KEGG   PATHWAY: pxn00260
Entry
pxn00260                    Pathway                                
Name
Glycine, serine and threonine metabolism - Pseudomonas xantholysinigenes
Description
Serine is derived from 3-phospho-D-glycerate, an intermediate of glycolysis [MD:M00020], and glycine is derived from serine. Threonine is an essential amino acid, which animals cannot synthesize. In bacteria and plants, threonine is derived from aspartate [MD:M00018].
Class
Metabolism; Amino acid metabolism
Pathway map
pxn00260  Glycine, serine and threonine metabolism
pxn00260

Module
pxn_M00018  Threonine biosynthesis, aspartate => homoserine => threonine [PATH:pxn00260]
pxn_M00020  Serine biosynthesis, glycerate-3P => serine [PATH:pxn00260]
pxn_M00555  Betaine biosynthesis, choline => betaine [PATH:pxn00260]
pxn_M00621  Glycine cleavage system [PATH:pxn00260]
pxn_M00975  Betaine degradation, bacteria, betaine => pyruvate [PATH:pxn00260]
Other DBs
GO: 0006544 0006563 0070178 0006566
Organism
Pseudomonas xantholysinigenes [GN:pxn]
Gene
HU772_017450  aspartate kinase [KO:K00928] [EC:2.7.2.4]
HU772_007720  asd; aspartate-semialdehyde dehydrogenase [KO:K00133] [EC:1.2.1.11]
HU772_019310  homoserine dehydrogenase [KO:K00003] [EC:1.1.1.3]
HU772_000420  homoserine kinase [KO:K02204] [EC:2.7.1.39]
HU772_019305  thrC; threonine synthase [KO:K01733] [EC:4.2.3.1]
HU772_001725  low specificity L-threonine aldolase [KO:K01620] [EC:4.1.2.48]
HU772_021320  serine hydroxymethyltransferase [KO:K00600] [EC:2.1.2.1]
HU772_001730  serine hydroxymethyltransferase [KO:K00600] [EC:2.1.2.1]
HU772_020855  2-hydroxyacid dehydrogenase [KO:K00018] [EC:1.1.1.29]
HU772_004245  D-glycerate dehydrogenase [KO:K00090] [EC:1.1.1.79 1.1.1.81 1.1.1.215]
HU772_013225  glycerate kinase [KO:K00865] [EC:2.7.1.165]
HU772_016850  glycerate kinase [KO:K11529] [EC:2.7.1.165]
HU772_023125  gpmI; 2,3-bisphosphoglycerate-independent phosphoglycerate mutase [KO:K15633] [EC:5.4.2.12]
HU772_023635  serA; phosphoglycerate dehydrogenase [KO:K00058] [EC:1.1.1.95 1.1.1.399]
HU772_006785  serC; 3-phosphoserine/phosphohydroxythreonine transaminase [KO:K00831] [EC:2.6.1.52]
HU772_022390  serB; phosphoserine phosphatase SerB [KO:K01079] [EC:3.1.3.3]
HU772_022760  flavin monoamine oxidase family protein [KO:K00274] [EC:1.4.3.4]
HU772_019880  gcvP; aminomethyl-transferring glycine dehydrogenase [KO:K00281] [EC:1.4.4.2]
HU772_023850  gcvP; aminomethyl-transferring glycine dehydrogenase [KO:K00281] [EC:1.4.4.2]
HU772_019890  gcvT; glycine cleavage system aminomethyltransferase GcvT [KO:K00605] [EC:2.1.2.10]
HU772_023860  gcvT; glycine cleavage system aminomethyltransferase GcvT [KO:K00605] [EC:2.1.2.10]
HU772_016360  lpdA; dihydrolipoyl dehydrogenase [KO:K00382] [EC:1.8.1.4]
HU772_017385  lpdA; dihydrolipoyl dehydrogenase [KO:K00382] [EC:1.8.1.4]
HU772_024755  lpdA; dihydrolipoyl dehydrogenase [KO:K00382] [EC:1.8.1.4]
HU772_019875  gcvH; glycine cleavage system protein GcvH [KO:K02437]
HU772_023855  gcvH; glycine cleavage system protein GcvH [KO:K02437]
HU772_003700  pssA; CDP-diacylglycerol--serine O-phosphatidyltransferase [KO:K17103] [EC:2.7.8.8]
HU772_023170  betA; choline dehydrogenase [KO:K00108] [EC:1.1.99.1]
