KEGG   PATHWAY: pfs00760
Entry
pfs00760                    Pathway                                
Name
Nicotinate and nicotinamide metabolism - Pseudomonas fluorescens SBW25
Class
Metabolism; Metabolism of cofactors and vitamins
Pathway map
pfs00760  Nicotinate and nicotinamide metabolism
pfs00760

Module
pfs_M00115  NAD biosynthesis, aspartate => quinolinate => NAD [PATH:pfs00760]
pfs_M00622  Nicotinate degradation, nicotinate => fumarate [PATH:pfs00760]
Other DBs
UMBBD: nic
GO: 0046497 0006769
Organism
Pseudomonas fluorescens SBW25 [GN:pfs]
Gene
PFLU_1465  nadB; L-aspartate oxidase (EC [KO:K00278] [EC:1.4.3.16]
PFLU_4902  Quinolinate synthase A (EC [KO:K03517] [EC:2.5.1.72]
PFLU_0796  nadC; Quinolinate phosphoribosyltransferase [decarboxylating] (EC [KO:K00767] [EC:2.4.2.19]
PFLU_0547  pncB; Nicotinate phosphoribosyltransferase (NAPRTase) (EC [KO:K00763] [EC:6.3.4.21]
PFLU_2520  pncB; Nicotinate phosphoribosyltransferase (NAPRTase) (EC [KO:K00763] [EC:6.3.4.21]
PFLU_1708  Putative 5'-nucleotidase [KO:K01081] [EC:3.1.3.5]
PFLU_2214  5'-nucleotidase (EC [KO:K03787] [EC:3.1.3.5 3.1.3.6]
PFLU_1299  surE; 5'-nucleotidase SurE (EC (Nucleoside 5'-monophosphate phosphohydrolase) [KO:K03787] [EC:3.1.3.5 3.1.3.6]
PFLU_5426  Probable nicotinate-nucleotide adenylyltransferase (EC (Deamido-NAD(+) diphosphorylase) (Deamido-NAD(+) pyrophosphorylase) (Nicotinate mononucleotide adenylyltransferase) (NaMN adenylyltransferase) [KO:K00969] [EC:2.7.7.18]
PFLU_4504  Uncharacterized protein [KO:K04765] [EC:3.6.1.9]
PFLU_2778  NAD-capped RNA hydrolase NudC (DeNADding enzyme NudC) (EC (NADH pyrophosphatase) (EC [KO:K03426] [EC:3.6.1.22]
PFLU_0546  nadE; NH(3)-dependent NAD(+) synthetase (EC [KO:K01916] [EC:6.3.1.5]
PFLU_2521  nadE; NH(3)-dependent NAD(+) synthetase (EC [KO:K01916] [EC:6.3.1.5]
PFLU_1188  CinA domain-containing protein [KO:K03743] [EC:3.5.1.42]
PFLU_2674  NAD kinase [KO:K00858] [EC:2.7.1.23]
PFLU_1569  sthA; Soluble pyridine nucleotide transhydrogenase (STH) (EC (NAD(P)(+) transhydrogenase [B-specific]) [KO:K00322] [EC:1.6.1.1]
PFLU_0112  Proton-translocating NAD(P)(+) transhydrogenase (EC [KO:K00324] [EC:7.1.1.1]
PFLU_0113  pntAA; NAD(P) transhydrogenase subunit alpha 1 (EC [KO:K00324] [EC:7.1.1.1]
PFLU_0111  pntB; NAD(P) transhydrogenase subunit beta [KO:K00325] [EC:7.1.1.1]
PFLU_2802  Isoquinoline 1-oxidoreductase alpha subunit (EC [KO:K18029] [EC:1.17.2.1]
PFLU_2803  Putative cytochrome C aldehyde dehydrogenase [KO:K18030] [EC:1.17.2.1]
PFLU_2799  Putative monooxygenase [KO:K14974] [EC:1.14.13.114]
PFLU_2800  Uncharacterized protein [KO:K18028] [EC:1.13.11.9]
PFLU_2798  Putative alpha/beta hydrolase [KO:K15357] [EC:3.5.1.106]
PFLU_2796  Putative isochorismatase [KO:K13995] [EC:3.5.1.107]
PFLU_2797  Maleate isomerase (EC (Maleate cis-trans isomerase) [KO:K01799] [EC:5.2.1.1]
PFLU_4039  Putative succinate-semialdehyde dehydrogenase [NADP+] [KO:K00135] [EC:1.2.1.16 1.2.1.79 1.2.1.20]
PFLU_1938  gabD2; Succinate-semialdehyde dehydrogenase (EC [KO:K00135] [EC:1.2.1.16 1.2.1.79 1.2.1.20]
PFLU_0180  gabD; Succinate-semialdehyde dehydrogenase [NADP+] (EC [KO:K00135] [EC:1.2.1.16 1.2.1.79 1.2.1.20]
PFLU_4212  Putative aldehyde dehydrogenase [KO:K08324] [EC:1.2.1.16 1.2.1.24]
Compound
C00003  NAD+
C00006  NADP+
C00022  Pyruvate
C00042  Succinate
C00049  L-Aspartate
C00111  Glycerone phosphate
C00122  Fumarate
C00153  Nicotinamide
