KEGG PATHWAY: ppeg00260

PATHWAY: ppeg00260

Entry

ppeg00260                   Pathway

Name

Glycine, serine and threonine metabolism - Pseudomonas pergaminensis

Description

Serine is derived from 3-phospho-D-glycerate, an intermediate of glycolysis [MD:M00020], and glycine is derived from serine. Threonine is an essential amino acid, which animals cannot synthesize. In bacteria and plants, threonine is derived from aspartate [MD:M00018].

Class

Metabolism; Amino acid metabolism

Pathway map

ppeg00260

Glycine, serine and threonine metabolism

Module

ppeg_M00018

Threonine biosynthesis, aspartate => homoserine => threonine [PATH:ppeg00260]

ppeg_M00020

Serine biosynthesis, glycerate-3P => serine [PATH:ppeg00260]

ppeg_M00338

Cysteine biosynthesis, homocysteine + serine => cysteine [PATH:ppeg00260]

ppeg_M00555

Betaine biosynthesis, choline => betaine [PATH:ppeg00260]

ppeg_M00621

Glycine cleavage system [PATH:ppeg00260]

ppeg_M00975

Betaine degradation, bacteria, betaine => pyruvate [PATH:ppeg00260]

Other DBs

GO:	0006544 0006563 0070178 0006566

Organism

Pseudomonas pergaminensis [GN:ppeg]

Gene

KUA23_00180

trpA; tryptophan synthase subunit alpha [KO:K01695] [EC:4.2.1.20]

KUA23_00185

trpB; tryptophan synthase subunit beta [KO:K01696] [EC:4.2.1.20]

KUA23_00385

[KO:K02204] [EC:2.7.1.39]

KUA23_01690

gpmI; 2,3-bisphosphoglycerate-independent phosphoglycerate mutase [KO:K15633] [EC:5.4.2.12]

KUA23_02580

serB; phosphoserine phosphatase SerB [KO:K01079] [EC:3.1.3.3]

KUA23_04820

[KO:K00018] [EC:1.1.1.29]

KUA23_05035

[KO:K00090] [EC:1.1.1.79 1.1.1.81 1.1.1.215]

KUA23_05395

[KO:K01752] [EC:4.3.1.17]

KUA23_07605

[KO:K00130] [EC:1.2.1.8]

KUA23_08500

serC; 3-phosphoserine/phosphohydroxythreonine transaminase [KO:K00831] [EC:2.6.1.52]

KUA23_09300

[KO:K11529] [EC:2.7.1.165]

KUA23_09415

lpdA; dihydrolipoyl dehydrogenase [KO:K00382] [EC:1.8.1.4]

KUA23_10290

[KO:K18896] [EC:2.1.1.156]

KUA23_12830

ilvA; threonine ammonia-lyase, biosynthetic [KO:K01754] [EC:4.3.1.19]

KUA23_13635

pssA; CDP-diacylglycerol--serine O-phosphatidyltransferase [KO:K00998] [EC:2.7.8.8]

KUA23_15495

[KO:K25316]

KUA23_15510

[KO:K00865] [EC:2.7.1.165]

KUA23_16230

[KO:K01697] [EC:4.2.1.22]

KUA23_16235

[KO:K01758] [EC:4.4.1.1]

KUA23_19590

lpdA; dihydrolipoyl dehydrogenase [KO:K00382] [EC:1.8.1.4]

KUA23_19920

[KO:K00274] [EC:1.4.3.4]

KUA23_20325

asd; aspartate-semialdehyde dehydrogenase [KO:K00133] [EC:1.2.1.11]

KUA23_21335

[KO:K00836] [EC:2.6.1.76]

KUA23_22615

thrH; bifunctional phosphoserine phosphatase/homoserine phosphotransferase ThrH [KO:K02203] [EC:3.1.3.3 2.7.1.39]

KUA23_23220

[KO:K00928] [EC:2.7.2.4]

KUA23_23230

ltaE; low-specificity L-threonine aldolase [KO:K01620] [EC:4.1.2.48]

KUA23_24025

gcvH; glycine cleavage system protein GcvH [KO:K02437]

KUA23_24030

gcvP; aminomethyl-transferring glycine dehydrogenase [KO:K00281] [EC:1.4.4.2]

KUA23_24035

[KO:K01752] [EC:4.3.1.17]

KUA23_24040

gcvT; glycine cleavage system aminomethyltransferase GcvT [KO:K00605] [EC:2.1.2.10]

KUA23_24550

thrC; threonine synthase [KO:K01733] [EC:4.2.3.1]

KUA23_24555

[KO:K00003] [EC:1.1.1.3]

KUA23_25475

pssA; CDP-diacylglycerol--serine O-phosphatidyltransferase [KO:K17103] [EC:2.7.8.8]

KUA23_25980

glyA; serine hydroxymethyltransferase [KO:K00600] [EC:2.1.2.1]

KUA23_27635

soxG; sarcosine oxidase subunit gamma family protein [KO:K00305] [EC:1.5.3.24 1.5.3.1]

KUA23_27640

[KO:K00302] [EC:1.5.3.24 1.5.3.1]

KUA23_27645

[KO:K00304] [EC:1.5.3.24 1.5.3.1]

KUA23_27650

[KO:K00303] [EC:1.5.3.24 1.5.3.1]

KUA23_27655

glyA; serine hydroxymethyltransferase [KO:K00600] [EC:2.1.2.1]

KUA23_27665

[KO:K01620] [EC:4.1.2.48]

