KEGG   PATHWAY: tala03040
Entry
tala03040                   Pathway                                
Name
Spliceosome - Tyto alba (Barn owl)
Description
After transcription, eukaryotic mRNA precursors contain protein-coding exons and noncoding introns. In the following splicing, introns are excised and exons are joined by a macromolecular complex, the spliceosome. The standard spliceosome is made up of five small nuclear ribonucleoproteins (snRNPs), U1, U2, U4, U5, and U6 snRNPs, and several spliceosome-associated proteins (SAPs). Spliceosomes are not a simple stable complex, but a dynamic family of particles that assemble on the mRNA precursor and help fold it into a conformation that allows transesterification to proceed. Various spliceosome forms (e.g. A-, B- and C-complexes) have been identified.
Class
Genetic Information Processing; Transcription
Pathway map
tala03040  Spliceosome
tala03040

Other DBs
GO: 0005681
Organism
Tyto alba (Barn owl) [GN:tala]
Gene
116963940  U2 spliceosomal RNA [KO:K14277]
122154713  U4 spliceosomal RNA [KO:K14278]
116963577  U5 spliceosomal RNA [KO:K14279]
116963578  U6 spliceosomal RNA [KO:K14280]
104355850  DDX46; probable ATP-dependent RNA helicase DDX46 [KO:K12811] [EC:5.6.2.7]
104368079  DHX38; pre-mRNA-splicing factor ATP-dependent RNA helicase PRP16 [KO:K12815] [EC:5.6.2.6]
104360719  CDC40; pre-mRNA-processing factor 17 [KO:K12816]
104359151  PRPF18; pre-mRNA-splicing factor 18 isoform X1 [KO:K12817]
104358083  DHX8; ATP-dependent RNA helicase DHX8 [KO:K12818] [EC:5.6.2.6]
104359843  SLU7; pre-mRNA-splicing factor SLU7 [KO:K12819]
104369109  DHX15; pre-mRNA-splicing factor ATP-dependent RNA helicase DHX15 [KO:K12820] [EC:5.6.2.6]
104358833  SNRPB; small nuclear ribonucleoprotein-associated proteins B and B' [KO:K11086]
104356499  SNRPD1; small nuclear ribonucleoprotein Sm D1 [KO:K11087]
116960105  SNRPD2; small nuclear ribonucleoprotein Sm D2 [KO:K11096]
104359249  SNRPD3; small nuclear ribonucleoprotein Sm D3 [KO:K11088]
116965592  SNRPE; small nuclear ribonucleoprotein E [KO:K11097]
104363526  SNRPF; small nuclear ribonucleoprotein F [KO:K11098]
104357042  SNRPC; U1 small nuclear ribonucleoprotein C [KO:K11095]
104359889  PRPF40A; pre-mRNA-processing factor 40 homolog A isoform X1 [KO:K12821]
104362088  RBM25; RNA-binding protein 25 isoform X1 [KO:K12822]
104355783  DDX5; probable ATP-dependent RNA helicase DDX5 isoform X1 [KO:K12823] [EC:5.6.2.7]
104367720  TCERG1; transcription elongation regulator 1 isoform X1 [KO:K12824]
104355602  SNRPA1; U2 small nuclear ribonucleoprotein A' [KO:K11092]
104356041  SNRPB2; U2 small nuclear ribonucleoprotein B'' [KO:K11094]
104359217  SF3A1; splicing factor 3A subunit 1 [KO:K12825]
104359149  SF3A2; splicing factor 3A subunit 2 [KO:K12826]
104368088  SF3A3; splicing factor 3A subunit 3 [KO:K12827]
104363222  SF3B1; splicing factor 3B subunit 1 isoform X1 [KO:K12828]
104364410  SF3B3; splicing factor 3B subunit 3 [KO:K12830]
116960035  SF3B4; splicing factor 3B subunit 4 isoform X1 [KO:K12831]
116965927  SF3B5; splicing factor 3B subunit 5 [KO:K12832]
104369446  SF3B6; splicing factor 3B subunit 6 [KO:K12833]
