KEGG   PATHWAY: sclv00983
Entry
sclv00983                   Pathway                                
Name
Drug metabolism - other enzymes - Styela clava (leathery sea squirt)
Class
Metabolism; Xenobiotics biodegradation and metabolism
Pathway map
sclv00983  Drug metabolism - other enzymes
sclv00983

Organism
Styela clava (leathery sea squirt) [GN:sclv]
Gene
120337834  LOW QUALITY PROTEIN: hypoxanthine-guanine phosphoribosyltransferase-like [KO:K00760] [EC:2.4.2.8]
120345456  inosine-5'-monophosphate dehydrogenase 2-like isoform X1 [KO:K00088] [EC:1.1.1.205]
120325778  inosine-5'-monophosphate dehydrogenase 2-like [KO:K00088] [EC:1.1.1.205]
120326697  GMP synthase [glutamine-hydrolyzing]-like [KO:K01951] [EC:6.3.5.2]
120344512  probable thiopurine S-methyltransferase [KO:K00569] [EC:2.1.1.67]
120336567  probable thiopurine S-methyltransferase [KO:K00569] [EC:2.1.1.67]
120345631  probable thiopurine S-methyltransferase [KO:K00569] [EC:2.1.1.67]
120345635  thiopurine S-methyltransferase-like [KO:K00569] [EC:2.1.1.67]
120345905  thiopurine S-methyltransferase-like [KO:K00569] [EC:2.1.1.67]
120346479  probable thiopurine S-methyltransferase isoform X1 [KO:K00569] [EC:2.1.1.67]
120346892  thiopurine S-methyltransferase-like [KO:K00569] [EC:2.1.1.67]
120341498  thiopurine S-methyltransferase-like [KO:K00569] [EC:2.1.1.67]
120341527  thiopurine S-methyltransferase-like [KO:K00569] [EC:2.1.1.67]
120325471  thiopurine S-methyltransferase-like [KO:K00569] [EC:2.1.1.67]
120325513  thiopurine S-methyltransferase-like [KO:K00569] [EC:2.1.1.67]
120343470  xanthine dehydrogenase/oxidase-like [KO:K00106] [EC:1.17.1.4 1.17.3.2]
120338173  abscisic-aldehyde oxidase-like isoform X1 [KO:K00106] [EC:1.17.1.4 1.17.3.2]
120340015  indole-3-acetaldehyde oxidase-like [KO:K00106] [EC:1.17.1.4 1.17.3.2]
120342206  xanthine dehydrogenase/oxidase-like isoform X1 [KO:K00106] [EC:1.17.1.4 1.17.3.2]
120342361  xanthine dehydrogenase/oxidase-like [KO:K00106] [EC:1.17.1.4 1.17.3.2]
120342964  xanthine dehydrogenase/oxidase-like isoform X1 [KO:K00106] [EC:1.17.1.4 1.17.3.2]
120344374  inosine triphosphate pyrophosphatase-like [KO:K01519] [EC:3.6.1.66]
120339382  fatty acyl-CoA hydrolase precursor, medium chain-like [KO:K01044] [EC:3.1.1.1]
120339584  carboxylesterase 1D-like [KO:K01044] [EC:3.1.1.1]
120335133  uncharacterized protein LOC120335133 isoform X1 [KO:K03927] [EC:3.1.1.1 3.1.1.84 3.1.1.56]
120335093  uncharacterized protein LOC120335093 [KO:K03927] [EC:3.1.1.1 3.1.1.84 3.1.1.56]
120335134  uncharacterized protein LOC120335134 [KO:K03927] [EC:3.1.1.1 3.1.1.84 3.1.1.56]
120327972  UDP-glucuronosyltransferase 2B31-like [KO:K00699] [EC:2.4.1.17]
120328250  LOW QUALITY PROTEIN: beta-glucuronidase-like [KO:K01195] [EC:3.2.1.31]
120328481  cytidine deaminase-like [KO:K01489] [EC:3.5.4.5]
120331939  cytidine deaminase-like [KO:K01489] [EC:3.5.4.5]
120345830  dihydropyrimidine dehydrogenase [NADP(+)]-like [KO:K00207] [EC:1.3.1.2]
120331016  dihydropyrimidinase-like [KO:K01464] [EC:3.5.2.2]
120331030  dihydropyrimidinase-like [KO:K01464] [EC:3.5.2.2]
