KEGG   PATHWAY: sasa00983
Entry
sasa00983                   Pathway                                
Name
Drug metabolism - other enzymes - Salmo salar (Atlantic salmon)
Class
Metabolism; Xenobiotics biodegradation and metabolism
Pathway map
sasa00983  Drug metabolism - other enzymes
sasa00983

Organism
Salmo salar (Atlantic salmon) [GN:sasa]
Gene
106573384  hypoxanthine-guanine phosphoribosyltransferase-like [KO:K00760] [EC:2.4.2.8]
106561348  hypoxanthine-guanine phosphoribosyltransferase-like [KO:K00760] [EC:2.4.2.8]
106612046  hprt1; hypoxanthine phosphoribosyltransferase 1 [KO:K00760] [EC:2.4.2.8]
106609577  inosine-5'-monophosphate dehydrogenase 1a-like [KO:K00088] [EC:1.1.1.205]
106566785  inosine-5'-monophosphate dehydrogenase 2 [KO:K00088] [EC:1.1.1.205]
106573524  inosine-5'-monophosphate dehydrogenase 1b [KO:K00088] [EC:1.1.1.205]
106576497  inosine-5'-monophosphate dehydrogenase 2-like [KO:K00088] [EC:1.1.1.205]
106561215  inosine-5'-monophosphate dehydrogenase 1a [KO:K00088] [EC:1.1.1.205]
100306833  imdh1; Inosine-5-monophosphate dehydrogenase 1 [KO:K00088] [EC:1.1.1.205]
100196657  impdh2; inosine monophosphate dehydrogenase 2 [KO:K00088] [EC:1.1.1.205]
106613353  GMP synthase [glutamine-hydrolyzing]-like [KO:K01951] [EC:6.3.5.2]
106581456  GMP synthase [glutamine-hydrolyzing] [KO:K01951] [EC:6.3.5.2]
106570045  probable thiopurine S-methyltransferase [KO:K00569] [EC:2.1.1.67]
100196246  tpmt; Probable thiopurine S-methyltransferase [KO:K00569] [EC:2.1.1.67]
100380763  xdh; xanthine dehydrogenase [KO:K00106] [EC:1.17.1.4 1.17.3.2]
100196134  itpa; inosine triphosphatase [KO:K01519] [EC:3.6.1.66]
106561275  uncharacterized LOC106561275 [KO:K03927] [EC:3.1.1.1 3.1.1.84 3.1.1.56]
106569965  UDP-glucuronosyltransferase 2B20-like [KO:K00699] [EC:2.4.1.17]
106604038  UDP-glucuronosyltransferase 2C1-like [KO:K00699] [EC:2.4.1.17]
106604039  UDP-glucuronosyltransferase 2C1-like [KO:K00699] [EC:2.4.1.17]
106608682  UDP-glucuronosyltransferase 2A1-like [KO:K00699] [EC:2.4.1.17]
106568567  UDP-glucuronosyltransferase 2A1-like [KO:K00699] [EC:2.4.1.17]
106567102  UDP-glucuronosyltransferase 2A2-like [KO:K00699] [EC:2.4.1.17]
106567841  UDP-glucuronosyltransferase-like [KO:K00699] [EC:2.4.1.17]
106581797  UDP-glucuronosyltransferase-like [KO:K00699] [EC:2.4.1.17]
106593806  UDP-glucuronosyltransferase 1-1-like [KO:K00699] [EC:2.4.1.17]
106577690  UDP-glucuronosyltransferase 1-2-like [KO:K00699] [EC:2.4.1.17]
106580020  UDP-glucuronosyltransferase 2A2-like [KO:K00699] [EC:2.4.1.17]
100194842  ud2a2; UDP-glucuronosyltransferase 2A2 [KO:K00699] [EC:2.4.1.17]
106581954  UDP-glucuronosyltransferase-like [KO:K00699] [EC:2.4.1.17]
106581876  UDP-glucuronosyltransferase-like [KO:K00699] [EC:2.4.1.17]
106590122  UDP-glucuronosyltransferase 2A1-like [KO:K00699] [EC:2.4.1.17]
106603975  beta-glucuronidase-like [KO:K01195] [EC:3.2.1.31]
106567395  beta-glucuronidase-like [KO:K01195] [EC:3.2.1.31]
106608798  cytidine deaminase-like [KO:K01489] [EC:3.5.4.5]
106572574  cda; cytidine deaminase [KO:K01489] [EC:3.5.4.5]