104362104  PHF5A; PHD finger-like domain-containing protein 5A [KO:K12834]
104368427  DDX42; ATP-dependent RNA helicase DDX42 [KO:K12835] [EC:5.6.2.7]
104356544  U2AF1; splicing factor U2AF 35 kDa subunit isoform X2 [KO:K12836]
104366025  PUF60; poly(U)-binding-splicing factor PUF60 isoform X1 [KO:K12838]
104359517  SMNDC1; survival of motor neuron-related-splicing factor 30 isoform X1 [KO:K12839]
104355968  RBM17; splicing factor 45 isoform X1 [KO:K12840]
104369471  calcium homeostasis endoplasmic reticulum protein isoform X1 [KO:K12841]
104361642  U2 snRNP-associated SURP motif-containing protein isoform X4 [KO:K12842]
104356282  RP9; retinitis pigmentosa 9 protein [KO:K19604]
104368848  LSM3; U6 snRNA-associated Sm-like protein LSm3 [KO:K12622]
104369455  LSM4; U6 snRNA-associated Sm-like protein LSm4 isoform X1 [KO:K12623]
104355997  U6 snRNA-associated Sm-like protein LSm5 [KO:K12624]
104359781  LSM5; U6 snRNA-associated Sm-like protein LSm5 [KO:K12624]
104356732  LSM6; U6 snRNA-associated Sm-like protein LSm6 [KO:K12625]
122153660  LSM7; U6 snRNA-associated Sm-like protein LSm7 [KO:K12626]
104365499  LSM8; LSM8 homolog, U6 small nuclear RNA associated [KO:K12627]
104362653  PRPF3; U4/U6 small nuclear ribonucleoprotein Prp3 isoform X1 [KO:K12843]
104367541  PRPF4; U4/U6 small nuclear ribonucleoprotein Prp4 [KO:K12662]
104358209  PPIH; peptidyl-prolyl cis-trans isomerase H isoform X2 [KO:K09567] [EC:5.2.1.8]
104358528  SNU13; LOW QUALITY PROTEIN: NHP2-like protein 1 [KO:K12845]
104368948  SNRNP27; U4/U6.U5 small nuclear ribonucleoprotein 27 kDa protein [KO:K12846]
116963812  USP39; U4/U6.U5 tri-snRNP-associated protein 2 [KO:K12847]
104364177  ZMAT2; zinc finger matrin-type protein 2 [KO:K12848]
104364074  PRPF38A; pre-mRNA-splicing factor 38A [KO:K12849]
104369541  PRPF38B; pre-mRNA-splicing factor 38B [KO:K12850]
104361740  EFTUD2; 116 kDa U5 small nuclear ribonucleoprotein component [KO:K12852]
104357099  SNRNP200; U5 small nuclear ribonucleoprotein 200 kDa helicase [KO:K12854] [EC:5.6.2.6]
104365629  PRPF6; pre-mRNA-processing factor 6 [KO:K12855]
104355462  PRPF8; pre-mRNA-processing-splicing factor 8 [KO:K12856]
104358750  SNRNP40; U5 small nuclear ribonucleoprotein 40 kDa protein [KO:K12857]
116962935  DDX23; probable ATP-dependent RNA helicase DDX23 isoform X1 [KO:K12858] [EC:5.6.2.7]
104369143  TXNL4A; thioredoxin-like protein 4A isoform X1 [KO:K12859]
104362794  PRPF19; pre-mRNA-processing factor 19 [KO:K10599] [EC:2.3.2.27]
104359355  CDC5L; cell division cycle 5-like protein [KO:K12860]
104363147  BCAS2; pre-mRNA-splicing factor SPF27 [KO:K12861]
104355885  PLRG1; pleiotropic regulator 1 [KO:K12862]
104365366  CWC15; spliceosome-associated protein CWC15 homolog [KO:K12863]
104360876  CTNNBL1; beta-catenin-like protein 1 [KO:K12864]
104366767  HSPA8; heat shock cognate 71 kDa protein [KO:K03283]
104359888  WBP11; WW domain-binding protein 11 [KO:K12866]
104367384  SNW1; SNW domain-containing protein 1 [KO:K06063]
104364600  SYF2; pre-mRNA-splicing factor SYF2 [KO:K12868]
104358579  CRNKL1; crooked neck-like protein 1 [KO:K12869]
104356567  ISY1; pre-mRNA-splicing factor ISY1 homolog [KO:K12870]
104360240  PPIE; peptidyl-prolyl cis-trans isomerase E [KO:K09564] [EC:5.2.1.8]
