KEGG   PATHWAY: sall00260
Entry
sall00260                   Pathway                                
Name
Glycine, serine and threonine metabolism - Streptomyces noursei ZPM
Description
Serine is derived from 3-phospho-D-glycerate, an intermediate of glycolysis [MD:M00020], and glycine is derived from serine. Threonine is an essential amino acid, which animals cannot synthesize. In bacteria and plants, threonine is derived from aspartate [MD:M00018].
Class
Metabolism; Amino acid metabolism
Pathway map
sall00260  Glycine, serine and threonine metabolism
sall00260

Module
sall_M00018  Threonine biosynthesis, aspartate => homoserine => threonine [PATH:sall00260]
sall_M00020  Serine biosynthesis, glycerate-3P => serine [PATH:sall00260]
sall_M00033  Ectoine biosynthesis, aspartate => ectoine [PATH:sall00260]
sall_M00338  Cysteine biosynthesis, homocysteine + serine => cysteine [PATH:sall00260]
sall_M00621  Glycine cleavage system [PATH:sall00260]
Other DBs
GO: 0006544 0006563 0070178 0006566
Organism
Streptomyces noursei ZPM [GN:sall]
Gene
SAZ_23895  aspartokinase [KO:K00928] [EC:2.7.2.4]
SAZ_16860  aspartate-semialdehyde dehydrogenase [KO:K00133] [EC:1.2.1.11]
SAZ_23900  aspartate-semialdehyde dehydrogenase [KO:K00133] [EC:1.2.1.11]
SAZ_28935  homoserine dehydrogenase [KO:K00003] [EC:1.1.1.3]
SAZ_28945  homoserine kinase [KO:K00872] [EC:2.7.1.39]
SAZ_36825  threonine synthase [KO:K01733] [EC:4.2.3.1]
SAZ_28940  threonine synthase [KO:K01733] [EC:4.2.3.1]
SAZ_09955  pyridoxal-5'-phosphate-dependent protein subunit beta [KO:K01733] [EC:4.2.3.1]
SAZ_25605  threonine synthase [KO:K01733] [EC:4.2.3.1]
SAZ_09745  threonine aldolase [KO:K01620] [EC:4.1.2.48]
SAZ_26850  serine hydroxymethyltransferase [KO:K00600] [EC:2.1.2.1]
SAZ_28985  serine hydroxymethyltransferase [KO:K00600] [EC:2.1.2.1]
SAZ_29575  serine hydroxymethyltransferase [KO:K00600] [EC:2.1.2.1]
SAZ_01595  serine--glyoxylate aminotransferase [KO:K00830] [EC:2.6.1.44 2.6.1.45 2.6.1.51]
SAZ_33425  glycerate kinase [KO:K00865] [EC:2.7.1.165]
SAZ_25245  gpmA; phosphoglyceromutase [KO:K01834] [EC:5.4.2.11]
SAZ_23770  hypothetical protein [KO:K15634] [EC:5.4.2.11]
SAZ_35855  2-hydroxyacid dehydrogenase [KO:K00058] [EC:1.1.1.95 1.1.1.399]
SAZ_29825  3-phosphoglycerate dehydrogenase [KO:K00058] [EC:1.1.1.95 1.1.1.399]
SAZ_25895  phosphoserine aminotransferase [KO:K00831] [EC:2.6.1.52]
SAZ_22665  hydrolase [KO:K01079] [EC:3.1.3.3]
SAZ_12895  phosphoserine phosphatase [KO:K01079] [EC:3.1.3.3]
SAZ_07915  2-amino-3-ketobutyrate CoA ligase [KO:K00639] [EC:2.3.1.29]
SAZ_07920  tdh; L-threonine 3-dehydrogenase [KO:K00060] [EC:1.1.1.103]
SAZ_08845  glycine dehydrogenase [KO:K00281] [EC:1.4.4.2]
SAZ_29585  glycine cleavage system protein T [KO:K00605] [EC:2.1.2.10]
SAZ_04950  dihydrolipoyl dehydrogenase [KO:K00382] [EC:1.8.1.4]
SAZ_14645  dihydrolipoamide dehydrogenase [KO:K00382] [EC:1.8.1.4]
SAZ_29580  glycine cleavage system protein H [KO:K02437]
SAZ_35100  amino acid oxidase [KO:K00273] [EC:1.4.3.3]
SAZ_40100  serine/threonine protein kinase [KO:K00613] [EC:2.1.4.1]
SAZ_33430  phosphatidylserine synthase [KO:K17103] [EC:2.7.8.8]
