KEGG   PATHWAY: pleu04390
Entry
pleu04390                   Pathway                                
Name
Hippo signaling pathway - Peromyscus leucopus (white-footed mouse)
Description
Hippo signaling is an evolutionarily conserved signaling pathway that controls organ size from flies to humans. In humans and mice, the pathway consists of the MST1 and MST2 kinases, their cofactor Salvador and LATS1 and LATS2. In response to high cell densities, activated LATS1/2 phosphorylates the transcriptional coactivators YAP and TAZ, promoting its cytoplasmic localization, leading to cell apoptosis and restricting organ size overgrowth. When the Hippo pathway is inactivated at low cell density, YAP/TAZ translocates into the nucleus to bind to the transcription enhancer factor (TEAD/TEF) family of transcriptional factors to promote cell growth and proliferation. YAP/TAZ also interacts with other transcriptional factors or signaling molecules, by which Hippo pathway-mediated processes are interconnected with those of other key signaling cascades, such as those mediated by TGF-beta and Wnt growth factors.
Class
Environmental Information Processing; Signal transduction
Pathway map
pleu04390  Hippo signaling pathway
pleu04390

Other DBs
GO: 0035329
Organism
Peromyscus leucopus (white-footed mouse) [GN:pleu]
Gene
114680598  Actg1; LOW QUALITY PROTEIN: actin, cytoplasmic 2 [KO:K05692]
114681065  Pard6a; partitioning defective 6 homolog alpha isoform X1 [KO:K06093]
114681161  [KO:K16622]
114681165  [KO:K16622]
114681270  Ctnnb1; catenin beta-1 isoform X1 [KO:K02105]
114681319  Wnt7a; protein Wnt-7a [KO:K00572]
114681446  Bbc3; bcl-2-binding component 3 isoform X1 [KO:K10132]
114681591  Tcf7l1; transcription factor 7-like 1 isoform X1 [KO:K04490]
114681722  Bmpr1b; bone morphogenetic protein receptor type-1B isoform X1 [KO:K13578] [EC:2.7.11.30]
114682558  Llgl1; LOW QUALITY PROTEIN: lethal(2) giant larvae protein homolog 1 [KO:K06094]
114682816  Lef1; lymphoid enhancer-binding factor 1 isoform X1 [KO:K04492]
114682971  Wnt3a; protein Wnt-3a [KO:K00312]
114683006  Wnt9a; protein Wnt-9a [KO:K01064]
114683042  Ppp2ca; serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform [KO:K04382] [EC:3.1.3.16]
114683055  Tcf7; transcription factor 7 isoform X2 [KO:K02620]
114683308  Dvl3; segment polarity protein dishevelled homolog DVL-3 isoform X1 [KO:K02353]
114683440  [KO:K05689]
114683476  Fbxw11; F-box/WD repeat-containing protein 11 isoform X1 [KO:K03362]
114683953  [KO:K06269] [EC:3.1.3.16]
114684070  Frmd6; FERM domain-containing protein 6 isoform X1 [KO:K16822]
114684081  Apc2; LOW QUALITY PROTEIN: adenomatous polyposis coli protein 2 [KO:K02085]
114684143  Sav1; protein salvador homolog 1 isoform X1 [KO:K16686]
114684256  [KO:K05692]
114684419  Tp53bp2; apoptosis-stimulating of p53 protein 2 [KO:K16823]
114684737  Scrib; LOW QUALITY PROTEIN: protein scribble homolog [KO:K16175]
114685302  Tgfb1; transforming growth factor beta-1 proprotein [KO:K13375]
114685621  Tp73; tumor protein p73 [KO:K10148]
114685750  Bmpr2; bone morphogenetic protein receptor type-2 [KO:K04671] [EC:2.7.11.30]
114685753  Fzd7; frizzled-7 [KO:K02432]
114685987  Ppp1ca; serine/threonine-protein phosphatase PP1-alpha catalytic subunit [KO:K06269] [EC:3.1.3.16]
