KEGG   PATHWAY: pmoe00260
Entry
pmoe00260                   Pathway                                
Name
Glycine, serine and threonine metabolism - Pseudomonas monsensis
Description
Serine is derived from 3-phospho-D-glycerate, an intermediate of glycolysis [MD:M00020], and glycine is derived from serine. Threonine is an essential amino acid, which animals cannot synthesize. In bacteria and plants, threonine is derived from aspartate [MD:M00018].
Class
Metabolism; Amino acid metabolism
Pathway map
pmoe00260  Glycine, serine and threonine metabolism
pmoe00260

Module
pmoe_M00018  Threonine biosynthesis, aspartate => homoserine => threonine [PATH:pmoe00260]
pmoe_M00020  Serine biosynthesis, glycerate-3P => serine [PATH:pmoe00260]
pmoe_M00338  Cysteine biosynthesis, homocysteine + serine => cysteine [PATH:pmoe00260]
pmoe_M00555  Betaine biosynthesis, choline => betaine [PATH:pmoe00260]
pmoe_M00621  Glycine cleavage system [PATH:pmoe00260]
pmoe_M00975  Betaine degradation, bacteria, betaine => pyruvate [PATH:pmoe00260]
Other DBs
GO: 0006544 0006563 0070178 0006566
Organism
Pseudomonas monsensis [GN:pmoe]
Gene
HV782_021855  aspartate kinase [KO:K00928] [EC:2.7.2.4]
HV782_010720  asd; aspartate-semialdehyde dehydrogenase [KO:K00133] [EC:1.2.1.11]
HV782_006210  homoserine dehydrogenase [KO:K00003] [EC:1.1.1.3]
HV782_001320  homoserine kinase [KO:K02204] [EC:2.7.1.39]
HV782_009965  thrH; bifunctional phosphoserine phosphatase/homoserine phosphotransferase ThrH [KO:K02203] [EC:3.1.3.3 2.7.1.39]
HV782_006215  thrC; threonine synthase [KO:K01733] [EC:4.2.3.1]
HV782_021865  ltaE; low-specificity L-threonine aldolase [KO:K01620] [EC:4.1.2.48]
HV782_026895  low specificity L-threonine aldolase [KO:K01620] [EC:4.1.2.48]
HV782_008455  serine hydroxymethyltransferase [KO:K00600] [EC:2.1.2.1]
HV782_025160  serine hydroxymethyltransferase [KO:K00600] [EC:2.1.2.1]
HV782_026885  serine hydroxymethyltransferase [KO:K00600] [EC:2.1.2.1]
HV782_024270  2-hydroxyacid dehydrogenase [KO:K00018] [EC:1.1.1.29]
HV782_005725  D-glycerate dehydrogenase [KO:K00090] [EC:1.1.1.79 1.1.1.81 1.1.1.215]
HV782_014280  glycerate kinase [KO:K00865] [EC:2.7.1.165]
HV782_008985  glycerate kinase [KO:K11529] [EC:2.7.1.165]
HV782_002715  gpmI; 2,3-bisphosphoglycerate-independent phosphoglycerate mutase [KO:K15633] [EC:5.4.2.12]
HV782_027755  serA; phosphoglycerate dehydrogenase [KO:K00058] [EC:1.1.1.95 1.1.1.399]
HV782_020820  serC; 3-phosphoserine/phosphohydroxythreonine transaminase [KO:K00831] [EC:2.6.1.52]
HV782_003495  serB; phosphoserine phosphatase SerB [KO:K01079] [EC:3.1.3.3]
HV782_027260  flavin monoamine oxidase family protein [KO:K00274] [EC:1.4.3.4]
HV782_022435  gcvP; aminomethyl-transferring glycine dehydrogenase [KO:K00281] [EC:1.4.4.2]
HV782_027940  gcvP; aminomethyl-transferring glycine dehydrogenase [KO:K00281] [EC:1.4.4.2]
HV782_022445  gcvT; glycine cleavage system aminomethyltransferase GcvT [KO:K00605] [EC:2.1.2.10]
HV782_027955  gcvT; glycine cleavage system aminomethyltransferase GcvT [KO:K00605] [EC:2.1.2.10]
HV782_000850  lpdA; dihydrolipoyl dehydrogenase [KO:K00382] [EC:1.8.1.4]
HV782_009105  lpdA; dihydrolipoyl dehydrogenase [KO:K00382] [EC:1.8.1.4]
HV782_017965  lpdA; dihydrolipoyl dehydrogenase [KO:K00382] [EC:1.8.1.4]
HV782_022430  gcvH; glycine cleavage system protein GcvH [KO:K02437]
HV782_027950  gcvH; glycine cleavage system protein GcvH [KO:K02437]
HV782_015625  pssA; CDP-diacylglycerol--serine O-phosphatidyltransferase [KO:K00998] [EC:2.7.8.8]
