KEGG   PATHWAY: rme00630
Entry
rme00630                    Pathway                                
Name
Glyoxylate and dicarboxylate metabolism - Cupriavidus metallidurans
Class
Metabolism; Carbohydrate metabolism
Pathway map
rme00630  Glyoxylate and dicarboxylate metabolism
rme00630

Module
rme_M00012  Glyoxylate cycle [PATH:rme00630]
rme_M00621  Glycine cleavage system [PATH:rme00630]
Other DBs
GO: 0046487 0043648
Organism
Cupriavidus metallidurans [GN:rme]
Gene
Rmet_0106  atoB; acetyl-CoA acetyltransferase [KO:K00626] [EC:2.3.1.9]
Rmet_0118  ycdW; 2-ketoacid reductase [KO:K12972] [EC:1.1.1.79 1.1.1.81]
Rmet_0404  ttuC; tartrate dehydrogenase/decarboxylase [KO:K07246] [EC:1.1.1.93 4.1.1.73 1.1.1.83]
Rmet_0405  ttuD; hydroxypyruvate reductase [KO:K11529] [EC:2.7.1.165]
Rmet_0553  fdsG; NAD-dependent formate dehydrogenase gamma subunit [KO:K00127]
Rmet_0554  fdsB; NAD-dependent formate dehydrogenase beta subunit [KO:K00124]
Rmet_0555  fdsA; NAD-dependent formate dehydrogenase alpha subunit [KO:K00123] [EC:1.17.1.9]
Rmet_0557  fdsD; NAD-dependent formate dehydrogenase delta subunit [KO:K00126] [EC:1.17.1.9]
Rmet_1061  [KO:K01895] [EC:6.2.1.1]
Rmet_1199  lpdA; Dihydrolipoamide dehydrogenase [KO:K00382] [EC:1.8.1.4]
Rmet_1333  phaB2; 3-oxoacyl-(acyl-carrier-protein) reductase (protein belongs to CMGI-2) [KO:K00023] [EC:1.1.1.36]
Rmet_1357  phaA; Acetyl-CoA acetyltransferase (Acetoacetyl-CoA thiolase) [KO:K00626] [EC:2.3.1.9]
Rmet_1358  phaB; Acetoacetyl-CoA reductase [KO:K00023] [EC:1.1.1.36]
Rmet_1362  bktB; acetyl-CoA acetyltransferase [KO:K00626] [EC:2.3.1.9]
Rmet_1385  aceA; isocitrate lyase [KO:K01637] [EC:4.1.3.1 4.1.3.30]
Rmet_1390  aceB; malate synthase A [KO:K01638] [EC:2.3.3.9]
Rmet_1500  cbbS; ribulose 1,5-bisphosphate carboxylase/oxygenase, RuBisCO (type I) small subunit (CbbS) [KO:K01602] [EC:4.1.1.39]
Rmet_1501  cbbL; ribulose 1,5-bisphosphate carboxylase/oxygenase, RuBisCo (type I) large subunit (CbbL) [KO:K01601] [EC:4.1.1.39]
Rmet_1514  cbbZ1; phosphoglycolate phosphatase (PGP) [KO:K01091] [EC:3.1.3.18]
Rmet_1586  prpC; 2-methylcitrate synthase [KO:K01659] [EC:2.3.3.5]
Rmet_1632  garR; tartronate semialdehyde reductase [KO:K00042] [EC:1.1.1.60]
Rmet_1672  [KO:K17865] [EC:4.2.1.55]
Rmet_2048  odhL; dihydrolipoamide dehydrogenase (E3 component) [KO:K00382] [EC:1.8.1.4]
Rmet_2236  purU; formyltetrahydrofolate hydrolase [KO:K01433] [EC:3.5.1.10]
Rmet_2270  acs; acetyl-CoA synthetase [KO:K01895] [EC:6.2.1.1]
Rmet_2398  [KO:K00382] [EC:1.8.1.4]
Rmet_2438  gph; phosphoglycolate phosphatase [KO:K01091] [EC:3.1.3.18]
Rmet_2446  tiaE; 2-keto-D-gluconate reductase (glyoxalate reductase) (2-ketoaldonate reductase) [KO:K00090] [EC:1.1.1.79 1.1.1.81 1.1.1.215]
Rmet_2481  gltA; citrate synthase [KO:K01647] [EC:2.3.3.1]
Rmet_2489  mdh; malate dehydrogenase [KO:K00024] [EC:1.1.1.37]
Rmet_2492  acnA2; aconitate hydratase 1 [KO:K27802]
Rmet_2513  [KO:K05825] [EC:2.6.1.-]
Rmet_2680  glyA; serine hydroxymethyltransferase [KO:K00600] [EC:2.1.2.1]
Rmet_2758  fdhC; Formate dehydrogenase subunit C [KO:K00127]
Rmet_2760  fdhB; formate dehydrogenase iron-sulfur subunit [KO:K00124]
Rmet_2761  fdhA; formate dehydrogenase alpha subunit (Fe4S4 domain) [KO:K00123] [EC:1.17.1.9]
