KEGG   PATHWAY: pgd00260
Entry
pgd00260                    Pathway                                
Name
Glycine, serine and threonine metabolism - Phaeobacter gallaeciensis DSM 26640
Description
Serine is derived from 3-phospho-D-glycerate, an intermediate of glycolysis [MD:M00020], and glycine is derived from serine. Threonine is an essential amino acid, which animals cannot synthesize. In bacteria and plants, threonine is derived from aspartate [MD:M00018].
Class
Metabolism; Amino acid metabolism
Pathway map
pgd00260  Glycine, serine and threonine metabolism
pgd00260

Module
pgd_M00020  Serine biosynthesis, glycerate-3P => serine [PATH:pgd00260]
pgd_M00555  Betaine biosynthesis, choline => betaine [PATH:pgd00260]
pgd_M00621  Glycine cleavage system [PATH:pgd00260]
Other DBs
GO: 0006544 0006563 0070178 0006566
Organism
Phaeobacter gallaeciensis DSM 26640 [GN:pgd]
Gene
Gal_01041  aspartate kinase [KO:K00928] [EC:2.7.2.4]
Gal_00100  aspartate semialdehyde dehydrogenase [KO:K00133] [EC:1.2.1.11]
Gal_02626  homoserine dehydrogenase [KO:K00003] [EC:1.1.1.3]
Gal_02874  threonine synthase [KO:K01733] [EC:4.2.3.1]
Gal_00891  L-threonine aldolase [KO:K01620] [EC:4.1.2.48]
Gal_00934  Glycine/serine hydroxymethyltransferase [KO:K00600] [EC:2.1.2.1]
Gal_02218  serine hydroxymethyltransferase [KO:K00600] [EC:2.1.2.1]
Gal_00997  Serine-pyruvate aminotransferase/archaeal aspartate aminotransferase [KO:K00830] [EC:2.6.1.44 2.6.1.45 2.6.1.51]
Gal_00773  Phosphoglycerate dehydrogenase [KO:K12972] [EC:1.1.1.79 1.1.1.81]
Gal_00111  Putative glycerate kinase [KO:K11529] [EC:2.7.1.165]
Gal_03229  phosphoglycerate mutase [KO:K15633] [EC:5.4.2.12]
Gal_03682  D-3-phosphoglycerate dehydrogenase [KO:K00058] [EC:1.1.1.95 1.1.1.399]
Gal_03683  phosphoserine aminotransferase apoenzyme [KO:K00831] [EC:2.6.1.52]
Gal_03685  phosphoserine phosphatase SerB [KO:K01079] [EC:3.1.3.3]
Gal_03500  2-amino-3-ketobutyrate coenzyme A ligase [KO:K00639] [EC:2.3.1.29]
Gal_03499  Threonine dehydrogenase [KO:K00060] [EC:1.1.1.103]
Gal_01363  5-aminolevulinic acid synthase [KO:K00643] [EC:2.3.1.37]
Gal_02948  glycine dehydrogenase (decarboxylating) [KO:K00281] [EC:1.4.4.2]
Gal_04252  glycine dehydrogenase (decarboxylating) [KO:K00281] [EC:1.4.4.2]
Gal_04254  glycine cleavage system T protein [KO:K00605] [EC:2.1.2.10]
Gal_01585  dihydrolipoamide dehydrogenase [KO:K00382] [EC:1.8.1.4]
Gal_03147  dihydrolipoamide dehydrogenase [KO:K00382] [EC:1.8.1.4]
Gal_04321  dihydrolipoamide dehydrogenase [KO:K00382] [EC:1.8.1.4]
Gal_04257  dihydrolipoamide dehydrogenase [KO:K00382] [EC:1.8.1.4]
Gal_02949  glycine cleavage system H protein [KO:K02437]
Gal_04253  glycine cleavage system H protein [KO:K02437]
Gal_00468  Xaa-Pro aminopeptidase [KO:K08688] [EC:3.5.3.3]
