KEGG   PATHWAY: scan03013
Entry
scan03013                   Pathway                                
Name
Nucleocytoplasmic transport - Serinus canaria (common canary)
Description
The exchange of molecules between the nucleus and cytoplasm is mediated through nuclear pore complexes (NPCs) embedded in the nuclear envelope. The NPC is composed of highly conserved, distinct structural modules: the inner pore ring, the cytoplasmic and nuclear rings as well as the cytoplasmic filaments and the nuclear basket. Nuclear transport receptors (e.g. importins and exportins) mediate translocation of cargos through the NPC. Cargo proteins harbouring a nuclear export signal (NES) bind to exportins and Ran-GTP to form an export complex in the nucleoplasm. Nuclear export of bulk mRNA is provided by the non-karyopherin transport proteins TAP-p15 in a Ran-GTP-independent manner. Several EJC factors are known to function in mRNA export.
Class
Genetic Information Processing; Translation
Pathway map
scan03013  Nucleocytoplasmic transport
scan03013

Other DBs
GO: 0050658
Organism
Serinus canaria (common canary) [GN:scan]
Gene
103812880  nucleoporin NUP42-like [KO:K14321]
115485584  nucleoporin NUP42-like [KO:K14321]
103819029  GLE1; nucleoporin GLE1 [KO:K18723]
103824337  ATP-dependent RNA helicase DDX19B [KO:K18655] [EC:5.6.2.7]
103818751  RAE1; mRNA export factor [KO:K14298]
103824472  NUP98; nuclear pore complex protein Nup98-Nup96 [KO:K14297]
103818993  NUP214; nuclear pore complex protein Nup214 isoform X1 [KO:K14317]
103820064  NUP88; nuclear pore complex protein Nup88 [KO:K14318]
103812650  RGPD4; ranBP2-like and GRIP domain-containing protein 4 isoform X1 [KO:K12172] [EC:2.3.2.-]
103813293  RANGAP1; ran GTPase-activating protein 1 [KO:K14319]
103817546  UBE2I; SUMO-conjugating enzyme UBC9 [KO:K10577]
103814499  SUMO1; small ubiquitin-related modifier 1 [KO:K12160]
108962677  SUMO2; small ubiquitin-related modifier 2 [KO:K12160]
103815697  small ubiquitin-related modifier 3 isoform X1 [KO:K12160]
103822297  NUP160; nuclear pore complex protein Nup160 [KO:K14303]
103819994  NUP85; nuclear pore complex protein Nup85 [KO:K14304]
103824153  SEC13; protein SEC13 homolog [KO:K14004]
103813453  NUP107; nuclear pore complex protein Nup107 [KO:K14301]
103818505  NUP133; nuclear pore complex protein Nup133 [KO:K14300]
103815864  SEH1L; nucleoporin SEH1 isoform X1 [KO:K14299]
103820567  NUP43; nucleoporin Nup43 [KO:K14305]
103819652  NUP37; nucleoporin Nup37 [KO:K14302]
103821793  AHCTF1; LOW QUALITY PROTEIN: protein ELYS [KO:K25129]
103824266  LOW QUALITY PROTEIN: nuclear pore glycoprotein p62-like [KO:K14306]
103824264  NUP62CL; nucleoporin-62 C-terminal-like protein isoform X2 [KO:K14306]
103812546  NUP58; nucleoporin p58/p45 isoform X1 [KO:K14307]
103823429  NUP54; nucleoporin p54 isoform X2 [KO:K14308]
103813374  NUP205; nuclear pore complex protein Nup205 [KO:K14310]
103819017  NUP188; nucleoporin NUP188 homolog [KO:K14311]
103821069  NUP155; nuclear pore complex protein Nup155 [KO:K14312]
103816659  NUP93; nuclear pore complex protein Nup93 isoform X3 [KO:K14309]
103814564  NUP35; nucleoporin NUP35 isoform X1 [KO:K14313]
103815038  NDC1; nucleoporin NDC1 isoform X2 [KO:K14315]
103817108  NUP210; nuclear pore membrane glycoprotein 210 isoform X1 [KO:K14314]
103820223  POM121; nuclear envelope pore membrane protein POM 121 [KO:K14316]
103824926  TMEM33; transmembrane protein 33 [KO:K20724]
103814805  TPR; nucleoprotein TPR isoform X3 [KO:K09291]
103820446  NUP50; nuclear pore complex protein Nup50 [KO:K14295]
103813350  NUP153; nuclear pore complex protein Nup153 isoform X1 [KO:K14296]
103815493  SENP2; sentrin-specific protease 2 [KO:K03345] [EC:3.4.22.68]
103827143  KPNA1; importin subunit alpha-5 [KO:K23940]
103817618  KPNA7; importin subunit alpha-8 isoform X2 [KO:K15043]
103819776  KPNA2; importin subunit alpha-1 [KO:K15043]
103815270  KPNA4; importin subunit alpha-3 [KO:K23583]
103827397  KPNA3; importin subunit alpha-4 [KO:K23583]
103823483  KPNA6; importin subunit alpha-7 [KO:K15042]
103818410  KPNA5; importin subunit alpha-6 [KO:K15042]