Rmet_2821  garR; 2-hydroxy-3-oxopropionate reductase (Tartronate semialdehyde reductase) [KO:K00042] [EC:1.1.1.60]
Rmet_2850  hutG1; N-Formylglutamate amidohydrolase [KO:K01458] [EC:3.5.1.68]
Rmet_2926  glcD; glycolate oxidase subunit, FAD-linked [KO:K00104] [EC:1.1.99.14]
Rmet_2928  glcE; glycolate oxidase FAD binding subunit [KO:K11472] [EC:1.1.99.14]
Rmet_2929  glcF; glycolate oxidase iron-sulfur subunit [KO:K11473] [EC:1.1.99.14]
Rmet_3177  cbbZ2; phosphoglycolate phosphatase (PGP) [KO:K01091] [EC:3.1.3.18]
Rmet_3448  gcl; glyoxylate carboligase [KO:K01608] [EC:4.1.1.47]
Rmet_3449  hyi; hydroxypyruvate isomerase [KO:K01816] [EC:5.3.1.22]
Rmet_3450  glxR; tartronate semialdehyde reductase, NADH-dependent [KO:K00042] [EC:1.1.1.60]
Rmet_3451  ttuD2; hydroxypyruvate reductase [KO:K11529] [EC:2.7.1.165]
Rmet_3480  gcvT; aminomethyltransferase, tetrahydrofolate-dependent, subunit (T protein) of glycine cleavage complex [KO:K00605] [EC:2.1.2.10]
Rmet_3481  gcvH; glycine cleavage complex lipoylprotein [KO:K02437]
Rmet_3482  gcvP; glycine decarboxylase, PLP-dependent, subunit (protein P) of glycine cleavage complex [KO:K00281] [EC:1.4.4.2]
Rmet_3805  [KO:K00626] [EC:2.3.1.9]
Rmet_4216  lpdA2; dihydrolipoamide dehydrogenase [KO:K00382] [EC:1.8.1.4]
Rmet_4240  acnA3; aconitate hydratase 1 [KO:K27802]
Rmet_4268  citA; citrate synthase [KO:K01647] [EC:2.3.3.1]
Rmet_4361  frc; formyl-CoA transferase, NAD(P)-binding, CaiB/BaiF family [KO:K07749] [EC:2.8.3.16]
Rmet_4413  [KO:K00626] [EC:2.3.1.9]
Rmet_4428  [KO:K14449] [EC:4.2.1.148]
Rmet_4737  aceA; Isocitrate lyase [KO:K01637] [EC:4.1.3.1 4.1.3.30]
Rmet_4768  eda; 2-keto-3-deoxy-phosphogluconate aldolase [KO:K01625] [EC:4.1.2.14 4.1.3.42]
Rmet_4888  lpdA; dihydrolipoamide dehydrogenase [KO:K00382] [EC:1.8.1.4]
Rmet_4946  [KO:K01647] [EC:2.3.3.1]
Rmet_5123  phaB3; acetoacetyl-CoA reductase [KO:K00023] [EC:1.1.1.36]
Rmet_5296  acnB; bifunctional aconitate hydratase 2/2-methylisocitrate dehydratase [KO:K01682] [EC:4.2.1.3 4.2.1.99]
Rmet_5380  [KO:K01647] [EC:2.3.3.1]
Rmet_5499  [KO:K00626] [EC:2.3.1.9]
Rmet_5510  [KO:K00626] [EC:2.3.1.9]
Rmet_5540  [KO:K00626] [EC:2.3.1.9]
Rmet_5576  [KO:K05825] [EC:2.6.1.-]
Rmet_5599  katA; catalase [KO:K03781] [EC:1.11.1.6]
Rmet_5630  sgaA; Serine-glyoxylate aminotransferase (SGAT) [KO:K00830] [EC:2.6.1.44 2.6.1.45 2.6.1.51]
Rmet_5743  [KO:K01895] [EC:6.2.1.1]
Rmet_6545  [KO:K07130] [EC:3.5.1.9]
Compound
C00007  Oxygen
C00011  CO2
C00014  Ammonia
C00022  Pyruvate
C00024  Acetyl-CoA
C00025  L-Glutamate
C00026  2-Oxoglutarate
C00027  Hydrogen peroxide
C00033  Acetate
C00036  Oxaloacetate
C00037  Glycine
C00042  Succinate
C00048  Glyoxylate
C00049  L-Aspartate
C00058  Formate
C00064  L-Glutamine
C00065  L-Serine
C00091  Succinyl-CoA
C00100  Propanoyl-CoA
C00111  Glycerone phosphate
C00136  Butanoyl-CoA
C00149  (S)-Malate
C00158  Citrate
C00160  Glycolate
C00168  Hydroxypyruvate
C00197  3-Phospho-D-glycerate
C00209  Oxalate
C00258  D-Glycerate
C00266  Glycolaldehyde
C00311  Isocitrate
C00313  Oxalyl-CoA
C00332  Acetoacetyl-CoA
C00417  cis-Aconitate
C00552  meso-Tartaric acid
C00631  2-Phospho-D-glycerate
C00683  (S)-Methylmalonyl-CoA
C00798  Formyl-CoA
C00877  Crotonoyl-CoA
C00888  Pentanoyl-CoA
C00898  (R,R)-Tartaric acid
C00975  Dihydroxyfumarate
