KEGG   PATHWAY: sgh00983
Entry
sgh00983                    Pathway                                
Name
Drug metabolism - other enzymes - Sinocyclocheilus grahami (golden-line barbel)
Class
Metabolism; Xenobiotics biodegradation and metabolism
Pathway map
sgh00983  Drug metabolism - other enzymes
sgh00983

Organism
Sinocyclocheilus grahami (golden-line barbel) [GN:sgh]
Gene
107601120  hypoxanthine-guanine phosphoribosyltransferase [KO:K00760] [EC:2.4.2.8]
107570646  hypoxanthine-guanine phosphoribosyltransferase-like [KO:K00760] [EC:2.4.2.8]
107570647  hypoxanthine-guanine phosphoribosyltransferase-like [KO:K00760] [EC:2.4.2.8]
107560739  hypoxanthine-guanine phosphoribosyltransferase-like isoform X1 [KO:K00760] [EC:2.4.2.8]
107559153  hypoxanthine-guanine phosphoribosyltransferase-like [KO:K00760] [EC:2.4.2.8]
107590397  inosine-5'-monophosphate dehydrogenase 1b-like isoform X1 [KO:K00088] [EC:1.1.1.205]
107553880  inosine-5'-monophosphate dehydrogenase 1b isoform X1 [KO:K00088] [EC:1.1.1.205]
107559456  inosine-5'-monophosphate dehydrogenase 1a isoform X1 [KO:K00088] [EC:1.1.1.205]
107599814  inosine-5'-monophosphate dehydrogenase 1a-like [KO:K00088] [EC:1.1.1.205]
107556494  inosine-5'-monophosphate dehydrogenase 2-like [KO:K00088] [EC:1.1.1.205]
107591776  impdh2; inosine-5'-monophosphate dehydrogenase 2 isoform X1 [KO:K00088] [EC:1.1.1.205]
107557175  gmps; GMP synthase [glutamine-hydrolyzing] [KO:K01951] [EC:6.3.5.2]
107566581  GMP synthase [glutamine-hydrolyzing]-like [KO:K01951] [EC:6.3.5.2]
107591974  probable thiopurine S-methyltransferase isoform X1 [KO:K00569] [EC:2.1.1.67]
107594783  xanthine dehydrogenase/oxidase-like [KO:K00106] [EC:1.17.1.4 1.17.3.2]
107592779  xanthine dehydrogenase/oxidase-like [KO:K00106] [EC:1.17.1.4 1.17.3.2]
107581499  inosine triphosphate pyrophosphatase-like [KO:K01519] [EC:3.6.1.66]
107597797  itpa; inosine triphosphate pyrophosphatase [KO:K01519] [EC:3.6.1.66]
107589308  uncharacterized protein LOC107589308 [KO:K03927] [EC:3.1.1.1 3.1.1.84 3.1.1.56]
107595238  uncharacterized protein LOC107595238 [KO:K03927] [EC:3.1.1.1 3.1.1.84 3.1.1.56]
107581545  UDP-glucuronosyltransferase 1-1-like [KO:K00699] [EC:2.4.1.17]
107557224  UDP-glucuronosyltransferase 2B17-like isoform X1 [KO:K00699] [EC:2.4.1.17]
107548539  UDP-glucuronosyltransferase 2C1-like isoform X1 [KO:K00699] [EC:2.4.1.17]
107556030  UDP-glucuronosyltransferase 2C1-like [KO:K00699] [EC:2.4.1.17]
107556031  UDP-glucuronosyltransferase 2C1-like isoform X1 [KO:K00699] [EC:2.4.1.17]
107555941  UDP-glucuronosyltransferase 1-6-like isoform X1 [KO:K00699] [EC:2.4.1.17]
107572565  UDP-glucuronosyltransferase 2B31-like [KO:K00699] [EC:2.4.1.17]
107564400  UDP-glucuronosyltransferase 2C1-like isoform X1 [KO:K00699] [EC:2.4.1.17]
107572263  UDP-glucuronosyltransferase 2A1-like [KO:K00699] [EC:2.4.1.17]
107552046  UDP-glucuronosyltransferase 2C1-like [KO:K00699] [EC:2.4.1.17]
107594390  UDP-glucuronosyltransferase 2C1-like [KO:K00699] [EC:2.4.1.17]