114686016  Fzd9; frizzled-9 [KO:K02842]
114686321  Lats1; serine/threonine-protein kinase LATS1 isoform X1 [KO:K08791] [EC:2.7.11.1]
114686522  Amh; muellerian-inhibiting factor [KO:K04665]
114686858  Ppp2r1a; serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform [KO:K03456]
114687170  Tead2; transcriptional enhancer factor TEF-4 isoform X1 [KO:K09448]
114687963  Fzd1; frizzled-1 [KO:K02432]
114689852  Wwc1; protein KIBRA isoform X2 [KO:K16685]
114690183  Smad4; mothers against decapentaplegic homolog 4 isoform X1 [KO:K04501]
114690258  Ppp2r1b; serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A beta isoform isoform X2 [KO:K03456]
114690275  Bmp5; bone morphogenetic protein 5 [KO:K04663]
114690442  Axin2; axin-2 [KO:K04385]
114690920  [KO:K04674] [EC:2.7.11.30]
114691394  Frmd1; FERM domain-containing protein 1 [KO:K16821]
114691442  Ywhae; 14-3-3 protein epsilon isoform X1 [KO:K06630]
114691539  Smad3; mothers against decapentaplegic homolog 3 [KO:K23605]
114691745  [KO:K04674] [EC:2.7.11.30]
114692035  [KO:K20013]
114692606  Ywhab; 14-3-3 protein beta/alpha [KO:K16197]
114692673  Pard6b; partitioning defective 6 homolog beta [KO:K06093]
114693042  Ppp2r2d; serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B delta isoform isoform X1 [KO:K04354]
114693208  Dlg4; disks large homolog 4 isoform X2 [KO:K11828]
114693209  Dvl2; LOW QUALITY PROTEIN: segment polarity protein dishevelled homolog DVL-2 [KO:K02353]
114693690  Fzd10; frizzled-10 [KO:K02842]
114693748  Patj; LOW QUALITY PROTEIN: inaD-like protein [KO:K06092]
114693850  Lats2; serine/threonine-protein kinase LATS2 isoform X1 [KO:K08791] [EC:2.7.11.1]
114694003  Nf2; merlin isoform X1 [KO:K16684]
114694046  Ywhah; 14-3-3 protein eta [KO:K16198]
114694261  [KO:K08960] [EC:2.7.11.1]
114694411  Mob1a; MOB kinase activator 1A [KO:K06685]
114694443  Ctnna2; LOW QUALITY PROTEIN: catenin alpha-2 [KO:K05691]
114694498  Ccnd1; G1/S-specific cyclin-D1 isoform X2 [KO:K04503]
114694717  Wnt2; protein Wnt-2 [KO:K00182]
114694878  Smad7; mothers against decapentaplegic homolog 7 [KO:K19631]
114694883  Smad2; mothers against decapentaplegic homolog 2 [KO:K04500]
114694904  Pard6g; partitioning defective 6 homolog gamma [KO:K06093]
114695317  Prkci; protein kinase C iota type isoform X1 [KO:K06069] [EC:2.7.11.13]
114695353  Sox2; transcription factor SOX-2 [KO:K16796]
114695609  Wnt16; protein Wnt-16 [KO:K01558]
114695763  Fzd8; frizzled-8 [KO:K02375]
114695903  Dlg2; disks large homolog 2 isoform X3 [KO:K12075]
114696047  Bmp4; bone morphogenetic protein 4 [KO:K04662]
114696098  Nkd2; protein naked cuticle homolog 2 [KO:K03213]
114696284  Ppp1cb; serine/threonine-protein phosphatase PP1-beta catalytic subunit [KO:K06269] [EC:3.1.3.16]
114696529  Itgb2; integrin beta-2 [KO:K06464]
114697060  Tcf7l2; transcription factor 7-like 2 isoform X1 [KO:K04491]
114697207  Wnt4; protein Wnt-4 [KO:K00408]
114697594  Tead1; transcriptional enhancer factor TEF-1 isoform X1 [KO:K09448]
114697632  [KO:K21098]
114697765  Mpp5; MAGUK p55 subfamily member 5 isoform X2 [KO:K06091]
114697904  Tgfb3; transforming growth factor beta-3 proprotein [KO:K13377]