120336608  beta-ureidopropionase-like [KO:K01431] [EC:3.5.1.6]
120336610  beta-ureidopropionase-like [KO:K01431] [EC:3.5.1.6]
120331497  uridine phosphorylase 1-like [KO:K00757] [EC:2.4.2.3]
120331498  uridine phosphorylase 1-like [KO:K00757] [EC:2.4.2.3]
120342808  uridine phosphorylase 2-like [KO:K00757] [EC:2.4.2.3]
120343926  uridine-cytidine kinase 2-B-like [KO:K00876] [EC:2.7.1.48]
120345268  uridine-cytidine kinase-like 1 isoform X1 [KO:K00876] [EC:2.7.1.48]
120342857  thymidine kinase, cytosolic-like [KO:K00857] [EC:2.7.1.21]
120339528  uridine 5'-monophosphate synthase-like [KO:K13421] [EC:2.4.2.10 4.1.1.23]
120336400  UMP-CMP kinase-like [KO:K13800] [EC:2.7.4.14]
120334005  UMP-CMP kinase-like [KO:K13800] [EC:2.7.4.14]
120340964  ribonucleoside-diphosphate reductase large subunit-like [KO:K10807] [EC:1.17.4.1]
120329712  ribonucleoside-diphosphate reductase subunit M2 B-like [KO:K10808] [EC:1.17.4.1]
120348609  ribonucleoside-diphosphate reductase subunit M2 B-like isoform X1 [KO:K10808] [EC:1.17.4.1]
120328132  nucleoside diphosphate kinase 7-like [KO:K00940] [EC:2.7.4.6]
120331101  nucleoside diphosphate kinase B-like [KO:K00940] [EC:2.7.4.6]
120333456  deoxyuridine 5'-triphosphate nucleotidohydrolase, mitochondrial-like [KO:K01520] [EC:3.6.1.23]
120326277  arylamine N-acetyltransferase 2-like [KO:K00622] [EC:2.3.1.5]
120348690  arylamine N-acetyltransferase 1-like [KO:K00622] [EC:2.3.1.5]
120325539  arylamine N-acetyltransferase 2-like [KO:K00622] [EC:2.3.1.5]
120343237  glutathione S-transferase theta-1-like [KO:K00799] [EC:2.5.1.18]
120344569  microsomal glutathione S-transferase 3-like [KO:K00799] [EC:2.5.1.18]
120328055  glutathione S-transferase P-like [KO:K00799] [EC:2.5.1.18]
120336821  glutathione S-transferase omega-1-like [KO:K00799] [EC:2.5.1.18]
120336831  microsomal glutathione S-transferase 1-like [KO:K00799] [EC:2.5.1.18]
120336832  microsomal glutathione S-transferase 1-like [KO:K00799] [EC:2.5.1.18]
120336834  microsomal glutathione S-transferase 1-like isoform X1 [KO:K00799] [EC:2.5.1.18]
120336835  microsomal glutathione S-transferase 1-like [KO:K00799] [EC:2.5.1.18]
120336836  microsomal glutathione S-transferase 1-like isoform X1 [KO:K00799] [EC:2.5.1.18]
120336837  microsomal glutathione S-transferase 1-like [KO:K00799] [EC:2.5.1.18]
120337489  microsomal glutathione S-transferase 3-like [KO:K00799] [EC:2.5.1.18]
120337668  glutathione S-transferase Mu 1-like [KO:K00799] [EC:2.5.1.18]
120337677  glutathione S-transferase 2-like [KO:K00799] [EC:2.5.1.18]
120337709  glutathione S-transferase class-mu 26 kDa isozyme 47-like [KO:K00799] [EC:2.5.1.18]
120337852  glutathione S-transferase Mu 1-like [KO:K00799] [EC:2.5.1.18]
120337997  glutathione S-transferase-like [KO:K00799] [EC:2.5.1.18]
120338048  glutathione S-transferase class-mu 26 kDa isozyme-like [KO:K00799] [EC:2.5.1.18]
120329556  microsomal glutathione S-transferase 3-like [KO:K00799] [EC:2.5.1.18]
120338387  glutathione S-transferase Mu 1-like [KO:K00799] [EC:2.5.1.18]
120329830  microsomal glutathione S-transferase 3-like [KO:K00799] [EC:2.5.1.18]
