KEGG PATHWAY: sft00240

PATHWAY: sft00240

Entry

sft00240                    Pathway

Name

Pyrimidine metabolism - Shigella flexneri NCTC1 (serotype 2a)

Class

Metabolism; Nucleotide metabolism

Pathway map

sft00240

Pyrimidine metabolism

Module

sft_M00051

De novo pyrimidine biosynthesis, glutamine (+ PRPP) => UMP [PATH:sft00240]

sft_M00052

Pyrimidine ribonucleotide biosynthesis, UMP => UDP/UTP,CDP/CTP [PATH:sft00240]

sft_M00053

Deoxyribonucleotide biosynthesis, ADP/GDP/CDP/UDP => dATP/dGTP/dCTP/dUTP [PATH:sft00240]

sft_M00938

Pyrimidine deoxyribonucleotide biosynthesis, UDP => dTTP [PATH:sft00240]

sft_M00939

Pyrimidine degradation, uracil => 3-hydroxypropanoate [PATH:sft00240]

Other DBs

GO:	0006220 0006213

Organism

Shigella flexneri NCTC1 (serotype 2a) [GN:sft]

Gene

NCTC1_00030

carB; carbamoyl phosphate synthase large subunit,Carbamoyl-phosphate synthase large chain,carbamoyl phosphate synthase large subunit,Carbamoylphosphate synthase small subunit,carbamoyl-phosphate synthase, large subunit,Carbamoyl-phosphate synthase L chain, ATP binding domain [KO:K01955] [EC:6.3.5.5]

NCTC1_00029

carA; carbamoyl phosphate synthase small subunit,Carbamoyl-phosphate synthase small chain,carbamoyl phosphate synthase small subunit,Carbamoylphosphate synthase small subunit,carbamoyl-phosphate synthase, small subunit,Carbamoyl-phosphate synthase small chain, CPSase domain [KO:K01956] [EC:6.3.5.5]

NCTC1_04610

pyrB; aspartate carbamoyltransferase catalytic subunit,Aspartate carbamoyltransferase catalytic chain,aspartate carbamoyltransferase catalytic subunit,Aspartate carbamoyltransferase, catalytic chain,aspartate carbamoyltransferase,Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain [KO:K00609] [EC:2.1.3.2]

NCTC1_04611

pyrI; aspartate carbamoyltransferase regulatory subunit,Aspartate carbamoyltransferase regulatory chain,aspartate carbamoyltransferase regulatory subunit,aspartate carbamoyltransferase, regulatory subunit,Aspartate carbamoyltransferase regulatory chain, allosteric domain [KO:K00610]

NCTC1_01116

pyrC; dihydroorotase,Dihydroorotase,dihydroorotase, Dihydroorotase,dihydroorotase, homodimeric type,Amidohydrolase family [KO:K01465] [EC:3.5.2.3]

NCTC1_00982

pyrD; dihydroorotate dehydrogenase 2,Dihydroorotate dehydrogenase (quinone),dihydroorotate dehydrogenase 2,Dihydroorotate dehydrogenase,dihydroorotate dehydrogenase (fumarate),Dihydroorotate dehydrogenase [KO:K00254] [EC:1.3.5.2]

NCTC1_03976

pyrE; orotate phosphoribosyltransferase,Orotate phosphoribosyltransferase,orotate phosphoribosyltransferase,Phosphoribosyl transferase domain [KO:K00762] [EC:2.4.2.10]

NCTC1_01358

pyrF; orotidine 5'-phosphate decarboxylase,Orotidine 5'-phosphate decarboxylase,orotidine 5'-phosphate decarboxylase,Orotidine-5'-phosphate decarboxylase,orotidine 5'-phosphate decarboxylase,Orotidine 5'-phosphate decarboxylase / HUMPS family [KO:K01591] [EC:4.1.1.23]

NCTC1_00166

pyrH; uridylate kinase,Uridylate kinase,uridylate kinase,Uridylate kinase,UMP kinase,Amino acid kinase family [KO:K09903] [EC:2.7.4.22]

NCTC1_02819

ndk; nucleoside diphosphate kinase,Nucleoside diphosphate kinase,mulitfunctional nucleoside diphosphate kinase/apyrimidinic endonuclease/3'-,Nucleoside diphosphate kinase,Nucleoside diphosphate kinase [KO:K00940] [EC:2.7.4.6]

