KEGG   PATHWAY: psf00260
Entry
psf00260                    Pathway                                
Name
Glycine, serine and threonine metabolism - Pseudovibrio sp. FO-BEG1
Description
Serine is derived from 3-phospho-D-glycerate, an intermediate of glycolysis [MD:M00020], and glycine is derived from serine. Threonine is an essential amino acid, which animals cannot synthesize. In bacteria and plants, threonine is derived from aspartate [MD:M00018].
Class
Metabolism; Amino acid metabolism
Pathway map
psf00260  Glycine, serine and threonine metabolism
psf00260

Module
psf_M00018  Threonine biosynthesis, aspartate => homoserine => threonine [PATH:psf00260]
psf_M00020  Serine biosynthesis, glycerate-3P => serine [PATH:psf00260]
psf_M00555  Betaine biosynthesis, choline => betaine [PATH:psf00260]
psf_M00621  Glycine cleavage system [PATH:psf00260]
psf_M00975  Betaine degradation, bacteria, betaine => pyruvate [PATH:psf00260]
Other DBs
GO: 0006544 0006563 0070178 0006566
Organism
Pseudovibrio sp. FO-BEG1 [GN:psf]
Gene
PSE_0010  aspartate kinase [KO:K00928] [EC:2.7.2.4]
PSE_4900  asd; Aspartate-semialdehyde dehydrogenase [KO:K00133] [EC:1.2.1.11]
PSE_3533  hom; Homoserine dehydrogenase [KO:K00003] [EC:1.1.1.3]
PSE_1572  thrB; Homoserine kinase [KO:K02204] [EC:2.7.1.39]
PSE_1564  thrC; Threonine synthase [KO:K01733] [EC:4.2.3.1]
PSE_4783  ltaE; Low specificity L-threonine aldolase [KO:K01620] [EC:4.1.2.48]
PSE_3588  Glycine hydroxymethyltransferase [KO:K00600] [EC:2.1.2.1]
PSE_4842  Glycine hydroxymethyltransferase [KO:K00600] [EC:2.1.2.1]
PSE_2125  hprA; Glycerate dehydrogenase [KO:K00018] [EC:1.1.1.29]
PSE_1068  D-isomer specific 2-hydroxyacid dehydrogenase family protein [KO:K12972] [EC:1.1.1.79 1.1.1.81]
PSE_0806  ttuD; hydroxypyruvate reductase [KO:K11529] [EC:2.7.1.165]
PSE_0524  gpmA; 2,3-bisphosphoglycerate-dependent phosphoglycerate mutase [KO:K01834] [EC:5.4.2.11]
PSE_0520  gpmA; 2,3-bisphosphoglycerate-dependent phosphoglycerate mutase [KO:K01834] [EC:5.4.2.11]
PSE_3911  D-isomer specific 2-hydroxyacid dehydrogenase, NAD-binding protein [KO:K00058] [EC:1.1.1.95 1.1.1.399]
PSE_4670  serA; D-3-phosphoglycerate dehydrogenase (PdxB) [KO:K00058] [EC:1.1.1.95 1.1.1.399]
PSE_4671  serC; Phosphoserine aminotransferase (PdxF) [KO:K00831] [EC:2.6.1.52]
PSE_4227  protein containing Phosphoserine phosphatase SerB//Haloacid dehalogenase-like hydrolase [KO:K01079] [EC:3.1.3.3]
PSE_1769  5-aminolevulinic acid synthase [KO:K00643] [EC:2.3.1.37]
PSE_p0337  tyramine oxidase [KO:K00276] [EC:1.4.3.21]
PSE_1577  glycine dehydrogenase subunit 1 [KO:K00282] [EC:1.4.4.2]
PSE_1578  glycine dehydrogenase subunit 2 [KO:K00283] [EC:1.4.4.2]
PSE_1575  glycine cleavage system T protein [KO:K00605] [EC:2.1.2.10]
PSE_0619  dihydrolipoamide dehydrogenase [KO:K00382] [EC:1.8.1.4]
PSE_3292  dihydrolipoamide dehydrogenase [KO:K00382] [EC:1.8.1.4]
PSE_1576  Glycine cleavage H-protein, subgroup [KO:K02437]
PSE_2670  pssA; CDP-diacylglycerol--serine O-phosphatidyltransferase [KO:K17103] [EC:2.7.8.8]
PSE_0428  betA; Choline dehydrogenase [KO:K00108] [EC:1.1.99.1]
PSE_0427  betB; Betaine aldehyde dehydrogenase [KO:K00130] [EC:1.2.1.8]
PSE_2955  ring hydroxylating dioxygenase, alpha-subunit [KO:K00479] [EC:1.14.13.251]
PSE_2954  iron-sulfur cluster-binding protein [KO:K21832] [EC:1.14.13.251]