HV782_024670  pssA; CDP-diacylglycerol--serine O-phosphatidyltransferase [KO:K17103] [EC:2.7.8.8]
HV782_027060  betA; choline dehydrogenase [KO:K00108] [EC:1.1.99.1]
HV782_022860  aldehyde dehydrogenase family protein [KO:K00130] [EC:1.2.1.8]
HV782_027055  betB; betaine-aldehyde dehydrogenase [KO:K00130] [EC:1.2.1.8]
HV782_016610  aldehyde dehydrogenase family protein [KO:K00130] [EC:1.2.1.8]
HV782_026915  gbcA; glycine-betaine demethylase subunit GbcA [KO:K00479] [EC:1.14.13.251]
HV782_026910  gbcB; glycine-betaine demethylase subunit GbcB [KO:K21832] [EC:1.14.13.251]
HV782_026950  dgcA; dimethylglycine demethylation protein DgcA [KO:K21833] [EC:1.5.7.3]
HV782_026945  dgcB; dimethylglycine demethylation protein DgcB [KO:K21834]
HV782_026940  electron transfer flavoprotein subunit alpha/FixB family protein [KO:K25960]
HV782_026935  electron transfer flavoprotein subunit beta [KO:K25961]
HV782_026870  sarcosine oxidase subunit alpha [KO:K00302] [EC:1.5.3.24 1.5.3.1]
HV782_026880  sarcosine oxidase subunit beta [KO:K00303] [EC:1.5.3.24 1.5.3.1]
HV782_026865  sarcosine oxidase subunit gamma family protein [KO:K00305] [EC:1.5.3.24 1.5.3.1]
HV782_026875  sarcosine oxidase subunit delta [KO:K00304] [EC:1.5.3.24 1.5.3.1]
HV782_012800  pyridoxal-phosphate dependent enzyme [KO:K01697] [EC:4.2.1.22]
HV782_012795  cystathionine gamma-synthase [KO:K01758] [EC:4.4.1.1]
HV782_005665  L-serine ammonia-lyase [KO:K01752] [EC:4.3.1.17]
HV782_022440  L-serine ammonia-lyase [KO:K01752] [EC:4.3.1.17]
HV782_027025  L-serine ammonia-lyase [KO:K01752] [EC:4.3.1.17]
HV782_014395  ilvA; threonine ammonia-lyase, biosynthetic [KO:K01754] [EC:4.3.1.19]
HV782_027725  ilvA; threonine ammonia-lyase, biosynthetic [KO:K01754] [EC:4.3.1.19]
HV782_013485  amino acid deaminase [KO:K01753] [EC:4.3.1.18]
HV782_016190  aspartate/glutamate racemase family protein [KO:K25316] [EC:5.1.1.10]
HV782_001560  trpA; tryptophan synthase subunit alpha [KO:K01695] [EC:4.2.1.20]
HV782_001555  trpB; tryptophan synthase subunit beta [KO:K01696] [EC:4.2.1.20]
HV782_020095  aspartate aminotransferase family protein [KO:K00836] [EC:2.6.1.76]
Compound
C00011  CO2
C00014  Ammonia
C00022  Pyruvate
C00037  Glycine
C00048  Glyoxylate
C00049  L-Aspartate
C00065  L-Serine
C00078  L-Tryptophan
C00097  L-Cysteine
C00101  Tetrahydrofolate
C00109  2-Oxobutanoate
C00114  Choline
C00143  5,10-Methylenetetrahydrofolate
C00168  Hydroxypyruvate
C00188  L-Threonine
C00197  3-Phospho-D-glycerate
C00213  Sarcosine
C00258  D-Glycerate
C00263  L-Homoserine
C00300  Creatine
C00430  5-Aminolevulinate
C00441  L-Aspartate 4-semialdehyde
C00546  Methylglyoxal
C00576  Betaine aldehyde
C00581  Guanidinoacetate
C00631  2-Phospho-D-glycerate
C00719  Betaine
C00740  D-Serine
C00986  1,3-Diaminopropane
C01005  O-Phospho-L-serine
C01026  N,N-Dimethylglycine
C01102  O-Phospho-L-homoserine
C01242  [Protein]-S8-aminomethyldihydrolipoyllysine
C01888  Aminoacetone
C02051  Lipoylprotein
C02291  L-Cystathionine
C02737  Phosphatidylserine
C02972  Dihydrolipoylprotein
C03082  4-Phospho-L-aspartate
C03194  (R)-1-Aminopropan-2-ol
C03232  3-Phosphonooxypyruvate
C03283  L-2,4-Diaminobutanoate
C03508  L-2-Amino-3-oxobutanoic acid
C05519  L-Allothreonine
C06231  Ectoine
C06442  N(gamma)-Acetyldiaminobutyrate
C16432  5-Hydroxyectoine
C19929  N(alpha)-Acetyl-L-2,4-diaminobutyrate
Reference
  Authors
Nishizuka Y, Seyama Y, Ikai A, Ishimura Y, Kawaguchi A (eds).
