KEGG   PATHWAY: rot00260
Entry
rot00260                    Pathway                                
Name
Glycine, serine and threonine metabolism - Roseivivax sp. THAF197b
Description
Serine is derived from 3-phospho-D-glycerate, an intermediate of glycolysis [MD:M00020], and glycine is derived from serine. Threonine is an essential amino acid, which animals cannot synthesize. In bacteria and plants, threonine is derived from aspartate [MD:M00018].
Class
Metabolism; Amino acid metabolism
Pathway map
rot00260  Glycine, serine and threonine metabolism
rot00260

Module
rot_M00020  Serine biosynthesis, glycerate-3P => serine [PATH:rot00260]
rot_M00033  Ectoine biosynthesis, aspartate => ectoine [PATH:rot00260]
rot_M00555  Betaine biosynthesis, choline => betaine [PATH:rot00260]
rot_M00621  Glycine cleavage system [PATH:rot00260]
Other DBs
GO: 0006544 0006563 0070178 0006566
Organism
Roseivivax sp. THAF197b [GN:rot]
Gene
FIV09_15475  thrA; Bifunctional aspartokinase/homoserine dehydrogenase 1 [KO:K00928] [EC:2.7.2.4]
FIV09_05925  lysC; Aspartokinase [KO:K00928] [EC:2.7.2.4]
FIV09_00690  asd2; Aspartate-semialdehyde dehydrogenase 2 [KO:K00133] [EC:1.2.1.11]
FIV09_07365  hom; Homoserine dehydrogenase [KO:K00003] [EC:1.1.1.3]
FIV09_14850  thrC; Threonine synthase [KO:K01733] [EC:4.2.3.1]
FIV09_16675  ltaE; Low specificity L-threonine aldolase [KO:K01620] [EC:4.1.2.48]
FIV09_03005  glyA1; Serine hydroxymethyltransferase 1 [KO:K00600] [EC:2.1.2.1]
FIV09_12740  Soluble hydrogenase 42 kDa subunit [KO:K00830] [EC:2.6.1.44 2.6.1.45 2.6.1.51]
FIV09_07300  Soluble hydrogenase 42 kDa subunit [KO:K00830] [EC:2.6.1.44 2.6.1.45 2.6.1.51]
FIV09_01540  ghrA; Glyoxylate/hydroxypyruvate reductase A [KO:K12972] [EC:1.1.1.79 1.1.1.81]
FIV09_07135  ttuD2; Putative hydroxypyruvate reductase [KO:K11529] [EC:2.7.1.165]
FIV09_02570  ttuD1; Putative hydroxypyruvate reductase [KO:K11529] [EC:2.7.1.165]
FIV09_00610  gpmI; 2,3-bisphosphoglycerate-independent phosphoglycerate mutase [KO:K15633] [EC:5.4.2.12]
FIV09_00970  serA; D-3-phosphoglycerate dehydrogenase [KO:K00058] [EC:1.1.1.95 1.1.1.399]
FIV09_00965  serC; Phosphoserine aminotransferase [KO:K00831] [EC:2.6.1.52]
FIV09_00960  serB; Phosphoserine phosphatase [KO:K01079] [EC:3.1.3.3]
FIV09_11250  hemA1; 5-aminolevulinate synthase [KO:K00643] [EC:2.3.1.37]
FIV09_18215  hemA2; 5-aminolevulinate synthase [KO:K00643] [EC:2.3.1.37]
FIV09_04530  gcvP; Glycine dehydrogenase (decarboxylating) [KO:K00281] [EC:1.4.4.2]
FIV09_04520  gcvT1; Aminomethyltransferase [KO:K00605] [EC:2.1.2.10]
FIV09_01315  lpd3; Dihydrolipoyl dehydrogenase 3 [KO:K00382] [EC:1.8.1.4]
FIV09_00385  lpdA; Dihydrolipoyl dehydrogenase [KO:K00382] [EC:1.8.1.4]
FIV09_04525  gcvH; Glycine cleavage system H protein [KO:K02437]
FIV09_17195  Creatinase [KO:K08688] [EC:3.5.3.3]
FIV09_14920  CDP-alcohol phosphatidyltransferase [KO:K17103] [EC:2.7.8.8]