114698210  Tgfb2; transforming growth factor beta-2 proprotein isoform X1 [KO:K13376]
114698309  Amot; angiomotin isoform X1 [KO:K16819]
114698498  Ppp2cb; serine/threonine-protein phosphatase 2A catalytic subunit beta isoform [KO:K04382] [EC:3.1.3.16]
114698626  Ccn2; LOW QUALITY PROTEIN: CCN family member 2 [KO:K06827]
114698691  Wnt11; protein Wnt-11 isoform X1 [KO:K01384]
114698856  Ywhaq; 14-3-3 protein theta [KO:K16197]
114698923  [KO:K16682]
114699199  Wnt7b; protein Wnt-7b isoform X1 [KO:K00572]
114699332  Bmpr1a; bone morphogenetic protein receptor type-1A isoform X1 [KO:K04673] [EC:2.7.11.30]
114699428  [KO:K20012]
114699539  Bmp2; bone morphogenetic protein 2 isoform X1 [KO:K21283]
114699911  Fzd6; frizzled-6 [KO:K02376]
114700224  Dlg5; disks large homolog 5 isoform X2 [KO:K24050]
114700236  Gli2; zinc finger protein GLI2 [KO:K16798]
114700344  [KO:K06464]
114700757  Wnt5b; protein Wnt-5b [KO:K00444]
114701114  Ctnna3; catenin alpha-3 isoform X2 [KO:K05691]
114701432  Tead4; transcriptional enhancer factor TEF-3 isoform X1 [KO:K09448]
114701440  Ccnd2; G1/S-specific cyclin-D2 [KO:K10151]
114701479  Gsk3b; glycogen synthase kinase-3 beta isoform X1 [KO:K03083] [EC:2.7.11.26]
114701602  Ppp2r2b; serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B beta isoform isoform X3 [KO:K04354]
114701714  [KO:K16144]
114701727  Areg; amphiregulin [KO:K09782]
114701734  Rassf6; ras association domain-containing protein 6 [KO:K09854]
114701947  Wwtr1; WW domain-containing transcription regulator protein 1 isoform X1 [KO:K16820]
114701991  Myc; myc proto-oncogene protein [KO:K04377]
114702071  Ppp2r2c; protein phosphatase 2, regulatory subunit B, gamma isoform X1 [KO:K04354]
114702120  Wnt5a; protein Wnt-5a isoform X1 [KO:K00444]
114702202  Wnt9b; protein Wnt-9b [KO:K01064]
114702239  Fzd2; frizzled-2 [KO:K02235]
114702271  Wnt3; proto-oncogene Wnt-3 [KO:K00312]
114702344  Tgfbr1; TGF-beta receptor type-1 isoform X1 [KO:K04674] [EC:2.7.11.30]
114703181  Dlg3; disks large homolog 3 isoform X1 [KO:K21098]
114703630  Stk3; serine/threonine-protein kinase 3 isoform X1 [KO:K04412]
114703643  Ywhaz; 14-3-3 protein zeta/delta [KO:K16197]
114703913  Csnk1d; casein kinase I isoform X3 [KO:K08959] [EC:2.7.11.1]
114704570  Ppp1cc; serine/threonine-protein phosphatase PP1-gamma catalytic subunit isoform X1 [KO:K06269] [EC:3.1.3.16]
114704977  Tgfbr2; TGF-beta receptor type-2 isoform X1 [KO:K04388] [EC:2.7.11.30]
114705069  Fzd5; frizzled-5 [KO:K02375]
114705104  Ctnna1; catenin alpha-1 isoform X1 [KO:K05691]
114705120  Apc; adenomatous polyposis coli protein isoform X1 [KO:K02085]
114705144  Wnt8a; protein Wnt-8a [KO:K00714]
114705331  Ccnd3; G1/S-specific cyclin-D3 isoform X1 [KO:K10152]
114705499  Actb; actin, cytoplasmic 1 [KO:K05692]
114705578  Id1; DNA-binding protein inhibitor ID-1 isoform X1 [KO:K04680]
114705775  Pard3; partitioning defective 3 homolog isoform X1 [KO:K04237]
114705804  Crb2; protein crumbs homolog 2 [KO:K16681]
114706150  Tead3; transcriptional enhancer factor TEF-5 [KO:K09448]
114706531  Gdf5; growth/differentiation factor 5 [KO:K04664]
114706749  Mob1b; MOB kinase activator 1B [KO:K06685]
114707070  Llgl2; LLGL scribble cell polarity complex component 2 isoform X7 [KO:K06094]
