10.1016/S0167-4838(00)00203-X
Reference
PMID:15520012
  Authors
Chen X, Jhee KH, Kruger WD
  Title
Production of the neuromodulator H2S by cystathionine beta-synthase via the condensation of cysteine and homocysteine.
  Journal
J Biol Chem 279:52082-6 (2004)
DOI:10.1074/jbc.C400481200
Related
pathway
rtg00010  Glycolysis / Gluconeogenesis
rtg00020  Citrate cycle (TCA cycle)
rtg00230  Purine metabolism
rtg00250  Alanine, aspartate and glutamate metabolism
rtg00270  Cysteine and methionine metabolism
rtg00290  Valine, leucine and isoleucine biosynthesis
rtg00300  Lysine biosynthesis
rtg00330  Arginine and proline metabolism
rtg00460  Cyanoamino acid metabolism
rtg00470  D-Amino acid metabolism
rtg00564  Glycerophospholipid metabolism
rtg00600  Sphingolipid metabolism
rtg00620  Pyruvate metabolism
rtg00630  Glyoxylate and dicarboxylate metabolism
rtg00640  Propanoate metabolism
rtg00680  Methane metabolism
rtg00860  Porphyrin metabolism
rtg00920  Sulfur metabolism
KO pathway
ko00260   
LinkDB

DBGET integrated database retrieval system