120347351  glutathione S-transferase 1-like [KO:K00799] [EC:2.5.1.18]
120347905  glutathione S-transferase omega-1-like [KO:K00799] [EC:2.5.1.18]
120347906  glutathione S-transferase omega-1-like [KO:K00799] [EC:2.5.1.18]
120339806  glutathione S-transferase Mu 2-like [KO:K00799] [EC:2.5.1.18]
120348049  glutathione S-transferase omega-1-like [KO:K00799] [EC:2.5.1.18]
120348302  glutathione S-transferase Mu 2-like isoform X1 [KO:K00799] [EC:2.5.1.18]
120348612  glutathione S-transferase Mu 4-like [KO:K00799] [EC:2.5.1.18]
120332505  glutathione S-transferase 1-like [KO:K00799] [EC:2.5.1.18]
120332562  glutathione S-transferase 1-like [KO:K00799] [EC:2.5.1.18]
120332578  glutathione S-transferase D4-like [KO:K00799] [EC:2.5.1.18]
120332655  glutathione S-transferase 1-like [KO:K00799] [EC:2.5.1.18]
120332740  glutathione S-transferase 1-like [KO:K00799] [EC:2.5.1.18]
120332776  glutathione S-transferase 1-like [KO:K00799] [EC:2.5.1.18]
120332806  glutathione S-transferase D7-like [KO:K00799] [EC:2.5.1.18]
120332883  glutathione S-transferase 1-like [KO:K00799] [EC:2.5.1.18]
120332884  glutathione S-transferase 1-like [KO:K00799] [EC:2.5.1.18]
120332887  glutathione S-transferase 1-like [KO:K00799] [EC:2.5.1.18]
120332909  glutathione S-transferase 1-like [KO:K00799] [EC:2.5.1.18]
120333066  glutathione S-transferase 1-like [KO:K00799] [EC:2.5.1.18]
120333067  glutathione S-transferase 1-like [KO:K00799] [EC:2.5.1.18]
120333069  glutathione S-transferase 1-like [KO:K00799] [EC:2.5.1.18]
120333098  glutathione S-transferase 1-like [KO:K00799] [EC:2.5.1.18]
120333102  glutathione S-transferase 2-like [KO:K00799] [EC:2.5.1.18]
120333103  uncharacterized protein LOC120333103 [KO:K00799] [EC:2.5.1.18]
120333133  glutathione S-transferase 1-like [KO:K00799] [EC:2.5.1.18]
120333201  glutathione S-transferase D7-like [KO:K00799] [EC:2.5.1.18]
120333235  glutathione S-transferase D4-like [KO:K00799] [EC:2.5.1.18]
120333236  glutathione S-transferase 1-like [KO:K00799] [EC:2.5.1.18]
120326005  glutathione S-transferase omega-1-like [KO:K00799] [EC:2.5.1.18]
120334143  glutathione S-transferase D5-like [KO:K00799] [EC:2.5.1.18]
Compound
C00003  NAD+
C00006  NADP+
C02320  R-S-Glutathione
C02380  6-Mercaptopurine
C04242  5-Fluorodeoxyuridine monophosphate
C04646  6-Thioinosine-5'-monophosphate
C05361  Hydrazine
C06108  Fluoroacetate
C06837  Azathioprine
C07054  Isoniazid
C07446  Isonicotinic acid
C07447  Acetylhydrazine
C07585  N-Acetylisoniazid
C07648  Thioguanine
C07649  5-FU
C11173  SN-38
C11376  SN38 glucuronide
C11736  5-Fluorodeoxyuridine
C12650  Capecitabine
C12673  Tegafur
C12739  5'-Deoxy-5-fluorouridine
C13252  Carmofur
C16542  APC
C16543  NPC
C16613  6-Thiourate
C16614  6-Methylmercaptopurine
C16615  6-Methylthiopurine 5'-monophosphate ribonucleotide
C16616  6-Mercaptopurine ribonucleoside 5'-diphosphate
C16617  6-Mercaptopurine ribonucleoside triphosphate
C16618  6-Thioxanthine 5'-monophosphate
C16619  6-Thioguanosine monophosphate
C16620  6-Methylthioguanosine monophosphate
C16621  1-Methyl-4-nitroimidazole
C16622  N,N'-Diacetylhydrazine