Gal_00469  Phosphatidylserine synthase [KO:K17103] [EC:2.7.8.8]
Gal_01234  choline dehydrogenase [KO:K00108] [EC:1.1.99.1]
Gal_01233  betaine aldehyde dehydrogenase [KO:K00130] [EC:1.2.1.8]
Gal_01999  dimethylglycine dehydrogenase [KO:K00315] [EC:1.5.8.4]
Gal_00601  Glycine cleavage system T protein (aminomethyltransferase) [KO:K00315] [EC:1.5.8.4]
Gal_03876  dimethylglycine dehydrogenase [KO:K00315] [EC:1.5.8.4]
Gal_03372  dimethylglycine dehydrogenase [KO:K00315] [EC:1.5.8.4]
Gal_01480  sarcosine oxidase, alpha subunit family, heterotetrameric form [KO:K00302] [EC:1.5.3.24 1.5.3.1]
Gal_01478  sarcosine oxidase, beta subunit family, heterotetrameric form [KO:K00303] [EC:1.5.3.24 1.5.3.1]
Gal_01481  Sarcosine oxidase gamma subunit [KO:K00305] [EC:1.5.3.24 1.5.3.1]
Gal_01479  Sarcosine oxidase delta subunit [KO:K00304] [EC:1.5.3.24 1.5.3.1]
Gal_01012  L-serine dehydratase, iron-sulfur-dependent, single chain form [KO:K01752] [EC:4.3.1.17]
Gal_03697  Threonine dehydratase [KO:K01754] [EC:4.3.1.19]
Gal_03042  Threonine dehydratase [KO:K01754] [EC:4.3.1.19]
Gal_03558  L-threonine ammonia-lyase [KO:K01754] [EC:4.3.1.19]
Gal_03007  tryptophan synthase, alpha chain [KO:K01695] [EC:4.2.1.20]
Gal_03013  tryptophan synthase, beta chain [KO:K01696] [EC:4.2.1.20]
Gal_02709  Xaa-Pro aminopeptidase [KO:K15783] [EC:3.5.4.44]
Gal_02710  Adenosylmethionine-8-amino-7-oxononanoate aminotransferase [KO:K15785] [EC:2.6.1.76]
Compound
C00011  CO2
C00014  Ammonia
C00022  Pyruvate
C00037  Glycine
C00048  Glyoxylate
C00049  L-Aspartate
C00065  L-Serine
C00078  L-Tryptophan
C00097  L-Cysteine
C00101  Tetrahydrofolate
C00109  2-Oxobutanoate
C00114  Choline
C00143  5,10-Methylenetetrahydrofolate
C00168  Hydroxypyruvate
C00188  L-Threonine
C00197  3-Phospho-D-glycerate
C00213  Sarcosine
C00258  D-Glycerate
C00263  L-Homoserine
C00300  Creatine
C00430  5-Aminolevulinate
C00441  L-Aspartate 4-semialdehyde
C00546  Methylglyoxal
C00576  Betaine aldehyde
C00581  Guanidinoacetate
C00631  2-Phospho-D-glycerate
C00719  Betaine
C00740  D-Serine
C00986  1,3-Diaminopropane
C01005  O-Phospho-L-serine
C01026  N,N-Dimethylglycine
C01102  O-Phospho-L-homoserine
C01242  [Protein]-S8-aminomethyldihydrolipoyllysine
C01888  Aminoacetone
C02051  Lipoylprotein
C02291  L-Cystathionine
C02737  Phosphatidylserine
C02972  Dihydrolipoylprotein
C03082  4-Phospho-L-aspartate
C03194  (R)-1-Aminopropan-2-ol
C03232  3-Phosphonooxypyruvate
C03283  L-2,4-Diaminobutanoate
C03508  L-2-Amino-3-oxobutanoic acid
C05519  L-Allothreonine
C06231  Ectoine
C06442  N(gamma)-Acetyldiaminobutyrate
C16432  5-Hydroxyectoine
C19929  N(alpha)-Acetyl-L-2,4-diaminobutyrate
Reference
  Authors
Nishizuka Y, Seyama Y, Ikai A, Ishimura Y, Kawaguchi A (eds).
