KEGG   PATHWAY: pcad00190
Entry
pcad00190                   Pathway                                
Name
Oxidative phosphorylation - Physeter macrocephalus (sperm whale)
Class
Metabolism; Energy metabolism
Pathway map
pcad00190  Oxidative phosphorylation
pcad00190

Module
pcad_M00142  NADH:ubiquinone oxidoreductase, mitochondria [PATH:pcad00190]
pcad_M00143  NADH dehydrogenase (ubiquinone) Fe-S protein/flavoprotein complex, mitochondria [PATH:pcad00190]
pcad_M00148  Succinate dehydrogenase (ubiquinone) [PATH:pcad00190]
pcad_M00151  Cytochrome bc1 complex respiratory unit [PATH:pcad00190]
pcad_M00152  Cytochrome bc1 complex [PATH:pcad00190]
pcad_M00160  V-type ATPase, eukaryotes [PATH:pcad00190]
Organism
Physeter macrocephalus (sperm whale) [GN:pcad]
Gene
102973178  [KO:K03942] [EC:7.1.1.2]
102973423  [KO:K01507] [EC:3.6.1.1]
102973627  ATP6V1C2; V-type proton ATPase subunit C 2 isoform X2 [KO:K02148]
102973655  NDUFS3; NADH dehydrogenase [ubiquinone] iron-sulfur protein 3, mitochondrial [KO:K03936] [EC:7.1.1.2]
102973684  [KO:K02140]
102973745  [KO:K02152]
102973995  [KO:K02260]
102974022  NDUFS5; NADH dehydrogenase [ubiquinone] iron-sulfur protein 5 [KO:K03938]
102974195  ATP5MF; ATP synthase subunit f, mitochondrial [KO:K02130]
102974199  SDHD; succinate dehydrogenase [ubiquinone] cytochrome b small subunit, mitochondrial isoform X1 [KO:K00237]
102974489  [KO:K02263]
102974535  NDUFS4; NADH dehydrogenase [ubiquinone] iron-sulfur protein 4, mitochondrial isoform X3 [KO:K03937]
102974600  NDUFS7; NADH dehydrogenase [ubiquinone] iron-sulfur protein 7, mitochondrial [KO:K03940] [EC:7.1.1.2]
102974806  [KO:K02258]
102974829  NDUFA8; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 8 [KO:K03952]
102975060  [KO:K00419]
102975289  ATP6V0A4; V-type proton ATPase 116 kDa subunit a 4 [KO:K02154]
102975464  ATP5F1D; ATP synthase subunit delta, mitochondrial [KO:K02134]
102975681  ATP5PF; ATP synthase-coupling factor 6, mitochondrial [KO:K02131]
102976000  ATP6V0A1; V-type proton ATPase 116 kDa subunit a 1 isoform X1 [KO:K02154]
102976162  NDUFB6; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 6 isoform X1 [KO:K03962]
102976248  ATP6V1D; V-type proton ATPase subunit D [KO:K02149]
102976386  NDUFA4L2; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 4-like 2 [KO:K03948]
102976499  NDUFAB1; acyl carrier protein, mitochondrial [KO:K03955]
102976522  NDUFB7; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 7 [KO:K03963]
102976848  ATP5F1C; ATP synthase subunit gamma, mitochondrial isoform X1 [KO:K02136]
102977269  [KO:K00416]
102977457  [KO:K08738]
102977740  [KO:K03944]
102977860  ATP6V1B2; V-type proton ATPase subunit B, brain isoform [KO:K02147]
102977966  [KO:K02271]
102977972  [KO:K00417]
102978040  ATP6AP1; V-type proton ATPase subunit S1 [KO:K03662]
102978136  ATP5PD; ATP synthase subunit d, mitochondrial [KO:K02138]
102978194  [KO:K08738]
102978471  [KO:K08738]
102978613  ATP6V0C; V-type proton ATPase 16 kDa proteolipid subunit c [KO:K02155]
102978713  [KO:K02140]
102978880  [KO:K00414]
102979050  [KO:K00417]
102979493  TCIRG1; V-type proton ATPase 116 kDa subunit a 3 [KO:K02154]
102979558  [KO:K02270]
102979925  NDUFA5; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 5 [KO:K03949]
102980141  [KO:K02263]
102980282  [KO:K08738]
102980309  [KO:K00417]
102980336  NDUFB4; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 4 [KO:K03960]
102980395  [KO:K03955]
102980571  NDUFV3; NADH dehydrogenase [ubiquinone] flavoprotein 3, mitochondrial isoform X1 [KO:K03944]
102980589  [KO:K02265]
102980620  ATP5MG; ATP synthase subunit g, mitochondrial isoform X1 [KO:K02140]
102980725  [KO:K02128]
102980736  [KO:K02140]
102980876  ATP6V0D2; V-type proton ATPase subunit d 2 [KO:K02146]
102980990  ATP5PO; ATP synthase subunit O, mitochondrial [KO:K02137]
