KEGG   PATHWAY: pleu03440
Entry
pleu03440                   Pathway                                
Name
Homologous recombination - Peromyscus leucopus (white-footed mouse)
Description
Homologous recombination (HR) is essential for the accurate repair of DNA double-strand breaks (DSBs), potentially lethal lesions. HR takes place in the late S-G2 phase of the cell cycle and involves the generation of a single-stranded region of DNA, followed by strand invasion, formation of a Holliday junction, DNA synthesis using the intact strand as a template, branch migration and resolution. It is investigated that RecA/Rad51 family proteins play a central role. The breast cancer susceptibility protein Brca2 and the RecQ helicase BLM (Bloom syndrome mutated) are tumor suppressors that maintain genome integrity, at least in part, through HR.
Class
Genetic Information Processing; Replication and repair
Pathway map
pleu03440  Homologous recombination
pleu03440

Other DBs
GO: 0000724
Organism
Peromyscus leucopus (white-footed mouse) [GN:pleu]
Gene
114682573  Top3a; DNA topoisomerase 3-alpha isoform X1 [KO:K03165] [EC:5.6.2.1]
114682715  Top3b; DNA topoisomerase 3-beta-1 [KO:K03165] [EC:5.6.2.1]
114682837  Brca1; LOW QUALITY PROTEIN: breast cancer type 1 susceptibility protein [KO:K10605] [EC:2.3.2.27]
114684355  Pold1; DNA polymerase delta catalytic subunit isoform X2 [KO:K02327] [EC:2.7.7.7]
114684452  Ssbp1; single-stranded DNA-binding protein, mitochondrial [KO:K03111]
114684999  Mre11; double-strand break repair protein MRE11 isoform X1 [KO:K10865]
114686004  Pold4; DNA polymerase delta subunit 4 [KO:K03505]
114689416  Uimc1; BRCA1-A complex subunit RAP80 isoform X1 [KO:K20775]
114690277  Atm; serine-protein kinase ATM [KO:K04728] [EC:2.7.11.1]
114691427  Rpa1; replication protein A 70 kDa DNA-binding subunit [KO:K07466]
114691558  Rad51d; DNA repair protein RAD51 homolog 4 [KO:K10871]
114691769  Abraxas1; BRCA1-A complex subunit Abraxas 1 [KO:K20774]
114692201  Palb2; partner and localizer of BRCA2 isoform X1 [KO:K10897]
114692894  Eme1; crossover junction endonuclease EME1 [KO:K10882] [EC:3.1.22.-]
114693467  Rpa3; replication protein A 14 kDa subunit [KO:K10740]
114693525  Topbp1; LOW QUALITY PROTEIN: DNA topoisomerase 2-binding protein 1 [KO:K10728]
114693607  Bard1; BRCA1-associated RING domain protein 1 [KO:K10683]
114693982  Pold2; DNA polymerase delta subunit 2 [KO:K02328]
114694580  Rad54b; DNA repair and recombination protein RAD54B isoform X1 [KO:K10877] [EC:5.6.2.-]
114694600  Nbn; nibrin isoform X1 [KO:K10867]
114695639  [KO:K11864] [EC:3.4.19.-]
114695734  [KO:K20774]
114696195  Blm; Bloom syndrome protein [KO:K10901] [EC:5.6.2.4]
114696301  Babam2; BRISC and BRCA1-A complex member 2 isoform X1 [KO:K12173]
114696789  [KO:K19528]
114696998  Rpa4; replication protein A 30 kDa subunit [KO:K10741]
114697673  [KO:K10728]
114697777  [KO:K10869]
114698163  Rbbp8; DNA endonuclease RBBP8 isoform X1 [KO:K20773] [EC:3.1.-.-]
114698711  Pold3; LOW QUALITY PROTEIN: DNA polymerase delta subunit 3 [KO:K03504]
114699159  Brca2; LOW QUALITY PROTEIN: breast cancer type 2 susceptibility protein [KO:K08775]
114699268  Rad51c; DNA repair protein RAD51 homolog 3 isoform X4 [KO:K10870]
114699285  Brip1; Fanconi anemia group J protein [KO:K15362] [EC:5.6.2.3]
114700060  Xrcc2; DNA repair protein XRCC2 [KO:K10879]
114700644  Sycp3; synaptonemal complex protein 3 [KO:K19528]
114700750  Rad52; DNA repair protein RAD52 homolog isoform X1 [KO:K10873]
114703062  Xrcc3; DNA repair protein XRCC3 [KO:K10880]
114704631  Rad51; DNA repair protein RAD51 homolog 1 [KO:K04482]
114705962  Rpa2; replication protein A 32 kDa subunit [KO:K10739]
114706183  Brcc3; lys-63-specific deubiquitinase BRCC36 isoform X1 [KO:K11864] [EC:3.4.19.-]
114706887  Rad54l; DNA repair and recombination protein RAD54-like [KO:K10875] [EC:5.6.2.-]
114709144  Mus81; crossover junction endonuclease MUS81 [KO:K08991] [EC:3.1.22.-]
114709584  Babam1; BRISC and BRCA1-A complex member 1 [KO:K20776]
114709924  [KO:K11864] [EC:3.4.19.-]
114710587  [KO:K10870]
Reference
PMID:18086882
  Authors
Maloisel L, Fabre F, Gangloff S.
  Title
DNA polymerase delta is preferentially recruited during homologous recombination to promote heteroduplex DNA extension.
  Journal
Mol Cell Biol 28:1373-82 (2008)
DOI:10.1128/MCB.01651-07
Reference
PMID:17571595
  Authors
Haruta-Takahashi N, Iwasaki H.
  Title
[Recombination mediators]
  Journal
Seikagaku 79:449-53 (2007)
Reference
PMID:18430459
  Authors
Ouyang KJ, Woo LL, Ellis NA.
  Title
Homologous recombination and maintenance of genome integrity: Cancer and aging through the prism of human RecQ helicases.
  Journal
Mech Ageing Dev 129:425-40 (2008)
DOI:10.1016/j.mad.2008.03.003
Reference
PMID:15902993
  Authors
Kawabata M, Kawabata T, Nishibori M.
  Title
Role of recA/RAD51 family proteins in mammals.
  Journal
Acta Med Okayama 59:1-9 (2005)
DOI:10.18926/AMO/31987
Reference
PMID:12589470
  Authors
Prado F, Cortes-Ledesma F, Huertas P, Aguilera A.
  Title
Mitotic recombination in Saccharomyces cerevisiae.
  Journal
Curr Genet 42:185-98 (2003)
DOI:10.1007/s00294-002-0346-3
Reference
PMID:16935872
  Authors
Heyer WD, Li X, Rolfsmeier M, Zhang XP.
  Title
Rad54: the Swiss Army knife of homologous recombination?
  Journal
Nucleic Acids Res 34:4115-25 (2006)
DOI:10.1093/nar/gkl481
Reference
PMID:17395553
  Authors
Michel B, Boubakri H, Baharoglu Z, LeMasson M, Lestini R.
  Title
Recombination proteins and rescue of arrested replication forks.
  Journal
DNA Repair (Amst) 6:967-80 (2007)
DOI:10.1016/j.dnarep.2007.02.016
KO pathway
ko03440   

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