KEGG   PATHWAY: reb00260
Entry
reb00260                    Pathway                                
Name
Glycine, serine and threonine metabolism - Rhodococcus erythropolis BG43
Description
Serine is derived from 3-phospho-D-glycerate, an intermediate of glycolysis [MD:M00020], and glycine is derived from serine. Threonine is an essential amino acid, which animals cannot synthesize. In bacteria and plants, threonine is derived from aspartate [MD:M00018].
Class
Metabolism; Amino acid metabolism
Pathway map
reb00260  Glycine, serine and threonine metabolism
reb00260

Module
reb_M00018  Threonine biosynthesis, aspartate => homoserine => threonine [PATH:reb00260]
reb_M00020  Serine biosynthesis, glycerate-3P => serine [PATH:reb00260]
reb_M00033  Ectoine biosynthesis, aspartate => ectoine [PATH:reb00260]
reb_M00338  Cysteine biosynthesis, homocysteine + serine => cysteine [PATH:reb00260]
reb_M00621  Glycine cleavage system [PATH:reb00260]
Other DBs
GO: 0006544 0006563 0070178 0006566
Organism
Rhodococcus erythropolis BG43 [GN:reb]
Gene
XU06_02230  aspartate kinase [KO:K00928] [EC:2.7.2.4]
XU06_02235  aspartate-semialdehyde dehydrogenase [KO:K00133] [EC:1.2.1.11]
XU06_18390  homoserine dehydrogenase [KO:K00003] [EC:1.1.1.3]
XU06_18380  serine kinase [KO:K00872] [EC:2.7.1.39]
XU06_18385  threonine synthase [KO:K01733] [EC:4.2.3.1]
XU06_27080  threonine aldolase [KO:K01620] [EC:4.1.2.48]
XU06_20050  serine hydroxymethyltransferase [KO:K00600] [EC:2.1.2.1]
XU06_18350  serine hydroxymethyltransferase [KO:K00600] [EC:2.1.2.1]
XU06_16755  hypothetical protein [KO:K00865] [EC:2.7.1.165]
XU06_07975  gpmA; phosphoglyceromutase [KO:K01834] [EC:5.4.2.11]
XU06_00325  phosphoglycerate kinase [KO:K15634] [EC:5.4.2.11]
XU06_11045  nucleotide pyrophosphatase [KO:K15633] [EC:5.4.2.12]
XU06_11465  3-phosphoglycerate dehydrogenase [KO:K00058] [EC:1.1.1.95 1.1.1.399]
XU06_21900  phosphoserine aminotransferase [KO:K00831] [EC:2.6.1.52]
XU06_11250  phosphoserine phosphatase [KO:K01079] [EC:3.1.3.3]
XU06_06150  amino acid oxidase [KO:K00274] [EC:1.4.3.4]
XU06_15045  glycine dehydrogenase [KO:K00281] [EC:1.4.4.2]
XU06_16795  glycine cleavage system protein T [KO:K00605] [EC:2.1.2.10]
XU06_29385  dihydrolipoamide dehydrogenase [KO:K00382] [EC:1.8.1.4]
XU06_07550  dihydrolipoyl dehydrogenase [KO:K00382] [EC:1.8.1.4]
XU06_29005  dihydrolipoamide dehydrogenase [KO:K00382] [EC:1.8.1.4]
XU06_21785  dihydrolipoamide dehydrogenase [KO:K00382] [EC:1.8.1.4]
XU06_15070  glycine cleavage system protein H [KO:K02437]
XU06_07435  CDP-diacylglycerol--serine O-phosphatidyltransferase [KO:K17103] [EC:2.7.8.8]
XU06_20875  phenylacetaldehyde dehydrogenase [KO:K00130] [EC:1.2.1.8]
XU06_29095  hypothetical protein [KO:K00130] [EC:1.2.1.8]
