KEGG   PATHWAY: vsh00260
Entry
vsh00260                    Pathway                                
Name
Glycine, serine and threonine metabolism - Vibrio mediterranei
Description
Serine is derived from 3-phospho-D-glycerate, an intermediate of glycolysis [MD:M00020], and glycine is derived from serine. Threonine is an essential amino acid, which animals cannot synthesize. In bacteria and plants, threonine is derived from aspartate [MD:M00018].
Class
Metabolism; Amino acid metabolism
Pathway map
vsh00260  Glycine, serine and threonine metabolism
vsh00260

Module
vsh_M00018  Threonine biosynthesis, aspartate => homoserine => threonine [PATH:vsh00260]
vsh_M00020  Serine biosynthesis, glycerate-3P => serine [PATH:vsh00260]
vsh_M00555  Betaine biosynthesis, choline => betaine [PATH:vsh00260]
vsh_M00621  Glycine cleavage system [PATH:vsh00260]
Other DBs
GO: 0006544 0006563 0070178 0006566
Organism
Vibrio mediterranei [GN:vsh]
Gene
BSZ05_08395  aspartate kinase [KO:K00928] [EC:2.7.2.4]
BSZ05_04620  lysine-sensitive aspartokinase 3 [KO:K00928] [EC:2.7.2.4]
BSZ05_03495  bifunctional aspartate kinase/homoserine dehydrogenase I [KO:K12524] [EC:2.7.2.4 1.1.1.3]
BSZ05_04930  bifunctional aspartate kinase/homoserine dehydrogenase II [KO:K12525] [EC:2.7.2.4 1.1.1.3]
BSZ05_11490  aspartate-semialdehyde dehydrogenase [KO:K00133] [EC:1.2.1.11]
BSZ05_01280  aspartate-semialdehyde dehydrogenase [KO:K00133] [EC:1.2.1.11]
BSZ05_03490  homoserine kinase [KO:K00872] [EC:2.7.1.39]
BSZ05_03485  threonine synthase [KO:K01733] [EC:4.2.3.1]
BSZ05_23370  low-specificity L-threonine aldolase [KO:K01620] [EC:4.1.2.48]
BSZ05_24250  glyA; serine hydroxymethyltransferase [KO:K00600] [EC:2.1.2.1]
BSZ05_13990  serine hydroxymethyltransferase [KO:K00600] [EC:2.1.2.1]
BSZ05_10090  glyA; serine hydroxymethyltransferase [KO:K00600] [EC:2.1.2.1]
BSZ05_04615  alanine--glyoxylate aminotransferase [KO:K00830] [EC:2.6.1.44 2.6.1.45 2.6.1.51]
BSZ05_09065  glycerate dehydrogenase [KO:K00018] [EC:1.1.1.29]
BSZ05_08730  glycerate kinase [KO:K00865] [EC:2.7.1.165]
BSZ05_07635  phosphoglycerate mutase (2,3-diphosphoglycerate-independent) [KO:K15633] [EC:5.4.2.12]
BSZ05_13700  3-phosphoglycerate dehydrogenase [KO:K00058] [EC:1.1.1.95 1.1.1.399]
BSZ05_17110  hypothetical protein [KO:K00058] [EC:1.1.1.95 1.1.1.399]
BSZ05_08565  D-3-phosphoglycerate dehydrogenase [KO:K00058] [EC:1.1.1.95 1.1.1.399]
BSZ05_15915  phosphoserine transaminase [KO:K00831] [EC:2.6.1.52]
BSZ05_13695  phosphoserine aminotransferase [KO:K00831] [EC:2.6.1.52]
BSZ05_09755  phosphoserine phosphatase SerB [KO:K01079] [EC:3.1.3.3]
BSZ05_24410  NAD(P)-dependent oxidoreductase [KO:K16066] [EC:1.1.1.381 1.1.1.-]