103821671  KPNB1; LOW QUALITY PROTEIN: importin subunit beta-1 [KO:K14293]
103819532  TNPO1; transportin-1 isoform X1 [KO:K18752]
103823257  transportin-1-like [KO:K18752]
103822498  TNPO3; transportin-3 [KO:K15436]
103812287  IPO5; importin-5 [KO:K20222]
103827038  IPO7; importin-7 isoform X1 [KO:K20223]
103819705  IPO8; importin-8 isoform X1 [KO:K18755]
103822438  IPO9; importin-9 [KO:K20224]
103823129  IPO11; importin-11 [KO:K25201]
103814962  IPO13; importin-13 isoform X1 [KO:K25202]
103823206  SNUPN; snurportin-1 [KO:K13151]
103819237  XPO1; exportin-1 [KO:K14290]
103818773  CSE1L; exportin-2 isoform X2 [KO:K18423]
103820398  XPOT; exportin-T isoform X2 [KO:K14288]
103827313  XPO4; exportin-4 [KO:K25203]
103821649  XPO5; exportin-5 [KO:K14289]
103817770  XPO6; exportin-6 isoform X2 [KO:K25204]
103824525  XPO7; exportin-7 [KO:K18460]
103818200  RAN; GTP-binding nuclear protein Ran [KO:K07936]
103818713  EEF1A2; elongation factor 1-alpha 2 [KO:K03231]
103819723  EEF1A1; elongation factor 1-alpha 1 [KO:K03231]
103823240  phosphorylated adapter RNA export protein [KO:K14291]
103821859  NCBP1; nuclear cap-binding protein subunit 1 [KO:K12882]
103815404  NCBP2; nuclear cap-binding protein subunit 2 isoform X2 [KO:K12883]
103824214  nuclear cap-binding protein subunit 2 [KO:K12883]
103815271  NMD3; 60S ribosomal export protein NMD3 [KO:K07562]
103825232  RBM8A; RNA-binding protein 8A [KO:K12876]
103815035  MAGOH; protein mago nashi homolog [KO:K12877]
103821751  CASC3; protein CASC3 [KO:K14323]
103821332  EIF4A3; eukaryotic initiation factor 4A-III [KO:K13025] [EC:5.6.2.7]
103827315  SAP18; histone deacetylase complex subunit SAP18 [KO:K14324]
103824362  RNPS1; RNA-binding protein with serine-rich domain 1 [KO:K14325]
103826539  PNN; pinin [KO:K13114]
103819915  LOW QUALITY PROTEIN: THO complex subunit 4 [KO:K12881]
115484521  LOW QUALITY PROTEIN: THO complex subunit 4-like [KO:K12881]
103824543  UPF1; regulator of nonsense transcripts 1 isoform X1 [KO:K14326] [EC:5.6.2.5 5.6.2.3]
103813572  UPF2; regulator of nonsense transcripts 2 [KO:K14327]
103816397  UPF3B; regulator of nonsense transcripts 3B [KO:K14328]
103812387  UPF3A; regulator of nonsense transcripts 3A [KO:K14328]
103816374  NXT2; NTF2-related export protein 2 isoform X1 [KO:K14285]
103823569  SRRM1; LOW QUALITY PROTEIN: serine/arginine repetitive matrix protein 1 [KO:K13171]
103815984  THOC1; THO complex subunit 1 isoform X1 [KO:K12878]
103816527  THOC2; THO complex subunit 2 [KO:K12879]
103817988  THOC5; THO complex subunit 5 homolog isoform X2 [KO:K13174]
103817074  THOC7; THO complex subunit 7 homolog isoform X1 [KO:K13176]
103817351  THOC3; THO complex subunit 3 [KO:K12880]
Reference
PMID:16777596
  Authors
Tran EJ, Wente SR
  Title
Dynamic nuclear pore complexes: life on the edge.
  Journal
Cell 125:1041-53 (2006)
DOI:10.1016/j.cell.2006.05.027
Reference
PMID:15519698
  Authors
Rodriguez MS, Dargemont C, Stutz F
  Title
Nuclear export of RNA.
  Journal
Biol Cell 96:639-55 (2004)
DOI:10.1016/j.biolcel.2004.04.014
Reference
PMID:18313922
  Authors
Palancade B, Doye V
  Title
Sumoylating and desumoylating enzymes at nuclear pores: underpinning their unexpected duties?
  Journal
Trends Cell Biol 18:174-83 (2008)
DOI:10.1016/j.tcb.2008.02.001
Reference
PMID:15901496
  Authors
Reed R, Cheng H
  Title
TREX, SR proteins and export of mRNA.
  Journal
Curr Opin Cell Biol 17:269-73 (2005)
DOI:10.1016/j.ceb.2005.04.011
Reference
PMID:16314458
  Authors
Tange TO, Shibuya T, Jurica MS, Moore MJ
  Title
Biochemical analysis of the EJC reveals two new factors and a stable tetrameric protein core.
  Journal
RNA 11:1869-83 (2005)
DOI:10.1261/rna.2155905
Reference
PMID:28673770
  Authors
Beck M, Schirmacher P, Singer S
  Title
Alterations of the nuclear transport system in hepatocellular carcinoma - New basis for therapeutic strategies.
  Journal
J Hepatol 67:1051-1061 (2017)
DOI:10.1016/j.jhep.2017.06.021
Related
pathway
scan03015  mRNA surveillance pathway
KO pathway
ko03013   
LinkDB

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