PSE_p0029  aminomethyl transferase family protein [KO:K00315] [EC:1.5.8.4]
PSE_2958  sarcosine oxidase, alpha subunit family protein [KO:K00302] [EC:1.5.3.24 1.5.3.1]
PSE_1847  sarcosine oxidase, alpha subunit family protein [KO:K00302] [EC:1.5.3.24 1.5.3.1]
PSE_1845  sarcosine oxidase, beta subunit family protein [KO:K00303] [EC:1.5.3.24 1.5.3.1]
PSE_2960  sarcosine oxidase, beta subunit family protein [KO:K00303] [EC:1.5.3.24 1.5.3.1]
PSE_1848  sarcosine oxidase gamma subunit protein [KO:K00305] [EC:1.5.3.24 1.5.3.1]
PSE_2957  Sarcosine oxidase gamma subunit [KO:K00305] [EC:1.5.3.24 1.5.3.1]
PSE_1846  Sarcosine oxidase, delta subunit, heterotetrameric [KO:K00304] [EC:1.5.3.24 1.5.3.1]
PSE_2959  Sarcosine oxidase, delta subunit, heterotetrameric [KO:K00304] [EC:1.5.3.24 1.5.3.1]
PSE_0057  metB; Cystathionine gamma-synthase [KO:K01758] [EC:4.4.1.1]
PSE_0091  sdaA; L-serine dehydratase 1 [KO:K01752] [EC:4.3.1.17]
PSE_1826  L-serine dehydratase, iron-sulfur-dependent, alpha subunit [KO:K01752] [EC:4.3.1.17]
PSE_1898  L-serine dehydratase, iron-sulfur-dependent, alpha subunit [KO:K01752] [EC:4.3.1.17]
PSE_2839  sdaA; L-serine dehydratase 1 [KO:K01752] [EC:4.3.1.17]
PSE_1254  protein containing Pyridoxal phosphate-dependent enzyme, beta subunit domain [KO:K01754] [EC:4.3.1.19]
PSE_3598  tdcB; Threonine dehydratase II [KO:K01754] [EC:4.3.1.19]
PSE_1840  Pyridoxal-5'-phosphate-dependent protein beta subunit [KO:K01754] [EC:4.3.1.19]
PSE_4894  ilvA; Threonine dehydratase biosynthetic [KO:K01754] [EC:4.3.1.19]
PSE_4131  serine/threonine dehydratase [KO:K01754] [EC:4.3.1.19]
PSE_p0290  tdcB; Threonine dehydratase [KO:K01754] [EC:4.3.1.19]
PSE_3114  protein containing Alanine racemase region domain [KO:K25317] [EC:5.1.1.10]
PSE_0341  tryptophan synthase subunit alpha [KO:K01695] [EC:4.2.1.20]
PSE_0327  tryptophan synthase subunit beta [KO:K01696] [EC:4.2.1.20]
PSE_2644  tryptophan synthase subunit beta [KO:K01696] [EC:4.2.1.20]
Compound
C00011  CO2
C00014  Ammonia
C00022  Pyruvate
C00037  Glycine
C00048  Glyoxylate
C00049  L-Aspartate
C00065  L-Serine
C00078  L-Tryptophan
C00097  L-Cysteine
C00101  Tetrahydrofolate
C00109  2-Oxobutanoate
C00114  Choline
C00143  5,10-Methylenetetrahydrofolate
C00168  Hydroxypyruvate
C00188  L-Threonine
C00197  3-Phospho-D-glycerate
C00213  Sarcosine
C00258  D-Glycerate
C00263  L-Homoserine
C00300  Creatine
C00430  5-Aminolevulinate
C00441  L-Aspartate 4-semialdehyde
C00546  Methylglyoxal
C00576  Betaine aldehyde
C00581  Guanidinoacetate
C00631  2-Phospho-D-glycerate
C00719  Betaine
C00740  D-Serine
C00986  1,3-Diaminopropane
C01005  O-Phospho-L-serine
C01026  N,N-Dimethylglycine
C01102  O-Phospho-L-homoserine
C01242  [Protein]-S8-aminomethyldihydrolipoyllysine
C01888  Aminoacetone
C02051  Lipoylprotein
C02291  L-Cystathionine
C02737  Phosphatidylserine
C02972  Dihydrolipoylprotein
C03082  4-Phospho-L-aspartate
C03194  (R)-1-Aminopropan-2-ol
C03232  3-Phosphonooxypyruvate
C03283  L-2,4-Diaminobutanoate
C03508  L-2-Amino-3-oxobutanoic acid
C05519  L-Allothreonine
C06231  Ectoine
C06442  N(gamma)-Acetyldiaminobutyrate
C16432  5-Hydroxyectoine
C19929  N(alpha)-Acetyl-L-2,4-diaminobutyrate
Reference
  Authors
Nishizuka Y, Seyama Y, Ikai A, Ishimura Y, Kawaguchi A (eds).