114707196  Crb1; protein crumbs homolog 1 [KO:K16681]
114707263  Wnt2b; protein Wnt-2b [KO:K00182]
114707293  Fzd3; frizzled-3 isoform X1 [KO:K02329]
114707321  Ppp2r2a; serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B alpha isoform isoform X1 [KO:K04354]
114707598  [KO:K20012]
114707644  Limd1; LIM domain-containing protein 1 [KO:K16682]
114707997  Yap1; transcriptional coactivator YAP1 isoform X1 [KO:K16687]
114708003  [KO:K16060]
114708004  [KO:K16060]
114708125  Btrc; F-box/WD repeat-containing protein 1A isoform X1 [KO:K03362]
114708149  Wnt8b; protein Wnt-8b [KO:K00714]
114708251  Dvl1; segment polarity protein dishevelled homolog DVL-1 isoform X1 [KO:K02353]
114708277  Prkcz; LOW QUALITY PROTEIN: protein kinase C zeta type [KO:K18952] [EC:2.7.11.13]
114708354  Fgf1; fibroblast growth factor 1 isoform X1 [KO:K18496]
114708499  Nkd1; protein naked cuticle homolog 1 [KO:K03213]
114708546  Wnt10b; protein Wnt-10b [KO:K01357]
114708572  Wnt1; proto-oncogene Wnt-1 [KO:K03209]
114708721  Ajuba; LIM domain-containing protein ajuba [KO:K16682]
114708968  Birc5; baculoviral IAP repeat-containing protein 5 isoform X1 [KO:K08731]
114709215  Smad1; mothers against decapentaplegic homolog 1 [KO:K04676]
114709307  Wnt10a; LOW QUALITY PROTEIN: protein Wnt-10a [KO:K01357]
114709311  Wnt6; protein Wnt-6 [KO:K00445]
114709464  Snai2; zinc finger protein SNAI2 [KO:K05706]
114709466  Axin1; axin-1 isoform X1 [KO:K02157]
114709772  Id2; DNA-binding protein inhibitor ID-2 [KO:K17693]
114709820  Bmp7; bone morphogenetic protein 7 [KO:K16621]
114710020  Dlg1; disks large homolog 1 isoform X1 [KO:K12076]
114710296  Ywhag; 14-3-3 protein gamma [KO:K16198]
114710323  Serpine1; plasminogen activator inhibitor 1 [KO:K03982]
114710567  Bmp6; bone morphogenetic protein 6 [KO:K16620]
114710708  Fzd4; frizzled-4 [KO:K02354]
114710959  Rassf1; ras association domain-containing protein 1 isoform X1 [KO:K09850]
Reference
PMID:22750148
  Authors
Schroeder MC, Halder G
  Title
Regulation of the Hippo pathway by cell architecture and mechanical signals.
  Journal
Semin Cell Dev Biol 23:803-11 (2012)
DOI:10.1016/j.semcdb.2012.06.001
Reference
PMID:21808241
  Authors
Zhao B, Tumaneng K, Guan KL
  Title
The Hippo pathway in organ size control, tissue regeneration and stem cell self-renewal.
  Journal
Nat Cell Biol 13:877-83 (2011)
DOI:10.1038/ncb2303
Reference
PMID:21874053
  Authors
Mauviel A, Nallet-Staub F, Varelas X
  Title
Integrating developmental signals: a Hippo in the (path)way.
  Journal
Oncogene 31:1743-56 (2012)
DOI:10.1038/onc.2011.363
Reference
PMID:21084559
  Authors
Zhao B, Li L, Guan KL
  Title
Hippo signaling at a glance.
  Journal
J Cell Sci 123:4001-6 (2010)
DOI:10.1242/jcs.069070
Reference
PMID:20439427
  Authors
Zhao B, Li L, Lei Q, Guan KL
  Title
The Hippo-YAP pathway in organ size control and tumorigenesis: an updated version.
  Journal
Genes Dev 24:862-74 (2010)
DOI:10.1101/gad.1909210
Reference
PMID:23034192
  Authors
Tremblay AM, Camargo FD
  Title
Hippo signaling in mammalian stem cells.
  Journal
Semin Cell Dev Biol 23:818-26 (2012)
DOI:10.1016/j.semcdb.2012.08.001
Reference
PMID:21138973
  Authors
Halder G, Johnson RL
  Title
Hippo signaling: growth control and beyond.