106590862  cytidine deaminase-like [KO:K01489] [EC:3.5.4.5]
100286653  cdd; Cytidine deaminase [KO:K01489] [EC:3.5.4.5]
100195250  typh; Thymidine phosphorylase [KO:K00758] [EC:2.4.2.4]
106598776  dpyd; dihydropyrimidine dehydrogenase [KO:K00207] [EC:1.3.1.2]
106568897  dihydropyrimidine dehydrogenase [NADP(+)] [KO:K00207] [EC:1.3.1.2]
106578501  dihydropyrimidine dehydrogenase [NADP(+)]-like [KO:K00207] [EC:1.3.1.2]
100380817  dpys; dihydropyrimidinase [KO:K01464] [EC:3.5.2.2]
100286709  upb1; beta-ureidopropionase 1 [KO:K01431] [EC:3.5.1.6]
106581814  uridine phosphorylase 2-like [KO:K00757] [EC:2.4.2.3]
106586173  uridine phosphorylase 2-like [KO:K00757] [EC:2.4.2.3]
100196719  upp1; uridine phosphorylase 1 [KO:K00757] [EC:2.4.2.3]
106594171  uridine phosphorylase 1-like [KO:K00757] [EC:2.4.2.3]
106596151  uridine phosphorylase 1-like [KO:K00757] [EC:2.4.2.3]
106569943  uridine-cytidine kinase 1-like [KO:K00876] [EC:2.7.1.48]
106562869  uridine-cytidine kinase 1-like [KO:K00876] [EC:2.7.1.48]
106572454  uridine-cytidine kinase-like 1 [KO:K00876] [EC:2.7.1.48]
106560433  uridine-cytidine kinase 2-A-like [KO:K00876] [EC:2.7.1.48]
106566584  uckl1; uridine-cytidine kinase 1 like 1 [KO:K00876] [EC:2.7.1.48]
106569706  UCK2; uridine-cytidine kinase 2-B [KO:K00876] [EC:2.7.1.48]
106584056  UCK2; uridine-cytidine kinase 2-A [KO:K00876] [EC:2.7.1.48]
100380824  uckl1; uridine-cytidine kinase 1-like 1 [KO:K00876] [EC:2.7.1.48]
100195700  uck2; Uridine-cytidine kinase 2 [KO:K00876] [EC:2.7.1.48]
106591566  thymidine kinase, cytosolic-like [KO:K00857] [EC:2.7.1.21]
106561984  thymidine kinase 2, mitochondrial-like [KO:K00857] [EC:2.7.1.21]
106564352  thymidine kinase, cytosolic-like [KO:K00857] [EC:2.7.1.21]
106587284  thymidine kinase 2, mitochondrial-like [KO:K00857] [EC:2.7.1.21]
100196419  kith; Thymidine kinase, cytosolic [KO:K00857] [EC:2.7.1.21]
100380605  pyr5; Uridine 5-monophosphate synthase [KO:K13421] [EC:2.4.2.10 4.1.1.23]
106581832  uridine 5'-monophosphate synthase-like [KO:K13421] [EC:2.4.2.10 4.1.1.23]
106598849  UMP-CMP kinase-like [KO:K13800] [EC:2.7.4.14]
106568761  UMP-CMP kinase [KO:K13800] [EC:2.7.4.14]
106584236  UMP-CMP kinase-like [KO:K13800] [EC:2.7.4.14]
106596444  adenylate kinase isoenzyme 1-like [KO:K13800] [EC:2.7.4.14]
100195484  rir1; Ribonucleoside-diphosphate reductase large subunit [KO:K10807] [EC:1.17.4.1]
106567863  ribonucleoside-diphosphate reductase large subunit [KO:K10807] [EC:1.17.4.1]
106570792  ribonucleoside-diphosphate reductase subunit M2 B-like [KO:K10808] [EC:1.17.4.1]
100194994  rir2; Ribonucleoside-diphosphate reductase subunit M2 [KO:K10808] [EC:1.17.4.1]
106607664  rrm2; ribonucleotide reductase regulatory subunit M2 [KO:K10808] [EC:1.17.4.1]
106600677  nucleoside diphosphate kinase-like [KO:K00940] [EC:2.7.4.6]
106608324  nme6; NME/NM23 nucleoside diphosphate kinase 6 [KO:K00940] [EC:2.7.4.6]
106565719  nucleoside diphosphate kinase B-like [KO:K00940] [EC:2.7.4.6]
100196339  nme3; NME/NM23 nucleoside diphosphate kinase 3 [KO:K00940] [EC:2.7.4.6]