SAZ_34800  betaine-aldehyde dehydrogenase [KO:K00130] [EC:1.2.1.8]
SAZ_26745  betaine-aldehyde dehydrogenase [KO:K00130] [EC:1.2.1.8]
SAZ_00815  aldehyde dehydrogenase [KO:K00130] [EC:1.2.1.8]
SAZ_30495  gamma-aminobutyraldehyde dehydrogenase [KO:K00130] [EC:1.2.1.8]
SAZ_30520  gamma-aminobutyraldehyde dehydrogenase [KO:K00130] [EC:1.2.1.8]
SAZ_07405  sarcosine dehydrogenase [KO:K00309] [EC:1.5.3.10]
SAZ_07400  methyltryptophan oxidase [KO:K00301] [EC:1.5.3.1]
SAZ_04785  type 11 methyltransferase [KO:K18896] [EC:2.1.1.156]
SAZ_18740  cystathionine beta-synthase [KO:K01697] [EC:4.2.1.22]
SAZ_39735  cystathionine beta-synthase [KO:K01697] [EC:4.2.1.22]
SAZ_22690  cystathionine gamma-lyase [KO:K01758] [EC:4.4.1.1]
SAZ_29570  serine dehydratase [KO:K01752] [EC:4.3.1.17]
SAZ_08480  threonine dehydratase [KO:K01754] [EC:4.3.1.19]
SAZ_27375  threonine dehydratase [KO:K01754] [EC:4.3.1.19]
SAZ_40210  threonine dehydratase [KO:K01754] [EC:4.3.1.19]
SAZ_05020  aspartate racemase [KO:K25316] [EC:5.1.1.10]
SAZ_13890  tryptophan synthase subunit alpha [KO:K01695] [EC:4.2.1.20]
SAZ_32700  tryptophan synthase subunit alpha [KO:K01695] [EC:4.2.1.20]
SAZ_13895  tryptophan synthase subunit beta [KO:K01696] [EC:4.2.1.20]
SAZ_06460  tryptophan synthase subunit beta [KO:K06001] [EC:4.2.1.20]
SAZ_13190  diadenosine tetraphosphatase [KO:K00836] [EC:2.6.1.76]
SAZ_12500  2,4-diaminobutyrate 4-aminotransferase [KO:K00836] [EC:2.6.1.76]
SAZ_13185  2,4-diaminobutyric acid acetyltransferase [KO:K06718] [EC:2.3.1.178]
SAZ_13195  ectC; ectoine synthase [KO:K06720] [EC:4.2.1.108]
SAZ_13200  multidrug DMT transporter permease [KO:K10674] [EC:1.14.11.55]
SAZ_12105  pyridoxal-dependent decarboxylase [KO:K13745] [EC:4.1.1.86]
SAZ_13770  amino acid decarboxylase [KO:K13745] [EC:4.1.1.86]
Compound
C00011  CO2
C00014  Ammonia
C00022  Pyruvate
C00037  Glycine
C00048  Glyoxylate
C00049  L-Aspartate
C00065  L-Serine
C00078  L-Tryptophan
C00097  L-Cysteine
C00101  Tetrahydrofolate
C00109  2-Oxobutanoate
C00114  Choline
C00143  5,10-Methylenetetrahydrofolate
C00168  Hydroxypyruvate
C00188  L-Threonine
C00197  3-Phospho-D-glycerate
C00213  Sarcosine
C00258  D-Glycerate
C00263  L-Homoserine
C00300  Creatine
C00430  5-Aminolevulinate
C00441  L-Aspartate 4-semialdehyde
C00546  Methylglyoxal
C00576  Betaine aldehyde
C00581  Guanidinoacetate
C00631  2-Phospho-D-glycerate
C00719  Betaine
C00740  D-Serine
C00986  1,3-Diaminopropane
C01005  O-Phospho-L-serine
C01026  N,N-Dimethylglycine
C01102  O-Phospho-L-homoserine
C01242  [Protein]-S8-aminomethyldihydrolipoyllysine
C01888  Aminoacetone
C02051  Lipoylprotein
C02291  L-Cystathionine
C02737  Phosphatidylserine
C02972  Dihydrolipoylprotein
C03082  4-Phospho-L-aspartate
C03194  (R)-1-Aminopropan-2-ol
C03232  3-Phosphonooxypyruvate
C03283  L-2,4-Diaminobutanoate
C03508  L-2-Amino-3-oxobutanoic acid
C05519  L-Allothreonine
C06231  Ectoine
C06442  N(gamma)-Acetyldiaminobutyrate
C16432  5-Hydroxyectoine
C19929  N(alpha)-Acetyl-L-2,4-diaminobutyrate
Reference
  Authors
Nishizuka Y, Seyama Y, Ikai A, Ishimura Y, Kawaguchi A (eds).
