Entry Name Wnt signaling pathway - Peromyscus leucopus (white-footed mouse)
Description Wnt proteins are secreted morphogens that are required for basic developmental processes, such as cell-fate specification, progenitor-cell proliferation and the control of asymmetric cell division, in many different species and organs. There are at least three different Wnt pathways: the canonical pathway, the planar cell polarity (PCP) pathway and the Wnt/Ca2+ pathway. In the canonical Wnt pathway, the major effect of Wnt ligand binding to its receptor is the stabilization of cytoplasmic beta-catenin through inhibition of the bea-catenin degradation complex. Beta-catenin is then free to enter the nucleus and activate Wnt-regulated genes through its interaction with TCF (T-cell factor) family transcription factors and concomitant recruitment of coactivators. Planar cell polarity (PCP) signaling leads to the activation of the small GTPases RHOA (RAS homologue gene-family member A) and RAC1, which activate the stress kinase JNK (Jun N-terminal kinase) and ROCK (RHO-associated coiled-coil-containing protein kinase 1) and leads to remodelling of the cytoskeleton and changes in cell adhesion and motility. WNT-Ca2+ signalling is mediated through G proteins and phospholipases and leads to transient increases in cytoplasmic free calcium that subsequently activate the kinase PKC (protein kinase C) and CAMKII (calcium calmodulin mediated kinase II) and the phosphatase calcineurin.
Class Environmental Information Processing; Signal transductionBRITE hierarchy
Pathway map Other DBs Organism Peromyscus leucopus (white-footed mouse) [GN:
pleu ]
Gene 114680645 Rac3; ras-related C3 botulinum toxin substrate 3 isoform X1 [KO:K07861 ]
114680674 Plcb3; LOW QUALITY PROTEIN: 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3 [KO:K05858 ] [EC:3.1.4.11 ]
114681035 Nfatc3; nuclear factor of activated T-cells, cytoplasmic 3 isoform X1 [KO:K17333 ]
114682064 Sfrp4; LOW QUALITY PROTEIN: secreted frizzled-related protein 4 [KO:K02185 ]
114682227 Camk2d; calcium/calmodulin-dependent protein kinase type II subunit delta isoform X1 [KO:K04515 ] [EC:2.7.11.17 ]
114682246 Chd8; chromodomain-helicase-DNA-binding protein 8 isoform X1 [KO:K04494 ] [EC:5.6.2.-]
114682539 Tbl1xr1; F-box-like/WD repeat-containing protein TBL1XR1 [KO:K04508 ]
114683255 Ppp3ca; serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform isoform X1 [KO:K04348 ] [EC:3.1.3.16 ]
114683308 Dvl3; segment polarity protein dishevelled homolog DVL-3 isoform X1 [KO:K02353 ]
114683476 Fbxw11; F-box/WD repeat-containing protein 11 isoform X1 [KO:K03362 ]
114683949 Daam1; disheveled-associated activator of morphogenesis 1 isoform X1 [KO:K04512 ]
114684081 Apc2; LOW QUALITY PROTEIN: adenomatous polyposis coli protein 2 [KO:K02085 ]
114684433 Nfatc2; nuclear factor of activated T-cells, cytoplasmic 2 isoform X1 [KO:K17332 ]
114688161 Tle2; LOW QUALITY PROTEIN: transducin-like enhancer protein 2 [KO:K04497 ]
114690183 Smad4; mothers against decapentaplegic homolog 4 isoform X1 [KO:K04501 ]
114693209 Dvl2; LOW QUALITY PROTEIN: segment polarity protein dishevelled homolog DVL-2 [KO:K02353 ]
114693781 Ror1; LOW QUALITY PROTEIN: inactive tyrosine-protein kinase transmembrane receptor ROR1 [KO:K05122 ] [EC:2.7.10.1 ]
114693978 Camk2b; calcium/calmodulin-dependent protein kinase type II subunit beta isoform X7 [KO:K04515 ] [EC:2.7.11.17 ]
114694590 Lrp5; low-density lipoprotein receptor-related protein 5 isoform X1 [KO:K03068 ]
114694913 Nfatc1; nuclear factor of activated T-cells, cytoplasmic 1 isoform X1 [KO:K04446 ]
114698117 Lgr6; LOW QUALITY PROTEIN: leucine-rich repeat-containing G-protein coupled receptor 6 [KO:K08399 ]
114698759 Ccar2; cell cycle and apoptosis regulator protein 2 isoform X3 [KO:K25816 ]
114698768 Ppp3cc; serine/threonine-protein phosphatase 2B catalytic subunit gamma isoform [KO:K04348 ] [EC:3.1.3.16 ]
114699039 Lgr5; leucine-rich repeat-containing G-protein coupled receptor 5 isoform X1 [KO:K04308 ]
