KEGG   PATHWAY: vam00061
Entry
vam00061                    Pathway                                
Name
Fatty acid biosynthesis - Variovorax sp. PMC12
Class
Metabolism; Lipid metabolism
Pathway map
vam00061  Fatty acid biosynthesis
vam00061

Module
vam_M00082  Fatty acid biosynthesis, initiation [PATH:vam00061]
vam_M00083  Fatty acid biosynthesis, elongation [PATH:vam00061]
vam_M00086  beta-Oxidation, acyl-CoA synthesis [PATH:vam00061]
Other DBs
GO: 0006633
Organism
Variovorax sp. PMC12 [GN:vam]
Gene
C4F17_07585  acetyl-CoA carboxylase carboxyltransferase subunit alpha [KO:K01962] [EC:6.4.1.2 2.1.3.15]
C4F17_27095  acetyl-CoA carboxylase biotin carboxyl carrier protein subunit [KO:K02160]
C4F17_14435  acetyl-CoA carboxylase biotin carboxyl carrier protein [KO:K02160]
C4F17_27115  acetyl-CoA carboxylase biotin carboxyl carrier protein subunit [KO:K02160]
C4F17_27100  accC; acetyl-CoA carboxylase biotin carboxylase subunit [KO:K01961] [EC:6.4.1.2 6.3.4.14]
C4F17_14430  accC; acetyl-CoA carboxylase biotin carboxylase subunit [KO:K01961] [EC:6.4.1.2 6.3.4.14]
C4F17_11350  acetyl-CoA carboxylase carboxyltransferase subunit beta [KO:K01963] [EC:6.4.1.2 2.1.3.15]
C4F17_20360  acetyl/propionyl-CoA carboxylase subunit alpha [KO:K11263] [EC:6.4.1.2 6.4.1.3 6.3.4.14]
C4F17_11465  fabD; [acyl-carrier-protein] S-malonyltransferase [KO:K00645] [EC:2.3.1.39]
C4F17_01185  hypothetical protein [KO:K00648] [EC:2.3.1.180]
C4F17_03630  hypothetical protein [KO:K00648] [EC:2.3.1.180]
C4F17_11470  3-oxoacyl-ACP synthase [KO:K00648] [EC:2.3.1.180]
C4F17_01215  beta-ketoacyl synthase [KO:K00647] [EC:2.3.1.41]
C4F17_17490  beta-ketoacyl-[acyl-carrier-protein] synthase II [KO:K00647] [EC:2.3.1.41]
C4F17_16020  beta-ketoacyl synthase [KO:K00647] [EC:2.3.1.41]
C4F17_11450  fabF; beta-ketoacyl-[acyl-carrier-protein] synthase II [KO:K09458] [EC:2.3.1.179]
C4F17_18895  beta-ketoacyl-[acyl-carrier-protein] synthase family protein [KO:K09458] [EC:2.3.1.179]
C4F17_00705  beta-ketoacyl-[acyl-carrier-protein] synthase family protein [KO:K09458] [EC:2.3.1.179]
C4F17_01065  oxidoreductase [KO:K00059] [EC:1.1.1.100]
C4F17_20535  oxidoreductase [KO:K00059] [EC:1.1.1.100]
C4F17_30735  3-oxoacyl-ACP reductase [KO:K00059] [EC:1.1.1.100]
C4F17_30810  3-oxoacyl-ACP reductase [KO:K00059] [EC:1.1.1.100]
C4F17_30830  NAD(P)-dependent oxidoreductase [KO:K00059] [EC:1.1.1.100]
C4F17_31300  3-oxoacyl-ACP reductase [KO:K00059] [EC:1.1.1.100]
C4F17_29765  oxidoreductase [KO:K00059] [EC:1.1.1.100]
C4F17_14140  beta-ketoacyl-ACP reductase [KO:K00059] [EC:1.1.1.100]
C4F17_16940  short-chain dehydrogenase [KO:K00059] [EC:1.1.1.100]
C4F17_11460  fabG; 3-oxoacyl-ACP reductase [KO:K00059] [EC:1.1.1.100]
C4F17_01415  3-oxoacyl-ACP reductase [KO:K00059] [EC:1.1.1.100]
C4F17_12700  3-oxoacyl-ACP reductase [KO:K00059] [EC:1.1.1.100]
C4F17_06205  3-oxoacyl-ACP reductase FabG [KO:K00059] [EC:1.1.1.100]
C4F17_00055  oxidoreductase [KO:K00059] [EC:1.1.1.100]
C4F17_10895  short-chain dehydrogenase [KO:K00059] [EC:1.1.1.100]
C4F17_31315  short-chain dehydrogenase [KO:K00059] [EC:1.1.1.100]
C4F17_10845  short-chain dehydrogenase [KO:K00059] [EC:1.1.1.100]