100194591  nme1; non-metastatic cells 1 protein [KO:K00940] [EC:2.7.4.6]
100196066  nme7; NME/NM23 family member 7 [KO:K00940] [EC:2.7.4.6]
100136353  NDKA; nucleoside diphosphate kinase [KO:K00940] [EC:2.7.4.6]
100196215  ndka; Nucleoside diphosphate kinase A [KO:K00940] [EC:2.7.4.6]
106589447  nucleoside diphosphate kinase A-like [KO:K00940] [EC:2.7.4.6]
106562484  dut; deoxyuridine triphosphatase [KO:K01520] [EC:3.6.1.23]
106562547  deoxyuridine 5'-triphosphate nucleotidohydrolase-like [KO:K01520] [EC:3.6.1.23]
100380666  perm; eosinophil peroxidase [KO:K10789] [EC:1.11.2.2]
106562381  ARY1; arylamine N-acetyltransferase, pineal gland isozyme NAT-10-like [KO:K00622] [EC:2.3.1.5]
106587573  ARY1; arylamine N-acetyltransferase, pineal gland isozyme NAT-10-like [KO:K00622] [EC:2.3.1.5]
106579764  MGST3; microsomal glutathione S-transferase 3-like [KO:K00799] [EC:2.5.1.18]
106600407  MGST3; microsomal glutathione S-transferase 3-like [KO:K00799] [EC:2.5.1.18]
106612563  glutathione S-transferase A2-like [KO:K00799] [EC:2.5.1.18]
106575060  microsomal glutathione S-transferase 1-like [KO:K00799] [EC:2.5.1.18]
106575061  microsomal glutathione S-transferase 1-like [KO:K00799] [EC:2.5.1.18]
106569406  MGST3; microsomal glutathione S-transferase 3-like [KO:K00799] [EC:2.5.1.18]
106570366  glutathione S-transferase A-like [KO:K00799] [EC:2.5.1.18]
106566372  glutathione S-transferase Mu 3-like [KO:K00799] [EC:2.5.1.18]
106562827  gstt2b; glutathione S-transferase theta 2B [KO:K00799] [EC:2.5.1.18]
106580120  GSTT1; glutathione S-transferase theta-1-like [KO:K00799] [EC:2.5.1.18]
100196463  gsta; Glutathione S-transferase A [KO:K00799] [EC:2.5.1.18]
100196443  gsto1; glutathione S-transferase omega 1 [KO:K00799] [EC:2.5.1.18]
100196430  mgst2; microsomal glutathione S-transferase 2 [KO:K00799] [EC:2.5.1.18]
106590880  microsomal glutathione S-transferase 1-like [KO:K00799] [EC:2.5.1.18]
106585460  GSTT1; glutathione S-transferase theta-1-like [KO:K00799] [EC:2.5.1.18]
100195726  gsta3; glutathione S-transferase alpha 3 [KO:K00799] [EC:2.5.1.18]
100136484  GSTP1; glutathione S-transferase P [KO:K23790] [EC:2.5.1.18]
106611535  GSTP1; glutathione S-transferase P-like [KO:K23790] [EC:2.5.1.18]
106611534  GSTP1; glutathione S-transferase P-like [KO:K23790] [EC:2.5.1.18]
Compound
C00003  NAD+
C00006  NADP+
C02320  R-S-Glutathione
C02380  6-Mercaptopurine
C04242  5-Fluorodeoxyuridine monophosphate
C04646  6-Thioinosine-5'-monophosphate
C05361  Hydrazine
C06108  Fluoroacetate
C06837  Azathioprine
C07054  Isoniazid
C07446  Isonicotinic acid
C07447  Acetylhydrazine
C07585  N-Acetylisoniazid
C07648  Thioguanine
C07649  5-FU
C11173  SN-38
C11376  SN38 glucuronide
C11736  5-Fluorodeoxyuridine
C12650  Capecitabine
C12673  Tegafur
C12739  5'-Deoxy-5-fluorouridine
C13252  Carmofur
C16542  APC
C16543  NPC
C16613  6-Thiourate
C16614  6-Methylmercaptopurine
C16615  6-Methylthiopurine 5'-monophosphate ribonucleotide
C16616  6-Mercaptopurine ribonucleoside 5'-diphosphate