HU772_021120  aldehyde dehydrogenase family protein [KO:K00130] [EC:1.2.1.8]
HU772_023165  betB; betaine-aldehyde dehydrogenase [KO:K00130] [EC:1.2.1.8]
HU772_001690  gbcA; glycine-betaine demethylase subunit GbcA [KO:K00479] [EC:1.14.13.251]
HU772_001695  gbcB; glycine-betaine demethylase subunit GbcB [KO:K21832] [EC:1.14.13.251]
HU772_001665  dgcA; dimethylglycine demethylation protein DgcA [KO:K21833] [EC:1.5.7.3]
HU772_001670  dgcB; dimethylglycine demethylation protein DgcB [KO:K21834]
HU772_001675  electron transfer flavoprotein subunit alpha/FixB family protein [KO:K25960]
HU772_001680  electron transfer flavoprotein subunit beta [KO:K25961]
HU772_001745  sarcosine oxidase subunit alpha [KO:K00302] [EC:1.5.3.24 1.5.3.1]
HU772_001735  sarcosine oxidase subunit beta family protein [KO:K00303] [EC:1.5.3.24 1.5.3.1]
HU772_001750  sarcosine oxidase subunit gamma family protein [KO:K00305] [EC:1.5.3.24 1.5.3.1]
HU772_001740  sarcosine oxidase subunit delta [KO:K00304] [EC:1.5.3.24 1.5.3.1]
HU772_018130  PLP-dependent aspartate aminotransferase family protein [KO:K01758] [EC:4.4.1.1]
HU772_013345  L-serine ammonia-lyase [KO:K01752] [EC:4.3.1.17]
HU772_019885  L-serine ammonia-lyase [KO:K01752] [EC:4.3.1.17]
HU772_001605  L-serine ammonia-lyase [KO:K01752] [EC:4.3.1.17]
HU772_012020  ilvA; threonine ammonia-lyase, biosynthetic [KO:K01754] [EC:4.3.1.19]
HU772_017920  threonine dehydratase [KO:K01754] [EC:4.3.1.19]
HU772_023605  ilvA; threonine ammonia-lyase, biosynthetic [KO:K01754] [EC:4.3.1.19]
HU772_015025  pyridoxal-phosphate dependent enzyme [KO:K17989] [EC:4.3.1.17 4.3.1.19]
HU772_000190  trpA; tryptophan synthase subunit alpha [KO:K01695] [EC:4.2.1.20]
HU772_000195  trpB; tryptophan synthase subunit beta [KO:K01696] [EC:4.2.1.20]
HU772_016500  aspartate aminotransferase family protein [KO:K00836] [EC:2.6.1.76]
Compound
C00011  CO2
C00014  Ammonia
C00022  Pyruvate
C00037  Glycine
C00048  Glyoxylate
C00049  L-Aspartate
C00065  L-Serine
C00078  L-Tryptophan
C00097  L-Cysteine
C00101  Tetrahydrofolate
C00109  2-Oxobutanoate
C00114  Choline
C00143  5,10-Methylenetetrahydrofolate
C00168  Hydroxypyruvate
C00188  L-Threonine
C00197  3-Phospho-D-glycerate
C00213  Sarcosine
C00258  D-Glycerate
C00263  L-Homoserine
C00300  Creatine
C00430  5-Aminolevulinate
C00441  L-Aspartate 4-semialdehyde
C00546  Methylglyoxal
C00576  Betaine aldehyde
C00581  Guanidinoacetate
C00631  2-Phospho-D-glycerate
C00719  Betaine
C00740  D-Serine
C00986  1,3-Diaminopropane
C01005  O-Phospho-L-serine
C01026  N,N-Dimethylglycine
C01102  O-Phospho-L-homoserine
C01242  [Protein]-S8-aminomethyldihydrolipoyllysine
C01888  Aminoacetone
C02051  Lipoylprotein
C02291  L-Cystathionine
C02737  Phosphatidylserine
C02972  Dihydrolipoylprotein
C03082  4-Phospho-L-aspartate
C03194  (R)-1-Aminopropan-2-ol
C03232  3-Phosphonooxypyruvate
C03283  L-2,4-Diaminobutanoate
C03508  L-2-Amino-3-oxobutanoic acid
C05519  L-Allothreonine
C06231  Ectoine
C06442  N(gamma)-Acetyldiaminobutyrate
C16432  5-Hydroxyectoine
C19929  N(alpha)-Acetyl-L-2,4-diaminobutyrate
Reference
  Authors
Nishizuka Y, Seyama Y, Ikai A, Ishimura Y, Kawaguchi A (eds).
