KEGG   PATHWAY: vei00260
Entry
vei00260                    Pathway                                
Name
Glycine, serine and threonine metabolism - Verminephrobacter eiseniae
Description
Serine is derived from 3-phospho-D-glycerate, an intermediate of glycolysis [MD:M00020], and glycine is derived from serine. Threonine is an essential amino acid, which animals cannot synthesize. In bacteria and plants, threonine is derived from aspartate [MD:M00018].
Class
Metabolism; Amino acid metabolism
Pathway map
vei00260  Glycine, serine and threonine metabolism
vei00260

Module
vei_M00018  Threonine biosynthesis, aspartate => homoserine => threonine [PATH:vei00260]
vei_M00020  Serine biosynthesis, glycerate-3P => serine [PATH:vei00260]
vei_M00555  Betaine biosynthesis, choline => betaine [PATH:vei00260]
vei_M00621  Glycine cleavage system [PATH:vei00260]
vei_M00919  Ectoine degradation, ectoine => aspartate [PATH:vei00260]
vei_M00975  Betaine degradation, bacteria, betaine => pyruvate [PATH:vei00260]
Other DBs
GO: 0006544 0006563 0070178 0006566
Organism
Verminephrobacter eiseniae [GN:vei]
Gene
Veis_4940  aspartate kinase [KO:K00928] [EC:2.7.2.4]
Veis_4872  aspartate semialdehyde dehydrogenase [KO:K00133] [EC:1.2.1.11]
Veis_2663  homoserine dehydrogenase [KO:K00003] [EC:1.1.1.3]
Veis_1843  homoserine kinase [KO:K02204] [EC:2.7.1.39]
Veis_2664  L-threonine synthase [KO:K01733] [EC:4.2.3.1]
Veis_1686  L-threonine aldolase [KO:K01620] [EC:4.1.2.48]
Veis_4246  serine hydroxymethyltransferase [KO:K00600] [EC:2.1.2.1]
Veis_0512  D-isomer specific 2-hydroxyacid dehydrogenase, NAD-binding [KO:K12972] [EC:1.1.1.79 1.1.1.81]
Veis_2069  D-isomer specific 2-hydroxyacid dehydrogenase, NAD-binding [KO:K00090] [EC:1.1.1.79 1.1.1.81 1.1.1.215]
Veis_0928  Hydroxypyruvate reductase [KO:K11529] [EC:2.7.1.165]
Veis_0036  phosphoglycerate mutase [KO:K01834] [EC:5.4.2.11]
Veis_1461  phosphoglycerate mutase [KO:K15634] [EC:5.4.2.11]
Veis_1484  phosphoglycerate mutase [KO:K15634] [EC:5.4.2.11]
Veis_3989  D-isomer specific 2-hydroxyacid dehydrogenase, NAD-binding [KO:K00058] [EC:1.1.1.95 1.1.1.399]
Veis_4913  D-isomer specific 2-hydroxyacid dehydrogenase, NAD-binding [KO:K00058] [EC:1.1.1.95 1.1.1.399]
Veis_1307  D-3-phosphoglycerate dehydrogenase [KO:K00058] [EC:1.1.1.95 1.1.1.399]
Veis_2017  D-isomer specific 2-hydroxyacid dehydrogenase, NAD-binding [KO:K00058] [EC:1.1.1.95 1.1.1.399]
Veis_2905  D-isomer specific 2-hydroxyacid dehydrogenase, NAD-binding [KO:K00058] [EC:1.1.1.95 1.1.1.399]
Veis_3120  aminotransferase [KO:K00831] [EC:2.6.1.52]
Veis_4883  phosphoserine phosphatase SerB [KO:K01079] [EC:3.1.3.3]
Veis_0808  amine oxidase [KO:K00274] [EC:1.4.3.4]
Veis_3959  glycine dehydrogenase [KO:K00281] [EC:1.4.4.2]
Veis_2459  glycine dehydrogenase (decarboxylating) alpha subunit [KO:K00282] [EC:1.4.4.2]
Veis_2458  glycine dehydrogenase (decarboxylating) beta subunit [KO:K00283] [EC:1.4.4.2]
Veis_3957  glycine cleavage system T protein [KO:K00605] [EC:2.1.2.10]
Veis_1917  dihydrolipoamide dehydrogenase [KO:K00382] [EC:1.8.1.4]
Veis_3977  dihydrolipoamide dehydrogenase [KO:K00382] [EC:1.8.1.4]
Veis_3958  glycine cleavage system H protein [KO:K02437]