BSZ05_21875  glycine C-acetyltransferase [KO:K00639] [EC:2.3.1.29]
BSZ05_21880  L-threonine 3-dehydrogenase [KO:K00060] [EC:1.1.1.103]
BSZ05_24260  glycine dehydrogenase (aminomethyl-transferring) [KO:K00281] [EC:1.4.4.2]
BSZ05_24240  gcvT; glycine cleavage system protein T [KO:K00605] [EC:2.1.2.10]
BSZ05_04125  dihydrolipoyl dehydrogenase [KO:K00382] [EC:1.8.1.4]
BSZ05_17780  dihydrolipoyl dehydrogenase [KO:K00382] [EC:1.8.1.4]
BSZ05_24255  glycine cleavage system protein H [KO:K02437]
BSZ05_24405  hypothetical protein [KO:K00613] [EC:2.1.4.1]
BSZ05_05570  pssA; phosphatidylserine synthase [KO:K00998] [EC:2.7.8.8]
BSZ05_18495  choline dehydrogenase [KO:K00108] [EC:1.1.99.1]
BSZ05_18500  betaine-aldehyde dehydrogenase [KO:K00130] [EC:1.2.1.8]
BSZ05_16780  L-serine ammonia-lyase [KO:K01752] [EC:4.3.1.17]
BSZ05_00010  L-serine ammonia-lyase [KO:K01752] [EC:4.3.1.17]
BSZ05_00140  L-serine ammonia-lyase [KO:K01752] [EC:4.3.1.17]
BSZ05_06200  PLP-dependent threonine dehydratase [KO:K01754] [EC:4.3.1.19]
BSZ05_20300  amino acid deaminase [KO:K01753] [EC:4.3.1.18]
BSZ05_20680  aspartate racemase [KO:K25316] [EC:5.1.1.10]
BSZ05_12595  tryptophan synthase subunit alpha [KO:K01695] [EC:4.2.1.20]
BSZ05_12600  tryptophan synthase subunit beta [KO:K01696] [EC:4.2.1.20]
BSZ05_20055  tryptophan synthase subunit beta [KO:K01696] [EC:4.2.1.20]
BSZ05_00400  aminotransferase class III [KO:K00836] [EC:2.6.1.76]
Compound
C00011  CO2
C00014  Ammonia
C00022  Pyruvate
C00037  Glycine
C00048  Glyoxylate
C00049  L-Aspartate
C00065  L-Serine
C00078  L-Tryptophan
C00097  L-Cysteine
C00101  Tetrahydrofolate
C00109  2-Oxobutanoate
C00114  Choline
C00143  5,10-Methylenetetrahydrofolate
C00168  Hydroxypyruvate
C00188  L-Threonine
C00197  3-Phospho-D-glycerate
C00213  Sarcosine
C00258  D-Glycerate
C00263  L-Homoserine
C00300  Creatine
C00430  5-Aminolevulinate
C00441  L-Aspartate 4-semialdehyde
C00546  Methylglyoxal
C00576  Betaine aldehyde
C00581  Guanidinoacetate
C00631  2-Phospho-D-glycerate
C00719  Betaine
C00740  D-Serine
C00986  1,3-Diaminopropane
C01005  O-Phospho-L-serine
C01026  N,N-Dimethylglycine
C01102  O-Phospho-L-homoserine
C01242  [Protein]-S8-aminomethyldihydrolipoyllysine
C01888  Aminoacetone
C02051  Lipoylprotein
C02291  L-Cystathionine
C02737  Phosphatidylserine
C02972  Dihydrolipoylprotein
C03082  4-Phospho-L-aspartate
C03194  (R)-1-Aminopropan-2-ol
C03232  3-Phosphonooxypyruvate
C03283  L-2,4-Diaminobutanoate
C03508  L-2-Amino-3-oxobutanoic acid
C05519  L-Allothreonine
C06231  Ectoine
C06442  N(gamma)-Acetyldiaminobutyrate
C16432  5-Hydroxyectoine
C19929  N(alpha)-Acetyl-L-2,4-diaminobutyrate
Reference
  Authors
Nishizuka Y, Seyama Y, Ikai A, Ishimura Y, Kawaguchi A (eds).