XU06_07140  FAD-dependent oxidoreductase [KO:K00301] [EC:1.5.3.1]
XU06_20125  cystathionine beta-synthase [KO:K01697] [EC:4.2.1.22]
XU06_11550  cystathionine gamma-lyase [KO:K01758] [EC:4.4.1.1]
XU06_11980  serine ammonia-lyase [KO:K01752] [EC:4.3.1.17]
XU06_20115  threonine dehydratase [KO:K01754] [EC:4.3.1.19]
XU06_26260  pyridoxal-5'-phosphate-dependent protein subunit beta [KO:K01754] [EC:4.3.1.19]
XU06_16365  threonine dehydratase [KO:K01754] [EC:4.3.1.19]
XU06_09685  threonine dehydratase [KO:K01754] [EC:4.3.1.19]
XU06_04685  amino acid deaminase [KO:K01753] [EC:4.3.1.18]
XU06_30255  hypothetical protein [KO:K01695] [EC:4.2.1.20]
XU06_15670  tryptophan synthase subunit alpha [KO:K01695] [EC:4.2.1.20]
XU06_30250  tryptophan synthase subunit beta [KO:K01696] [EC:4.2.1.20]
XU06_15675  tryptophan synthase subunit beta [KO:K01696] [EC:4.2.1.20]
XU06_04080  tryptophan synthase subunit beta [KO:K06001] [EC:4.2.1.20]
XU06_17685  diaminobutyrate--2-oxoglutarate aminotransferase [KO:K00836] [EC:2.6.1.76]
XU06_17680  2,4-diaminobutyric acid acetyltransferase [KO:K06718] [EC:2.3.1.178]
XU06_17690  ectC; L-ectoine synthase [KO:K06720] [EC:4.2.1.108]
XU06_31605  multidrug DMT transporter permease [KO:K10674] [EC:1.14.11.55]
Compound
C00011  CO2
C00014  Ammonia
C00022  Pyruvate
C00037  Glycine
C00048  Glyoxylate
C00049  L-Aspartate
C00065  L-Serine
C00078  L-Tryptophan
C00097  L-Cysteine
C00101  Tetrahydrofolate
C00109  2-Oxobutanoate
C00114  Choline
C00143  5,10-Methylenetetrahydrofolate
C00168  Hydroxypyruvate
C00188  L-Threonine
C00197  3-Phospho-D-glycerate
C00213  Sarcosine
C00258  D-Glycerate
C00263  L-Homoserine
C00300  Creatine
C00430  5-Aminolevulinate
C00441  L-Aspartate 4-semialdehyde
C00546  Methylglyoxal
C00576  Betaine aldehyde
C00581  Guanidinoacetate
C00631  2-Phospho-D-glycerate
C00719  Betaine
C00740  D-Serine
C00986  1,3-Diaminopropane
C01005  O-Phospho-L-serine
C01026  N,N-Dimethylglycine
C01102  O-Phospho-L-homoserine
C01242  [Protein]-S8-aminomethyldihydrolipoyllysine
C01888  Aminoacetone
C02051  Lipoylprotein
C02291  L-Cystathionine
C02737  Phosphatidylserine
C02972  Dihydrolipoylprotein
C03082  4-Phospho-L-aspartate
C03194  (R)-1-Aminopropan-2-ol
C03232  3-Phosphonooxypyruvate
C03283  L-2,4-Diaminobutanoate
C03508  L-2-Amino-3-oxobutanoic acid
C05519  L-Allothreonine
C06231  Ectoine
C06442  N(gamma)-Acetyldiaminobutyrate
C16432  5-Hydroxyectoine
C19929  N(alpha)-Acetyl-L-2,4-diaminobutyrate
Reference
  Authors
Nishizuka Y, Seyama Y, Ikai A, Ishimura Y, Kawaguchi A (eds).
  Title
[Cellular Functions and Metabolic Maps] (In Japanese)
  Journal
Tokyo Kagaku Dojin (1997)
Reference
PMID:11823218
  Authors
Kuhlmann AU, Bremer E.
