KEGG   PATHWAY: ron00260
Entry
ron00260                    Pathway                                
Name
Glycine, serine and threonine metabolism - Raoultella ornithinolytica S12
Description
Serine is derived from 3-phospho-D-glycerate, an intermediate of glycolysis [MD:M00020], and glycine is derived from serine. Threonine is an essential amino acid, which animals cannot synthesize. In bacteria and plants, threonine is derived from aspartate [MD:M00018].
Class
Metabolism; Amino acid metabolism
Pathway map
ron00260  Glycine, serine and threonine metabolism
ron00260

Module
ron_M00018  Threonine biosynthesis, aspartate => homoserine => threonine [PATH:ron00260]
ron_M00020  Serine biosynthesis, glycerate-3P => serine [PATH:ron00260]
ron_M00338  Cysteine biosynthesis, homocysteine + serine => cysteine [PATH:ron00260]
ron_M00621  Glycine cleavage system [PATH:ron00260]
Other DBs
GO: 0006544 0006563 0070178 0006566
Organism
Raoultella ornithinolytica S12 [GN:ron]
Gene
TE10_03675  aspartate kinase [KO:K00928] [EC:2.7.2.4]
TE10_05790  thrA; aspartate kinase [KO:K12524] [EC:2.7.2.4 1.1.1.3]
TE10_02815  metL; aspartate kinase [KO:K12525] [EC:2.7.2.4 1.1.1.3]
TE10_00585  aspartate-semialdehyde dehydrogenase [KO:K00133] [EC:1.2.1.11]
TE10_05795  serine kinase [KO:K00872] [EC:2.7.1.39]
TE10_05800  threonine synthase [KO:K01733] [EC:4.2.3.1]
TE10_10245  threonine aldolase [KO:K01620] [EC:4.1.2.48]
TE10_21235  serine hydroxymethyltransferase [KO:K00600] [EC:2.1.2.1]
TE10_11185  ghrA; bifunctional glyoxylate/hydroxypyruvate reductase A [KO:K12972] [EC:1.1.1.79 1.1.1.81]
TE10_21720  2-hydroxyacid dehydrogenase [KO:K12972] [EC:1.1.1.79 1.1.1.81]
TE10_01210  bifunctional glyoxylate/hydroxypyruvate reductase B [KO:K00090] [EC:1.1.1.79 1.1.1.81 1.1.1.215]
TE10_22595  glycerate kinase [KO:K00865] [EC:2.7.1.165]
TE10_24660  glycerate kinase [KO:K00865] [EC:2.7.1.165]
TE10_15275  hydroxypyruvate reductase [KO:K11529] [EC:2.7.1.165]
TE10_09600  gpmA; phosphoglyceromutase [KO:K01834] [EC:5.4.2.11]
TE10_05750  phosphoglycerate mutase [KO:K15634] [EC:5.4.2.11]
TE10_01480  phosphoglyceromutase [KO:K15633] [EC:5.4.2.12]
TE10_23320  3-phosphoglycerate dehydrogenase [KO:K00058] [EC:1.1.1.95 1.1.1.399]
TE10_23645  D-3-phosphoglycerate dehydrogenase [KO:K00058] [EC:1.1.1.95 1.1.1.399]
TE10_08995  dihydrofolate reductase [KO:K00058] [EC:1.1.1.95 1.1.1.399]
TE10_10405  3-phosphoserine/phosphohydroxythreonine aminotransferase [KO:K00831] [EC:2.6.1.52]
TE10_05715  serB; phosphoserine phosphatase [KO:K01079] [EC:3.1.3.3]
TE10_15600  malonic semialdehyde reductase [KO:K16066] [EC:1.1.1.381 1.1.1.-]
TE10_01505  2-amino-3-ketobutyrate CoA ligase [KO:K00639] [EC:2.3.1.29]