  Title
[Cellular Functions and Metabolic Maps] (In Japanese)
  Journal
Tokyo Kagaku Dojin (1997)
Reference
PMID:11823218
  Authors
Kuhlmann AU, Bremer E.
  Title
Osmotically regulated synthesis of the compatible solute ectoine in Bacillus pasteurii and related Bacillus spp.
  Journal
Appl Environ Microbiol 68:772-83 (2002)
DOI:10.1128/AEM.68.2.772-783.2002
Reference
PMID:10473374
  Authors
Canovas D, Borges N, Vargas C, Ventosa A, Nieto JJ, Santos H.
  Title
Role of Ngamma-acetyldiaminobutyrate as an enzyme stabilizer and an intermediate in the biosynthesis of hydroxyectoine.
  Journal
Appl Environ Microbiol 65:3774-9 (1999)
DOI:10.1128/AEM.65.9.3774-3779.1999
Reference
PMID:17636255
  Authors
Bursy J, Pierik AJ, Pica N, Bremer E.
  Title
Osmotically induced synthesis of the compatible solute hydroxyectoine is mediated by an evolutionarily conserved ectoine hydroxylase.
  Journal
J Biol Chem 282:31147-55 (2007)
DOI:10.1074/jbc.M704023200
Reference
PMID:16707670
  Authors
Garcia-Estepa R, Argandona M, Reina-Bueno M, Capote N, Iglesias-Guerra F, Nieto JJ, Vargas C.
  Title
The ectD gene, which is involved in the synthesis of the compatible solute hydroxyectoine, is essential for thermoprotection of the halophilic bacterium Chromohalobacter salexigens.
  Journal
J Bacteriol 188:3774-84 (2006)
DOI:10.1128/JB.00136-06
Reference
PMID:15470257
  Authors
Arevalo-Rodriguez M, Pan X, Boeke JD, Heitman J
  Title
FKBP12 controls aspartate pathway flux in Saccharomyces cerevisiae to prevent toxic intermediate accumulation.
  Journal
Eukaryot Cell 3:1287-96 (2004)
DOI:10.1128/EC.3.5.1287-1296.2004
Reference
PMID:7639721
  Authors
Rees WD, Hay SM
  Title
The biosynthesis of threonine by mammalian cells: expression of a complete bacterial biosynthetic pathway in an animal cell.
  Journal
Biochem J 309 ( Pt 3):999-1007 (1995)
DOI:10.1042/bj3090999
Reference
PMID:11341914
  Authors
Jacques SL, Nieman C, Bareich D, Broadhead G, Kinach R, Honek JF, Wright GD
  Title
Characterization of yeast homoserine dehydrogenase, an antifungal target: the invariant histidine 309 is important for enzyme integrity.
  Journal
Biochim Biophys Acta 1544:28-41 (2001)
DOI:10.1016/S0167-4838(00)00203-X
Reference
PMID:15520012
  Authors
Chen X, Jhee KH, Kruger WD
  Title
Production of the neuromodulator H2S by cystathionine beta-synthase via the condensation of cysteine and homocysteine.
  Journal
J Biol Chem 279:52082-6 (2004)
DOI:10.1074/jbc.C400481200
Related
pathway
vsh00010  Glycolysis / Gluconeogenesis
vsh00020  Citrate cycle (TCA cycle)
vsh00230  Purine metabolism
vsh00250  Alanine, aspartate and glutamate metabolism
vsh00270  Cysteine and methionine metabolism
vsh00290  Valine, leucine and isoleucine biosynthesis
vsh00300  Lysine biosynthesis
vsh00330  Arginine and proline metabolism
vsh00460  Cyanoamino acid metabolism
vsh00470  D-Amino acid metabolism
vsh00564  Glycerophospholipid metabolism
vsh00600  Sphingolipid metabolism
vsh00620  Pyruvate metabolism
vsh00630  Glyoxylate and dicarboxylate metabolism
vsh00640  Propanoate metabolism
vsh00680  Methane metabolism
vsh00860  Porphyrin metabolism
vsh00920  Sulfur metabolism
KO pathway
ko00260   
LinkDB

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