  Title
Osmotically regulated synthesis of the compatible solute ectoine in Bacillus pasteurii and related Bacillus spp.
  Journal
Appl Environ Microbiol 68:772-83 (2002)
DOI:10.1128/AEM.68.2.772-783.2002
Reference
PMID:10473374
  Authors
Canovas D, Borges N, Vargas C, Ventosa A, Nieto JJ, Santos H.
  Title
Role of Ngamma-acetyldiaminobutyrate as an enzyme stabilizer and an intermediate in the biosynthesis of hydroxyectoine.
  Journal
Appl Environ Microbiol 65:3774-9 (1999)
DOI:10.1128/AEM.65.9.3774-3779.1999
Reference
PMID:17636255
  Authors
Bursy J, Pierik AJ, Pica N, Bremer E.
  Title
Osmotically induced synthesis of the compatible solute hydroxyectoine is mediated by an evolutionarily conserved ectoine hydroxylase.
  Journal
J Biol Chem 282:31147-55 (2007)
DOI:10.1074/jbc.M704023200
Reference
PMID:16707670
  Authors
Garcia-Estepa R, Argandona M, Reina-Bueno M, Capote N, Iglesias-Guerra F, Nieto JJ, Vargas C.
  Title
The ectD gene, which is involved in the synthesis of the compatible solute hydroxyectoine, is essential for thermoprotection of the halophilic bacterium Chromohalobacter salexigens.
  Journal
J Bacteriol 188:3774-84 (2006)
DOI:10.1128/JB.00136-06
Reference
PMID:15470257
  Authors
Arevalo-Rodriguez M, Pan X, Boeke JD, Heitman J
  Title
FKBP12 controls aspartate pathway flux in Saccharomyces cerevisiae to prevent toxic intermediate accumulation.
  Journal
Eukaryot Cell 3:1287-96 (2004)
DOI:10.1128/EC.3.5.1287-1296.2004
Reference
PMID:7639721
  Authors
Rees WD, Hay SM
  Title
The biosynthesis of threonine by mammalian cells: expression of a complete bacterial biosynthetic pathway in an animal cell.
  Journal
Biochem J 309 ( Pt 3):999-1007 (1995)
DOI:10.1042/bj3090999
Reference
PMID:11341914
  Authors
Jacques SL, Nieman C, Bareich D, Broadhead G, Kinach R, Honek JF, Wright GD
  Title
Characterization of yeast homoserine dehydrogenase, an antifungal target: the invariant histidine 309 is important for enzyme integrity.
  Journal
Biochim Biophys Acta 1544:28-41 (2001)
DOI:10.1016/S0167-4838(00)00203-X
Reference
PMID:15520012
  Authors
Chen X, Jhee KH, Kruger WD
  Title
Production of the neuromodulator H2S by cystathionine beta-synthase via the condensation of cysteine and homocysteine.
  Journal
J Biol Chem 279:52082-6 (2004)
DOI:10.1074/jbc.C400481200
Related
pathway
reb00010  Glycolysis / Gluconeogenesis
reb00020  Citrate cycle (TCA cycle)
reb00230  Purine metabolism
reb00250  Alanine, aspartate and glutamate metabolism
reb00270  Cysteine and methionine metabolism
reb00290  Valine, leucine and isoleucine biosynthesis
reb00300  Lysine biosynthesis
reb00330  Arginine and proline metabolism
reb00460  Cyanoamino acid metabolism
reb00470  D-Amino acid metabolism
reb00564  Glycerophospholipid metabolism
reb00600  Sphingolipid metabolism
reb00620  Pyruvate metabolism
reb00630  Glyoxylate and dicarboxylate metabolism
reb00640  Propanoate metabolism
reb00680  Methane metabolism
reb00860  Porphyrin metabolism
reb00920  Sulfur metabolism
KO pathway
ko00260   
LinkDB

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