  Journal
Development 138:9-22 (2011)
DOI:10.1242/dev.045500
Reference
PMID:22658639
  Authors
Ramos A, Camargo FD
  Title
The Hippo signaling pathway and stem cell biology.
  Journal
Trends Cell Biol 22:339-46 (2012)
DOI:10.1016/j.tcb.2012.04.006
Reference
PMID:20951342
  Authors
Pan D
  Title
The hippo signaling pathway in development and cancer.
  Journal
Dev Cell 19:491-505 (2010)
DOI:10.1016/j.devcel.2010.09.011
Reference
PMID:21324984
  Authors
Bao Y, Hata Y, Ikeda M, Withanage K
  Title
Mammalian Hippo pathway: from development to cancer and beyond.
  Journal
J Biochem 149:361-79 (2011)
DOI:10.1093/jb/mvr021
Reference
PMID:18955139
  Authors
Zhao B, Lei QY, Guan KL
  Title
The Hippo-YAP pathway: new connections between regulation of organ size and cancer.
  Journal
Curr Opin Cell Biol 20:638-46 (2008)
DOI:10.1016/j.ceb.2008.10.001
Reference
PMID:20945341
  Authors
Chan SW, Lim CJ, Chen L, Chong YF, Huang C, Song H, Hong W
  Title
The Hippo pathway in biological control and cancer development.
  Journal
J Cell Physiol 226:928-39 (2011)
DOI:10.1002/jcp.22435
Reference
PMID:18328423
  Authors
Zeng Q, Hong W
  Title
The emerging role of the hippo pathway in cell contact inhibition, organ size control, and cancer development in mammals.
  Journal
Cancer Cell 13:188-92 (2008)
DOI:10.1016/j.ccr.2008.02.011
Reference
PMID:19846288
  Authors
Badouel C, Garg A, McNeill H
  Title
Herding Hippos: regulating growth in flies and man.
  Journal
Curr Opin Cell Biol 21:837-43 (2009)
DOI:10.1016/j.ceb.2009.09.010
Reference
PMID:17975546
  Authors
Buttitta LA, Edgar BA
  Title
How size is controlled: from Hippos to Yorkies.
  Journal
Nat Cell Biol 9:1225-7 (2007)
DOI:10.1038/ncb1107-1225
Reference
PMID:22683405
  Authors
Liu AM, Wong KF, Jiang X, Qiao Y, Luk JM
  Title
Regulators of mammalian Hippo pathway in cancer.
  Journal
Biochim Biophys Acta 1826:357-64 (2012)
DOI:10.1016/j.bbcan.2012.05.006
Reference
PMID:22830020
  Authors
Fausti F, Di Agostino S, Sacconi A, Strano S, Blandino G
  Title
Hippo and rassf1a Pathways: A Growing Affair.
  Journal
Mol Biol Int 2012:307628 (2012)
DOI:10.1155/2012/307628
Reference
PMID:22895435
  Authors
Halder G, Dupont S, Piccolo S
  Title
Transduction of mechanical and cytoskeletal cues by YAP and TAZ.
  Journal
Nat Rev Mol Cell Biol 13:591-600 (2012)
DOI:10.1038/nrm3416
Reference
PMID:22153608
  Authors
Varelas X, Wrana JL
  Title
Coordinating developmental signaling: novel roles for the Hippo pathway.
  Journal
Trends Cell Biol 22:88-96 (2012)
DOI:10.1016/j.tcb.2011.10.002
Reference
PMID:21376238
  Authors
Schlegelmilch K, Mohseni M, Kirak O, Pruszak J, Rodriguez JR, Zhou D, Kreger BT, Vasioukhin V, Avruch J, Brummelkamp TR, Camargo FD
  Title
Yap1 acts downstream of alpha-catenin to control epidermal proliferation.
  Journal
Cell 144:782-95 (2011)
DOI:10.1016/j.cell.2011.02.031
Related
pathway
pleu04120  Ubiquitin mediated proteolysis
pleu04310  Wnt signaling pathway
pleu04350  TGF-beta signaling pathway
pleu04520  Adherens junction
pleu04530  Tight junction
KO pathway
ko04390   

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