NCTC1_03075

mazG; nucleoside triphosphate pyrophosphohydrolase,Nucleoside triphosphate pyrophosphohydrolase,nucleoside triphosphate pyrophosphohydrolase,MazG family protein,MazG nucleotide pyrophosphohydrolase domain [KO:K04765] [EC:3.6.1.9]

NCTC1_03563

maf1; Maf-like protein,Maf-like protein yhdE,Maf-like protein,Nucleotide-binding protein implicated in inhibition of septum formation,septum formation protein Maf,Maf-like protein [KO:K06287] [EC:3.6.1.-]

NCTC1_03389

Protein of unknown function DUF45 [KO:K07043] [EC:3.6.1.-]

NCTC1_03074

pyrG; CTP synthetase,CTP synthase,CTP synthetase,Carbamoylphosphate synthase small subunit,CTP synthase,CTP synthase N-terminus [KO:K01937] [EC:6.3.4.2]

NCTC1_00941

cmk; cytidylate kinase,Cytidylate kinase,cytidylate kinase,Cytidylate kinase,cytidylate kinase,Cytidylate kinase [KO:K00945] [EC:2.7.4.25]

NCTC1_01577

nudG; pyrimidine (deoxy)nucleoside triphosphate pyrophosphohydrolase,CTP pyrophosphohydrolase,pyrimidine (deoxy)nucleoside triphosphate pyrophosphohydrolase,NTP pyrophosphohydrolases containing a Zn-finger, probably nucleic-acid-binding,mutator mutT protein,NUDIX domain [KO:K08320] [EC:3.6.1.65]

NCTC1_02340

udk; Uridine/cytidine kinase,Uridine kinase,uridine/cytidine kinase,uridine kinase,Phosphoribulokinase / Uridine kinase family [KO:K00876] [EC:2.7.1.48]

NCTC1_00439

ushA; bifunctional UDP-sugar hydrolase/5'-nucleotidase periplasmic,hypothetical protein,bifunctional UDP-sugar hydrolase/5'-nucleotidase periplasmic precursor,Predicted RNA-binding protein, contains TRAM domain,NAD nucleotidase,5'-nucleotidase, C-terminal domain [KO:K11751] [EC:3.1.3.5 3.6.1.45]

NCTC1_03045

surE; stationary phase survival protein SurE,5'/3'-nucleotidase SurE,5'(3')-nucleotidase/polyphosphatase, 5'/3'-nucleotidaseSurE,Survival protein SurE [KO:K03787] [EC:3.1.3.5 3.1.3.6]

NCTC1_00659

nagD_2; UMP phosphatase,hypothetical protein,UMP phosphatase,Glycerol dehydrogenase and related enzymes,HAD hydrolase [KO:K02566] [EC:3.1.3.5]

NCTC1_04784

yjjG; nucleotidase,Pyrimidine 5'-nucleotidase YjjG,dUMP phosphatase,Predicted hydrolase (HAD superfamily),HAD hydrolase,haloacid dehalogenase-like hydrolase [KO:K08723] [EC:3.1.3.-]

NCTC1_04226

udp; uridine phosphorylase,Uridine phosphorylase,uridine phosphorylase,uridine phosphorylase,Phosphorylase superfamily [KO:K00757] [EC:2.4.2.3]

NCTC1_00339

yaiE; protein yaiE,hypothetical protein,hypothetical protein,Uncharacterized protein conserved in bacteria,Protein of unknown function (DUF1255) [KO:K09913] [EC:2.4.2.1 2.4.2.2]

NCTC1_02795

upp; uracil phosphoribosyltransferase,Uracil phosphoribosyltransferase,uracil phosphoribosyltransferase,Phosphoribosyl transferase domain [KO:K00761] [EC:2.4.2.9]

NCTC1_04642

cpdB; bifunctional 2',3'-cyclic nucleotide 2'-phosphodiesterase/3'-nucleotidase periplasmic protein,2',3'-cyclic-nucleotide 2'-phosphodiesterase/3'-nucleotidase precursor,bifunctional 2',3'-cyclic nucleotide 2'-phosphodiesterase/3'-nucleotidase periplasmic precursor protein,2',3'-cyclic-nucleotide 2'-phosphodiesterase,5'-nucleotidase, C-terminal domain [KO:K01119] [EC:3.1.4.16 3.1.3.6]