KUA23_27675

gbcB; glycine-betaine demethylase subunit GbcB [KO:K21832] [EC:1.14.13.251]

KUA23_27680

gbcA; glycine-betaine demethylase subunit GbcA [KO:K00479] [EC:1.14.13.251]

KUA23_27685

[KO:K25961]

KUA23_27690

[KO:K25960]

KUA23_27695

dgcB; dimethylglycine demethylation protein DgcB [KO:K21834]

KUA23_27700

dgcA; dimethylglycine demethylation protein DgcA [KO:K21833] [EC:1.5.7.3]

KUA23_27770

[KO:K01752] [EC:4.3.1.17]

KUA23_27800

betB; betaine-aldehyde dehydrogenase [KO:K00130] [EC:1.2.1.8]

KUA23_27805

betA; choline dehydrogenase [KO:K00108] [EC:1.1.99.1]

KUA23_28490

ilvA; threonine ammonia-lyase, biosynthetic [KO:K01754] [EC:4.3.1.19]

KUA23_28525

serA; phosphoglycerate dehydrogenase [KO:K00058] [EC:1.1.1.95 1.1.1.399]

KUA23_28740

gcvH; glycine cleavage system protein GcvH [KO:K02437]

KUA23_28745

gcvT; glycine cleavage system aminomethyltransferase GcvT [KO:K00605] [EC:2.1.2.10]

Compound

C00011

CO2

C00014

Ammonia

C00022

Pyruvate

C00037

Glycine

C00048

Glyoxylate

C00049

L-Aspartate

C00065

L-Serine

C00078

L-Tryptophan

C00097

L-Cysteine

C00101

Tetrahydrofolate

C00109

2-Oxobutanoate

C00114

Choline

C00143

5,10-Methylenetetrahydrofolate

C00168

Hydroxypyruvate

C00188

L-Threonine

C00197

3-Phospho-D-glycerate

C00213

Sarcosine

C00258

D-Glycerate

C00263

L-Homoserine

C00300

Creatine

C00430

5-Aminolevulinate

C00441

L-Aspartate 4-semialdehyde

C00546

Methylglyoxal

C00576

Betaine aldehyde

C00581

Guanidinoacetate

C00631

2-Phospho-D-glycerate

C00719

Betaine

C00740

D-Serine

C00986

1,3-Diaminopropane

C01005

O-Phospho-L-serine

C01026

N,N-Dimethylglycine

C01102

O-Phospho-L-homoserine

C01242

[Protein]-S8-aminomethyldihydrolipoyllysine

C01888

Aminoacetone

C02051

Lipoylprotein

C02291

L-Cystathionine

C02737

Phosphatidylserine

C02972

Dihydrolipoylprotein

C03082

4-Phospho-L-aspartate

C03194

(R)-1-Aminopropan-2-ol

C03232

3-Phosphonooxypyruvate

C03283

L-2,4-Diaminobutanoate

C03508

L-2-Amino-3-oxobutanoic acid

C05519

L-Allothreonine

C06231

Ectoine

C06442

N(gamma)-Acetyldiaminobutyrate

C16432

5-Hydroxyectoine

C19929

N(alpha)-Acetyl-L-2,4-diaminobutyrate

C23135

(2S,3S)-2-Acetamido-3-hydroxy-4-aminobutyrate

C23136

4-Amino-L-allothreonine

Reference

Authors

Nishizuka Y, Seyama Y, Ikai A, Ishimura Y, Kawaguchi A (eds).

Title

[Cellular Functions and Metabolic Maps] (In Japanese)

Journal

Tokyo Kagaku Dojin (1997)

Reference

PMID:11823218

Authors

Kuhlmann AU, Bremer E.

Title

Osmotically regulated synthesis of the compatible solute ectoine in Bacillus pasteurii and related Bacillus spp.

Journal

Appl Environ Microbiol 68:772-83 (2002)
DOI:10.1128/AEM.68.2.772-783.2002

Reference

PMID:10473374

Authors

Canovas D, Borges N, Vargas C, Ventosa A, Nieto JJ, Santos H.

Title

Role of Ngamma-acetyldiaminobutyrate as an enzyme stabilizer and an intermediate in the biosynthesis of hydroxyectoine.

Journal

Appl Environ Microbiol 65:3774-9 (1999)
DOI:10.1128/AEM.65.9.3774-3779.1999

Reference

PMID:17636255

Authors

Bursy J, Pierik AJ, Pica N, Bremer E.

Title

Osmotically induced synthesis of the compatible solute hydroxyectoine is mediated by an evolutionarily conserved ectoine hydroxylase.

Journal

J Biol Chem 282:31147-55 (2007)
DOI:10.1074/jbc.M704023200

Reference

PMID:16707670

Authors

Garcia-Estepa R, Argandona M, Reina-Bueno M, Capote N, Iglesias-Guerra F, Nieto JJ, Vargas C.

Title

The ectD gene, which is involved in the synthesis of the compatible solute hydroxyectoine, is essential for thermoprotection of the halophilic bacterium Chromohalobacter salexigens.

Journal

J Bacteriol 188:3774-84 (2006)
DOI:10.1128/JB.00136-06

Reference

PMID:15470257

Authors

Arevalo-Rodriguez M, Pan X, Boeke JD, Heitman J

Title

FKBP12 controls aspartate pathway flux in Saccharomyces cerevisiae to prevent toxic intermediate accumulation.

Journal

Eukaryot Cell 3:1287-96 (2004)
DOI:10.1128/EC.3.5.1287-1296.2004

Reference

PMID:7639721