114700198 Ppp3cb; serine/threonine-protein phosphatase 2B catalytic subunit beta isoform isoform X1 [KO:K04348 ] [EC:3.1.3.16 ]
114700207 Camk2g; calcium/calmodulin-dependent protein kinase type II subunit gamma isoform X1 [KO:K04515 ] [EC:2.7.11.17 ]
114702109 Lgr4; leucine-rich repeat-containing G-protein coupled receptor 4 isoform X1 [KO:K04309 ]
114702169 Daam2; disheveled-associated activator of morphogenesis 2 isoform X1 [KO:K04512 ]
114703666 Plcb4; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-4 isoform X2 [KO:K05858 ] [EC:3.1.4.11 ]
114703672 Plcb1; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1 isoform X1 [KO:K05858 ] [EC:3.1.4.11 ]
114706127 Ppard; peroxisome proliferator-activated receptor delta [KO:K04504 ]
114706446 Sfrp5; LOW QUALITY PROTEIN: secreted frizzled-related protein 5 [KO:K02222 ]
114707396 Camk2a; LOW QUALITY PROTEIN: calcium/calmodulin-dependent protein kinase type II subunit alpha [KO:K04515 ] [EC:2.7.11.17 ]
114707535 Rac1; ras-related C3 botulinum toxin substrate 1 isoform X1 [KO:K04392 ]
114708098 Tle7; LOW QUALITY PROTEIN: transducin-like enhancer protein 7 [KO:K04497 ]
114708110 Lzts2; leucine zipper putative tumor suppressor 2 isoform X1 [KO:K26471 ]
114708125 Btrc; F-box/WD repeat-containing protein 1A isoform X1 [KO:K03362 ]
114708251 Dvl1; segment polarity protein dishevelled homolog DVL-1 isoform X1 [KO:K02353 ]
114708726 Nfatc4; nuclear factor of activated T-cells, cytoplasmic 4 [KO:K17334 ]
114710353 Lrp6; low-density lipoprotein receptor-related protein 6 isoform X1 [KO:K03068 ]
Compound Reference Authors Hatsell S, Rowlands T, Hiremath M, Cowin P.
Title Beta-catenin and Tcfs in mammary development and cancer.
Journal Reference Authors Yang Y.
Title Wnts and wing: Wnt signaling in vertebrate limb development and musculoskeletal morphogenesis.
Journal Reference Authors Kalderon D.
Title Similarities between the Hedgehog and Wnt signaling pathways.
Journal Reference Authors Nusse R.
Title Wnts and Hedgehogs: lipid-modified proteins and similarities in signaling mechanisms at the cell surface.
Journal Reference Authors Jope RS, Johnson GV.
Title The glamour and gloom of glycogen synthase kinase-3.
Journal Reference Authors Veeman MT, Axelrod JD, Moon RT.
Title A second canon. Functions and mechanisms of beta-catenin-independent Wnt signaling.
Journal Reference Authors Sun TQ, Lu B, Feng JJ, Reinhard C, Jan YN, Fantl WJ, Williams LT.
Title PAR-1 is a Dishevelled-associated kinase and a positive regulator of Wnt signalling.
Journal Reference Authors Saito-Diaz K, Chen TW, Wang X, Thorne CA, Wallace HA, Page-McCaw A, Lee E
Title The way Wnt works: Components and mechanism.
Journal Reference Authors Carethers JM
Title Intersection of transforming growth factor-beta and Wnt signaling pathways in colorectal cancer and metastasis.
Journal Reference Authors Lin Z, Gao C, Ning Y, He X, Wu W, Chen YG
Title The pseudoreceptor BMP and activin membrane-bound inhibitor positively modulates Wnt/beta-catenin signaling.
Journal Reference Authors Niehrs C
Title The complex world of WNT receptor signalling.
Journal Reference Authors Abou Ziki MD, Mani A
Title Wnt signaling, a novel pathway regulating blood pressure? State of the art review.
Journal Reference Authors He Y, Ki H, Kim H, Kim K
Title delta-Catenin interacts with LEF-1 and negatively regulates its transcriptional activity.
Journal Reference Authors Esaki N, Enomoto A, Takagishi M, Mizutani Y, Iida T, Ushida K, Shiraki Y, Mii S, Takahashi M
Title The Daple-CK1epsilon complex regulates Dvl2 phosphorylation and canonical Wnt signaling.
Journal Reference Authors Yiew NKH, Chatterjee TK, Tang YL, Pellenberg R, Stansfield BK, Bagi Z, Fulton DJ, Stepp DW, Chen W, Patel V, Kamath VM, Litwin SE, Hui DY, Rudich SM, Kim HW, Weintraub NL
Title A novel role for the Wnt inhibitor APCDD1 in adipocyte differentiation: Implications for diet-induced obesity.
Journal Related KO pathway