C00163  Propanoate
C00232  Succinate semialdehyde
C00253  Nicotinate
C00334  4-Aminobutanoate
C00455  Nicotinamide D-ribonucleotide
C00745  Nicotine
C00857  Deamino-NAD+
C00922  2,3-Dimethylmaleate
C01020  6-Hydroxynicotinate
C01056  (S)-6-Hydroxynicotine
C01059  2,5-Dihydroxypyridine
C01185  Nicotinate D-ribonucleotide
C01297  6-Hydroxypseudooxynicotine
C01384  Maleic acid
C01596  Maleamate
C02295  Methylitaconate
C02918  1-Methylnicotinamide
C02930  2-Methyleneglutarate
C03043  (R)-6-Hydroxynicotine
C03056  2,6-Dihydroxypyridine
C03150  Nicotinamide-beta-riboside
C03458  2,3,6-Trihydroxypyridine
C03652  (2R,3S)-2,3-Dimethylmalate
C03722  Quinolinate
C04226  6-Oxo-1,4,5,6-tetrahydronicotinate
C05380  Nicotinurate
C05840  Iminoaspartate
C05841  Nicotinate D-ribonucleoside
C05842  N1-Methyl-2-pyridone-5-carboxamide
C05843  N1-Methyl-4-pyridone-5-carboxamide
C06178  1-Methylpyrrolinium
C15523  2,6-Dihydroxynicotinate
C15986  2,6-Dihydroxypseudooxynicotine
C15987  4-Methylaminobutyrate
C16151  2,6-Dihydroxy-N-methylmyosmine
C16152  Blue pigment
C16159  2-Formylglutarate
C16386  (R)-Nicotine
C16390  (S)-2-(Hydroxymethyl)glutarate
C18232  N-Formylmaleamic acid
C19567  4-Oxo-1-(3-pyridyl)-1-butanone
C19569  3-Succinoylpyridine
C19631  6-Hydroxy-3-succinoylpyridine
C20361  Pseudooxynicotine
C20381  3,3'-Bipyridine-2,2',5,5',6,6'-hexol
C21075  5-(N-Methyl-4,5-dihydro-1H-pyrrol-2-yl)pyridin-2-ol
C21154  N-Methylmyosmine
Reference
PMID:13475371
  Authors
BEHRMAN EJ, STANIER RY.
  Title
The bacterial oxidation of nicotinic acid.
  Journal
J Biol Chem 228:923-45 (1957)
Reference
PMID:16894175
  Authors
Alhapel A, Darley DJ, Wagener N, Eckel E, Elsner N, Pierik AJ.
  Title
Molecular and functional analysis of nicotinate catabolism in Eubacterium barkeri.
  Journal
Proc Natl Acad Sci U S A 103:12341-6 (2006)
DOI:10.1073/pnas.0601635103
Reference
PMID:11514508
  Authors
Baitsch D, Sandu C, Brandsch R, Igloi GL.
  Title
Gene cluster on pAO1 of Arthrobacter nicotinovorans involved in degradation of the plant alkaloid nicotine: cloning, purification, and characterization of 2,6-dihydroxypyridine 3-hydroxylase.
  Journal
J Bacteriol 183:5262-7 (2001)
DOI:10.1128/JB.183.18.5262-5267.2001
Reference
PMID:16321959
  Authors
Sachelaru P, Schiltz E, Igloi GL, Brandsch R.
  Title
An alpha/beta-fold C--C bond hydrolase is involved in a central step of nicotine catabolism by Arthrobacter nicotinovorans.
  Journal
J Bacteriol 187:8516-9 (2005)
DOI:10.1128/JB.187.24.8516-8519.2005
Reference
PMID:5835946
  Authors
Gherna RL, Richardson SH, Rittenberg SC
  Title
The bacterial oxidation of nicotine. VI. The metabolism of 2,6-dihydroxypseudooxynicotine.
  Journal
J Biol Chem 240:3669-74 (1965)
Reference
PMID:21953451
  Authors
Galeazzi L, Bocci P, Amici A, Brunetti L, Ruggieri S, Romine M, Reed S, Osterman AL, Rodionov DA, Sorci L, Raffaelli N
  Title
Identification of nicotinamide mononucleotide deamidase of the bacterial pyridine nucleotide cycle reveals a novel broadly conserved amidohydrolase family.
  Journal
J Biol Chem 286:40365-75 (2011)
DOI:10.1074/jbc.M111.275818
Related
pathway
pfs00020  Citrate cycle (TCA cycle)
pfs00250  Alanine, aspartate and glutamate metabolism
pfs00380  Tryptophan metabolism
pfs00620  Pyruvate metabolism
pfs00660  C5-Branched dibasic acid metabolism
KO pathway
ko00760   
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