107558044  UDP-glucuronosyltransferase-like [KO:K00699] [EC:2.4.1.17]
107558046  UDP-glucuronosyltransferase 1-6-like [KO:K00699] [EC:2.4.1.17]
107556441  UDP-glucuronosyltransferase 1-5-like isoform X1 [KO:K00699] [EC:2.4.1.17]
107591494  LOW QUALITY PROTEIN: beta-glucuronidase-like [KO:K01195] [EC:3.2.1.31]
107563433  gusb; beta-glucuronidase [KO:K01195] [EC:3.2.1.31]
107555991  cytidine deaminase-like [KO:K01489] [EC:3.5.4.5]
107574529  cytidine deaminase-like [KO:K01489] [EC:3.5.4.5]
107597094  cytidine deaminase-like [KO:K01489] [EC:3.5.4.5]
107563138  cytidine deaminase-like [KO:K01489] [EC:3.5.4.5]
107563140  cytidine deaminase-like [KO:K01489] [EC:3.5.4.5]
107563141  cytidine deaminase-like [KO:K01489] [EC:3.5.4.5]
107599502  cytidine deaminase-like [KO:K01489] [EC:3.5.4.5]
107572847  putative cytidine deaminase [KO:K01489] [EC:3.5.4.5]
107580729  thymidine phosphorylase-like [KO:K00758] [EC:2.4.2.4]
107590279  LOW QUALITY PROTEIN: dihydropyrimidine dehydrogenase [NADP(+)]-like [KO:K00207] [EC:1.3.1.2]
107594652  dpyd; dihydropyrimidine dehydrogenase [NADP(+)] isoform X1 [KO:K00207] [EC:1.3.1.2]
107570487  dihydropyrimidine dehydrogenase [NADP(+)]-like [KO:K00207] [EC:1.3.1.2]
107589900  dihydropyrimidine dehydrogenase [NADP(+)]-like [KO:K00207] [EC:1.3.1.2]
107556952  dpys; dihydropyrimidinase [KO:K01464] [EC:3.5.2.2]
107602847  beta-ureidopropionase-like [KO:K01431] [EC:3.5.1.6]
107577092  upb1; beta-ureidopropionase [KO:K01431] [EC:3.5.1.6]
107569728  uridine phosphorylase 2-like [KO:K00757] [EC:2.4.2.3]
107579388  uridine phosphorylase 2-like [KO:K00757] [EC:2.4.2.3]
107568899  uridine phosphorylase 2-like [KO:K00757] [EC:2.4.2.3]
107568900  uridine phosphorylase 2-like [KO:K00757] [EC:2.4.2.3]
107596632  uridine phosphorylase 1-like [KO:K00757] [EC:2.4.2.3]
107570870  uridine-cytidine kinase-like 1 isoform X1 [KO:K00876] [EC:2.7.1.48]
107602209  uridine-cytidine kinase-like 1 isoform X1 [KO:K00876] [EC:2.7.1.48]
107593786  uridine-cytidine kinase 2-B [KO:K00876] [EC:2.7.1.48]
107593787  uridine-cytidine kinase 2-B-like [KO:K00876] [EC:2.7.1.48]
107598092  uridine-cytidine kinase-like 1 [KO:K00876] [EC:2.7.1.48]
107585889  uridine-cytidine kinase 2-A [KO:K00876] [EC:2.7.1.48]
107601315  uridine-cytidine kinase-like 1 [KO:K00876] [EC:2.7.1.48]
107549113  uridine-cytidine kinase 2-A-like [KO:K00876] [EC:2.7.1.48]
107599365  uridine-cytidine kinase 1-like [KO:K00876] [EC:2.7.1.48]
107585643  uridine-cytidine kinase 1 [KO:K00876] [EC:2.7.1.48]
107560789  uridine-cytidine kinase 2-B-like isoform X1 [KO:K00876] [EC:2.7.1.48]
107549990  uridine-cytidine kinase-like 1 isoform X1 [KO:K00876] [EC:2.7.1.48]
107564540  thymidine kinase 2, mitochondrial-like isoform X1 [KO:K00857] [EC:2.7.1.21]
107567629  tk1; thymidine kinase, cytosolic [KO:K00857] [EC:2.7.1.21]
107577227  thymidine kinase, cytosolic-like isoform X1 [KO:K00857] [EC:2.7.1.21]
107562214  tk2; thymidine kinase 2, mitochondrial isoform X1 [KO:K00857] [EC:2.7.1.21]