104368475  CCDC12; coiled-coil domain-containing protein 12 isoform X1 [KO:K12871]
104364007  RBM22; pre-mRNA-splicing factor RBM22 [KO:K12872]
104356524  BUD31; protein BUD31 homolog [KO:K12873]
104362407  AQR; RNA helicase aquarius [KO:K12874]
104355947  EIF4A3; eukaryotic initiation factor 4A-III [KO:K13025] [EC:5.6.2.7]
116962574  RBM8A; RNA-binding protein 8A [KO:K12876]
104361000  MAGOH; protein mago nashi homolog [KO:K12877]
104364718  THOC1; THO complex subunit 1 isoform X1 [KO:K12878]
104358885  THOC2; THO complex subunit 2 isoform X1 [KO:K12879]
104355694  THOC3; THO complex subunit 3 [KO:K12880]
104362367  ALYREF; THO complex subunit 4 [KO:K12881]
104358223  NCBP1; nuclear cap-binding protein subunit 1 [KO:K12882]
104359307  NCBP2; nuclear cap-binding protein subunit 2 [KO:K12883]
104356807  nuclear cap-binding protein subunit 2 [KO:K12883]
104363747  HNRNPA3; heterogeneous nuclear ribonucleoprotein A3 isoform X1 [KO:K12741]
104357095  RBMX; RNA-binding motif protein, X chromosome isoform X1 [KO:K12885]
104364121  HNRNPK; heterogeneous nuclear ribonucleoprotein K isoform X1 [KO:K12886]
104355992  HNRNPM; heterogeneous nuclear ribonucleoprotein M isoform X6 [KO:K12887]
104363887  HNRNPU; heterogeneous nuclear ribonucleoprotein U [KO:K12888]
104367754  SRSF1; serine/arginine-rich splicing factor 1 [KO:K12890]
104358337  SRSF2; serine/arginine-rich splicing factor 2 [KO:K12891]
104356379  SRSF3; serine/arginine-rich splicing factor 3 [KO:K12892]
104363783  serine/arginine-rich splicing factor 5 [KO:K12893]
104366764  SRSF5; serine/arginine-rich splicing factor 5 isoform X1 [KO:K12893]
104367040  SRSF4; serine/arginine-rich splicing factor 4 isoform X1 [KO:K12893]
104366511  SRSF6; serine/arginine-rich splicing factor 6 [KO:K12893]
104362249  serine/arginine-rich splicing factor 7-like isoform X1 [KO:K12896]
104368435  SRSF7; serine/arginine-rich splicing factor 7 [KO:K12896]
104366155  TRA2A; transformer-2 protein homolog alpha isoform X1 [KO:K12897]
104355778  TRA2B; transformer-2 protein homolog beta isoform X1 [KO:K12897]
104361112  SRSF10; serine/arginine-rich splicing factor 10 isoform X1 [KO:K12900]
Reference
PMID:19239890
  Authors
Wahl MC, Will CL, Luhrmann R
  Title
The spliceosome: design principles of a dynamic RNP machine.
  Journal
Cell 136:701-18 (2009)
DOI:10.1016/j.cell.2009.02.009
Reference
PMID:10978320
  Authors
Morris DP, Greenleaf AL
  Title
The splicing factor, Prp40, binds the phosphorylated carboxyl-terminal domain of RNA polymerase II.
  Journal
J Biol Chem 275:39935-43 (2000)
DOI:10.1074/jbc.M004118200
Reference
PMID:17537823
  Authors
Chen YI, Moore RE, Ge HY, Young MK, Lee TD, Stevens SW
  Title
Proteomic analysis of in vivo-assembled pre-mRNA splicing complexes expands the catalog of participating factors.
  Journal
Nucleic Acids Res 35:3928-44 (2007)
DOI:10.1093/nar/gkm347
Reference
PMID:19733268
  Authors
Ritchie DB, Schellenberg MJ, MacMillan AM
  Title
Spliceosome structure: piece by piece.
  Journal
Biochim Biophys Acta 1789:624-33 (2009)
DOI:10.1016/j.bbagrm.2009.08.010
KO pathway
ko03040   
LinkDB

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