C16623  Isonicotinylglycine
C16624  Isoniazid pyruvate
C16625  Isoniazid alpha-ketoglutaric acid
C16630  5,6-Dihydro-5-fluorouracil
C16631  alpha-Fluoro-beta-ureidopropionic acid
C16632  alpha-Fluoro-beta-alanine
C16633  5-Fluorouridine
C16634  5-Fluorouridine monophosphate
C16635  5'-Deoxy-5-fluorocytidine
C16641  Irinotecan
C21748  5-Fluorouridine diphosphate
C21749  5-Fluorouridine triphosphate
C21750  5-Fluorodeoxyuridine diphosphate
C21751  5-Fluorodeoxyuridine triphosphate
C21754  Isonicotinoyl radical
C21758  Hepatotoxins
C21759  Isonicotinoyl-NAD adduct
C21760  Isonicotinoyl-NADP adduct
D00238  Azathioprine (JP18/USP/INN)
D00346  Isoniazid (JP18/USP/INN)
D00584  Fluorouracil (JP18/USP/INN)
D01223  Capecitabine (JAN/USP/INN)
D01244  Tegafur (JP18/USAN/INN)
D01309  Doxifluridine (JP18/INN)
D01784  Carmofur (JP18/INN)
D04197  Floxuridine (USP/INN)
D04931  Mercaptopurine (INN)
D08086  Irinotecan (INN)
D08603  Tioguanine (INN)
Reference
  Authors
Kato R, Kamatari T (eds).
  Title
[Drug Metabolism] (In Japanese)
  Journal
Tokyo Kagaku Dojin (2000)
Reference
  Authors
Al Hadithy AF, de Boer NK, Derijks LJ, Escher JC, Mulder CJ, Brouwers JR.
  Title
Thiopurines in inflammatory bowel disease: pharmacogenetics, therapeutic drug monitoring and clinical recommendations.
  Journal
Dig Liver Dis 37:282-97 (2005)
DOI:10.1016/j.dld.2004.09.029
Reference
  Authors
Gearry RB, Barclay ML.
  Title
Azathioprine and 6-mercaptopurine pharmacogenetics and metabolite monitoring in inflammatory bowel disease.
  Journal
J Gastroenterol Hepatol 20:1149-57 (2005)
DOI:10.1111/j.1440-1746.2005.03832.x
Reference
  Authors
Gilissen LP, Derijks LJ, Verhoeven HM, Bierau J, Hooymans PM, Hommes DW, Engels LG.
  Title
Pancytopenia due to high 6-methylmercaptopurine levels in a 6-mercaptopurine treated patient with Crohn's disease.
  Journal
Dig Liver Dis 39:182-6 (2007)
DOI:10.1016/j.dld.2006.05.026
Reference
  Authors
Fischel JL, Formento P, Ciccolini J, Etienne-Grimaldi MC, Milano G.
  Title
Lack of contribution of dihydrofluorouracil and alpha-fluoro-beta-alanine to the cytotoxicity of 5'-deoxy-5-fluorouridine on human keratinocytes.
  Journal
Anticancer Drugs 15:969-74 (2004)
DOI:10.1097/00001813-200411000-00006
Reference
  Authors
Shimma N, Umeda I, Arasaki M, Murasaki C, Masubuchi K, Kohchi Y, Miwa M, Ura M, Sawada N, Tahara H, Kuruma I, Horii I, Ishitsuka H.
  Title
The design and synthesis of a new tumor-selective fluoropyrimidine carbamate, capecitabine.
  Journal
Bioorg Med Chem 8:1697-706 (2000)
DOI:10.1016/S0968-0896(00)00087-0
Reference
  Authors
Chung YL, Troy H, Judson IR, Leek R, Leach MO, Stubbs M, Harris AL, Griffiths JR
  Title
Noninvasive measurements of capecitabine metabolism in bladder tumors overexpressing thymidine phosphorylase by fluorine-19 magnetic resonance spectroscopy.
  Journal
Clin Cancer Res 10:3863-70 (2004)
DOI:10.1158/1078-0432.CCR-03-0237
Reference
  Authors
Mathijssen RH, van Alphen RJ, Verweij J, Loos WJ, Nooter K, Stoter G, Sparreboom A
  Title
Clinical pharmacokinetics and metabolism of irinotecan (CPT-11).