107577997  umps; uridine 5'-monophosphate synthase [KO:K13421] [EC:2.4.2.10 4.1.1.23]
107593778  UMP-CMP kinase-like [KO:K13800] [EC:2.7.4.14]
107559368  UMP-CMP kinase [KO:K13800] [EC:2.7.4.14]
107557082  ribonucleoside-diphosphate reductase large subunit [KO:K10807] [EC:1.17.4.1]
107590092  ribonucleoside-diphosphate reductase large subunit-like [KO:K10807] [EC:1.17.4.1]
107602598  ribonucleoside-diphosphate reductase subunit M2-like [KO:K10808] [EC:1.17.4.1]
107565196  ribonucleoside-diphosphate reductase subunit M2 B-like [KO:K10808] [EC:1.17.4.1]
107549099  ribonucleoside-diphosphate reductase subunit M2 [KO:K10808] [EC:1.17.4.1]
107556385  ribonucleoside-diphosphate reductase subunit M2 B-like [KO:K10808] [EC:1.17.4.1]
107561929  nme6; nucleoside diphosphate kinase 6 [KO:K00940] [EC:2.7.4.6]
107574626  nucleoside diphosphate kinase A-like isoform X1 [KO:K00940] [EC:2.7.4.6]
107573071  nucleoside diphosphate kinase isoform X1 [KO:K00940] [EC:2.7.4.6]
107567334  nucleoside diphosphate kinase A-like [KO:K00940] [EC:2.7.4.6]
107589089  nucleoside diphosphate kinase 6-like [KO:K00940] [EC:2.7.4.6]
107553633  nucleoside diphosphate kinase, mitochondrial-like [KO:K00940] [EC:2.7.4.6]
107580790  nucleoside diphosphate kinase 3-like [KO:K00940] [EC:2.7.4.6]
107590639  nucleoside diphosphate kinase 7-like [KO:K00940] [EC:2.7.4.6]
107548663  nucleoside diphosphate kinase 7-like [KO:K00940] [EC:2.7.4.6]
107558983  nucleoside diphosphate kinase A-like isoform X1 [KO:K00940] [EC:2.7.4.6]
107580281  deoxyuridine 5'-triphosphate nucleotidohydrolase-like [KO:K01520] [EC:3.6.1.23]
107595387  dut; deoxyuridine 5'-triphosphate nucleotidohydrolase, mitochondrial [KO:K01520] [EC:3.6.1.23]
107569391  eosinophil peroxidase-like [KO:K10789] [EC:1.11.2.2]
107551480  arylamine N-acetyltransferase, pineal gland isozyme NAT-10-like [KO:K00622] [EC:2.3.1.5]
107588554  arylamine N-acetyltransferase, pineal gland isozyme NAT-10-like [KO:K00622] [EC:2.3.1.5]
107561782  microsomal glutathione S-transferase 3-like [KO:K00799] [EC:2.5.1.18]
107594552  microsomal glutathione S-transferase 1-like [KO:K00799] [EC:2.5.1.18]
107595683  glutathione S-transferase theta-1-like [KO:K00799] [EC:2.5.1.18]
107600045  glutathione S-transferase theta-1-like isoform X1 [KO:K00799] [EC:2.5.1.18]
107602832  glutathione S-transferase theta-1-like [KO:K00799] [EC:2.5.1.18]
107559317  glutathione S-transferase omega-1-like [KO:K00799] [EC:2.5.1.18]
107559318  glutathione S-transferase omega-1-like isoform X1 [KO:K00799] [EC:2.5.1.18]
107567457  glutathione S-transferase theta-1-like [KO:K00799] [EC:2.5.1.18]
107579102  microsomal glutathione S-transferase 2-like [KO:K00799] [EC:2.5.1.18]
107573328  microsomal glutathione S-transferase 3-like [KO:K00799] [EC:2.5.1.18]
107550498  glutathione S-transferase Mu 3-like [KO:K00799] [EC:2.5.1.18]
107550499  glutathione S-transferase Mu 1-like [KO:K00799] [EC:2.5.1.18]
107593307  microsomal glutathione S-transferase 3-like [KO:K00799] [EC:2.5.1.18]