NCTC1_02474

psuK; putative Sugar kinase, ribokinase family,Pseudouridine kinase,pseudouridine kinase,Uncharacterized enzyme involved in pigment biosynthesis,ribokinase,pfkB family carbohydrate kinase [KO:K16328] [EC:2.7.1.83]

NCTC1_02473

psuG; indigoidine synthase A like protein,Pseudouridine-5'-phosphate glycosidase,Uncharacterized enzyme involved in pigment biosynthesis,Indigoidine synthase A like protein [KO:K16329] [EC:4.2.1.70]

NCTC1_02470

rihB; Pyrimidine-specific ribonucleoside hydrolase rihB,Pyrimidine-specific ribonucleoside hydrolase rihB,ribonucleoside hydrolase 2,Inosine-uridine preferring nucleoside hydrolase [KO:K10213] [EC:3.2.2.8]

NCTC1_00678

rihA; ribonucleoside hydrolase 1,Pyrimidine-specific ribonucleoside hydrolase rihA,ribonucleoside hydrolase 1,Inosine-uridine preferring nucleoside hydrolase [KO:K01250] [EC:3.2.2.-]

NCTC1_00027

rihC; ribonucleoside hydrolase RihC,Non-specific ribonucleoside hydrolase rihC,ribonucleoside hydrolase RihC,Inosine-uridine preferring nucleoside hydrolase [KO:K12700] [EC:3.2.2.-]

NCTC1_03088

ygdH; LOG family protein ygdH,conserved hypothetical protein,Domain of unknown function (DUF3412) [KO:K06966] [EC:3.2.2.10 3.2.2.-]

NCTC1_02448

cdd; cytidine deaminase,Cytidine deaminase,cytidine deaminase,Cytidine deaminase,cytidine deaminase,Cytidine and deoxycytidylate deaminase zinc-binding region [KO:K01489] [EC:3.5.4.5]

NCTC1_04618

nrdD; anaerobic ribonucleoside triphosphate reductase,Anaerobic ribonucleoside-triphosphate reductase,anaerobic ribonucleoside triphosphate reductase,anaerobic ribonucleoside-triphosphate reductase,Glycine radical [KO:K21636] [EC:1.1.98.6]

NCTC1_02339

dcd; deoxycytidine triphosphate deaminase,Deoxycytidine triphosphate deaminase,deoxycytidine triphosphate deaminase,2'-deoxycytidine 5'-triphosphate deaminase (DCD) [KO:K01494] [EC:3.5.4.13]

NCTC1_02972

nrdE; ribonucleotide-diphosphate reductase subunit alpha,Ribonucleoside-diphosphate reductase 2 subunit alpha,ribonucleotide-diphosphate reductase subunit alpha,ribonucleoside-diphosphate reductase, class 1b, alpha subunit,Ribonucleotide reductase, barrel domain [KO:K00525] [EC:1.17.4.1]

NCTC1_02549

nrdA; ribonucleotide-diphosphate reductase subunit alpha,Ribonucleoside-diphosphate reductase 1 subunit alpha,ribonucleotide-diphosphate reductase subunit alpha,ribonucleoside-diphosphate reductase, alpha subunit,Ribonucleotide reductase, barrel domain [KO:K00525] [EC:1.17.4.1]

NCTC1_02973

nrdF; ribonucleotide-diphosphate reductase subunit beta,Ribonucleoside-diphosphate reductase 2 subunit beta,ribonucleotide-diphosphate reductase subunit beta,Ribonucleotide reductase, beta subunit,ribonucleoside-diphosphate reductase, class 1b, beta subunit,Ribonucleotide reductase, small chain [KO:K00526] [EC:1.17.4.1]

NCTC1_02550

nrdB; putative ribonucleotide reductase, beta subunit,Ribonucleoside-diphosphate reductase 1 subunit beta,ribonucleotide-diphosphate reductase subunit beta,Ribonucleotide reductase, beta subunit,ribonucleoside-diphosphate reductase, class 1b, beta subunit,Ribonucleotide reductase, small chain [KO:K00526] [EC:1.17.4.1]