  Title
[Cellular Functions and Metabolic Maps] (In Japanese)
  Journal
Tokyo Kagaku Dojin (1997)
Reference
PMID:11823218
  Authors
Kuhlmann AU, Bremer E.
  Title
Osmotically regulated synthesis of the compatible solute ectoine in Bacillus pasteurii and related Bacillus spp.
  Journal
Appl Environ Microbiol 68:772-83 (2002)
DOI:10.1128/AEM.68.2.772-783.2002
Reference
PMID:10473374
  Authors
Canovas D, Borges N, Vargas C, Ventosa A, Nieto JJ, Santos H.
  Title
Role of Ngamma-acetyldiaminobutyrate as an enzyme stabilizer and an intermediate in the biosynthesis of hydroxyectoine.
  Journal
Appl Environ Microbiol 65:3774-9 (1999)
DOI:10.1128/AEM.65.9.3774-3779.1999
Reference
PMID:17636255
  Authors
Bursy J, Pierik AJ, Pica N, Bremer E.
  Title
Osmotically induced synthesis of the compatible solute hydroxyectoine is mediated by an evolutionarily conserved ectoine hydroxylase.
  Journal
J Biol Chem 282:31147-55 (2007)
DOI:10.1074/jbc.M704023200
Reference
PMID:16707670
  Authors
Garcia-Estepa R, Argandona M, Reina-Bueno M, Capote N, Iglesias-Guerra F, Nieto JJ, Vargas C.
  Title
The ectD gene, which is involved in the synthesis of the compatible solute hydroxyectoine, is essential for thermoprotection of the halophilic bacterium Chromohalobacter salexigens.
  Journal
J Bacteriol 188:3774-84 (2006)
DOI:10.1128/JB.00136-06
Reference
PMID:15470257
  Authors
Arevalo-Rodriguez M, Pan X, Boeke JD, Heitman J
  Title
FKBP12 controls aspartate pathway flux in Saccharomyces cerevisiae to prevent toxic intermediate accumulation.
  Journal
Eukaryot Cell 3:1287-96 (2004)
DOI:10.1128/EC.3.5.1287-1296.2004
Reference
PMID:7639721
  Authors
Rees WD, Hay SM
  Title
The biosynthesis of threonine by mammalian cells: expression of a complete bacterial biosynthetic pathway in an animal cell.
  Journal
Biochem J 309 ( Pt 3):999-1007 (1995)
DOI:10.1042/bj3090999
Reference
PMID:11341914
  Authors
Jacques SL, Nieman C, Bareich D, Broadhead G, Kinach R, Honek JF, Wright GD
  Title
Characterization of yeast homoserine dehydrogenase, an antifungal target: the invariant histidine 309 is important for enzyme integrity.
  Journal
Biochim Biophys Acta 1544:28-41 (2001)
DOI:10.1016/S0167-4838(00)00203-X
Reference
PMID:15520012
  Authors
Chen X, Jhee KH, Kruger WD
  Title
Production of the neuromodulator H2S by cystathionine beta-synthase via the condensation of cysteine and homocysteine.
  Journal
J Biol Chem 279:52082-6 (2004)
DOI:10.1074/jbc.C400481200
Related
pathway
psf00010  Glycolysis / Gluconeogenesis
psf00020  Citrate cycle (TCA cycle)
psf00230  Purine metabolism
psf00250  Alanine, aspartate and glutamate metabolism
psf00270  Cysteine and methionine metabolism
psf00290  Valine, leucine and isoleucine biosynthesis
psf00300  Lysine biosynthesis
psf00330  Arginine and proline metabolism
psf00460  Cyanoamino acid metabolism
psf00470  D-Amino acid metabolism
psf00564  Glycerophospholipid metabolism
psf00600  Sphingolipid metabolism
psf00620  Pyruvate metabolism
psf00630  Glyoxylate and dicarboxylate metabolism
psf00640  Propanoate metabolism
psf00680  Methane metabolism
psf00860  Porphyrin metabolism
psf00920  Sulfur metabolism
KO pathway
ko00260   
LinkDB

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