107578494  microsomal glutathione S-transferase 1-like [KO:K00799] [EC:2.5.1.18]
107591812  glutathione S-transferase Mu 3-like isoform X1 [KO:K00799] [EC:2.5.1.18]
107548781  glutathione S-transferase theta-1-like [KO:K00799] [EC:2.5.1.18]
107601879  glutathione S-transferase omega-1-like isoform X1 [KO:K00799] [EC:2.5.1.18]
107561968  glutathione S-transferase-like [KO:K00799] [EC:2.5.1.18]
107555141  microsomal glutathione S-transferase 1-like [KO:K00799] [EC:2.5.1.18]
107601880  glutathione S-transferase omega-1-like [KO:K00799] [EC:2.5.1.18]
107597693  microsomal glutathione S-transferase 3-like [KO:K00799] [EC:2.5.1.18]
107597728  glutathione S-transferase 3-like [KO:K00799] [EC:2.5.1.18]
107566738  glutathione S-transferase A-like [KO:K00799] [EC:2.5.1.18]
107568012  glutathione S-transferase A-like [KO:K00799] [EC:2.5.1.18]
107550274  glutathione S-transferase theta-1-like [KO:K00799] [EC:2.5.1.18]
107556847  glutathione S-transferase P-like [KO:K23790] [EC:2.5.1.18]
107589127  glutathione S-transferase P-like [KO:K23790] [EC:2.5.1.18]
Compound
C00003  NAD+
C00006  NADP+
C02320  R-S-Glutathione
C02380  6-Mercaptopurine
C04242  5-Fluorodeoxyuridine monophosphate
C04646  6-Thioinosine-5'-monophosphate
C05361  Hydrazine
C06108  Fluoroacetate
C06837  Azathioprine
C07054  Isoniazid
C07446  Isonicotinic acid
C07447  Acetylhydrazine
C07585  N-Acetylisoniazid
C07648  Thioguanine
C07649  5-FU
C11173  SN-38
C11376  SN38 glucuronide
C11736  5-Fluorodeoxyuridine
C12650  Capecitabine
C12673  Tegafur
C12739  5'-Deoxy-5-fluorouridine
C13252  Carmofur
C16542  APC
C16543  NPC
C16613  6-Thiourate
C16614  6-Methylmercaptopurine
C16615  6-Methylthiopurine 5'-monophosphate ribonucleotide
C16616  6-Mercaptopurine ribonucleoside 5'-diphosphate
C16617  6-Mercaptopurine ribonucleoside triphosphate
C16618  6-Thioxanthine 5'-monophosphate
C16619  6-Thioguanosine monophosphate
C16620  6-Methylthioguanosine monophosphate
C16621  1-Methyl-4-nitroimidazole
C16622  N,N'-Diacetylhydrazine
C16623  Isonicotinylglycine
C16624  Isoniazid pyruvate
C16625  Isoniazid alpha-ketoglutaric acid
C16630  5,6-Dihydro-5-fluorouracil
C16631  alpha-Fluoro-beta-ureidopropionic acid
C16632  alpha-Fluoro-beta-alanine
C16633  5-Fluorouridine
C16634  5-Fluorouridine monophosphate
C16635  5'-Deoxy-5-fluorocytidine
C16641  Irinotecan
C21748  5-Fluorouridine diphosphate
C21749  5-Fluorouridine triphosphate
C21750  5-Fluorodeoxyuridine diphosphate
C21751  5-Fluorodeoxyuridine triphosphate
C21754  Isonicotinoyl radical
C21758  Hepatotoxins
C21759  Isonicotinoyl-NAD adduct
C21760  Isonicotinoyl-NADP adduct
D00238  Azathioprine (JP18/USP/INN)
D00346  Isoniazid (JP18/USP/INN)
D00584  Fluorouracil (JP18/USP/INN)
D01223  Capecitabine (JAN/USP/INN)
D01244  Tegafur (JP18/USAN/INN)
D01309  Doxifluridine (JP18/INN)
D01784  Carmofur (JP18/INN)
D04197  Floxuridine (USP/INN)
D04931  Mercaptopurine (INN)
D08086  Irinotecan (INN)
D08603  Tioguanine (INN)
Reference
  Authors
Kato R, Kamatari T (eds).