Veis_1753  CDP-diacylglycerol--serine O-phosphatidyltransferase [KO:K17103] [EC:2.7.8.8]
Veis_3111  CDP-alcohol phosphatidyltransferase [KO:K17103] [EC:2.7.8.8]
Veis_3226  choline dehydrogenase [KO:K00108] [EC:1.1.99.1]
Veis_1939  aldehyde dehydrogenase (acceptor) [KO:K00130] [EC:1.2.1.8]
Veis_4057  Rieske (2Fe-2S) domain protein [KO:K00479] [EC:1.14.13.251]
Veis_4058  Oxidoreductase FAD-binding domain protein [KO:K21832] [EC:1.14.13.251]
Veis_4053  NADH:flavin oxidoreductase/NADH oxidase [KO:K21833] [EC:1.5.7.3]
Veis_4054  protein of unknown function DUF224, cysteine-rich region domain protein [KO:K21834]
Veis_4055  electron transfer flavoprotein, alpha subunit [KO:K25960]
Veis_4056  electron transfer flavoprotein, beta subunit [KO:K25961]
Veis_4048  sarcosine oxidase, alpha subunit family [KO:K00302] [EC:1.5.3.24 1.5.3.1]
Veis_4046  sarcosine oxidase, beta subunit family [KO:K00303] [EC:1.5.3.24 1.5.3.1]
Veis_4049  Sarcosine oxidase, gamma subunit [KO:K00305] [EC:1.5.3.24 1.5.3.1]
Veis_4047  Sarcosine oxidase, delta subunit, heterotetrameric [KO:K00304] [EC:1.5.3.24 1.5.3.1]
Veis_3225  L-serine ammonia-lyase [KO:K01752] [EC:4.3.1.17]
Veis_0303  L-threonine ammonia-lyase [KO:K01754] [EC:4.3.1.19]
Veis_4911  Threonine ammonia-lyase [KO:K01754] [EC:4.3.1.19]
Veis_2151  L-threonine ammonia-lyase [KO:K01754] [EC:4.3.1.19]
Veis_3329  D-serine deaminase [KO:K01753] [EC:4.3.1.18]
Veis_4867  tryptophan synthase, alpha chain [KO:K01695] [EC:4.2.1.20]
Veis_4868  tryptophan synthase, beta chain [KO:K01696] [EC:4.2.1.20]
Veis_1286  pyridoxal-phosphate dependent TrpB-like enzyme [KO:K06001] [EC:4.2.1.20]
Veis_2149  peptidase M24 [KO:K15783] [EC:3.5.4.44]
Veis_2148  Succinylglutamate desuccinylase/aspartoacylase [KO:K15784] [EC:3.5.1.125]
Veis_2145  aminotransferase [KO:K15785] [EC:2.6.1.76]
Veis_2146  succinate semialdehyde dehydrogenase [KO:K15786] [EC:1.2.1.-]
Compound
C00011  CO2
C00014  Ammonia
C00022  Pyruvate
C00037  Glycine
C00048  Glyoxylate
C00049  L-Aspartate
C00065  L-Serine
C00078  L-Tryptophan
C00097  L-Cysteine
C00101  Tetrahydrofolate
C00109  2-Oxobutanoate
C00114  Choline
C00143  5,10-Methylenetetrahydrofolate
C00168  Hydroxypyruvate
C00188  L-Threonine
C00197  3-Phospho-D-glycerate
C00213  Sarcosine
C00258  D-Glycerate
C00263  L-Homoserine
C00300  Creatine
C00430  5-Aminolevulinate
C00441  L-Aspartate 4-semialdehyde
C00546  Methylglyoxal
C00576  Betaine aldehyde
C00581  Guanidinoacetate
C00631  2-Phospho-D-glycerate
C00719  Betaine
C00740  D-Serine
C00986  1,3-Diaminopropane
C01005  O-Phospho-L-serine
C01026  N,N-Dimethylglycine
C01102  O-Phospho-L-homoserine
C01242  [Protein]-S8-aminomethyldihydrolipoyllysine
C01888  Aminoacetone
C02051  Lipoylprotein
C02291  L-Cystathionine
C02737  Phosphatidylserine
C02972  Dihydrolipoylprotein
C03082  4-Phospho-L-aspartate
C03194  (R)-1-Aminopropan-2-ol
C03232  3-Phosphonooxypyruvate
C03283  L-2,4-Diaminobutanoate
C03508  L-2-Amino-3-oxobutanoic acid
C05519  L-Allothreonine
C06231  Ectoine
C06442  N(gamma)-Acetyldiaminobutyrate
C16432  5-Hydroxyectoine
C19929  N(alpha)-Acetyl-L-2,4-diaminobutyrate
Reference
  Authors
Nishizuka Y, Seyama Y, Ikai A, Ishimura Y, Kawaguchi A (eds).