  Title
[Cellular Functions and Metabolic Maps] (In Japanese)
  Journal
Tokyo Kagaku Dojin (1997)
Reference
PMID:11823218
  Authors
Kuhlmann AU, Bremer E.
  Title
Osmotically regulated synthesis of the compatible solute ectoine in Bacillus pasteurii and related Bacillus spp.
  Journal
Appl Environ Microbiol 68:772-83 (2002)
DOI:10.1128/AEM.68.2.772-783.2002
Reference
PMID:10473374
  Authors
Canovas D, Borges N, Vargas C, Ventosa A, Nieto JJ, Santos H.
  Title
Role of Ngamma-acetyldiaminobutyrate as an enzyme stabilizer and an intermediate in the biosynthesis of hydroxyectoine.
  Journal
Appl Environ Microbiol 65:3774-9 (1999)
DOI:10.1128/AEM.65.9.3774-3779.1999
Reference
PMID:17636255
  Authors
Bursy J, Pierik AJ, Pica N, Bremer E.
  Title
Osmotically induced synthesis of the compatible solute hydroxyectoine is mediated by an evolutionarily conserved ectoine hydroxylase.
  Journal
J Biol Chem 282:31147-55 (2007)
DOI:10.1074/jbc.M704023200
Reference
PMID:16707670
  Authors
Garcia-Estepa R, Argandona M, Reina-Bueno M, Capote N, Iglesias-Guerra F, Nieto JJ, Vargas C.
  Title
The ectD gene, which is involved in the synthesis of the compatible solute hydroxyectoine, is essential for thermoprotection of the halophilic bacterium Chromohalobacter salexigens.
  Journal
J Bacteriol 188:3774-84 (2006)
DOI:10.1128/JB.00136-06
Reference
PMID:15470257
  Authors
Arevalo-Rodriguez M, Pan X, Boeke JD, Heitman J
  Title
FKBP12 controls aspartate pathway flux in Saccharomyces cerevisiae to prevent toxic intermediate accumulation.
  Journal
Eukaryot Cell 3:1287-96 (2004)
DOI:10.1128/EC.3.5.1287-1296.2004
Reference
PMID:7639721
  Authors
Rees WD, Hay SM
  Title
The biosynthesis of threonine by mammalian cells: expression of a complete bacterial biosynthetic pathway in an animal cell.
  Journal
Biochem J 309 ( Pt 3):999-1007 (1995)
DOI:10.1042/bj3090999
Reference
PMID:11341914
  Authors
Jacques SL, Nieman C, Bareich D, Broadhead G, Kinach R, Honek JF, Wright GD
  Title
Characterization of yeast homoserine dehydrogenase, an antifungal target: the invariant histidine 309 is important for enzyme integrity.
  Journal
Biochim Biophys Acta 1544:28-41 (2001)
DOI:10.1016/S0167-4838(00)00203-X
Reference
PMID:15520012
  Authors
Chen X, Jhee KH, Kruger WD
  Title
Production of the neuromodulator H2S by cystathionine beta-synthase via the condensation of cysteine and homocysteine.
  Journal
J Biol Chem 279:52082-6 (2004)
DOI:10.1074/jbc.C400481200
Related
pathway
pmoe00010  Glycolysis / Gluconeogenesis
pmoe00020  Citrate cycle (TCA cycle)
pmoe00230  Purine metabolism
pmoe00250  Alanine, aspartate and glutamate metabolism
pmoe00270  Cysteine and methionine metabolism
pmoe00290  Valine, leucine and isoleucine biosynthesis
pmoe00300  Lysine biosynthesis
pmoe00330  Arginine and proline metabolism
pmoe00460  Cyanoamino acid metabolism
pmoe00470  D-Amino acid metabolism
pmoe00564  Glycerophospholipid metabolism
pmoe00620  Pyruvate metabolism
pmoe00630  Glyoxylate and dicarboxylate metabolism
pmoe00640  Propanoate metabolism
pmoe00680  Methane metabolism
pmoe00860  Porphyrin metabolism
pmoe00920  Sulfur metabolism
KO pathway
ko00260   
LinkDB

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