FIV09_06100  betA; Oxygen-dependent choline dehydrogenase [KO:K00108] [EC:1.1.99.1]
FIV09_12230  phdK; 2-formylbenzoate dehydrogenase [KO:K00130] [EC:1.2.1.8]
FIV09_06095  betB; NAD/NADP-dependent betaine aldehyde dehydrogenase [KO:K00130] [EC:1.2.1.8]
FIV09_01580  mlr1; 4-methylaminobutanoate oxidase (formaldehyde-forming) [KO:K00315] [EC:1.5.8.4]
FIV09_11760  gcvT2; Aminomethyltransferase [KO:K00302] [EC:1.5.3.24 1.5.3.1]
FIV09_11750  soxB; Sarcosine oxidase subunit beta [KO:K00303] [EC:1.5.3.24 1.5.3.1]
FIV09_11765  Sarcosine oxidase, gamma subunit family [KO:K00305] [EC:1.5.3.24 1.5.3.1]
FIV09_11755  Sarcosine oxidase, delta subunit family [KO:K00304] [EC:1.5.3.24 1.5.3.1]
FIV09_04330  tdcG; L-serine dehydratase TdcG [KO:K01752] [EC:4.3.1.17]
FIV09_17740  ilvA; L-threonine dehydratase biosynthetic IlvA [KO:K01754] [EC:4.3.1.19]
FIV09_13575  tdcB2; L-threonine dehydratase catabolic TdcB [KO:K01754] [EC:4.3.1.19]
FIV09_13190  trpA; Tryptophan synthase alpha chain [KO:K01695] [EC:4.2.1.20]
FIV09_13200  trpB; Tryptophan synthase beta chain [KO:K01696] [EC:4.2.1.20]
FIV09_15465  ectB; Diaminobutyrate--2-oxoglutarate transaminase [KO:K00836] [EC:2.6.1.76]
FIV09_15460  ectA; L-2,4-diaminobutyric acid acetyltransferase [KO:K06718] [EC:2.3.1.178]
FIV09_15470  ectC; L-ectoine synthase [KO:K06720] [EC:4.2.1.108]
FIV09_16800  Creatinase [KO:K15783] [EC:3.5.4.44]
FIV09_17800  tpa3; Taurine--pyruvate aminotransferase [KO:K15785] [EC:2.6.1.76]
FIV09_17805  gabD; Succinate-semialdehyde dehydrogenase [NADP(+)] GabD [KO:K15786] [EC:1.2.1.-]
Compound
C00011  CO2
C00014  Ammonia
C00022  Pyruvate
C00037  Glycine
C00048  Glyoxylate
C00049  L-Aspartate
C00065  L-Serine
C00078  L-Tryptophan
C00097  L-Cysteine
C00101  Tetrahydrofolate
C00109  2-Oxobutanoate
C00114  Choline
C00143  5,10-Methylenetetrahydrofolate
C00168  Hydroxypyruvate
C00188  L-Threonine
C00197  3-Phospho-D-glycerate
C00213  Sarcosine
C00258  D-Glycerate
C00263  L-Homoserine
C00300  Creatine
C00430  5-Aminolevulinate
C00441  L-Aspartate 4-semialdehyde
C00546  Methylglyoxal
C00576  Betaine aldehyde
C00581  Guanidinoacetate
C00631  2-Phospho-D-glycerate
C00719  Betaine
C00740  D-Serine
C00986  1,3-Diaminopropane
C01005  O-Phospho-L-serine
C01026  N,N-Dimethylglycine
C01102  O-Phospho-L-homoserine
C01242  [Protein]-S8-aminomethyldihydrolipoyllysine
C01888  Aminoacetone
C02051  Lipoylprotein
C02291  L-Cystathionine
C02737  Phosphatidylserine
C02972  Dihydrolipoylprotein
C03082  4-Phospho-L-aspartate
C03194  (R)-1-Aminopropan-2-ol
C03232  3-Phosphonooxypyruvate
C03283  L-2,4-Diaminobutanoate
C03508  L-2-Amino-3-oxobutanoic acid
C05519  L-Allothreonine
C06231  Ectoine
C06442  N(gamma)-Acetyldiaminobutyrate
C16432  5-Hydroxyectoine
C19929  N(alpha)-Acetyl-L-2,4-diaminobutyrate
Reference
  Authors
Nishizuka Y, Seyama Y, Ikai A, Ishimura Y, Kawaguchi A (eds).
