KEGG   PATHWAY: sly00053
Entry
sly00053                    Pathway                                
Name
Ascorbate and aldarate metabolism - Solanum lycopersicum (tomato)
Class
Metabolism; Carbohydrate metabolism
Pathway map
sly00053  Ascorbate and aldarate metabolism
sly00053

Module
sly_M00114  Ascorbate biosynthesis, plants, fructose-6P => ascorbate [PATH:sly00053]
Other DBs
GO: 0019852 0019577 0019572
Organism
Solanum lycopersicum (tomato) [GN:sly]
Gene
101246311  UDP-glucose 6-dehydrogenase 1 [KO:K00012] [EC:1.1.1.22]
101263958  UDP-glucose 6-dehydrogenase 2 [KO:K00012] [EC:1.1.1.22]
101261402  UDP-glucose 6-dehydrogenase 1-like [KO:K00012] [EC:1.1.1.22]
101259257  UDP-glucose 6-dehydrogenase 5-like isoform X2 [KO:K00012] [EC:1.1.1.22]
101247010  UDP-sugar pyrophosphorylase [KO:K12447] [EC:2.7.7.64]
101260589  glucuronokinase 1 [KO:K16190] [EC:2.7.1.43]
101254427  inositol oxygenase 1 [KO:K00469] [EC:1.13.99.1]
101265809  inositol oxygenase 5-like [KO:K00469] [EC:1.13.99.1]
101268447  probable inositol oxygenase isoform X1 [KO:K00469] [EC:1.13.99.1]
100316875  MIOX; myo-inositol oxygenase [KO:K00469] [EC:1.13.99.1]
101263222  inositol oxygenase 1 [KO:K00469] [EC:1.13.99.1]
101267438  aldose reductase [KO:K00002] [EC:1.1.1.2]
101256514  aldo-keto reductase 4B-like [KO:K00002] [EC:1.1.1.2]
101261840  L-gulonolactone oxidase 3 [KO:K00103] [EC:1.1.3.8]
101256030  probable L-gulonolactone oxidase 6 [KO:K00103] [EC:1.1.3.8]
100316902  GME1; GDP-mannose 3',5'-epimerase [KO:K10046] [EC:5.1.3.18 5.1.3.-]
100316874  GME2; GDP-mannose 3',5'-epimerase [KO:K10046] [EC:5.1.3.18 5.1.3.-]
101255942  GGP2; GDP-L-galactose phosphorylase [KO:K14190] [EC:2.7.7.69]
101055572  GGP; GDP-L-galactose phosphorylase [KO:K14190] [EC:2.7.7.69]
544014  IMP2; inositol monophosphatase 2 [KO:K10047] [EC:3.1.3.25 3.1.3.93]
544280  IMP1; inositol monophosphatase 1 [KO:K10047] [EC:3.1.3.25 3.1.3.93]
544013  IMP3; inositol monophosphatase 3 [KO:K10047] [EC:3.1.3.25 3.1.3.93]
101254644  bifunctional phosphatase IMPL2, chloroplastic [KO:K18649] [EC:3.1.3.25 3.1.3.93 3.1.3.15]
101254135  L-galactose dehydrogenase [KO:K17744] [EC:1.1.1.316]
544206  gldh; L-galactono-1,4-lactone dehydrogenase [KO:K00225] [EC:1.3.2.3]
101249858  UDP-glucuronate 4-epimerase 3 [KO:K08679] [EC:5.1.3.6]
101265133  UDP-glucuronate 4-epimerase 3 [KO:K08679] [EC:5.1.3.6]
101247369  UDP-glucuronate 4-epimerase 6 [KO:K08679] [EC:5.1.3.6]
101245594  UDP-glucuronate 4-epimerase 3-like [KO:K08679] [EC:5.1.3.6]
101250671  UDP-glucuronate 4-epimerase 2-like [KO:K08679] [EC:5.1.3.6]
101256973  UDP-glucuronate 4-epimerase 6-like [KO:K08679] [EC:5.1.3.6]
101251855  UDP-glucuronate 4-epimerase 1 [KO:K08679] [EC:5.1.3.6]
101257677  UDP-glucuronate 4-epimerase 1 [KO:K08679] [EC:5.1.3.6]
101266358  UDP-glucuronate 4-epimerase 5 [KO:K08679] [EC:5.1.3.6]
101256763  D-galacturonate reductase-like [KO:K19642] [EC:1.1.1.365]
778288  MDHAR; monodehydroascorbate reductase [KO:K08232] [EC:1.6.5.4]
101264360  AFRR; monodehydroascorbate reductase [KO:K08232] [EC:1.6.5.4]