  Journal
Clin Cancer Res 7:2182-94 (2001)
Reference
  Authors
Kita T, Tanigawara Y, Chikazawa S, Hatanaka H, Sakaeda T, Komada F, Iwakawa S, Okumura K.
  Title
N-Acetyltransferase2 genotype correlated with isoniazid acetylation in Japanese tuberculous patients.
  Journal
Biol Pharm Bull 24:544-9 (2001)
DOI:10.1248/bpb.24.544
Reference
  Authors
Miura K, Kinouchi M, Ishida K, Fujibuchi W, Naitoh T, Ogawa H, Ando T, Yazaki N, Watanabe K, Haneda S, Shibata C, Sasaki I
  Title
5-fu metabolism in cancer and orally-administrable 5-fu drugs.
  Journal
Cancers (Basel) 2:1717-30 (2010)
DOI:10.3390/cancers2031717
Reference
  Authors
Wang P, Pradhan K, Zhong XB, Ma X
  Title
Isoniazid metabolism and hepatotoxicity.
  Journal
Acta Pharm Sin B 6:384-392 (2016)
DOI:10.1016/j.apsb.2016.07.014
Reference
  Authors
Klein DJ, Boukouvala S, McDonagh EM, Shuldiner SR, Laurieri N, Thorn CF, Altman RB, Klein TE
  Title
PharmGKB summary: isoniazid pathway, pharmacokinetics.
  Journal
Pharmacogenet Genomics 26:436-44 (2016)
DOI:10.1097/FPC.0000000000000232
Reference
  Authors
Yamada S, Richardson K, Tang M, Halaschek-Wiener J, Cook VJ, Fitzgerald JM, Elwood K, Marra F, Brooks-Wilson A
  Title
Genetic variation in carboxylesterase genes and susceptibility to isoniazid-induced hepatotoxicity.
  Journal
Pharmacogenomics J 10:524-36 (2010)
DOI:10.1038/tpj.2010.5
Reference
  Authors
Vlasits J, Jakopitsch C, Bernroitner M, Zamocky M, Furtmuller PG, Obinger C
  Title
Mechanisms of catalase activity of heme peroxidases.
  Journal
Arch Biochem Biophys 500:74-81 (2010)
DOI:10.1016/j.abb.2010.04.018
Reference
  Authors
Khan SR, Morgan AG, Michail K, Srivastava N, Whittal RM, Aljuhani N, Siraki AG
  Title
Metabolism of isoniazid by neutrophil myeloperoxidase leads to isoniazid-NAD(+) adduct formation: A comparison of the reactivity of isoniazid with its known human metabolites.
  Journal
Biochem Pharmacol 106:46-55 (2016)
DOI:10.1016/j.bcp.2016.02.003
Reference
  Authors
Forbes LV, Furtmuller PG, Khalilova I, Turner R, Obinger C, Kettle AJ
  Title
Isoniazid as a substrate and inhibitor of myeloperoxidase: identification of amine adducts and the influence of superoxide dismutase on their formation.
  Journal
Biochem Pharmacol 84:949-60 (2012)
DOI:10.1016/j.bcp.2012.07.020
Reference
  Authors
Nguyen M, Quemard A, Broussy S, Bernadou J, Meunier B
  Title
Mn(III) pyrophosphate as an efficient tool for studying the mode of action of isoniazid on the InhA protein of Mycobacterium tuberculosis.
  Journal
Antimicrob Agents Chemother 46:2137-44 (2002)
DOI:10.1128/AAC.46.7.2137-2144.2002
Reference
PMID:9417034
  Authors
Rozwarski DA, Grant GA, Barton DH, Jacobs WR Jr, Sacchettini JC
  Title
Modification of the NADH of the isoniazid target (InhA) from Mycobacterium tuberculosis.
  Journal
Science 279:98-102 (1998)
DOI:10.1126/science.279.5347.98
Reference
  Authors
Argyrou A, Vetting MW, Blanchard JS
  Title
New insight into the mechanism of action of and resistance to isoniazid: interaction of Mycobacterium tuberculosis enoyl-ACP reductase with INH-NADP.
  Journal
J Am Chem Soc 129:9582-3 (2007)
DOI:10.1021/ja073160k
KO pathway
ko00983   
LinkDB

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