TE10_01500  tdh; L-threonine 3-dehydrogenase [KO:K00060] [EC:1.1.1.103]
TE10_12980  tynA; tyramine oxidase [KO:K00276] [EC:1.4.3.21]
TE10_23595  glycine dehydrogenase [KO:K00281] [EC:1.4.4.2]
TE10_23605  gcvT; glycine cleavage system protein T [KO:K00605] [EC:2.1.2.10]
TE10_14415  dihydrolipoamide dehydrogenase [KO:K00382] [EC:1.8.1.4]
TE10_06350  dihydrolipoamide dehydrogenase [KO:K00382] [EC:1.8.1.4]
TE10_23600  glycine cleavage system protein H [KO:K02437]
TE10_21415  pssA; phosphatidylserine synthase [KO:K00998] [EC:2.7.8.8]
TE10_24010  cystathionine beta-synthase [KO:K01697] [EC:4.2.1.22]
TE10_24015  cystathionine beta-lyase [KO:K01758] [EC:4.4.1.1]
TE10_18160  serine dehydratase [KO:K01752] [EC:4.3.1.17]
TE10_22655  serine dehydratase [KO:K01752] [EC:4.3.1.17]
TE10_11810  serine dehydratase [KO:K01752] [EC:4.3.1.17]
TE10_02980  threonine dehydratase [KO:K01754] [EC:4.3.1.19]
TE10_02105  D-serine dehydratase [KO:K01753] [EC:4.3.1.18]
TE10_05510  aldolase [KO:K01753] [EC:4.3.1.18]
TE10_22970  racemase [KO:K25316] [EC:5.1.1.10]
TE10_12440  tryptophan synthase subunit alpha [KO:K01695] [EC:4.2.1.20]
TE10_12445  tryptophan synthase subunit beta [KO:K01696] [EC:4.2.1.20]
TE10_14135  diaminobutyrate--2-oxoglutarate aminotransferase [KO:K00836] [EC:2.6.1.76]
TE10_14130  2,4-diaminobutyrate decarboxylase [KO:K13745] [EC:4.1.1.86]
Compound
C00011  CO2
C00014  Ammonia
C00022  Pyruvate
C00037  Glycine
C00048  Glyoxylate
C00049  L-Aspartate
C00065  L-Serine
C00078  L-Tryptophan
C00097  L-Cysteine
C00101  Tetrahydrofolate
C00109  2-Oxobutanoate
C00114  Choline
C00143  5,10-Methylenetetrahydrofolate
C00168  Hydroxypyruvate
C00188  L-Threonine
C00197  3-Phospho-D-glycerate
C00213  Sarcosine
C00258  D-Glycerate
C00263  L-Homoserine
C00300  Creatine
C00430  5-Aminolevulinate
C00441  L-Aspartate 4-semialdehyde
C00546  Methylglyoxal
C00576  Betaine aldehyde
C00581  Guanidinoacetate
C00631  2-Phospho-D-glycerate
C00719  Betaine
C00740  D-Serine
C00986  1,3-Diaminopropane
C01005  O-Phospho-L-serine
C01026  N,N-Dimethylglycine
C01102  O-Phospho-L-homoserine
C01242  [Protein]-S8-aminomethyldihydrolipoyllysine
C01888  Aminoacetone
C02051  Lipoylprotein
C02291  L-Cystathionine
C02737  Phosphatidylserine
C02972  Dihydrolipoylprotein
C03082  4-Phospho-L-aspartate
C03194  (R)-1-Aminopropan-2-ol
C03232  3-Phosphonooxypyruvate
C03283  L-2,4-Diaminobutanoate
C03508  L-2-Amino-3-oxobutanoic acid
C05519  L-Allothreonine
C06231  Ectoine
C06442  N(gamma)-Acetyldiaminobutyrate
C16432  5-Hydroxyectoine
C19929  N(alpha)-Acetyl-L-2,4-diaminobutyrate
Reference
  Authors
Nishizuka Y, Seyama Y, Ikai A, Ishimura Y, Kawaguchi A (eds).