NCTC1_02602

yfbR; 5'-nucleotidase yfbR,5'-nucleotidase yfbR,5'-nucleotidase,HD containing hydrolase-like enzyme [KO:K08722] [EC:3.1.3.89]

NCTC1_01155

tmk; thymidylate kinase,Thymidylate kinase,thymidylate kinase,thymidylate kinase,Thymidylate kinase [KO:K00943] [EC:2.7.4.9]

NCTC1_03974

dut; deoxyuridine 5'-triphosphate nucleotidohydrolase,Deoxyuridine 5'-triphosphate nucleotidohydrolase,deoxyuridine 5'-triphosphate nucleotidohydrolase,dUTP diphosphatase,dUTPase [KO:K01520] [EC:3.6.1.23]

NCTC1_04793

deoA; thymidine phosphorylase,Thymidine phosphorylase,thymidine phosphorylase,Thymidine phosphorylase,thymidine phosphorylase,Glycosyl transferase family, a/b domain [KO:K00758] [EC:2.4.2.4]

NCTC1_01308

tdk; thymidine kinase,Thymidine kinase,thymidine kinase,Thymidine kinase [KO:K00857] [EC:2.7.1.21]

NCTC1_03122

thyA; thymidylate synthase,Thymidylate synthase,thymidylate synthase,thymidylate synthase,Thymidylate synthase [KO:K00560] [EC:2.1.1.45]

NCTC1_02451

preT; putative oxidoreductase,NAD-dependent dihydropyrimidine dehydrogenase sunbunit PreT,dihydropyrimidine dehydrogenase subunit A,Protoporphyrinogen oxidase,glutamate synthase (NADPH), homotetrameric,Pyridine nucleotide-disulphide oxidoreductase [KO:K17722] [EC:1.3.1.1]

NCTC1_02453

preA_2; dihydropyrimidine dehydrogenase,NAD-dependent dihydropyrimidine dehydrogenase subunit PreA,dihydropyrimidine dehydrogenase subunit B,Dihydroorotate dehydrogenase,dihydroorotate dehydrogenase family protein,Dihydroorotate dehydrogenase [KO:K17723] [EC:1.3.1.1]

NCTC1_01054

rutA; putative monooxygenase rutA,Pyrimidine monooxygenase RutA,alkanesulfonate monooxygenase,pyrimidine utilization protein A,Luciferase-like monooxygenase [KO:K09018] [EC:1.14.99.46]

NCTC1_01049

rutF; Flavin reductase domain protein, FMN-binding protein,FMN reductase (NADH) RutF,4-hydroxyphenylacetate 3-monooxygenase reductase subunit,pyrimidine utilization flavin reductase protein F,Flavin reductase like domain [KO:K09024] [EC:1.5.1.-]

NCTC1_01053

rutB; putative synthetase,Peroxyureidoacrylate/ureidoacrylate amidohydrolase RutB,putative hydrolase,pyrimidine utilization protein B,Isochorismatase family [KO:K09020] [EC:3.5.1.110]

NCTC1_01052

rutC; protein rutC,Putative aminoacrylate peracid reductase RutC,putative endoribonuclease L-PSP,pyrimidine utilization protein C,Endoribonuclease L-PSP [KO:K09021]

NCTC1_01051

rutD; putative acetyltransferase,Putative aminoacrylate hydrolase RutD,acetoin dehydrogenase E2 subunit dihydrolipoyllysine-residue acetyltransferase,Esterase/lipase,pyrimidine utilization protein D,Alpha/beta hydrolase family [KO:K09023] [EC:3.5.1.-]

NCTC1_01685

ydfG; 3-hydroxy acid dehydrogenase,NADP-dependent 3-hydroxy acid dehydrogenase YdfG,malonic semialdehyde reductase,Outer membrane receptor for Fe3+-dicitrate,3-oxoacyl-[acyl-carrier-protein] reductase,short chain dehydrogenase [KO:K16066] [EC:1.1.1.381 1.1.1.-]

NCTC1_01050

rutE; putative Nitroreductase,Probable malonic semialdehyde reductase RutE,malonic semialdehyde reductase,Nitroreductase family [KO:K09019] [EC:1.1.1.-]

Compound

C00015

UDP

C00039

DNA

C00046

RNA

C00055

CMP

C00063

CTP

C00064