101253550  Monodehydroascorbate reductase (NADH)-like protein [KO:K08232] [EC:1.6.5.4]
101264282  L-ascorbate peroxidase 3 [KO:K00434] [EC:1.11.1.11]
778224  APX2; cytosolic ascorbate peroxidase 2 [KO:K00434] [EC:1.11.1.11]
778341  APX6; thylakoid-bound ascorbate peroxidase 6 [KO:K00434] [EC:1.11.1.11]
101258987  L-ascorbate peroxidase 2, cytosolic [KO:K00434] [EC:1.11.1.11]
101264583  L-ascorbate peroxidase 5 [KO:K00434] [EC:1.11.1.11]
101262528  APX7; stromal ascorbate peroxidase 7 [KO:K00434] [EC:1.11.1.11]
101264261  L-ascorbate peroxidase 3, peroxisomal [KO:K00434] [EC:1.11.1.11]
778223  APX1; cytosolic ascorbate peroxidase 1 [KO:K00434] [EC:1.11.1.11]
101257790  putative L-ascorbate peroxidase 6 isoform X1 [KO:K00434] [EC:1.11.1.11]
778229  DHAR1; dehydroascorbate reductase 1 [KO:K21888] [EC:1.8.5.1 2.5.1.18]
778343  DHAR2; dehydroascorbate reductase [KO:K21888] [EC:1.8.5.1 2.5.1.18]
101254215  uncharacterized protein LOC101254215 [KO:K21888] [EC:1.8.5.1 2.5.1.18]
101254961  L-ascorbate oxidase homolog [KO:K00423] [EC:1.10.3.3]
101263934  L-ascorbate oxidase homolog [KO:K00423] [EC:1.10.3.3]
101251411  L-ascorbate oxidase homolog [KO:K00423] [EC:1.10.3.3]
101258916  L-ascorbate oxidase [KO:K00423] [EC:1.10.3.3]
101253411  L-ascorbate oxidase-like isoform X1 [KO:K00423] [EC:1.10.3.3]
101266911  L-ascorbate oxidase homolog [KO:K00423] [EC:1.10.3.3]
104645747  aldehyde dehydrogenase family 3 member F1 [KO:K00128] [EC:1.2.1.3]
101247085  glutaredoxin-C3 [KO:K00128] [EC:1.2.1.3]
101250104  ALDH2B7a; aldehyde dehydrogenase family 2 member B7a [KO:K00128] [EC:1.2.1.3]
101262822  ALD3H1; aldehyde dehydrogenase family 3 member H2 [KO:K00128] [EC:1.2.1.3]
101267634  ADH3F1a; aldehyde dehydrogenase family 3 member F1 [KO:K00128] [EC:1.2.1.3]
101250474  aldehyde dehydrogenase family 2 member B7, mitochondrial [KO:K00128] [EC:1.2.1.3]
101254485  ADH2B7d; aldehyde dehydrogenase family 2 member B7d [KO:K00128] [EC:1.2.1.3]
101257095  aldehyde dehydrogenase family 2 member B7, mitochondrial-like [KO:K00128] [EC:1.2.1.3]
112940646  aldehyde dehydrogenase family 3 member F1-like [KO:K00128] [EC:1.2.1.3]
101252968  aldehyde dehydrogenase family 7 member B4 [KO:K14085] [EC:1.2.1.31 1.2.1.8 1.2.1.3]
Compound
C00022  Pyruvate
C00026  2-Oxoglutarate
C00029  UDP-glucose
C00072  Ascorbate
C00096  GDP-mannose
C00137  myo-Inositol
C00167  UDP-glucuronate
C00191  D-Glucuronate
C00216  D-Arabinose
C00231  D-Xylulose 5-phosphate
C00259  L-Arabinose
C00333  D-Galacturonate
C00433  2,5-Dioxopentanoate
C00545  L-Arabinonate
C00558  D-Tagaturonate
C00617  UDP-D-galacturonate
C00618  3-Dehydro-L-gulonate
C00652  D-Arabinono-1,4-lactone
C00679  5-Dehydro-4-deoxy-D-glucarate
C00684  2-Dehydro-3-deoxy-L-arabinonate
C00800  L-Gulonate
C00818  D-Glucarate
C00878  D-Arabinonate
C00879  D-Galactarate
C01040  L-Gulono-1,4-lactone
C01041  Monodehydroascorbate
C01101  L-Ribulose 5-phosphate
C01114  L-Arabinono-1,4-lactone
C01115  L-Galactono-1,4-lactone
