KEGG   PATHWAY: tcf00983
Entry
tcf00983                    Pathway                                
Name
Drug metabolism - other enzymes - Tigriopus californicus (tidepool copepod)
Class
Metabolism; Xenobiotics biodegradation and metabolism
Pathway map
tcf00983  Drug metabolism - other enzymes
tcf00983

Organism
Tigriopus californicus (tidepool copepod) [GN:tcf]
Gene
131892175  hypoxanthine-guanine phosphoribosyltransferase-like [KO:K00760] [EC:2.4.2.8]
131883477  hypoxanthine-guanine phosphoribosyltransferase-like [KO:K00760] [EC:2.4.2.8]
131891493  inosine-5'-monophosphate dehydrogenase 2-like [KO:K00088] [EC:1.1.1.205]
131882655  GMP synthase [glutamine-hydrolyzing]-like [KO:K01951] [EC:6.3.5.2]
131887381  probable thiopurine S-methyltransferase [KO:K00569] [EC:2.1.1.67]
131879398  uncharacterized protein LOC131879398 [KO:K00569] [EC:2.1.1.67]
131881123  uncharacterized protein LOC131881123 [KO:K00106] [EC:1.17.1.4 1.17.3.2]
131881124  uncharacterized protein LOC131881124 isoform X1 [KO:K00106] [EC:1.17.1.4 1.17.3.2]
131881125  uncharacterized protein LOC131881125 [KO:K00106] [EC:1.17.1.4 1.17.3.2]
131883888  xanthine dehydrogenase/oxidase-like [KO:K00106] [EC:1.17.1.4 1.17.3.2]
131884106  xanthine dehydrogenase/oxidase-like [KO:K00106] [EC:1.17.1.4 1.17.3.2]
131880538  inosine triphosphate pyrophosphatase-like [KO:K01519] [EC:3.6.1.66]
131891651  UDP-glucosyltransferase 2-like [KO:K00699] [EC:2.4.1.17]
131891653  2-hydroxyacylsphingosine 1-beta-galactosyltransferase-like [KO:K00699] [EC:2.4.1.17]
131890720  UDP-glucuronosyltransferase 2A3-like [KO:K00699] [EC:2.4.1.17]
131890885  UDP-glucuronosyltransferase 2B11-like [KO:K00699] [EC:2.4.1.17]
131885600  UDP-glucosyltransferase 2-like [KO:K00699] [EC:2.4.1.17]
131887960  UDP-glucosyltransferase 2-like isoform X1 [KO:K00699] [EC:2.4.1.17]
131881722  beta-glucuronidase-like [KO:K01195] [EC:3.2.1.31]
131881723  beta-glucuronidase-like [KO:K01195] [EC:3.2.1.31]
131886037  beta-glucuronidase-like [KO:K01195] [EC:3.2.1.31]
131877655  cytidine deaminase-like [KO:K01489] [EC:3.5.4.5]
131887041  thymidine phosphorylase-like [KO:K00758] [EC:2.4.2.4]
131890072  dihydropyrimidine dehydrogenase [NADP(+)]-like [KO:K00207] [EC:1.3.1.2]
131881359  dihydropyrimidinase-like [KO:K01464] [EC:3.5.2.2]
131881360  dihydropyrimidinase-like [KO:K01464] [EC:3.5.2.2]
131876807  beta-ureidopropionase-like [KO:K01431] [EC:3.5.1.6]
131881909  uridine phosphorylase 1-like [KO:K00757] [EC:2.4.2.3]
131886300  uridine-cytidine kinase-like 1 [KO:K00876] [EC:2.7.1.48]
131888727  uridine-cytidine kinase 2-like isoform X1 [KO:K00876] [EC:2.7.1.48]
131885018  thymidine kinase, cytosolic-like [KO:K00857] [EC:2.7.1.21]
131884669  uridine 5'-monophosphate synthase-like [KO:K13421] [EC:2.4.2.10 4.1.1.23]
131878972  UMP-CMP kinase-like [KO:K13800] [EC:2.7.4.14]
131893135  ribonucleoside-diphosphate reductase large subunit-like [KO:K10807] [EC:1.17.4.1]
131880718  ribonucleoside-diphosphate reductase subunit M2 B-like [KO:K10808] [EC:1.17.4.1]