C4F17_06560  fabZ; 3-hydroxyacyl-[acyl-carrier-protein] dehydratase FabZ [KO:K02372] [EC:4.2.1.59]
C4F17_05885  enoyl-[acyl-carrier-protein] reductase FabI [KO:K00208] [EC:1.3.1.9 1.3.1.10]
C4F17_25505  bifunctional NADH-specific enoyl-ACP reductase/trans-2-enoyl-CoA reductase [KO:K00209] [EC:1.3.1.9 1.3.1.44]
C4F17_20690  long-chain fatty acid--CoA ligase [KO:K01897] [EC:6.2.1.3]
C4F17_22050  AMP-dependent synthetase [KO:K01897] [EC:6.2.1.3]
C4F17_30785  long-chain fatty acid--CoA ligase [KO:K01897] [EC:6.2.1.3]
C4F17_16690  long-chain-fatty-acid--CoA ligase [KO:K01897] [EC:6.2.1.3]
C4F17_16730  dicarboxylate--CoA ligase PimA [KO:K01897] [EC:6.2.1.3]
C4F17_21205  long-chain fatty acid--CoA ligase [KO:K01897] [EC:6.2.1.3]
C4F17_10095  AMP-dependent synthetase [KO:K01897] [EC:6.2.1.3]
C4F17_11975  o-succinylbenzoate--CoA ligase [KO:K01897] [EC:6.2.1.3]
C4F17_21505  4-coumarate--CoA ligase [KO:K01897] [EC:6.2.1.3]
C4F17_22205  long-chain fatty acid--CoA ligase [KO:K01897] [EC:6.2.1.3]
Compound
C00024  Acetyl-CoA
C00083  Malonyl-CoA
C00154  Palmitoyl-CoA
C00173  Acyl-[acyl-carrier protein]
C00229  Acyl-carrier protein
C00249  Hexadecanoic acid
C00383  Malonate
C00638  Long-chain fatty acid
C00685  3-Oxoacyl-[acyl-carrier protein]
C00693  trans-2,3-Dehydroacyl-[acyl-carrier protein]
C00712  (9Z)-Octadecenoic acid
C01203  Oleoyl-[acyl-carrier protein]
C01209  Malonyl-[acyl-carrier protein]
C01271  (3R)-3-Hydroxyacyl-[acyl-carrier protein]
C01530  Octadecanoic acid
C01571  Decanoic acid
C02679  Dodecanoic acid
C02843  Long-chain acyl-CoA
C03939  Acetyl-[acyl-carrier protein]
C04088  Octadecanoyl-[acyl-carrier protein]
C04180  cis-Dec-3-enoyl-[acp]
C04246  But-2-enoyl-[acyl-carrier protein]
C04618  (3R)-3-Hydroxybutanoyl-[acyl-carrier protein]
C04619  (3R)-3-Hydroxydecanoyl-[acyl-carrier protein]
C04620  (3R)-3-Hydroxyoctanoyl-[acyl-carrier protein]
C04633  (3R)-3-Hydroxypalmitoyl-[acyl-carrier protein]
C04688  (3R)-3-Hydroxytetradecanoyl-[acyl-carrier protein]
C05223  Dodecanoyl-[acyl-carrier protein]
C05744  Acetoacetyl-[acp]
C05745  Butyryl-[acp]
C05746  3-Oxohexanoyl-[acp]
C05747  (3R)-3-Hydroxyhexanoyl-[acyl-carrier protein]
C05748  trans-Hex-2-enoyl-[acp]
C05749  Hexanoyl-[acp]
C05750  3-Oxooctanoyl-[acp]
C05751  trans-Oct-2-enoyl-[acp]
C05752  Octanoyl-[acp]
C05753  3-Oxodecanoyl-[acp]
C05754  trans-Dec-2-enoyl-[acp]
C05755  Decanoyl-[acp]
C05756  3-Oxododecanoyl-[acp]
C05757  (3R)-3-Hydroxydodecanoyl-[acyl-carrier protein]
C05758  trans-Dodec-2-enoyl-[acp]
C05759  3-Oxotetradecanoyl-[acp]
C05760  trans-Tetradec-2-enoyl-[acp]
C05761  Tetradecanoyl-[acp]
C05762  3-Oxohexadecanoyl-[acp]
C05763  trans-Hexadec-2-enoyl-[acp]
C05764  Hexadecanoyl-[acp]
C06423  Octanoic acid
C06424  Tetradecanoic acid
C08362  (9Z)-Hexadecenoic acid
C16219  3-Oxostearoyl-[acp]
C16220  (3R)-3-Hydroxyoctadecanoyl-[acyl-carrier protein]
C16221  (2E)-Octadecenoyl-[acp]
C16520  Hexadecenoyl-[acyl-carrier protein]
C20683  Long-chain acyl-[acyl-carrier protein]
C20794  n-7 Unsaturated acyl-[acyl-carrier protein]
Reference
PMID:12061798
  Authors
Salas JJ, Ohlrogge JB.