  Title
[Drug Metabolism] (In Japanese)
  Journal
Tokyo Kagaku Dojin (2000)
Reference
  Authors
Al Hadithy AF, de Boer NK, Derijks LJ, Escher JC, Mulder CJ, Brouwers JR.
  Title
Thiopurines in inflammatory bowel disease: pharmacogenetics, therapeutic drug monitoring and clinical recommendations.
  Journal
Dig Liver Dis 37:282-97 (2005)
DOI:10.1016/j.dld.2004.09.029
Reference
  Authors
Gearry RB, Barclay ML.
  Title
Azathioprine and 6-mercaptopurine pharmacogenetics and metabolite monitoring in inflammatory bowel disease.
  Journal
J Gastroenterol Hepatol 20:1149-57 (2005)
DOI:10.1111/j.1440-1746.2005.03832.x
Reference
  Authors
Gilissen LP, Derijks LJ, Verhoeven HM, Bierau J, Hooymans PM, Hommes DW, Engels LG.
  Title
Pancytopenia due to high 6-methylmercaptopurine levels in a 6-mercaptopurine treated patient with Crohn's disease.
  Journal
Dig Liver Dis 39:182-6 (2007)
DOI:10.1016/j.dld.2006.05.026
Reference
  Authors
Fischel JL, Formento P, Ciccolini J, Etienne-Grimaldi MC, Milano G.
  Title
Lack of contribution of dihydrofluorouracil and alpha-fluoro-beta-alanine to the cytotoxicity of 5'-deoxy-5-fluorouridine on human keratinocytes.
  Journal
Anticancer Drugs 15:969-74 (2004)
DOI:10.1097/00001813-200411000-00006
Reference
  Authors
Shimma N, Umeda I, Arasaki M, Murasaki C, Masubuchi K, Kohchi Y, Miwa M, Ura M, Sawada N, Tahara H, Kuruma I, Horii I, Ishitsuka H.
  Title
The design and synthesis of a new tumor-selective fluoropyrimidine carbamate, capecitabine.
  Journal
Bioorg Med Chem 8:1697-706 (2000)
DOI:10.1016/S0968-0896(00)00087-0
Reference
  Authors
Chung YL, Troy H, Judson IR, Leek R, Leach MO, Stubbs M, Harris AL, Griffiths JR
  Title
Noninvasive measurements of capecitabine metabolism in bladder tumors overexpressing thymidine phosphorylase by fluorine-19 magnetic resonance spectroscopy.
  Journal
Clin Cancer Res 10:3863-70 (2004)
DOI:10.1158/1078-0432.CCR-03-0237
Reference
  Authors
Mathijssen RH, van Alphen RJ, Verweij J, Loos WJ, Nooter K, Stoter G, Sparreboom A
  Title
Clinical pharmacokinetics and metabolism of irinotecan (CPT-11).
  Journal
Clin Cancer Res 7:2182-94 (2001)
Reference
  Authors
Kita T, Tanigawara Y, Chikazawa S, Hatanaka H, Sakaeda T, Komada F, Iwakawa S, Okumura K.