131890644  nucleoside diphosphate kinase 6-like [KO:K00940] [EC:2.7.4.6]
131878550  nucleoside diphosphate kinase B-like [KO:K00940] [EC:2.7.4.6]
131878956  nucleoside diphosphate kinase 7-like isoform X1 [KO:K00940] [EC:2.7.4.6]
131892582  uncharacterized protein LOC131892582 [KO:K01520] [EC:3.6.1.23]
131883354  uncharacterized protein LOC131883354 [KO:K01520] [EC:3.6.1.23]
131889514  uncharacterized protein LOC131889514 [KO:K01520] [EC:3.6.1.23]
131892322  myeloperoxidase-like [KO:K10789] [EC:1.11.2.2]
131893385  peroxidasin-like [KO:K10789] [EC:1.11.2.2]
131881259  chorion peroxidase-like [KO:K10789] [EC:1.11.2.2]
131881559  chorion peroxidase-like [KO:K10789] [EC:1.11.2.2]
131877769  myeloperoxidase-like isoform X1 [KO:K10789] [EC:1.11.2.2]
131892072  glutathione S-transferase theta-1-like [KO:K00799] [EC:2.5.1.18]
131893541  glutathione S-transferase Mu 1-like [KO:K00799] [EC:2.5.1.18]
131881981  glutathione S-transferase omega-1-like [KO:K00799] [EC:2.5.1.18]
131883154  glutathione S-transferase-like [KO:K00799] [EC:2.5.1.18]
131883634  probable glutathione S-transferase 6 [KO:K00799] [EC:2.5.1.18]
131884216  glutathione S-transferase Mu 1-like [KO:K00799] [EC:2.5.1.18]
131884581  glutathione S-transferase 1-1-like [KO:K00799] [EC:2.5.1.18]
131886166  microsomal glutathione S-transferase 1-like [KO:K00799] [EC:2.5.1.18]
131878165  glutathione S-transferase 1-like [KO:K00799] [EC:2.5.1.18]
131878693  glutathione S-transferase 1-like [KO:K00799] [EC:2.5.1.18]
131887800  microsomal glutathione S-transferase 1-like [KO:K00799] [EC:2.5.1.18]
131887802  microsomal glutathione S-transferase 1-like [KO:K00799] [EC:2.5.1.18]
131878864  glutathione S-transferase 3, mitochondrial-like [KO:K00799] [EC:2.5.1.18]
131879401  glutathione S-transferase 1-1-like [KO:K00799] [EC:2.5.1.18]
131879403  glutathione S-transferase 1-like [KO:K00799] [EC:2.5.1.18]
131880274  glutathione S-transferase 1-like [KO:K00799] [EC:2.5.1.18]
131880356  glutathione S-transferase 3, mitochondrial-like [KO:K00799] [EC:2.5.1.18]
Compound
C00003  NAD+
C00006  NADP+
C02320  R-S-Glutathione
C02380  6-Mercaptopurine
C04242  5-Fluorodeoxyuridine monophosphate
C04646  6-Thioinosine-5'-monophosphate
C05361  Hydrazine
C06108  Fluoroacetate
C06837  Azathioprine
C07054  Isoniazid
C07446  Isonicotinic acid
C07447  Acetylhydrazine
C07585  N-Acetylisoniazid
C07648  Thioguanine
C07649  5-FU
C11173  SN-38
C11376  SN38 glucuronide
C11736  5-Fluorodeoxyuridine
C12650  Capecitabine
C12673  Tegafur
C12739  5'-Deoxy-5-fluorouridine
C13252  Carmofur
C16542  APC
C16543  NPC
C16613  6-Thiourate
C16614  6-Methylmercaptopurine
C16615  6-Methylthiopurine 5'-monophosphate ribonucleotide
C16616  6-Mercaptopurine ribonucleoside 5'-diphosphate
C16617  6-Mercaptopurine ribonucleoside triphosphate
C16618  6-Thioxanthine 5'-monophosphate
C16619  6-Thioguanosine monophosphate
C16620  6-Methylthioguanosine monophosphate
C16621  1-Methyl-4-nitroimidazole
C16622  N,N'-Diacetylhydrazine
C16623  Isonicotinylglycine
C16624  Isoniazid pyruvate