C01146  2-Hydroxy-3-oxopropanoate
C01620  Threonate
C01825  L-Galactose
C02280  GDP-L-galactose
C02670  D-Glucuronolactone
C03033  beta-D-Glucuronoside
C03064  3-Dehydro-L-threonate
C03289  L-xylo-Hexulonolactone
C03291  L-Xylulose 5-phosphate
C03826  2-Dehydro-3-deoxy-D-xylonate
C03921  2-Dehydro-3-deoxy-D-glucarate
C04037  1-Phospho-alpha-D-galacturonate
C04575  (4R,5S)-4,5,6-Trihydroxy-2,3-dioxohexanoate
C05385  D-Glucuronate 1-phosphate
C05411  L-Xylonate
C05412  L-Lyxonate
C05422  Dehydroascorbate
C06316  Dehydro-D-arabinono-1,4-lactone
C14899  3-Dehydro-L-gulonate 6-phosphate
C15923  L-Gulose
C15924  L-Gulose 1-phosphate
C15925  GDP-L-gulose
C15926  beta-L-Galactose 1-phosphate
C15930  L-Galactonate
C16186  L-Ascorbate 6-phosphate
C20889  D-Galactaro-1,5-lactone
C20896  D-Galactaro-1,4-lactone
C21955  L-Galactono-1,5-lactone
Reference
PMID:17222174
  Authors
Linster CL, Van Schaftingen E
  Title
Vitamin C. Biosynthesis, recycling and degradation in mammals.
  Journal
FEBS J 274:1-22 (2007)
DOI:10.1111/j.1742-4658.2006.05607.x
Reference
PMID:15564123
  Authors
Valpuesta V, Botella MA.
  Title
Biosynthesis of L-ascorbic acid in plants: new pathways for an old antioxidant.
  Journal
Trends Plant Sci 9:573-7 (2004)
DOI:10.1016/j.tplants.2004.10.002
Reference
PMID:10517845
  Authors
Davey MW, Gilot C, Persiau G, Ostergaard J, Han Y, Bauw GC, Van Montagu MC.
  Title
Ascorbate biosynthesis in Arabidopsis cell suspension culture.
  Journal
Plant Physiol 121:535-43 (1999)
DOI:10.1104/pp.121.2.535
Reference
PMID:16595667
  Authors
Conklin PL, Gatzek S, Wheeler GL, Dowdle J, Raymond MJ, Rolinski S, Isupov M, Littlechild JA, Smirnoff N.
  Title
Arabidopsis thaliana VTC4 encodes L-galactose-1-P phosphatase, a plant ascorbic acid biosynthetic enzyme.
  Journal
J Biol Chem 281:15662-70 (2006)
DOI:10.1074/jbc.M601409200
Reference
PMID:17462988
  Authors
Linster CL, Gomez TA, Christensen KC, Adler LN, Young BD, Brenner C, Clarke SG.
  Title
Arabidopsis VTC2 Encodes a GDP-L-Galactose Phosphorylase, the Last Unknown Enzyme in the Smirnoff-Wheeler Pathway to Ascorbic Acid in Plants.
  Journal
J Biol Chem 282:18879-85 (2007)
DOI:10.1074/jbc.M702094200
Reference
PMID:14996803
  Authors
Campos E, Baldoma L, Aguilar J, Badia J.
  Title
Regulation of expression of the divergent ulaG and ulaABCDEF operons involved in LaAscorbate dissimilation in Escherichia coli.
  Journal
J Bacteriol 186:1720-8 (2004)
DOI:10.1128/JB.186.6.1720-1728.2004
Reference
PMID:12644495
  Authors
Zhang Z, Aboulwafa M, Smith MH, Saier MH Jr.
  Title
The ascorbate transporter of Escherichia coli.
  Journal
J Bacteriol 185:2243-50 (2003)
DOI:10.1128/JB.185.7.2243-2250.2003
Related
pathway
sly00020  Citrate cycle (TCA cycle)
sly00040  Pentose and glucuronate interconversions
sly00051  Fructose and mannose metabolism
sly00520  Amino sugar and nucleotide sugar metabolism
sly00630  Glyoxylate and dicarboxylate metabolism
KO pathway
ko00053   
LinkDB

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