C16617  6-Mercaptopurine ribonucleoside triphosphate
C16618  6-Thioxanthine 5'-monophosphate
C16619  6-Thioguanosine monophosphate
C16620  6-Methylthioguanosine monophosphate
C16621  1-Methyl-4-nitroimidazole
C16622  N,N'-Diacetylhydrazine
C16623  Isonicotinylglycine
C16624  Isoniazid pyruvate
C16625  Isoniazid alpha-ketoglutaric acid
C16630  5,6-Dihydro-5-fluorouracil
C16631  alpha-Fluoro-beta-ureidopropionic acid
C16632  alpha-Fluoro-beta-alanine
C16633  5-Fluorouridine
C16634  5-Fluorouridine monophosphate
C16635  5'-Deoxy-5-fluorocytidine
C16641  Irinotecan
C21748  5-Fluorouridine diphosphate
C21749  5-Fluorouridine triphosphate
C21750  5-Fluorodeoxyuridine diphosphate
C21751  5-Fluorodeoxyuridine triphosphate
C21754  Isonicotinoyl radical
C21758  Hepatotoxins
C21759  Isonicotinoyl-NAD adduct
C21760  Isonicotinoyl-NADP adduct
D00238  Azathioprine (JP18/USP/INN)
D00346  Isoniazid (JP18/USP/INN)
D00584  Fluorouracil (JP18/USP/INN)
D01223  Capecitabine (JAN/USP/INN)
D01244  Tegafur (JP18/USAN/INN)
D01309  Doxifluridine (JP18/INN)
D01784  Carmofur (JP18/INN)
D04197  Floxuridine (USP/INN)
D04931  Mercaptopurine (INN)
D08086  Irinotecan (INN)
D08603  Tioguanine (INN)
Reference
  Authors
Kato R, Kamatari T (eds).
  Title
[Drug Metabolism] (In Japanese)
  Journal
Tokyo Kagaku Dojin (2000)
Reference
  Authors
Al Hadithy AF, de Boer NK, Derijks LJ, Escher JC, Mulder CJ, Brouwers JR.
  Title
Thiopurines in inflammatory bowel disease: pharmacogenetics, therapeutic drug monitoring and clinical recommendations.
  Journal
Dig Liver Dis 37:282-97 (2005)
DOI:10.1016/j.dld.2004.09.029
Reference
  Authors
Gearry RB, Barclay ML.
  Title
Azathioprine and 6-mercaptopurine pharmacogenetics and metabolite monitoring in inflammatory bowel disease.
  Journal
J Gastroenterol Hepatol 20:1149-57 (2005)
DOI:10.1111/j.1440-1746.2005.03832.x
Reference
  Authors
Gilissen LP, Derijks LJ, Verhoeven HM, Bierau J, Hooymans PM, Hommes DW, Engels LG.
  Title
Pancytopenia due to high 6-methylmercaptopurine levels in a 6-mercaptopurine treated patient with Crohn's disease.
  Journal
Dig Liver Dis 39:182-6 (2007)
DOI:10.1016/j.dld.2006.05.026
Reference
  Authors
Fischel JL, Formento P, Ciccolini J, Etienne-Grimaldi MC, Milano G.
  Title
Lack of contribution of dihydrofluorouracil and alpha-fluoro-beta-alanine to the cytotoxicity of 5'-deoxy-5-fluorouridine on human keratinocytes.
  Journal
Anticancer Drugs 15:969-74 (2004)
DOI:10.1097/00001813-200411000-00006
Reference
  Authors
Shimma N, Umeda I, Arasaki M, Murasaki C, Masubuchi K, Kohchi Y, Miwa M, Ura M, Sawada N, Tahara H, Kuruma I, Horii I, Ishitsuka H.
  Title
The design and synthesis of a new tumor-selective fluoropyrimidine carbamate, capecitabine.
  Journal
Bioorg Med Chem 8:1697-706 (2000)
DOI:10.1016/S0968-0896(00)00087-0
Reference
  Authors
Chung YL, Troy H, Judson IR, Leek R, Leach MO, Stubbs M, Harris AL, Griffiths JR
  Title
Noninvasive measurements of capecitabine metabolism in bladder tumors overexpressing thymidine phosphorylase by fluorine-19 magnetic resonance spectroscopy.