C16625  Isoniazid alpha-ketoglutaric acid
C16630  5,6-Dihydro-5-fluorouracil
C16631  alpha-Fluoro-beta-ureidopropionic acid
C16632  alpha-Fluoro-beta-alanine
C16633  5-Fluorouridine
C16634  5-Fluorouridine monophosphate
C16635  5'-Deoxy-5-fluorocytidine
C16641  Irinotecan
C21748  5-Fluorouridine diphosphate
C21749  5-Fluorouridine triphosphate
C21750  5-Fluorodeoxyuridine diphosphate
C21751  5-Fluorodeoxyuridine triphosphate
C21754  Isonicotinoyl radical
C21758  Hepatotoxins
C21759  Isonicotinoyl-NAD adduct
C21760  Isonicotinoyl-NADP adduct
D00238  Azathioprine (JP18/USP/INN)
D00346  Isoniazid (JP18/USP/INN)
D00584  Fluorouracil (JP18/USP/INN)
D01223  Capecitabine (JAN/USP/INN)
D01244  Tegafur (JP18/USAN/INN)
D01309  Doxifluridine (JP18/INN)
D01784  Carmofur (JP18/INN)
D04197  Floxuridine (USP/INN)
D04931  Mercaptopurine (INN)
D08086  Irinotecan (INN)
D08603  Tioguanine (INN)
Reference
  Authors
Kato R, Kamatari T (eds).
  Title
[Drug Metabolism] (In Japanese)
  Journal
Tokyo Kagaku Dojin (2000)
Reference
  Authors
Al Hadithy AF, de Boer NK, Derijks LJ, Escher JC, Mulder CJ, Brouwers JR.
  Title
Thiopurines in inflammatory bowel disease: pharmacogenetics, therapeutic drug monitoring and clinical recommendations.
  Journal
Dig Liver Dis 37:282-97 (2005)
DOI:10.1016/j.dld.2004.09.029
Reference
  Authors
Gearry RB, Barclay ML.
  Title
Azathioprine and 6-mercaptopurine pharmacogenetics and metabolite monitoring in inflammatory bowel disease.
  Journal
J Gastroenterol Hepatol 20:1149-57 (2005)
DOI:10.1111/j.1440-1746.2005.03832.x
Reference
  Authors
Gilissen LP, Derijks LJ, Verhoeven HM, Bierau J, Hooymans PM, Hommes DW, Engels LG.
  Title
Pancytopenia due to high 6-methylmercaptopurine levels in a 6-mercaptopurine treated patient with Crohn's disease.
  Journal
Dig Liver Dis 39:182-6 (2007)
DOI:10.1016/j.dld.2006.05.026
Reference
  Authors
Fischel JL, Formento P, Ciccolini J, Etienne-Grimaldi MC, Milano G.
  Title
Lack of contribution of dihydrofluorouracil and alpha-fluoro-beta-alanine to the cytotoxicity of 5'-deoxy-5-fluorouridine on human keratinocytes.
  Journal
Anticancer Drugs 15:969-74 (2004)
DOI:10.1097/00001813-200411000-00006
Reference
  Authors
Shimma N, Umeda I, Arasaki M, Murasaki C, Masubuchi K, Kohchi Y, Miwa M, Ura M, Sawada N, Tahara H, Kuruma I, Horii I, Ishitsuka H.
  Title
The design and synthesis of a new tumor-selective fluoropyrimidine carbamate, capecitabine.
  Journal
Bioorg Med Chem 8:1697-706 (2000)
DOI:10.1016/S0968-0896(00)00087-0
Reference
  Authors
Chung YL, Troy H, Judson IR, Leek R, Leach MO, Stubbs M, Harris AL, Griffiths JR
  Title
Noninvasive measurements of capecitabine metabolism in bladder tumors overexpressing thymidine phosphorylase by fluorine-19 magnetic resonance spectroscopy.
  Journal
Clin Cancer Res 10:3863-70 (2004)
DOI:10.1158/1078-0432.CCR-03-0237
Reference
  Authors
Mathijssen RH, van Alphen RJ, Verweij J, Loos WJ, Nooter K, Stoter G, Sparreboom A
  Title
Clinical pharmacokinetics and metabolism of irinotecan (CPT-11).