  Title
[Cellular Functions and Metabolic Maps] (In Japanese)
  Journal
Tokyo Kagaku Dojin (1997)
Reference
PMID:11823218
  Authors
Kuhlmann AU, Bremer E.
  Title
Osmotically regulated synthesis of the compatible solute ectoine in Bacillus pasteurii and related Bacillus spp.
  Journal
Appl Environ Microbiol 68:772-83 (2002)
DOI:10.1128/AEM.68.2.772-783.2002
Reference
PMID:10473374
  Authors
Canovas D, Borges N, Vargas C, Ventosa A, Nieto JJ, Santos H.
  Title
Role of Ngamma-acetyldiaminobutyrate as an enzyme stabilizer and an intermediate in the biosynthesis of hydroxyectoine.
  Journal
Appl Environ Microbiol 65:3774-9 (1999)
DOI:10.1128/AEM.65.9.3774-3779.1999
Reference
PMID:17636255
  Authors
Bursy J, Pierik AJ, Pica N, Bremer E.
  Title
Osmotically induced synthesis of the compatible solute hydroxyectoine is mediated by an evolutionarily conserved ectoine hydroxylase.
  Journal
J Biol Chem 282:31147-55 (2007)
DOI:10.1074/jbc.M704023200
Reference
PMID:16707670
  Authors
Garcia-Estepa R, Argandona M, Reina-Bueno M, Capote N, Iglesias-Guerra F, Nieto JJ, Vargas C.
  Title
The ectD gene, which is involved in the synthesis of the compatible solute hydroxyectoine, is essential for thermoprotection of the halophilic bacterium Chromohalobacter salexigens.
  Journal
J Bacteriol 188:3774-84 (2006)
DOI:10.1128/JB.00136-06
Reference
PMID:15470257
  Authors
Arevalo-Rodriguez M, Pan X, Boeke JD, Heitman J
  Title
FKBP12 controls aspartate pathway flux in Saccharomyces cerevisiae to prevent toxic intermediate accumulation.
  Journal
Eukaryot Cell 3:1287-96 (2004)
DOI:10.1128/EC.3.5.1287-1296.2004
Reference
PMID:7639721
  Authors
Rees WD, Hay SM
  Title
The biosynthesis of threonine by mammalian cells: expression of a complete bacterial biosynthetic pathway in an animal cell.
  Journal
Biochem J 309 ( Pt 3):999-1007 (1995)
DOI:10.1042/bj3090999
Reference
PMID:11341914
  Authors
Jacques SL, Nieman C, Bareich D, Broadhead G, Kinach R, Honek JF, Wright GD
  Title
Characterization of yeast homoserine dehydrogenase, an antifungal target: the invariant histidine 309 is important for enzyme integrity.
  Journal
Biochim Biophys Acta 1544:28-41 (2001)
DOI:10.1016/S0167-4838(00)00203-X
Reference
PMID:15520012
  Authors
Chen X, Jhee KH, Kruger WD
  Title
Production of the neuromodulator H2S by cystathionine beta-synthase via the condensation of cysteine and homocysteine.
  Journal
J Biol Chem 279:52082-6 (2004)
DOI:10.1074/jbc.C400481200
Related
pathway
pgd00010  Glycolysis / Gluconeogenesis
pgd00020  Citrate cycle (TCA cycle)
pgd00230  Purine metabolism
pgd00250  Alanine, aspartate and glutamate metabolism
pgd00270  Cysteine and methionine metabolism
pgd00290  Valine, leucine and isoleucine biosynthesis
pgd00300  Lysine biosynthesis
pgd00330  Arginine and proline metabolism
pgd00460  Cyanoamino acid metabolism
pgd00470  D-Amino acid metabolism
pgd00564  Glycerophospholipid metabolism
pgd00600  Sphingolipid metabolism
pgd00620  Pyruvate metabolism
pgd00630  Glyoxylate and dicarboxylate metabolism
pgd00640  Propanoate metabolism
pgd00680  Methane metabolism
pgd00860  Porphyrin metabolism
pgd00920  Sulfur metabolism
KO pathway
ko00260   
LinkDB

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