  Journal
Clin Cancer Res 10:3863-70 (2004)
DOI:10.1158/1078-0432.CCR-03-0237
Reference
  Authors
Mathijssen RH, van Alphen RJ, Verweij J, Loos WJ, Nooter K, Stoter G, Sparreboom A
  Title
Clinical pharmacokinetics and metabolism of irinotecan (CPT-11).
  Journal
Clin Cancer Res 7:2182-94 (2001)
Reference
  Authors
Kita T, Tanigawara Y, Chikazawa S, Hatanaka H, Sakaeda T, Komada F, Iwakawa S, Okumura K.
  Title
N-Acetyltransferase2 genotype correlated with isoniazid acetylation in Japanese tuberculous patients.
  Journal
Biol Pharm Bull 24:544-9 (2001)
DOI:10.1248/bpb.24.544
Reference
  Authors
Miura K, Kinouchi M, Ishida K, Fujibuchi W, Naitoh T, Ogawa H, Ando T, Yazaki N, Watanabe K, Haneda S, Shibata C, Sasaki I
  Title
5-fu metabolism in cancer and orally-administrable 5-fu drugs.
  Journal
Cancers (Basel) 2:1717-30 (2010)
DOI:10.3390/cancers2031717
Reference
  Authors
Wang P, Pradhan K, Zhong XB, Ma X
  Title
Isoniazid metabolism and hepatotoxicity.
  Journal
Acta Pharm Sin B 6:384-392 (2016)
DOI:10.1016/j.apsb.2016.07.014
Reference
  Authors
Klein DJ, Boukouvala S, McDonagh EM, Shuldiner SR, Laurieri N, Thorn CF, Altman RB, Klein TE
  Title
PharmGKB summary: isoniazid pathway, pharmacokinetics.
  Journal
Pharmacogenet Genomics 26:436-44 (2016)
DOI:10.1097/FPC.0000000000000232
Reference
  Authors
Yamada S, Richardson K, Tang M, Halaschek-Wiener J, Cook VJ, Fitzgerald JM, Elwood K, Marra F, Brooks-Wilson A
  Title
Genetic variation in carboxylesterase genes and susceptibility to isoniazid-induced hepatotoxicity.
  Journal
Pharmacogenomics J 10:524-36 (2010)
DOI:10.1038/tpj.2010.5
Reference
  Authors
Vlasits J, Jakopitsch C, Bernroitner M, Zamocky M, Furtmuller PG, Obinger C
  Title
Mechanisms of catalase activity of heme peroxidases.
  Journal
Arch Biochem Biophys 500:74-81 (2010)
DOI:10.1016/j.abb.2010.04.018
Reference
  Authors
Khan SR, Morgan AG, Michail K, Srivastava N, Whittal RM, Aljuhani N, Siraki AG
  Title
Metabolism of isoniazid by neutrophil myeloperoxidase leads to isoniazid-NAD(+) adduct formation: A comparison of the reactivity of isoniazid with its known human metabolites.
  Journal
Biochem Pharmacol 106:46-55 (2016)
DOI:10.1016/j.bcp.2016.02.003
Reference
  Authors
Forbes LV, Furtmuller PG, Khalilova I, Turner R, Obinger C, Kettle AJ
  Title
Isoniazid as a substrate and inhibitor of myeloperoxidase: identification of amine adducts and the influence of superoxide dismutase on their formation.
  Journal
Biochem Pharmacol 84:949-60 (2012)
DOI:10.1016/j.bcp.2012.07.020
Reference
  Authors
Nguyen M, Quemard A, Broussy S, Bernadou J, Meunier B
  Title
Mn(III) pyrophosphate as an efficient tool for studying the mode of action of isoniazid on the InhA protein of Mycobacterium tuberculosis.
  Journal
Antimicrob Agents Chemother 46:2137-44 (2002)
DOI:10.1128/AAC.46.7.2137-2144.2002
Reference
PMID:9417034
  Authors
Rozwarski DA, Grant GA, Barton DH, Jacobs WR Jr, Sacchettini JC
  Title
Modification of the NADH of the isoniazid target (InhA) from Mycobacterium tuberculosis.
  Journal
Science 279:98-102 (1998)
DOI:10.1126/science.279.5347.98
Reference
  Authors
Argyrou A, Vetting MW, Blanchard JS
  Title
New insight into the mechanism of action of and resistance to isoniazid: interaction of Mycobacterium tuberculosis enoyl-ACP reductase with INH-NADP.
  Journal
J Am Chem Soc 129:9582-3 (2007)
DOI:10.1021/ja073160k
KO pathway
ko00983   
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