102981009  NDUFC2; NADH dehydrogenase [ubiquinone] 1 subunit C2 [KO:K03968]
102981449  ATP6V1H; V-type proton ATPase subunit H isoform X1 [KO:K02144]
102981654  [KO:K03949]
102981753  ATP5MC1; ATP synthase F(0) complex subunit C1, mitochondrial [KO:K02128]
102981803  NDUFB10; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 10 [KO:K03966]
102981962  [KO:K02266]
102982301  NDUFS6; NADH dehydrogenase [ubiquinone] iron-sulfur protein 6, mitochondrial [KO:K03939]
102982387  [KO:K02133] [EC:7.1.2.2]
102982476  [KO:K02267]
102982513  [KO:K02270]
102982604  NDUFA11; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 11 isoform X1 [KO:K03956]
102982622  NDUFA3; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 3 [KO:K03947]
102983006  [KO:K03958]
102983330  NDUFB3; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 3 [KO:K03959]
102983809  PPA2; inorganic pyrophosphatase 2, mitochondrial isoform X3 [KO:K01507] [EC:3.6.1.1]
102983888  [KO:K02257] [EC:2.5.1.141]
102984396  ATP6V1G2; V-type proton ATPase subunit G 2 isoform X1 [KO:K02152]
102984767  [KO:K02127]
102984789  [KO:K02128]
102984887  NDUFA13; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 13 [KO:K11353]
102985054  [KO:K02138]
102985671  [KO:K02265]
102985726  NDUFS1; NADH-ubiquinone oxidoreductase 75 kDa subunit, mitochondrial [KO:K03934] [EC:7.1.1.2]
102985766  [KO:K02267]
102985816  [KO:K00415]
102985837  [KO:K03661]
102985897  [KO:K02259] [EC:1.17.99.9]
102986020  [KO:K02271]
102986405  [KO:K00237]
102986579  [KO:K02272]
102986595  ATP5PB; ATP synthase F(0) complex subunit B1, mitochondrial [KO:K02127]
102986675  [KO:K08738]
102986706  PPA1; inorganic pyrophosphatase [KO:K01507] [EC:3.6.1.1]
102986775  NDUFA12; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 12 [KO:K11352]
102986853  [KO:K02128]
102986918  ATP6V0A2; V-type proton ATPase 116 kDa subunit a 2 isoform X3 [KO:K02154]
102987024  ATP5F1B; ATP synthase subunit beta, mitochondrial [KO:K02133] [EC:7.1.2.2]
102987053  [KO:K02264]
102987120  SDHA; succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial isoform X1 [KO:K00234] [EC:1.3.5.1]
102987138  [KO:K00420]
102987193  [KO:K03958]
102987198  [KO:K00418]
102987448  ATP6V1E1; V-type proton ATPase subunit E 1 [KO:K02150]
102987521  [KO:K03967]
102987604  SDHB; succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial [KO:K00235] [EC:1.3.5.1]
102987823  LHPP; phospholysine phosphohistidine inorganic pyrophosphate phosphatase [KO:K11725] [EC:3.6.1.1 3.1.3.-]
102987911  [KO:K00413]
102988081  SDHC; succinate dehydrogenase cytochrome b560 subunit, mitochondrial [KO:K00236]
102988154  ATP5MC3; ATP synthase F(0) complex subunit C3, mitochondrial [KO:K02128]
102988333  ATP6V1G3; V-type proton ATPase subunit G 3 [KO:K02152]
102988355  [KO:K02270]
102988418  NDUFA10; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 10, mitochondrial isoform X5 [KO:K03954]
102988957  NDUFC1; NADH dehydrogenase [ubiquinone] 1 subunit C1, mitochondrial [KO:K03967]
102988963  [KO:K03960]
102989820  ATP6V1E2; V-type proton ATPase subunit E 2 [KO:K02150]
102990190  NDUFS2; NADH dehydrogenase [ubiquinone] iron-sulfur protein 2, mitochondrial [KO:K03935] [EC:7.1.1.2]
102990513  [KO:K00411] [EC:7.1.1.8]
102990603  [KO:K03953]
102990622  ATP5MC2; ATP synthase F(0) complex subunit C2, mitochondrial isoform X2 [KO:K02128]
102990633  NDUFB9; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 9 [KO:K03965]
102990827  NDUFA4; cytochrome c oxidase subunit NDUFA4 [KO:K03948]
102990963  [KO:K00418]
102991268  NDUFB5; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 5, mitochondrial isoform X1 [KO:K03961]
102991400  ATP6V0B; V-type proton ATPase 21 kDa proteolipid subunit c'' isoform X1 [KO:K03661]
102991473  ATP6V0D1; V-type proton ATPase subunit d 1 isoform X1 [KO:K02146]