  Title
[Cellular Functions and Metabolic Maps] (In Japanese)
  Journal
Tokyo Kagaku Dojin (1997)
Reference
PMID:11823218
  Authors
Kuhlmann AU, Bremer E.
  Title
Osmotically regulated synthesis of the compatible solute ectoine in Bacillus pasteurii and related Bacillus spp.
  Journal
Appl Environ Microbiol 68:772-83 (2002)
DOI:10.1128/AEM.68.2.772-783.2002
Reference
PMID:10473374
  Authors
Canovas D, Borges N, Vargas C, Ventosa A, Nieto JJ, Santos H.
  Title
Role of Ngamma-acetyldiaminobutyrate as an enzyme stabilizer and an intermediate in the biosynthesis of hydroxyectoine.
  Journal
Appl Environ Microbiol 65:3774-9 (1999)
DOI:10.1128/AEM.65.9.3774-3779.1999
Reference
PMID:17636255
  Authors
Bursy J, Pierik AJ, Pica N, Bremer E.
  Title
Osmotically induced synthesis of the compatible solute hydroxyectoine is mediated by an evolutionarily conserved ectoine hydroxylase.
  Journal
J Biol Chem 282:31147-55 (2007)
DOI:10.1074/jbc.M704023200
Reference
PMID:16707670
  Authors
Garcia-Estepa R, Argandona M, Reina-Bueno M, Capote N, Iglesias-Guerra F, Nieto JJ, Vargas C.
  Title
The ectD gene, which is involved in the synthesis of the compatible solute hydroxyectoine, is essential for thermoprotection of the halophilic bacterium Chromohalobacter salexigens.
  Journal
J Bacteriol 188:3774-84 (2006)
DOI:10.1128/JB.00136-06
Reference
PMID:15470257
  Authors
Arevalo-Rodriguez M, Pan X, Boeke JD, Heitman J
  Title
FKBP12 controls aspartate pathway flux in Saccharomyces cerevisiae to prevent toxic intermediate accumulation.
  Journal
Eukaryot Cell 3:1287-96 (2004)
DOI:10.1128/EC.3.5.1287-1296.2004
Reference
PMID:7639721
  Authors
Rees WD, Hay SM
  Title
The biosynthesis of threonine by mammalian cells: expression of a complete bacterial biosynthetic pathway in an animal cell.
  Journal
Biochem J 309 ( Pt 3):999-1007 (1995)
DOI:10.1042/bj3090999
Reference
PMID:11341914
  Authors
Jacques SL, Nieman C, Bareich D, Broadhead G, Kinach R, Honek JF, Wright GD
  Title
Characterization of yeast homoserine dehydrogenase, an antifungal target: the invariant histidine 309 is important for enzyme integrity.
  Journal
Biochim Biophys Acta 1544:28-41 (2001)
DOI:10.1016/S0167-4838(00)00203-X
Reference
PMID:15520012
  Authors
Chen X, Jhee KH, Kruger WD
  Title
Production of the neuromodulator H2S by cystathionine beta-synthase via the condensation of cysteine and homocysteine.
  Journal
J Biol Chem 279:52082-6 (2004)
DOI:10.1074/jbc.C400481200
Related
pathway
rot00010  Glycolysis / Gluconeogenesis
rot00020  Citrate cycle (TCA cycle)
rot00230  Purine metabolism
rot00250  Alanine, aspartate and glutamate metabolism
rot00270  Cysteine and methionine metabolism
rot00290  Valine, leucine and isoleucine biosynthesis
rot00300  Lysine biosynthesis
rot00330  Arginine and proline metabolism
rot00460  Cyanoamino acid metabolism
rot00470  D-Amino acid metabolism
rot00564  Glycerophospholipid metabolism
rot00600  Sphingolipid metabolism
rot00620  Pyruvate metabolism
rot00630  Glyoxylate and dicarboxylate metabolism
rot00640  Propanoate metabolism
rot00680  Methane metabolism
rot00860  Porphyrin metabolism
rot00920  Sulfur metabolism
KO pathway
ko00260   
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