  Journal
Clin Cancer Res 7:2182-94 (2001)
Reference
  Authors
Kita T, Tanigawara Y, Chikazawa S, Hatanaka H, Sakaeda T, Komada F, Iwakawa S, Okumura K.
  Title
N-Acetyltransferase2 genotype correlated with isoniazid acetylation in Japanese tuberculous patients.
  Journal
Biol Pharm Bull 24:544-9 (2001)
DOI:10.1248/bpb.24.544
Reference
  Authors
Miura K, Kinouchi M, Ishida K, Fujibuchi W, Naitoh T, Ogawa H, Ando T, Yazaki N, Watanabe K, Haneda S, Shibata C, Sasaki I
  Title
5-fu metabolism in cancer and orally-administrable 5-fu drugs.
  Journal
Cancers (Basel) 2:1717-30 (2010)
DOI:10.3390/cancers2031717
Reference
  Authors
Wang P, Pradhan K, Zhong XB, Ma X
  Title
Isoniazid metabolism and hepatotoxicity.
  Journal
Acta Pharm Sin B 6:384-392 (2016)
DOI:10.1016/j.apsb.2016.07.014
Reference
  Authors
Klein DJ, Boukouvala S, McDonagh EM, Shuldiner SR, Laurieri N, Thorn CF, Altman RB, Klein TE
  Title
PharmGKB summary: isoniazid pathway, pharmacokinetics.
  Journal
Pharmacogenet Genomics 26:436-44 (2016)
DOI:10.1097/FPC.0000000000000232
Reference
  Authors
Yamada S, Richardson K, Tang M, Halaschek-Wiener J, Cook VJ, Fitzgerald JM, Elwood K, Marra F, Brooks-Wilson A
  Title
Genetic variation in carboxylesterase genes and susceptibility to isoniazid-induced hepatotoxicity.
  Journal
Pharmacogenomics J 10:524-36 (2010)
DOI:10.1038/tpj.2010.5
Reference
  Authors
Vlasits J, Jakopitsch C, Bernroitner M, Zamocky M, Furtmuller PG, Obinger C
  Title
Mechanisms of catalase activity of heme peroxidases.
  Journal
Arch Biochem Biophys 500:74-81 (2010)
DOI:10.1016/j.abb.2010.04.018
Reference
  Authors
Khan SR, Morgan AG, Michail K, Srivastava N, Whittal RM, Aljuhani N, Siraki AG
  Title
Metabolism of isoniazid by neutrophil myeloperoxidase leads to isoniazid-NAD(+) adduct formation: A comparison of the reactivity of isoniazid with its known human metabolites.
  Journal
Biochem Pharmacol 106:46-55 (2016)
DOI:10.1016/j.bcp.2016.02.003
Reference
  Authors
Forbes LV, Furtmuller PG, Khalilova I, Turner R, Obinger C, Kettle AJ
  Title
Isoniazid as a substrate and inhibitor of myeloperoxidase: identification of amine adducts and the influence of superoxide dismutase on their formation.
  Journal
Biochem Pharmacol 84:949-60 (2012)
DOI:10.1016/j.bcp.2012.07.020
Reference
  Authors
Nguyen M, Quemard A, Broussy S, Bernadou J, Meunier B
  Title
Mn(III) pyrophosphate as an efficient tool for studying the mode of action of isoniazid on the InhA protein of Mycobacterium tuberculosis.
  Journal
Antimicrob Agents Chemother 46:2137-44 (2002)
DOI:10.1128/AAC.46.7.2137-2144.2002
Reference
PMID:9417034
  Authors
Rozwarski DA, Grant GA, Barton DH, Jacobs WR Jr, Sacchettini JC
  Title
Modification of the NADH of the isoniazid target (InhA) from Mycobacterium tuberculosis.
  Journal
Science 279:98-102 (1998)
DOI:10.1126/science.279.5347.98
Reference
  Authors
Argyrou A, Vetting MW, Blanchard JS
  Title
New insight into the mechanism of action of and resistance to isoniazid: interaction of Mycobacterium tuberculosis enoyl-ACP reductase with INH-NADP.
  Journal
J Am Chem Soc 129:9582-3 (2007)
DOI:10.1021/ja073160k
KO pathway
ko00983   
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