  Title
Characterization of substrate specificity of plant FatA and FatB acyl-ACP thioesterases.
  Journal
Arch Biochem Biophys 403:25-34 (2002)
DOI:10.1016/S0003-9861(02)00017-6
Reference
PMID:12518017
  Authors
Zhang YM, Marrakchi H, White SW, Rock CO.
  Title
The application of computational methods to explore the diversity and structure of bacterial fatty acid synthase.
  Journal
J Lipid Res 44:1-10 (2003)
DOI:10.1194/jlr.R200016-JLR200
Reference
PMID:11337402
  Authors
Voelker T, Kinney AJ.
  Title
VARIATIONS IN THE BIOSYNTHESIS OF SEED-STORAGE LIPIDS.
  Journal
Annu Rev Plant Physiol Plant Mol Biol 52:335-361 (2001)
DOI:10.1146/annurev.arplant.52.1.335
Reference
PMID:17573542
  Authors
Barker GC, Larson TR, Graham IA, Lynn JR, King GJ.
  Title
Novel insights into seed fatty acid synthesis and modification pathways from genetic diversity and quantitative trait Loci analysis of the Brassica C genome.
  Journal
Plant Physiol 144:1827-42 (2007)
DOI:10.1104/pp.107.096172
Reference
PMID:30201289
  Authors
Bowman CE, Wolfgang MJ
  Title
Role of the malonyl-CoA synthetase ACSF3 in mitochondrial metabolism.
  Journal
Adv Biol Regul 71:34-40 (2019)
DOI:10.1016/j.jbior.2018.09.002
Reference
PMID:25203508
  Authors
Venkatesan R, Sah-Teli SK, Awoniyi LO, Jiang G, Prus P, Kastaniotis AJ, Hiltunen JK, Wierenga RK, Chen Z
  Title
Insights into mitochondrial fatty acid synthesis from the structure of heterotetrameric 3-ketoacyl-ACP reductase/3R-hydroxyacyl-CoA dehydrogenase.
  Journal
Nat Commun 5:4805 (2014)
DOI:10.1038/ncomms5805
Reference
PMID:19686777
  Authors
Hiltunen JK, Chen Z, Haapalainen AM, Wierenga RK, Kastaniotis AJ
  Title
Mitochondrial fatty acid synthesis--an adopted set of enzymes making a pathway of major importance for the cellular metabolism.
  Journal
Prog Lipid Res 49:27-45 (2010)
DOI:10.1016/j.plipres.2009.08.001
Reference
PMID:27553474
  Authors
Kastaniotis AJ, Autio KJ, Keratar JM, Monteuuis G, Makela AM, Nair RR, Pietikainen LP, Shvetsova A, Chen Z, Hiltunen JK
  Title
Mitochondrial fatty acid synthesis, fatty acids and mitochondrial physiology.
  Journal
Biochim Biophys Acta Mol Cell Biol Lipids 1862:39-48 (2017)
DOI:10.1016/j.bbalip.2016.08.011
Related
pathway
vam00020  Citrate cycle (TCA cycle)
vam00071  Fatty acid degradation
vam00410  beta-Alanine metabolism
vam00561  Glycerolipid metabolism
vam00564  Glycerophospholipid metabolism
vam00620  Pyruvate metabolism
vam00785  Lipoic acid metabolism
KO pathway
ko00061   
LinkDB

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