102991568  NDUFA2; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 2 [KO:K03946]
102992299  NDUFA7; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 7 [KO:K03951]
102992400  ATP5F1A; ATP synthase subunit alpha, mitochondrial [KO:K02132]
102992498  NDUFV2; NADH dehydrogenase [ubiquinone] flavoprotein 2, mitochondrial [KO:K03943] [EC:7.1.1.2]
102992584  ATP6V1C1; V-type proton ATPase subunit C 1 [KO:K02148]
102992690  ATP4B; potassium-transporting ATPase subunit beta [KO:K01543] [EC:7.2.2.19]
102992839  [KO:K00420]
102993375  [KO:K00420]
102993725  NDUFB8; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 8, mitochondrial [KO:K03964]
102993871  [KO:K02140]
102994019  NDUFB11; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 11, mitochondrial [KO:K11351]
102994540  ATP12A; potassium-transporting ATPase alpha chain 2 [KO:K01544] [EC:7.2.2.19]
102994597  ATP4A; potassium-transporting ATPase alpha chain 1 [KO:K01542] [EC:7.2.2.19]
102994748  ATP6V1F; V-type proton ATPase subunit F [KO:K02151]
102995354  ATP6V0E1; V-type proton ATPase subunit e 1 [KO:K02153]
102995627  NDUFS8; NADH dehydrogenase [ubiquinone] iron-sulfur protein 8, mitochondrial isoform X1 [KO:K03941] [EC:7.1.1.2]
102995688  [KO:K00415]
102995698  ATP6V0E2; V-type proton ATPase subunit e 2 [KO:K02153]
102995815  ATP6V1B1; V-type proton ATPase subunit B, kidney isoform [KO:K02147]
102995827  [KO:K02265]
102996128  NDUFA6; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 6 [KO:K03950]
102996142  [KO:K02270]
102996583  ATP6V1A; V-type proton ATPase catalytic subunit A [KO:K02145] [EC:7.1.2.2]
102996599  [KO:K02153]
102996653  [KO:K02266]
102997022  [KO:K02152]
112062206  [KO:K02153]
112062393  [KO:K02153]
112062454  [KO:K03948]
112062463  [KO:K03948]
112063186  [KO:K01507] [EC:3.6.1.1]
112063725  ATP5ME; ATP synthase subunit e, mitochondrial [KO:K02129]
112063836  [KO:K02129]
112063874  [KO:K08738]
112064644  [KO:K03948]
112064834  [KO:K02272]
112065786  [KO:K01507] [EC:3.6.1.1]
112065978  [KO:K02257] [EC:2.5.1.141]
112066265  [KO:K03958]
112066518  [KO:K03953]
112066660  [KO:K08738]
112066780  [KO:K03948]
112067434  [KO:K02273]
112067461  NDUFV1; NADH dehydrogenase [ubiquinone] flavoprotein 1, mitochondrial [KO:K03942] [EC:7.1.1.2]
114483880  [KO:K03942] [EC:7.1.1.2]
114486535  [KO:K02270]
809407  ATP6; ATP synthase F0 subunit 6 [KO:K02126]
809408  ATP8; ATP synthase F0 subunit 8 [KO:K02125]
809409  ND3; NADH dehydrogenase subunit 3 [KO:K03880] [EC:7.1.1.2]
809410  ND4; NADH dehydrogenase subunit 4 [KO:K03881] [EC:7.1.1.2]
809411  ND6; NADH dehydrogenase subunit 6 [KO:K03884] [EC:7.1.1.2]
809412  COX1; cytochrome c oxidase subunit I [KO:K02256] [EC:7.1.1.9]
809413  ND4L; NADH dehydrogenase subunit 4L [KO:K03882] [EC:7.1.1.2]
809414  CYTB; cytochrome b [KO:K00412]
809415  ND5; NADH dehydrogenase subunit 5 [KO:K03883] [EC:7.1.1.2]
809416  COX2; cytochrome c oxidase subunit II [KO:K02261]
809417  COX3; cytochrome c oxidase subunit III [KO:K02262]
809418  ND1; NADH dehydrogenase subunit 1 [KO:K03878] [EC:7.1.1.2]
809419  ND2; NADH dehydrogenase subunit 2 [KO:K03879] [EC:7.1.1.2]
Compound
C00001  H2O
C00002  ATP
C00003  NAD+
C00004  NADH
C00007  Oxygen
C00008  ADP
C00009  Orthophosphate
C00013  Diphosphate
C00042  Succinate
C00080  H+
C00122  Fumarate
C00536  Triphosphate
Reference
PMID:16469879
  Authors
Sazanov LA, Hinchliffe P.
  Title
Structure of the hydrophilic domain of respiratory complex I from Thermus thermophilus.
  Journal
Science 311:1430-6 (2006)
DOI:10.1126/science.1123809
Reference
PMID:16584177
  Authors
Hinchliffe P, Carroll J, Sazanov LA.
  Title
Identification of a novel subunit of respiratory complex I from Thermus thermophilus.
  Journal
Biochemistry 45:4413-20 (2006)
DOI:10.1021/bi0600998
KO pathway
ko00190   

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