  Title
[Cellular Functions and Metabolic Maps] (In Japanese)
  Journal
Tokyo Kagaku Dojin (1997)
Reference
PMID:11823218
  Authors
Kuhlmann AU, Bremer E.
  Title
Osmotically regulated synthesis of the compatible solute ectoine in Bacillus pasteurii and related Bacillus spp.
  Journal
Appl Environ Microbiol 68:772-83 (2002)
DOI:10.1128/AEM.68.2.772-783.2002
Reference
PMID:10473374
  Authors
Canovas D, Borges N, Vargas C, Ventosa A, Nieto JJ, Santos H.
  Title
Role of Ngamma-acetyldiaminobutyrate as an enzyme stabilizer and an intermediate in the biosynthesis of hydroxyectoine.
  Journal
Appl Environ Microbiol 65:3774-9 (1999)
DOI:10.1128/AEM.65.9.3774-3779.1999
Reference
PMID:17636255
  Authors
Bursy J, Pierik AJ, Pica N, Bremer E.
  Title
Osmotically induced synthesis of the compatible solute hydroxyectoine is mediated by an evolutionarily conserved ectoine hydroxylase.
  Journal
J Biol Chem 282:31147-55 (2007)
DOI:10.1074/jbc.M704023200
Reference
PMID:16707670
  Authors
Garcia-Estepa R, Argandona M, Reina-Bueno M, Capote N, Iglesias-Guerra F, Nieto JJ, Vargas C.
  Title
The ectD gene, which is involved in the synthesis of the compatible solute hydroxyectoine, is essential for thermoprotection of the halophilic bacterium Chromohalobacter salexigens.
  Journal
J Bacteriol 188:3774-84 (2006)
DOI:10.1128/JB.00136-06
Reference
PMID:15470257
  Authors
Arevalo-Rodriguez M, Pan X, Boeke JD, Heitman J
  Title
FKBP12 controls aspartate pathway flux in Saccharomyces cerevisiae to prevent toxic intermediate accumulation.
  Journal
Eukaryot Cell 3:1287-96 (2004)
DOI:10.1128/EC.3.5.1287-1296.2004
Reference
PMID:7639721
  Authors
Rees WD, Hay SM
  Title
The biosynthesis of threonine by mammalian cells: expression of a complete bacterial biosynthetic pathway in an animal cell.
  Journal
Biochem J 309 ( Pt 3):999-1007 (1995)
DOI:10.1042/bj3090999
Reference
PMID:11341914
  Authors
Jacques SL, Nieman C, Bareich D, Broadhead G, Kinach R, Honek JF, Wright GD
  Title
Characterization of yeast homoserine dehydrogenase, an antifungal target: the invariant histidine 309 is important for enzyme integrity.
  Journal
Biochim Biophys Acta 1544:28-41 (2001)
DOI:10.1016/S0167-4838(00)00203-X
Reference
PMID:15520012
  Authors
Chen X, Jhee KH, Kruger WD
  Title
Production of the neuromodulator H2S by cystathionine beta-synthase via the condensation of cysteine and homocysteine.
  Journal
J Biol Chem 279:52082-6 (2004)
DOI:10.1074/jbc.C400481200
Related
pathway
pxn00010  Glycolysis / Gluconeogenesis
pxn00020  Citrate cycle (TCA cycle)
pxn00230  Purine metabolism
pxn00250  Alanine, aspartate and glutamate metabolism
pxn00270  Cysteine and methionine metabolism
pxn00290  Valine, leucine and isoleucine biosynthesis
pxn00300  Lysine biosynthesis
pxn00330  Arginine and proline metabolism
pxn00460  Cyanoamino acid metabolism
pxn00470  D-Amino acid metabolism
pxn00564  Glycerophospholipid metabolism
pxn00620  Pyruvate metabolism
pxn00630  Glyoxylate and dicarboxylate metabolism
pxn00640  Propanoate metabolism
pxn00680  Methane metabolism
pxn00860  Porphyrin metabolism
pxn00920  Sulfur metabolism
KO pathway
ko00260   
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