  Title
[Cellular Functions and Metabolic Maps] (In Japanese)
  Journal
Tokyo Kagaku Dojin (1997)
Reference
PMID:11823218
  Authors
Kuhlmann AU, Bremer E.
  Title
Osmotically regulated synthesis of the compatible solute ectoine in Bacillus pasteurii and related Bacillus spp.
  Journal
Appl Environ Microbiol 68:772-83 (2002)
DOI:10.1128/AEM.68.2.772-783.2002
Reference
PMID:10473374
  Authors
Canovas D, Borges N, Vargas C, Ventosa A, Nieto JJ, Santos H.
  Title
Role of Ngamma-acetyldiaminobutyrate as an enzyme stabilizer and an intermediate in the biosynthesis of hydroxyectoine.
  Journal
Appl Environ Microbiol 65:3774-9 (1999)
DOI:10.1128/AEM.65.9.3774-3779.1999
Reference
PMID:17636255
  Authors
Bursy J, Pierik AJ, Pica N, Bremer E.
  Title
Osmotically induced synthesis of the compatible solute hydroxyectoine is mediated by an evolutionarily conserved ectoine hydroxylase.
  Journal
J Biol Chem 282:31147-55 (2007)
DOI:10.1074/jbc.M704023200
Reference
PMID:16707670
  Authors
Garcia-Estepa R, Argandona M, Reina-Bueno M, Capote N, Iglesias-Guerra F, Nieto JJ, Vargas C.
  Title
The ectD gene, which is involved in the synthesis of the compatible solute hydroxyectoine, is essential for thermoprotection of the halophilic bacterium Chromohalobacter salexigens.
  Journal
J Bacteriol 188:3774-84 (2006)
DOI:10.1128/JB.00136-06
Reference
PMID:15470257
  Authors
Arevalo-Rodriguez M, Pan X, Boeke JD, Heitman J
  Title
FKBP12 controls aspartate pathway flux in Saccharomyces cerevisiae to prevent toxic intermediate accumulation.
  Journal
Eukaryot Cell 3:1287-96 (2004)
DOI:10.1128/EC.3.5.1287-1296.2004
Reference
PMID:7639721
  Authors
Rees WD, Hay SM
  Title
The biosynthesis of threonine by mammalian cells: expression of a complete bacterial biosynthetic pathway in an animal cell.
  Journal
Biochem J 309 ( Pt 3):999-1007 (1995)
DOI:10.1042/bj3090999
Reference
PMID:11341914
  Authors
Jacques SL, Nieman C, Bareich D, Broadhead G, Kinach R, Honek JF, Wright GD
  Title
Characterization of yeast homoserine dehydrogenase, an antifungal target: the invariant histidine 309 is important for enzyme integrity.
  Journal
Biochim Biophys Acta 1544:28-41 (2001)
DOI:10.1016/S0167-4838(00)00203-X
Reference
PMID:15520012
  Authors
Chen X, Jhee KH, Kruger WD
  Title
Production of the neuromodulator H2S by cystathionine beta-synthase via the condensation of cysteine and homocysteine.
  Journal
J Biol Chem 279:52082-6 (2004)
DOI:10.1074/jbc.C400481200
Related
pathway
sall00010  Glycolysis / Gluconeogenesis
sall00020  Citrate cycle (TCA cycle)
sall00230  Purine metabolism
sall00250  Alanine, aspartate and glutamate metabolism
sall00270  Cysteine and methionine metabolism
sall00290  Valine, leucine and isoleucine biosynthesis
sall00300  Lysine biosynthesis
sall00330  Arginine and proline metabolism
sall00460  Cyanoamino acid metabolism
sall00470  D-Amino acid metabolism
sall00564  Glycerophospholipid metabolism
sall00600  Sphingolipid metabolism
sall00620  Pyruvate metabolism
sall00630  Glyoxylate and dicarboxylate metabolism
sall00640  Propanoate metabolism
sall00680  Methane metabolism
sall00860  Porphyrin metabolism
sall00920  Sulfur metabolism
KO pathway
ko00260   
LinkDB

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