  Title
N-Acetyltransferase2 genotype correlated with isoniazid acetylation in Japanese tuberculous patients.
  Journal
Biol Pharm Bull 24:544-9 (2001)
DOI:10.1248/bpb.24.544
Reference
  Authors
Miura K, Kinouchi M, Ishida K, Fujibuchi W, Naitoh T, Ogawa H, Ando T, Yazaki N, Watanabe K, Haneda S, Shibata C, Sasaki I
  Title
5-fu metabolism in cancer and orally-administrable 5-fu drugs.
  Journal
Cancers (Basel) 2:1717-30 (2010)
DOI:10.3390/cancers2031717
Reference
  Authors
Wang P, Pradhan K, Zhong XB, Ma X
  Title
Isoniazid metabolism and hepatotoxicity.
  Journal
Acta Pharm Sin B 6:384-392 (2016)
DOI:10.1016/j.apsb.2016.07.014
Reference
  Authors
Klein DJ, Boukouvala S, McDonagh EM, Shuldiner SR, Laurieri N, Thorn CF, Altman RB, Klein TE
  Title
PharmGKB summary: isoniazid pathway, pharmacokinetics.
  Journal
Pharmacogenet Genomics 26:436-44 (2016)
DOI:10.1097/FPC.0000000000000232
Reference
  Authors
Yamada S, Richardson K, Tang M, Halaschek-Wiener J, Cook VJ, Fitzgerald JM, Elwood K, Marra F, Brooks-Wilson A
  Title
Genetic variation in carboxylesterase genes and susceptibility to isoniazid-induced hepatotoxicity.
  Journal
Pharmacogenomics J 10:524-36 (2010)
DOI:10.1038/tpj.2010.5
Reference
  Authors
Vlasits J, Jakopitsch C, Bernroitner M, Zamocky M, Furtmuller PG, Obinger C
  Title
Mechanisms of catalase activity of heme peroxidases.
  Journal
Arch Biochem Biophys 500:74-81 (2010)
DOI:10.1016/j.abb.2010.04.018
Reference
  Authors
Khan SR, Morgan AG, Michail K, Srivastava N, Whittal RM, Aljuhani N, Siraki AG
  Title
Metabolism of isoniazid by neutrophil myeloperoxidase leads to isoniazid-NAD(+) adduct formation: A comparison of the reactivity of isoniazid with its known human metabolites.
  Journal
Biochem Pharmacol 106:46-55 (2016)
DOI:10.1016/j.bcp.2016.02.003
Reference
  Authors
Forbes LV, Furtmuller PG, Khalilova I, Turner R, Obinger C, Kettle AJ
  Title
Isoniazid as a substrate and inhibitor of myeloperoxidase: identification of amine adducts and the influence of superoxide dismutase on their formation.
  Journal
Biochem Pharmacol 84:949-60 (2012)
DOI:10.1016/j.bcp.2012.07.020
Reference
  Authors
Nguyen M, Quemard A, Broussy S, Bernadou J, Meunier B
  Title
Mn(III) pyrophosphate as an efficient tool for studying the mode of action of isoniazid on the InhA protein of Mycobacterium tuberculosis.
  Journal
Antimicrob Agents Chemother 46:2137-44 (2002)
DOI:10.1128/AAC.46.7.2137-2144.2002
Reference
PMID:9417034
  Authors
Rozwarski DA, Grant GA, Barton DH, Jacobs WR Jr, Sacchettini JC
  Title
Modification of the NADH of the isoniazid target (InhA) from Mycobacterium tuberculosis.
  Journal
Science 279:98-102 (1998)
DOI:10.1126/science.279.5347.98
Reference
  Authors
Argyrou A, Vetting MW, Blanchard JS
  Title
New insight into the mechanism of action of and resistance to isoniazid: interaction of Mycobacterium tuberculosis enoyl-ACP reductase with INH-NADP.
  Journal
J Am Chem Soc 129:9582-3 (2007)
DOI:10.1021/ja073160k
KO pathway
ko00983   
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