  Title
[Cellular Functions and Metabolic Maps] (In Japanese)
  Journal
Tokyo Kagaku Dojin (1997)
Reference
PMID:11823218
  Authors
Kuhlmann AU, Bremer E.
  Title
Osmotically regulated synthesis of the compatible solute ectoine in Bacillus pasteurii and related Bacillus spp.
  Journal
Appl Environ Microbiol 68:772-83 (2002)
DOI:10.1128/AEM.68.2.772-783.2002
Reference
PMID:10473374
  Authors
Canovas D, Borges N, Vargas C, Ventosa A, Nieto JJ, Santos H.
  Title
Role of Ngamma-acetyldiaminobutyrate as an enzyme stabilizer and an intermediate in the biosynthesis of hydroxyectoine.
  Journal
Appl Environ Microbiol 65:3774-9 (1999)
DOI:10.1128/AEM.65.9.3774-3779.1999
Reference
PMID:17636255
  Authors
Bursy J, Pierik AJ, Pica N, Bremer E.
  Title
Osmotically induced synthesis of the compatible solute hydroxyectoine is mediated by an evolutionarily conserved ectoine hydroxylase.
  Journal
J Biol Chem 282:31147-55 (2007)
DOI:10.1074/jbc.M704023200
Reference
PMID:16707670
  Authors
Garcia-Estepa R, Argandona M, Reina-Bueno M, Capote N, Iglesias-Guerra F, Nieto JJ, Vargas C.
  Title
The ectD gene, which is involved in the synthesis of the compatible solute hydroxyectoine, is essential for thermoprotection of the halophilic bacterium Chromohalobacter salexigens.
  Journal
J Bacteriol 188:3774-84 (2006)
DOI:10.1128/JB.00136-06
Reference
PMID:15470257
  Authors
Arevalo-Rodriguez M, Pan X, Boeke JD, Heitman J
  Title
FKBP12 controls aspartate pathway flux in Saccharomyces cerevisiae to prevent toxic intermediate accumulation.
  Journal
Eukaryot Cell 3:1287-96 (2004)
DOI:10.1128/EC.3.5.1287-1296.2004
Reference
PMID:7639721
  Authors
Rees WD, Hay SM
  Title
The biosynthesis of threonine by mammalian cells: expression of a complete bacterial biosynthetic pathway in an animal cell.
  Journal
Biochem J 309 ( Pt 3):999-1007 (1995)
DOI:10.1042/bj3090999
Reference
PMID:11341914
  Authors
Jacques SL, Nieman C, Bareich D, Broadhead G, Kinach R, Honek JF, Wright GD
  Title
Characterization of yeast homoserine dehydrogenase, an antifungal target: the invariant histidine 309 is important for enzyme integrity.
  Journal
Biochim Biophys Acta 1544:28-41 (2001)
DOI:10.1016/S0167-4838(00)00203-X
Reference
PMID:15520012
  Authors
Chen X, Jhee KH, Kruger WD
  Title
Production of the neuromodulator H2S by cystathionine beta-synthase via the condensation of cysteine and homocysteine.
  Journal
J Biol Chem 279:52082-6 (2004)
DOI:10.1074/jbc.C400481200
Related
pathway
vei00010  Glycolysis / Gluconeogenesis
vei00020  Citrate cycle (TCA cycle)
vei00230  Purine metabolism
vei00250  Alanine, aspartate and glutamate metabolism
vei00270  Cysteine and methionine metabolism
vei00290  Valine, leucine and isoleucine biosynthesis
vei00300  Lysine biosynthesis
vei00330  Arginine and proline metabolism
vei00460  Cyanoamino acid metabolism
vei00470  D-Amino acid metabolism
vei00564  Glycerophospholipid metabolism
vei00620  Pyruvate metabolism
vei00630  Glyoxylate and dicarboxylate metabolism
vei00640  Propanoate metabolism
vei00680  Methane metabolism
vei00860  Porphyrin metabolism
vei00920  Sulfur metabolism
KO pathway
ko00260   
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