  Title
[Cellular Functions and Metabolic Maps] (In Japanese)
  Journal
Tokyo Kagaku Dojin (1997)
Reference
PMID:11823218
  Authors
Kuhlmann AU, Bremer E.
  Title
Osmotically regulated synthesis of the compatible solute ectoine in Bacillus pasteurii and related Bacillus spp.
  Journal
Appl Environ Microbiol 68:772-83 (2002)
DOI:10.1128/AEM.68.2.772-783.2002
Reference
PMID:10473374
  Authors
Canovas D, Borges N, Vargas C, Ventosa A, Nieto JJ, Santos H.
  Title
Role of Ngamma-acetyldiaminobutyrate as an enzyme stabilizer and an intermediate in the biosynthesis of hydroxyectoine.
  Journal
Appl Environ Microbiol 65:3774-9 (1999)
DOI:10.1128/AEM.65.9.3774-3779.1999
Reference
PMID:17636255
  Authors
Bursy J, Pierik AJ, Pica N, Bremer E.
  Title
Osmotically induced synthesis of the compatible solute hydroxyectoine is mediated by an evolutionarily conserved ectoine hydroxylase.
  Journal
J Biol Chem 282:31147-55 (2007)
DOI:10.1074/jbc.M704023200
Reference
PMID:16707670
  Authors
Garcia-Estepa R, Argandona M, Reina-Bueno M, Capote N, Iglesias-Guerra F, Nieto JJ, Vargas C.
  Title
The ectD gene, which is involved in the synthesis of the compatible solute hydroxyectoine, is essential for thermoprotection of the halophilic bacterium Chromohalobacter salexigens.
  Journal
J Bacteriol 188:3774-84 (2006)
DOI:10.1128/JB.00136-06
Reference
PMID:15470257
  Authors
Arevalo-Rodriguez M, Pan X, Boeke JD, Heitman J
  Title
FKBP12 controls aspartate pathway flux in Saccharomyces cerevisiae to prevent toxic intermediate accumulation.
  Journal
Eukaryot Cell 3:1287-96 (2004)
DOI:10.1128/EC.3.5.1287-1296.2004
Reference
PMID:7639721
  Authors
Rees WD, Hay SM
  Title
The biosynthesis of threonine by mammalian cells: expression of a complete bacterial biosynthetic pathway in an animal cell.
  Journal
Biochem J 309 ( Pt 3):999-1007 (1995)
DOI:10.1042/bj3090999
Reference
PMID:11341914
  Authors
Jacques SL, Nieman C, Bareich D, Broadhead G, Kinach R, Honek JF, Wright GD
  Title
Characterization of yeast homoserine dehydrogenase, an antifungal target: the invariant histidine 309 is important for enzyme integrity.
  Journal
Biochim Biophys Acta 1544:28-41 (2001)
DOI:10.1016/S0167-4838(00)00203-X
Reference
PMID:15520012
  Authors
Chen X, Jhee KH, Kruger WD
  Title
Production of the neuromodulator H2S by cystathionine beta-synthase via the condensation of cysteine and homocysteine.
  Journal
J Biol Chem 279:52082-6 (2004)
DOI:10.1074/jbc.C400481200
Related
pathway
ron00010  Glycolysis / Gluconeogenesis
ron00020  Citrate cycle (TCA cycle)
ron00230  Purine metabolism
ron00250  Alanine, aspartate and glutamate metabolism
ron00270  Cysteine and methionine metabolism
ron00290  Valine, leucine and isoleucine biosynthesis
ron00300  Lysine biosynthesis
ron00330  Arginine and proline metabolism
ron00460  Cyanoamino acid metabolism
ron00470  D-Amino acid metabolism
ron00564  Glycerophospholipid metabolism
ron00600  Sphingolipid metabolism
ron00620  Pyruvate metabolism
ron00630  Glyoxylate and dicarboxylate metabolism
ron00640  Propanoate metabolism
ron00680  Methane metabolism
ron00860  Porphyrin metabolism
ron00920  Sulfur metabolism
KO pathway
ko00260   
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