C00988  2-Phosphoglycolate
C01127  4-Hydroxy-2-oxoglutarate
C01146  2-Hydroxy-3-oxopropanoate
C01182  D-Ribulose 1,5-bisphosphate
C01213  (R)-Methylmalonyl-CoA
C01380  Ethylene glycol
C01732  Mesaconate
C01989  3-Ethylmalate
C01990  3-Oxalomalate
C02123  3-Propylmalate
C02405  Formyl phosphate
C03217  2-Hydroxy-3-oxoadipate
C03459  2-Hydroxy-3-oxosuccinate
C03548  trans-2,3-Epoxysuccinate
C03561  (R)-3-Hydroxybutanoyl-CoA
C03618  L-threo-3-Methylaspartate
C04348  L-Malyl-CoA
C05840  Iminoaspartate
C06027  L-erythro-3-Methylmalyl-CoA
C06028  2-Methylfumaryl-CoA
C06049  N-Formylderivatives
C18026  (2S)-Ethylmalonyl-CoA
C18324  (2S)-Methylsuccinyl-CoA
C19838  D-erythro-3-Hydroxyaspartate
C20238  (2R)-Ethylmalonyl-CoA
C22337  D-Ribulose 1-phosphate
Reference
PMID:10978349
  Authors
Njau RK, Herndon CA, Hawes JW.
  Title
Novel beta-hydroxyacid dehydrogenases in Escherichia coli and Haemophilus influenzae.
  Journal
J Biol Chem 275:38780-6 (2000)
DOI:10.1074/jbc.M007432200
Reference
PMID:18065535
  Authors
Zarzycki J, Schlichting A, Strychalsky N, Muller M, Alber BE, Fuchs G
  Title
Mesaconyl-coenzyme A hydratase, a new enzyme of two central carbon metabolic pathways in bacteria.
  Journal
J Bacteriol 190:1366-74 (2008)
DOI:10.1128/JB.01621-07
Reference
PMID:18819910
  Authors
Erb TJ, Retey J, Fuchs G, Alber BE
  Title
Ethylmalonyl-CoA mutase from Rhodobacter sphaeroides defines a new subclade of coenzyme B12-dependent acyl-CoA mutases.
  Journal
J Biol Chem 283:32283-93 (2008)
DOI:10.1074/jbc.M805527200
Reference
PMID:9596633
  Authors
Coschigano KT, Melo-Oliveira R, Lim J, Coruzzi GM
  Title
Arabidopsis gls mutants and distinct Fd-GOGAT genes. Implications for photorespiration and primary nitrogen assimilation.
  Journal
Plant Cell 10:741-52 (1998)
DOI:10.1105/tpc.10.5.741
Reference
PMID:16407450
  Authors
Masclaux-Daubresse C, Reisdorf-Cren M, Pageau K, Lelandais M, Grandjean O, Kronenberger J, Valadier MH, Feraud M, Jouglet T, Suzuki A
  Title
Glutamine synthetase-glutamate synthase pathway and glutamate dehydrogenase play distinct roles in the sink-source nitrogen cycle in tobacco.
  Journal
Plant Physiol 140:444-56 (2006)
DOI:10.1104/pp.105.071910
Reference
PMID:21252347
  Authors
Khomyakova M, Bukmez O, Thomas LK, Erb TJ, Berg IA
  Title
A methylaspartate cycle in haloarchaea.
  Journal
Science 331:334-7 (2011)
DOI:10.1126/science.1196544
Reference
PMID:11513957
  Authors
Serrano JA, Bonete MJ
  Title
Sequencing, phylogenetic and transcriptional analysis of the glyoxylate bypass operon (ace) in the halophilic archaeon Haloferax volcanii.
  Journal
Biochim Biophys Acta 1520:154-62 (2001)
DOI:10.1016/S0167-4781(01)00263-9
Related
pathway
rme00010  Glycolysis / Gluconeogenesis
rme00020  Citrate cycle (TCA cycle)
rme00030  Pentose phosphate pathway
rme00053  Ascorbate and aldarate metabolism
rme00071  Fatty acid degradation
rme00230  Purine metabolism
rme00250  Alanine, aspartate and glutamate metabolism
rme00260  Glycine, serine and threonine metabolism
rme00270  Cysteine and methionine metabolism
rme00620  Pyruvate metabolism
rme00710  Carbon fixation by Calvin cycle
rme00750  Vitamin B6 metabolism
rme00910  Nitrogen metabolism
KO pathway
ko00630   

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